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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TGM3
Full Name:
Protein-glutamine gamma-glutamyltransferase E
Alias:
Transglutaminase E;Transglutaminase-3
Type:
Mass (Da):
76632
Number AA:
693
UniProt ID:
Q08188
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T22
F
N
R
Q
A
H
H
T
D
K
F
S
S
Q
E
Site 2
S27
H
H
T
D
K
F
S
S
Q
E
L
I
L
R
R
Site 3
S59
E
R
L
E
F
I
V
S
T
G
P
Y
P
S
E
Site 4
S65
V
S
T
G
P
Y
P
S
E
S
A
M
T
K
A
Site 5
T70
Y
P
S
E
S
A
M
T
K
A
V
F
P
L
S
Site 6
S77
T
K
A
V
F
P
L
S
N
G
S
S
G
G
W
Site 7
S85
N
G
S
S
G
G
W
S
A
V
L
Q
A
S
N
Site 8
T95
L
Q
A
S
N
G
N
T
L
T
I
S
I
S
S
Site 9
T97
A
S
N
G
N
T
L
T
I
S
I
S
S
P
A
Site 10
S99
N
G
N
T
L
T
I
S
I
S
S
P
A
S
A
Site 11
Y111
A
S
A
P
I
G
R
Y
T
M
A
L
Q
I
F
Site 12
T112
S
A
P
I
G
R
Y
T
M
A
L
Q
I
F
S
Site 13
S125
F
S
Q
G
G
I
S
S
V
K
L
G
T
F
I
Site 14
Y155
N
H
A
E
R
E
E
Y
V
Q
E
D
A
G
I
Site 15
S196
C
L
S
I
L
D
R
S
L
N
F
R
R
D
A
Site 16
T205
N
F
R
R
D
A
A
T
D
V
A
S
R
N
D
Site 17
Y215
A
S
R
N
D
P
K
Y
V
G
R
V
L
S
A
Site 18
S221
K
Y
V
G
R
V
L
S
A
M
I
N
S
N
D
Site 19
S238
G
V
L
A
G
N
W
S
G
T
Y
T
G
G
R
Site 20
Y241
A
G
N
W
S
G
T
Y
T
G
G
R
D
P
R
Site 21
T242
G
N
W
S
G
T
Y
T
G
G
R
D
P
R
S
Site 22
S249
T
G
G
R
D
P
R
S
W
N
G
S
V
E
I
Site 23
S253
D
P
R
S
W
N
G
S
V
E
I
L
K
N
W
Site 24
S266
N
W
K
K
S
G
F
S
P
V
R
Y
G
Q
C
Site 25
T295
G
I
P
S
R
V
I
T
N
F
N
S
A
H
D
Site 26
T303
N
F
N
S
A
H
D
T
D
R
N
L
S
V
D
Site 27
S308
H
D
T
D
R
N
L
S
V
D
V
Y
Y
D
P
Site 28
Y312
R
N
L
S
V
D
V
Y
Y
D
P
M
G
N
P
Site 29
Y313
N
L
S
V
D
V
Y
Y
D
P
M
G
N
P
L
Site 30
S324
G
N
P
L
D
K
G
S
D
S
V
W
N
F
H
Site 31
S341
N
E
G
W
F
V
R
S
D
L
G
P
S
Y
G
Site 32
Y347
R
S
D
L
G
P
S
Y
G
G
W
Q
V
L
D
Site 33
T356
G
W
Q
V
L
D
A
T
P
Q
E
R
S
Q
G
Site 34
S361
D
A
T
P
Q
E
R
S
Q
G
V
F
Q
C
G
Site 35
Y402
A
D
R
I
T
W
L
Y
D
N
T
T
G
K
Q
Site 36
S424
H
T
I
G
R
Y
I
S
T
K
A
V
G
S
N
Site 37
S430
I
S
T
K
A
V
G
S
N
A
R
M
D
V
T
Site 38
T437
S
N
A
R
M
D
V
T
D
K
Y
K
Y
P
E
Site 39
Y440
R
M
D
V
T
D
K
Y
K
Y
P
E
G
S
D
Site 40
Y442
D
V
T
D
K
Y
K
Y
P
E
G
S
D
Q
E
Site 41
S446
K
Y
K
Y
P
E
G
S
D
Q
E
R
Q
V
F
Site 42
T464
L
G
K
L
K
P
N
T
P
F
A
A
T
S
S
Site 43
S482
E
T
E
E
Q
E
P
S
I
I
G
K
L
K
V
Site 44
T512
L
K
N
L
S
R
D
T
K
T
V
T
V
N
M
Site 45
T514
N
L
S
R
D
T
K
T
V
T
V
N
M
T
A
Site 46
T516
S
R
D
T
K
T
V
T
V
N
M
T
A
W
T
Site 47
S538
V
H
E
V
W
K
D
S
A
T
M
S
L
D
P
Site 48
T540
E
V
W
K
D
S
A
T
M
S
L
D
P
E
E
Site 49
S542
W
K
D
S
A
T
M
S
L
D
P
E
E
E
A
Site 50
Y560
I
K
I
S
Y
A
Q
Y
E
K
Y
L
K
S
D
Site 51
Y563
S
Y
A
Q
Y
E
K
Y
L
K
S
D
N
M
I
Site 52
S635
C
V
L
M
V
E
G
S
G
L
L
L
G
N
L
Site 53
T648
N
L
K
I
D
V
P
T
L
G
P
K
E
G
S
Site 54
S664
V
R
F
D
I
L
P
S
R
S
G
T
K
Q
L
Site 55
T668
I
L
P
S
R
S
G
T
K
Q
L
L
A
D
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation