KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
PPP3CA
Full Name:
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
Alias:
Calcineurin A subunit alpha isoform; CALNA; CAM-PRP catalytic subunit; CAN; EC 3.1.3.16; P2BA; PP2BA; PP2B-alpha
Type:
Protein-serine phosphatase
Mass (Da):
58688
Number AA:
521
UniProt ID:
Q08209
International Prot ID:
IPI00179415
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005955
GO:0005829
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0005516
GO:0005506
PhosphoSite+
KinaseNET
Biological Process:
GO:0006470
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T14
I
D
P
K
L
S
T
T
D
R
V
V
K
A
V
Site 2
S26
K
A
V
P
F
P
P
S
H
R
L
T
A
K
E
Site 3
T30
F
P
P
S
H
R
L
T
A
K
E
V
F
D
N
Site 4
S59
K
E
G
R
L
E
E
S
V
A
L
R
I
I
T
Site 5
S107
K
L
F
E
V
G
G
S
P
A
N
T
R
Y
L
Site 6
T111
V
G
G
S
P
A
N
T
R
Y
L
F
L
G
D
Site 7
Y113
G
S
P
A
N
T
R
Y
L
F
L
G
D
Y
V
Site 8
Y119
R
Y
L
F
L
G
D
Y
V
D
R
G
Y
F
S
Site 9
Y159
E
C
R
H
L
T
E
Y
F
T
F
K
Q
E
C
Site 10
Y170
K
Q
E
C
K
I
K
Y
S
E
R
V
Y
D
A
Site 11
Y175
I
K
Y
S
E
R
V
Y
D
A
C
M
D
A
F
Site 12
Y224
R
F
K
E
P
P
A
Y
G
P
M
C
D
I
L
Site 13
Y258
N
T
V
R
G
C
S
Y
F
Y
S
Y
P
A
V
Site 14
Y288
H
E
A
Q
D
A
G
Y
R
M
Y
R
K
S
Q
Site 15
Y291
Q
D
A
G
Y
R
M
Y
R
K
S
Q
T
T
G
Site 16
S294
G
Y
R
M
Y
R
K
S
Q
T
T
G
F
P
S
Site 17
T297
M
Y
R
K
S
Q
T
T
G
F
P
S
L
I
T
Site 18
Y311
T
I
F
S
A
P
N
Y
L
D
V
Y
N
N
K
Site 19
Y315
A
P
N
Y
L
D
V
Y
N
N
K
A
A
V
L
Site 20
Y324
N
K
A
A
V
L
K
Y
E
N
N
V
M
N
I
Site 21
S373
V
N
V
L
N
I
C
S
D
D
E
L
G
S
E
Site 22
S379
C
S
D
D
E
L
G
S
E
E
D
G
F
D
G
Site 23
S411
G
K
M
A
R
V
F
S
V
L
R
E
E
S
E
Site 24
S417
F
S
V
L
R
E
E
S
E
S
V
L
T
L
K
Site 25
S419
V
L
R
E
E
S
E
S
V
L
T
L
K
G
L
Site 26
T422
E
E
S
E
S
V
L
T
L
K
G
L
T
P
T
Site 27
T427
V
L
T
L
K
G
L
T
P
T
G
M
L
P
S
Site 28
S434
T
P
T
G
M
L
P
S
G
V
L
S
G
G
K
Site 29
S438
M
L
P
S
G
V
L
S
G
G
K
Q
T
L
Q
Site 30
T443
V
L
S
G
G
K
Q
T
L
Q
S
A
T
V
E
Site 31
S462
D
E
A
I
K
G
F
S
P
Q
H
K
I
T
S
Site 32
S469
S
P
Q
H
K
I
T
S
F
E
E
A
K
G
L
Site 33
S492
P
R
R
D
A
M
P
S
D
A
N
L
N
S
I
Site 34
S498
P
S
D
A
N
L
N
S
I
N
K
A
L
T
S
Site 35
S505
S
I
N
K
A
L
T
S
E
T
N
G
T
D
S
Site 36
T510
L
T
S
E
T
N
G
T
D
S
N
G
S
N
S
Site 37
S512
S
E
T
N
G
T
D
S
N
G
S
N
S
S
N
Site 38
S515
N
G
T
D
S
N
G
S
N
S
S
N
I
Q
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation