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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PPID
Full Name:
Peptidyl-prolyl cis-trans isomerase D
Alias:
Cyclophilin D; Cyclophilin-40; Cyclophilin-related protein; CYP40; CYP-40; CYPD; EC 5.2.1.8; Peptidylprolyl isomerase D; PPIase; Rotamase
Type:
Enzyme, isomerase
Mass (Da):
40764
Number AA:
370
UniProt ID:
Q08752
International Prot ID:
IPI00003927
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0016018
GO:0031072
GO:0003755
PhosphoSite+
KinaseNET
Biological Process:
GO:0006457
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
P
S
P
Q
A
K
P
S
N
P
S
N
P
R
V
Site 2
T62
E
K
G
I
G
H
T
T
G
K
P
L
H
F
K
Site 3
S88
M
I
Q
G
G
D
F
S
N
Q
N
G
T
G
G
Site 4
Y99
G
T
G
G
E
S
I
Y
G
E
K
F
E
D
E
Site 5
Y110
F
E
D
E
N
F
H
Y
K
H
D
R
E
G
L
Site 6
S119
H
D
R
E
G
L
L
S
M
A
N
A
G
R
N
Site 7
S130
A
G
R
N
T
N
G
S
Q
F
F
I
T
T
V
Site 8
T139
F
F
I
T
T
V
P
T
P
H
L
D
G
K
H
Site 9
S198
G
I
F
P
K
D
G
S
G
D
S
H
P
D
F
Site 10
S201
P
K
D
G
S
G
D
S
H
P
D
F
P
E
D
Site 11
T223
V
D
K
I
L
L
I
T
E
D
L
K
N
I
G
Site 12
Y246
W
E
M
A
I
K
K
Y
A
E
V
L
R
Y
V
Site 13
Y252
K
Y
A
E
V
L
R
Y
V
D
S
S
K
A
V
Site 14
S255
E
V
L
R
Y
V
D
S
S
K
A
V
I
E
T
Site 15
S305
E
A
L
E
L
D
P
S
N
T
K
A
L
Y
R
Site 16
T307
L
E
L
D
P
S
N
T
K
A
L
Y
R
R
A
Site 17
Y311
P
S
N
T
K
A
L
Y
R
R
A
Q
G
W
Q
Site 18
Y365
K
D
K
E
K
A
V
Y
A
K
M
F
A
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation