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Updated November 2019
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Protein Info
Short Name:
ITK
Full Name:
Tyrosine-protein kinase ITK/TSK
Alias:
EC 2.7.10.2; EMT; Lyk; TLK; TSK
Type:
Protein-tyrosine kinase, TK group, Tec family
Mass (Da):
71831
Number AA:
620
UniProt ID:
Q08881
International Prot ID:
IPI00004566
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004715
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006968
GO:0007242
GO:0006468
Phosida
TranscriptoNet
STRING
Kinexus Products
Tyrosine-protein kinase ITK/TSK pan-specific antibody AB-NK274-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NK274-1#Tyrosine-protein kinase ITK/TSK Y512 phosphosite-specific antibody AB-PK666#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK666#Tyrosine-protein kinase ITK/TSK (C594-A613, human) peptide - Powder PE-01BDK85#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01BDK85#Tyrosine-protein kinase ITK/TSK (D509-S515, human) pY512 phosphopeptide - Powder PE-04ANB90#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04ANB90
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S15
E
E
Q
L
I
K
K
S
Q
Q
K
R
R
T
S
Site 2
T21
K
S
Q
Q
K
R
R
T
S
P
S
N
F
K
V
Site 3
S22
S
Q
Q
K
R
R
T
S
P
S
N
F
K
V
R
Site 4
S24
Q
K
R
R
T
S
P
S
N
F
K
V
R
F
F
Site 5
Y40
L
T
K
A
S
L
A
Y
F
E
D
R
H
G
K
Site 6
T50
D
R
H
G
K
K
R
T
L
K
G
S
I
E
L
Site 7
S54
K
K
R
T
L
K
G
S
I
E
L
S
R
I
K
Site 8
Y90
V
H
D
N
Y
L
L
Y
V
F
A
P
D
R
E
Site 9
S98
V
F
A
P
D
R
E
S
R
Q
R
W
V
L
A
Site 10
S115
E
E
T
R
N
N
N
S
L
V
P
K
Y
H
P
Site 11
S134
D
G
K
W
R
C
C
S
Q
L
E
K
L
A
T
Site 12
T141
S
Q
L
E
K
L
A
T
G
C
A
Q
Y
D
P
Site 13
Y146
L
A
T
G
C
A
Q
Y
D
P
T
K
N
A
S
Site 14
T149
G
C
A
Q
Y
D
P
T
K
N
A
S
K
K
P
Site 15
S153
Y
D
P
T
K
N
A
S
K
K
P
L
P
P
T
Site 16
T160
S
K
K
P
L
P
P
T
P
E
D
N
R
R
P
Site 17
Y180
E
T
V
V
I
A
L
Y
D
Y
Q
T
N
D
P
Site 18
Y182
V
V
I
A
L
Y
D
Y
Q
T
N
D
P
Q
E
Site 19
T184
I
A
L
Y
D
Y
Q
T
N
D
P
Q
E
L
A
Site 20
Y198
A
L
R
R
N
E
E
Y
C
L
L
D
S
S
E
Site 21
Y220
D
R
N
G
H
E
G
Y
V
P
S
S
Y
L
V
Site 22
S223
G
H
E
G
Y
V
P
S
S
Y
L
V
E
K
S
Site 23
S224
H
E
G
Y
V
P
S
S
Y
L
V
E
K
S
P
Site 24
Y225
E
G
Y
V
P
S
S
Y
L
V
E
K
S
P
N
Site 25
S230
S
S
Y
L
V
E
K
S
P
N
N
L
E
T
Y
Site 26
T236
K
S
P
N
N
L
E
T
Y
E
W
Y
N
K
S
Site 27
Y237
S
P
N
N
L
E
T
Y
E
W
Y
N
K
S
I
Site 28
S243
T
Y
E
W
Y
N
K
S
I
S
R
D
K
A
E
Site 29
S267
G
A
F
M
V
R
D
S
R
T
A
G
T
Y
T
Site 30
T272
R
D
S
R
T
A
G
T
Y
T
V
S
V
F
T
Site 31
Y273
D
S
R
T
A
G
T
Y
T
V
S
V
F
T
K
Site 32
T274
S
R
T
A
G
T
Y
T
V
S
V
F
T
K
A
Site 33
Y305
T
N
D
N
P
K
R
Y
Y
V
A
E
K
Y
V
Site 34
Y306
N
D
N
P
K
R
Y
Y
V
A
E
K
Y
V
F
Site 35
Y311
R
Y
Y
V
A
E
K
Y
V
F
D
S
I
P
L
Site 36
Y322
S
I
P
L
L
I
N
Y
H
Q
H
N
G
G
G
Site 37
Y336
G
L
V
T
R
L
R
Y
P
V
C
F
G
R
Q
Site 38
S361
G
K
W
V
I
D
P
S
E
L
T
F
V
Q
E
Site 39
T392
K
D
K
V
A
I
K
T
I
R
E
G
A
M
S
Site 40
S399
T
I
R
E
G
A
M
S
E
E
D
F
I
E
E
Site 41
Y446
E
H
G
C
L
S
D
Y
L
R
T
Q
R
G
L
Site 42
Y472
D
V
C
E
G
M
A
Y
L
E
E
A
C
V
I
Site 43
Y512
R
F
V
L
D
D
Q
Y
T
S
S
T
G
T
K
Tyrosine-protein kinase ITK/TSK Y512 phosphosite-specific antibody AB-PK666#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK666#Tyrosine-protein kinase ITK/TSK (D509-S515, human) pY512 phosphopeptide - Powder PE-04ANB90#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04ANB90
Site 44
T513
F
V
L
D
D
Q
Y
T
S
S
T
G
T
K
F
Site 45
S514
V
L
D
D
Q
Y
T
S
S
T
G
T
K
F
P
Site 46
S515
L
D
D
Q
Y
T
S
S
T
G
T
K
F
P
V
Site 47
T518
Q
Y
T
S
S
T
G
T
K
F
P
V
K
W
A
Site 48
S526
K
F
P
V
K
W
A
S
P
E
V
F
S
F
S
Site 49
S531
W
A
S
P
E
V
F
S
F
S
R
Y
S
S
K
Site 50
S533
S
P
E
V
F
S
F
S
R
Y
S
S
K
S
D
Site 51
Y535
E
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
Site 52
S536
V
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
Site 53
S537
F
S
F
S
R
Y
S
S
K
S
D
V
W
S
F
Site 54
S539
F
S
R
Y
S
S
K
S
D
V
W
S
F
G
V
Site 55
S543
S
S
K
S
D
V
W
S
F
G
V
L
M
W
E
Site 56
Y559
F
S
E
G
K
I
P
Y
E
N
R
S
N
S
E
Site 57
S563
K
I
P
Y
E
N
R
S
N
S
E
V
V
E
D
Site 58
S565
P
Y
E
N
R
S
N
S
E
V
V
E
D
I
S
Site 59
S572
S
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
Site 60
T573
E
V
V
E
D
I
S
T
G
F
R
L
Y
K
P
Site 61
Y578
I
S
T
G
F
R
L
Y
K
P
R
L
A
S
T
Site 62
S584
L
Y
K
P
R
L
A
S
T
H
V
Y
Q
I
M
Site 63
Y588
R
L
A
S
T
H
V
Y
Q
I
M
N
H
C
W
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation