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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DHX9
Full Name:
ATP-dependent RNA helicase A
Alias:
DDX9; DEAH (Asp-Glu-Ala-His) box polypeptide 9; DEAH-box protein 9; LKP; NDH II; NDH2; Nuclear DNA helicase II; RHA
Type:
Helicase; Nuclear receptor co-regulator; RNA processing; EC 3.6.1.-; RNA binding protein
Mass (Da):
140958
Number AA:
1270
UniProt ID:
Q08211
International Prot ID:
IPI00844578
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
GO:0005634
GO:0005730
Uniprot
OncoNet
Molecular Function:
GO:0000166
GO:0003676
GO:0003677
PhosphoSite+
KinaseNET
Biological Process:
GO:0000375
GO:0000377
GO:0000398
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y9
G
D
V
K
N
F
L
Y
A
W
C
G
K
R
K
Site 2
T18
W
C
G
K
R
K
M
T
P
S
Y
E
I
R
A
Site 3
S20
G
K
R
K
M
T
P
S
Y
E
I
R
A
V
G
Site 4
Y21
K
R
K
M
T
P
S
Y
E
I
R
A
V
G
N
Site 5
Y43
C
E
V
Q
V
E
G
Y
N
Y
T
G
M
G
N
Site 6
Y45
V
Q
V
E
G
Y
N
Y
T
G
M
G
N
S
T
Site 7
Y68
A
A
R
D
F
V
N
Y
L
V
R
I
N
E
I
Site 8
S87
V
P
A
F
G
V
A
S
P
P
P
L
T
D
T
Site 9
T92
V
A
S
P
P
P
L
T
D
T
P
D
T
T
A
Site 10
T94
S
P
P
P
L
T
D
T
P
D
T
T
A
N
A
Site 11
T97
P
L
T
D
T
P
D
T
T
A
N
A
E
G
D
Site 12
T98
L
T
D
T
P
D
T
T
A
N
A
E
G
D
L
Site 13
T107
N
A
E
G
D
L
P
T
T
M
G
G
P
L
P
Site 14
T108
A
E
G
D
L
P
T
T
M
G
G
P
L
P
P
Site 15
S125
A
L
K
A
E
N
N
S
E
V
G
A
S
G
Y
Site 16
S130
N
N
S
E
V
G
A
S
G
Y
G
V
P
G
P
Site 17
Y132
S
E
V
G
A
S
G
Y
G
V
P
G
P
T
W
Site 18
T138
G
Y
G
V
P
G
P
T
W
D
R
G
A
N
L
Site 19
Y148
R
G
A
N
L
K
D
Y
Y
S
R
K
E
E
Q
Site 20
Y149
G
A
N
L
K
D
Y
Y
S
R
K
E
E
Q
E
Site 21
S150
A
N
L
K
D
Y
Y
S
R
K
E
E
Q
E
V
Site 22
T160
E
E
Q
E
V
Q
A
T
L
E
S
E
E
V
D
Site 23
S163
E
V
Q
A
T
L
E
S
E
E
V
D
L
N
A
Site 24
T177
A
G
L
H
G
N
W
T
L
E
N
A
K
A
R
Site 25
Y188
A
K
A
R
L
N
Q
Y
F
Q
K
E
K
I
Q
Site 26
Y200
K
I
Q
G
E
Y
K
Y
T
Q
V
G
P
D
H
Site 27
T201
I
Q
G
E
Y
K
Y
T
Q
V
G
P
D
H
N
Site 28
S210
V
G
P
D
H
N
R
S
F
I
A
E
M
T
I
Site 29
T216
R
S
F
I
A
E
M
T
I
Y
I
K
Q
L
G
Site 30
Y218
F
I
A
E
M
T
I
Y
I
K
Q
L
G
R
R
Site 31
Y251
L
S
L
V
R
Q
L
Y
H
L
G
V
V
E
A
Site 32
Y259
H
L
G
V
V
E
A
Y
S
G
L
T
K
K
K
Site 33
T270
T
K
K
K
E
G
E
T
V
E
P
Y
K
V
N
Site 34
Y274
E
G
E
T
V
E
P
Y
K
V
N
L
S
Q
D
Site 35
S279
E
P
Y
K
V
N
L
S
Q
D
L
E
H
Q
L
Site 36
S321
K
L
A
Q
F
E
P
S
Q
R
Q
N
Q
V
G
Site 37
S333
Q
V
G
V
V
P
W
S
P
P
Q
S
N
W
N
Site 38
T356
E
G
P
L
A
F
A
T
P
E
Q
I
S
M
D
Site 39
S449
V
T
Q
P
R
R
I
S
A
V
S
V
A
E
R
Site 40
S452
P
R
R
I
S
A
V
S
V
A
E
R
V
A
F
Site 41
S468
R
G
E
E
P
G
K
S
C
G
Y
S
V
R
F
Site 42
Y471
E
P
G
K
S
C
G
Y
S
V
R
F
E
S
I
Site 43
S472
P
G
K
S
C
G
Y
S
V
R
F
E
S
I
L
Site 44
S477
G
Y
S
V
R
F
E
S
I
L
P
R
P
H
A
Site 45
Y564
N
C
P
I
I
E
V
Y
G
R
T
Y
P
V
Q
Site 46
Y568
I
E
V
Y
G
R
T
Y
P
V
Q
E
Y
F
L
Site 47
Y573
R
T
Y
P
V
Q
E
Y
F
L
E
D
C
I
Q
Site 48
Y616
N
L
I
C
G
D
E
Y
G
P
E
T
R
L
S
Site 49
T620
G
D
E
Y
G
P
E
T
R
L
S
M
S
Q
L
Site 50
S623
Y
G
P
E
T
R
L
S
M
S
Q
L
N
E
K
Site 51
S625
P
E
T
R
L
S
M
S
Q
L
N
E
K
E
T
Site 52
T632
S
Q
L
N
E
K
E
T
P
F
E
L
I
E
A
Site 53
Y664
L
P
G
W
N
L
I
Y
T
M
Q
K
H
L
E
Site 54
Y681
P
H
F
G
S
H
R
Y
Q
I
L
P
L
H
S
Site 55
S688
Y
Q
I
L
P
L
H
S
Q
I
P
R
E
E
Q
Site 56
Y748
A
H
N
N
M
T
N
Y
A
T
V
W
A
S
K
Site 57
T787
A
R
F
E
R
L
E
T
H
M
T
P
E
M
F
Site 58
T790
E
R
L
E
T
H
M
T
P
E
M
F
R
T
P
Site 59
T796
M
T
P
E
M
F
R
T
P
L
H
E
I
A
L
Site 60
Y902
N
E
G
K
R
L
G
Y
I
H
R
N
F
A
G
Site 61
S913
N
F
A
G
N
R
F
S
D
H
V
A
L
L
S
Site 62
T949
H
K
R
L
N
M
A
T
L
R
M
T
W
E
A
Site 63
T953
N
M
A
T
L
R
M
T
W
E
A
K
V
Q
L
Site 64
T1015
E
K
R
K
I
L
T
T
E
G
R
N
A
L
I
Site 65
S1025
R
N
A
L
I
H
K
S
S
V
N
C
P
F
S
Site 66
S1026
N
A
L
I
H
K
S
S
V
N
C
P
F
S
S
Site 67
S1032
S
S
V
N
C
P
F
S
S
Q
D
M
K
Y
P
Site 68
S1033
S
V
N
C
P
F
S
S
Q
D
M
K
Y
P
S
Site 69
Y1038
F
S
S
Q
D
M
K
Y
P
S
P
F
F
V
F
Site 70
S1040
S
Q
D
M
K
Y
P
S
P
F
F
V
F
G
E
Site 71
T1051
V
F
G
E
K
I
R
T
R
A
I
S
A
K
G
Site 72
S1142
I
R
Q
I
S
R
P
S
A
A
G
I
N
L
M
Site 73
S1152
G
I
N
L
M
I
G
S
T
R
Y
G
D
G
P
Site 74
T1153
I
N
L
M
I
G
S
T
R
Y
G
D
G
P
R
Site 75
Y1155
L
M
I
G
S
T
R
Y
G
D
G
P
R
P
P
Site 76
Y1167
R
P
P
K
M
A
R
Y
D
N
G
S
G
Y
R
Site 77
S1171
M
A
R
Y
D
N
G
S
G
Y
R
R
G
G
S
Site 78
Y1173
R
Y
D
N
G
S
G
Y
R
R
G
G
S
S
Y
Site 79
S1178
S
G
Y
R
R
G
G
S
S
Y
S
G
G
G
Y
Site 80
S1179
G
Y
R
R
G
G
S
S
Y
S
G
G
G
Y
G
Site 81
Y1180
Y
R
R
G
G
S
S
Y
S
G
G
G
Y
G
G
Site 82
S1181
R
R
G
G
S
S
Y
S
G
G
G
Y
G
G
G
Site 83
Y1185
S
S
Y
S
G
G
G
Y
G
G
G
Y
S
S
G
Site 84
Y1189
G
G
G
Y
G
G
G
Y
S
S
G
G
Y
G
S
Site 85
S1190
G
G
Y
G
G
G
Y
S
S
G
G
Y
G
S
G
Site 86
S1191
G
Y
G
G
G
Y
S
S
G
G
Y
G
S
G
G
Site 87
Y1194
G
G
Y
S
S
G
G
Y
G
S
G
G
Y
G
G
Site 88
S1196
Y
S
S
G
G
Y
G
S
G
G
Y
G
G
S
A
Site 89
Y1199
G
G
Y
G
S
G
G
Y
G
G
S
A
N
S
F
Site 90
S1202
G
S
G
G
Y
G
G
S
A
N
S
F
R
A
G
Site 91
S1205
G
Y
G
G
S
A
N
S
F
R
A
G
Y
G
A
Site 92
Y1210
A
N
S
F
R
A
G
Y
G
A
G
V
G
G
G
Site 93
Y1218
G
A
G
V
G
G
G
Y
R
G
V
S
R
G
G
Site 94
S1222
G
G
G
Y
R
G
V
S
R
G
G
F
R
G
N
Site 95
S1230
R
G
G
F
R
G
N
S
G
G
D
Y
R
G
P
Site 96
Y1234
R
G
N
S
G
G
D
Y
R
G
P
S
G
G
Y
Site 97
S1238
G
G
D
Y
R
G
P
S
G
G
Y
R
G
S
G
Site 98
Y1241
Y
R
G
P
S
G
G
Y
R
G
S
G
G
F
Q
Site 99
S1244
P
S
G
G
Y
R
G
S
G
G
F
Q
R
G
G
Site 100
Y1256
R
G
G
G
R
G
A
Y
G
T
G
Y
F
G
Q
Site 101
T1258
G
G
R
G
A
Y
G
T
G
Y
F
G
Q
G
R
Site 102
Y1260
R
G
A
Y
G
T
G
Y
F
G
Q
G
R
G
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation