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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PDE4C
Full Name:
cAMP-specific 3',5'-cyclic phosphodiesterase 4C
Alias:
CN4C; DPDE1; PDE21; Phosphodiesterase 4C, cAMP-specific; Phosphodiesterase E1 dunce
Type:
Nucleotide Metabolism - purine; Phosphodiesterase; EC 3.1.4.17
Mass (Da):
79902
Number AA:
712
UniProt ID:
Q08493
International Prot ID:
IPI00298070
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0004115
PhosphoSite+
KinaseNET
Biological Process:
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S14
G
E
G
A
E
A
C
S
R
L
S
R
S
R
G
Site 2
S17
A
E
A
C
S
R
L
S
R
S
R
G
R
H
S
Site 3
S19
A
C
S
R
L
S
R
S
R
G
R
H
S
M
T
Site 4
S24
S
R
S
R
G
R
H
S
M
T
R
A
P
K
H
Site 5
T26
S
R
G
R
H
S
M
T
R
A
P
K
H
L
W
Site 6
Y47
I
R
I
Q
Q
R
F
Y
S
D
P
D
K
S
A
Site 7
S48
R
I
Q
Q
R
F
Y
S
D
P
D
K
S
A
G
Site 8
S53
F
Y
S
D
P
D
K
S
A
G
C
R
E
R
D
Site 9
S62
G
C
R
E
R
D
L
S
P
R
P
E
L
R
K
Site 10
S70
P
R
P
E
L
R
K
S
R
L
S
W
P
V
S
Site 11
S73
E
L
R
K
S
R
L
S
W
P
V
S
S
C
R
Site 12
S77
S
R
L
S
W
P
V
S
S
C
R
R
F
D
L
Site 13
S78
R
L
S
W
P
V
S
S
C
R
R
F
D
L
E
Site 14
S89
F
D
L
E
N
G
L
S
C
G
R
R
A
L
D
Site 15
S99
R
R
A
L
D
P
Q
S
S
P
G
L
G
R
I
Site 16
S100
R
A
L
D
P
Q
S
S
P
G
L
G
R
I
M
Site 17
S114
M
Q
A
P
V
P
H
S
Q
R
R
E
S
F
L
Site 18
S119
P
H
S
Q
R
R
E
S
F
L
Y
R
S
D
S
Site 19
Y122
Q
R
R
E
S
F
L
Y
R
S
D
S
D
Y
E
Site 20
S124
R
E
S
F
L
Y
R
S
D
S
D
Y
E
L
S
Site 21
S126
S
F
L
Y
R
S
D
S
D
Y
E
L
S
P
K
Site 22
Y128
L
Y
R
S
D
S
D
Y
E
L
S
P
K
A
M
Site 23
S131
S
D
S
D
Y
E
L
S
P
K
A
M
S
R
N
Site 24
S136
E
L
S
P
K
A
M
S
R
N
S
S
V
A
S
Site 25
S139
P
K
A
M
S
R
N
S
S
V
A
S
D
L
H
Site 26
S140
K
A
M
S
R
N
S
S
V
A
S
D
L
H
G
Site 27
S143
S
R
N
S
S
V
A
S
D
L
H
G
E
D
M
Site 28
T164
Q
V
L
A
S
L
R
T
V
R
S
N
V
A
A
Site 29
S190
Q
G
P
V
G
N
P
S
S
S
N
Q
L
P
P
Site 30
S191
G
P
V
G
N
P
S
S
S
N
Q
L
P
P
A
Site 31
S192
P
V
G
N
P
S
S
S
N
Q
L
P
P
A
E
Site 32
T225
D
Q
L
E
T
L
Q
T
R
H
S
V
G
E
M
Site 33
S228
E
T
L
Q
T
R
H
S
V
G
E
M
A
S
N
Site 34
S234
H
S
V
G
E
M
A
S
N
K
F
K
R
I
L
Site 35
T246
R
I
L
N
R
E
L
T
H
L
S
E
T
S
R
Site 36
S249
N
R
E
L
T
H
L
S
E
T
S
R
S
G
N
Site 37
S254
H
L
S
E
T
S
R
S
G
N
Q
V
S
E
Y
Site 38
S259
S
R
S
G
N
Q
V
S
E
Y
I
S
R
T
F
Site 39
Y261
S
G
N
Q
V
S
E
Y
I
S
R
T
F
L
D
Site 40
S263
N
Q
V
S
E
Y
I
S
R
T
F
L
D
Q
Q
Site 41
T271
R
T
F
L
D
Q
Q
T
E
V
E
L
P
K
V
Site 42
S288
E
E
A
P
Q
P
M
S
R
I
S
G
L
H
G
Site 43
S291
P
Q
P
M
S
R
I
S
G
L
H
G
L
C
H
Site 44
T314
V
P
R
F
G
V
Q
T
D
Q
E
E
Q
L
A
Site 45
T327
L
A
K
E
L
E
D
T
N
K
W
G
L
D
V
Site 46
T362
Q
E
R
D
L
L
K
T
F
Q
I
P
A
D
T
Site 47
S455
A
L
M
Y
N
D
A
S
V
L
E
N
H
H
L
Site 48
S481
C
D
I
F
Q
N
L
S
A
K
Q
R
L
S
L
Site 49
S487
L
S
A
K
Q
R
L
S
L
R
R
M
V
I
D
Site 50
T499
V
I
D
M
V
L
A
T
D
M
S
K
H
M
N
Site 51
S502
M
V
L
A
T
D
M
S
K
H
M
N
L
L
A
Site 52
T513
N
L
L
A
D
L
K
T
M
V
E
T
K
K
V
Site 53
S548
L
V
H
C
A
D
L
S
N
P
T
K
P
L
P
Site 54
Y557
P
T
K
P
L
P
L
Y
R
Q
W
T
D
R
I
Site 55
T561
L
P
L
Y
R
Q
W
T
D
R
I
M
A
E
F
Site 56
S578
Q
G
D
R
E
R
E
S
G
L
D
I
S
P
M
Site 57
S583
R
E
S
G
L
D
I
S
P
M
C
D
K
H
T
Site 58
T590
S
P
M
C
D
K
H
T
A
S
V
E
K
S
Q
Site 59
S592
M
C
D
K
H
T
A
S
V
E
K
S
Q
V
G
Site 60
S596
H
T
A
S
V
E
K
S
Q
V
G
F
I
D
Y
Site 61
T626
D
A
Q
D
L
L
D
T
L
E
D
N
R
E
W
Site 62
Y634
L
E
D
N
R
E
W
Y
Q
S
K
I
P
R
S
Site 63
S636
D
N
R
E
W
Y
Q
S
K
I
P
R
S
P
S
Site 64
S641
Y
Q
S
K
I
P
R
S
P
S
D
L
T
N
P
Site 65
S643
S
K
I
P
R
S
P
S
D
L
T
N
P
E
R
Site 66
T646
P
R
S
P
S
D
L
T
N
P
E
R
D
G
P
Site 67
T679
E
E
E
E
G
E
E
T
A
L
A
K
E
A
L
Site 68
T691
E
A
L
E
L
P
D
T
E
L
L
S
P
E
A
Site 69
S695
L
P
D
T
E
L
L
S
P
E
A
G
P
D
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation