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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LOXL1
Full Name:
Lysyl oxidase homolog 1
Alias:
EC 1.4.3.-; LOL; Lysyl oxidase-like protein 1
Type:
Extracellular region, Proteinaceous extracellular matrix protein
Mass (Da):
63110
Number AA:
574
UniProt ID:
Q08397
International Prot ID:
IPI00001597
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005615
Uniprot
OncoNet
Molecular Function:
GO:0005507
PhosphoSite+
KinaseNET
Biological Process:
GO:0055114
GO:0018277
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S53
E
N
N
G
Q
V
Y
S
L
L
N
S
G
S
E
Site 2
S57
Q
V
Y
S
L
L
N
S
G
S
E
Y
V
P
A
Site 3
S59
Y
S
L
L
N
S
G
S
E
Y
V
P
A
G
P
Site 4
Y61
L
L
N
S
G
S
E
Y
V
P
A
G
P
Q
R
Site 5
S69
V
P
A
G
P
Q
R
S
E
S
S
S
R
V
L
Site 6
S71
A
G
P
Q
R
S
E
S
S
S
R
V
L
L
A
Site 7
S72
G
P
Q
R
S
E
S
S
S
R
V
L
L
A
G
Site 8
S73
P
Q
R
S
E
S
S
S
R
V
L
L
A
G
A
Site 9
S88
P
Q
A
Q
Q
R
R
S
H
G
S
P
R
R
R
Site 10
S91
Q
Q
R
R
S
H
G
S
P
R
R
R
Q
A
P
Site 11
S99
P
R
R
R
Q
A
P
S
L
P
L
P
G
R
V
Site 12
S108
P
L
P
G
R
V
G
S
D
T
V
R
G
Q
A
Site 13
T110
P
G
R
V
G
S
D
T
V
R
G
Q
A
R
H
Site 14
S136
R
E
V
A
V
G
D
S
T
G
M
A
R
A
R
Site 15
T137
E
V
A
V
G
D
S
T
G
M
A
R
A
R
T
Site 16
T144
T
G
M
A
R
A
R
T
S
V
S
Q
Q
R
H
Site 17
S145
G
M
A
R
A
R
T
S
V
S
Q
Q
R
H
G
Site 18
S147
A
R
A
R
T
S
V
S
Q
Q
R
H
G
G
S
Site 19
S154
S
Q
Q
R
H
G
G
S
A
S
S
V
S
A
S
Site 20
S156
Q
R
H
G
G
S
A
S
S
V
S
A
S
A
F
Site 21
S157
R
H
G
G
S
A
S
S
V
S
A
S
A
F
A
Site 22
S161
S
A
S
S
V
S
A
S
A
F
A
S
T
Y
R
Site 23
S165
V
S
A
S
A
F
A
S
T
Y
R
Q
Q
P
S
Site 24
T166
S
A
S
A
F
A
S
T
Y
R
Q
Q
P
S
Y
Site 25
S172
S
T
Y
R
Q
Q
P
S
Y
P
Q
Q
F
P
Y
Site 26
Y173
T
Y
R
Q
Q
P
S
Y
P
Q
Q
F
P
Y
P
Site 27
Y179
S
Y
P
Q
Q
F
P
Y
P
Q
A
P
F
V
S
Site 28
Y188
Q
A
P
F
V
S
Q
Y
E
N
Y
D
P
A
S
Site 29
Y191
F
V
S
Q
Y
E
N
Y
D
P
A
S
R
T
Y
Site 30
Y198
Y
D
P
A
S
R
T
Y
D
Q
G
F
V
Y
Y
Site 31
Y204
T
Y
D
Q
G
F
V
Y
Y
R
P
A
G
G
G
Site 32
Y205
Y
D
Q
G
F
V
Y
Y
R
P
A
G
G
G
V
Site 33
Y226
V
A
S
A
G
V
I
Y
P
Y
Q
P
R
A
R
Site 34
Y228
S
A
G
V
I
Y
P
Y
Q
P
R
A
R
Y
E
Site 35
Y234
P
Y
Q
P
R
A
R
Y
E
E
Y
G
G
G
E
Site 36
Y246
G
G
E
E
L
P
E
Y
P
P
Q
G
F
Y
P
Site 37
Y252
E
Y
P
P
Q
G
F
Y
P
A
P
E
R
P
Y
Site 38
Y259
Y
P
A
P
E
R
P
Y
V
P
P
P
P
P
P
Site 39
Y274
P
D
G
L
D
R
R
Y
S
H
S
L
Y
S
E
Site 40
S275
D
G
L
D
R
R
Y
S
H
S
L
Y
S
E
G
Site 41
S277
L
D
R
R
Y
S
H
S
L
Y
S
E
G
T
P
Site 42
Y279
R
R
Y
S
H
S
L
Y
S
E
G
T
P
G
F
Site 43
T283
H
S
L
Y
S
E
G
T
P
G
F
E
Q
A
Y
Site 44
Y290
T
P
G
F
E
Q
A
Y
P
D
P
G
P
E
A
Site 45
Y310
G
D
P
R
L
G
W
Y
P
P
Y
A
N
P
P
Site 46
Y313
R
L
G
W
Y
P
P
Y
A
N
P
P
P
E
A
Site 47
Y321
A
N
P
P
P
E
A
Y
G
P
P
R
A
L
E
Site 48
Y331
P
R
A
L
E
P
P
Y
L
P
V
R
S
S
D
Site 49
S336
P
P
Y
L
P
V
R
S
S
D
T
P
P
P
G
Site 50
S337
P
Y
L
P
V
R
S
S
D
T
P
P
P
G
G
Site 51
T339
L
P
V
R
S
S
D
T
P
P
P
G
G
E
R
Site 52
S355
G
A
Q
Q
G
R
L
S
V
G
S
V
Y
R
P
Site 53
S358
Q
G
R
L
S
V
G
S
V
Y
R
P
N
Q
N
Site 54
Y360
R
L
S
V
G
S
V
Y
R
P
N
Q
N
G
R
Site 55
Y378
D
L
V
P
D
P
N
Y
V
Q
A
S
T
Y
V
Site 56
Y384
N
Y
V
Q
A
S
T
Y
V
Q
R
A
H
L
Y
Site 57
S392
V
Q
R
A
H
L
Y
S
L
R
C
A
A
E
E
Site 58
Y414
Y
A
P
E
A
T
D
Y
D
V
R
V
L
L
R
Site 59
Y461
S
M
D
E
F
S
H
Y
D
L
L
D
A
A
T
Site 60
S479
V
A
E
G
H
K
A
S
F
C
L
E
D
S
T
Site 61
Y495
D
F
G
N
L
K
R
Y
A
C
T
S
H
T
Q
Site 62
S499
L
K
R
Y
A
C
T
S
H
T
Q
G
L
S
P
Site 63
T501
R
Y
A
C
T
S
H
T
Q
G
L
S
P
G
C
Site 64
S505
T
S
H
T
Q
G
L
S
P
G
C
Y
D
T
Y
Site 65
Y509
Q
G
L
S
P
G
C
Y
D
T
Y
N
A
D
I
Site 66
Y512
S
P
G
C
Y
D
T
Y
N
A
D
I
D
C
Q
Site 67
Y541
K
V
H
V
N
P
K
Y
I
V
L
E
S
D
F
Site 68
Y559
V
V
R
C
N
I
H
Y
T
G
R
Y
V
S
A
Site 69
T560
V
R
C
N
I
H
Y
T
G
R
Y
V
S
A
T
Site 70
Y563
N
I
H
Y
T
G
R
Y
V
S
A
T
N
C
K
Site 71
S565
H
Y
T
G
R
Y
V
S
A
T
N
C
K
I
V
Site 72
T567
T
G
R
Y
V
S
A
T
N
C
K
I
V
Q
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation