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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DSC1
Full Name:
Desmocollin-1
Alias:
CDHF1; desmocollin 1; desmocollin-1; desmosomal glycoprotein 2/3; DG2/DG3
Type:
Adhesion protein
Mass (Da):
100045
Number AA:
894
UniProt ID:
Q08554
International Prot ID:
IPI00216099
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030057
GO:0005921
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007156
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y34
C
D
A
C
Q
K
V
Y
L
R
V
P
S
H
L
Site 2
S39
K
V
Y
L
R
V
P
S
H
L
Q
A
E
T
L
Site 3
T45
P
S
H
L
Q
A
E
T
L
V
G
K
V
N
L
Site 4
S58
N
L
E
E
C
L
K
S
A
S
L
I
R
S
S
Site 5
S60
E
E
C
L
K
S
A
S
L
I
R
S
S
D
P
Site 6
S64
K
S
A
S
L
I
R
S
S
D
P
A
F
R
I
Site 7
T80
E
D
G
S
I
Y
T
T
H
D
L
I
L
S
S
Site 8
S86
T
T
H
D
L
I
L
S
S
E
R
K
S
F
S
Site 9
S87
T
H
D
L
I
L
S
S
E
R
K
S
F
S
I
Site 10
S91
I
L
S
S
E
R
K
S
F
S
I
F
L
S
D
Site 11
S93
S
S
E
R
K
S
F
S
I
F
L
S
D
G
Q
Site 12
S97
K
S
F
S
I
F
L
S
D
G
Q
R
R
E
Q
Site 13
S112
Q
E
I
K
V
V
L
S
A
R
E
N
K
S
P
Site 14
S118
L
S
A
R
E
N
K
S
P
K
K
R
H
T
K
Site 15
T124
K
S
P
K
K
R
H
T
K
D
T
A
L
K
R
Site 16
T127
K
K
R
H
T
K
D
T
A
L
K
R
S
K
R
Site 17
S132
K
D
T
A
L
K
R
S
K
R
R
W
A
P
I
Site 18
S443
V
I
N
E
A
Q
F
S
K
A
A
S
S
Q
T
Site 19
Y639
R
Q
R
Q
N
L
D
Y
N
Y
Y
S
V
P
I
Site 20
Y642
Q
N
L
D
Y
N
Y
Y
S
V
P
I
Q
I
K
Site 21
T657
D
R
H
G
L
V
A
T
H
M
L
T
V
R
V
Site 22
S736
A
Q
Q
N
L
I
V
S
N
T
E
G
P
G
E
Site 23
T738
Q
N
L
I
V
S
N
T
E
G
P
G
E
E
V
Site 24
T756
N
I
R
L
P
M
Q
T
S
N
I
C
D
T
S
Site 25
T768
D
T
S
M
S
V
G
T
V
G
G
Q
G
I
K
Site 26
T776
V
G
G
Q
G
I
K
T
Q
Q
S
F
E
M
V
Site 27
S779
Q
G
I
K
T
Q
Q
S
F
E
M
V
K
G
G
Site 28
T788
E
M
V
K
G
G
Y
T
L
D
S
N
K
G
G
Site 29
S791
K
G
G
Y
T
L
D
S
N
K
G
G
G
H
Q
Site 30
T799
N
K
G
G
G
H
Q
T
L
E
S
V
K
G
V
Site 31
S802
G
G
H
Q
T
L
E
S
V
K
G
V
G
Q
G
Site 32
T811
K
G
V
G
Q
G
D
T
G
R
Y
A
Y
T
D
Site 33
Y814
G
Q
G
D
T
G
R
Y
A
Y
T
D
W
Q
S
Site 34
Y816
G
D
T
G
R
Y
A
Y
T
D
W
Q
S
F
T
Site 35
T823
Y
T
D
W
Q
S
F
T
Q
P
R
L
G
E
K
Site 36
Y832
P
R
L
G
E
K
V
Y
L
C
G
Q
D
E
E
Site 37
Y846
E
H
K
H
C
E
D
Y
V
C
S
Y
N
Y
E
Site 38
Y850
C
E
D
Y
V
C
S
Y
N
Y
E
G
K
G
S
Site 39
Y852
D
Y
V
C
S
Y
N
Y
E
G
K
G
S
L
A
Site 40
S857
Y
N
Y
E
G
K
G
S
L
A
G
S
V
G
C
Site 41
S861
G
K
G
S
L
A
G
S
V
G
C
C
S
D
R
Site 42
S866
A
G
S
V
G
C
C
S
D
R
Q
E
E
E
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation