KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
SPIRE1
Full Name:
Protein spire homolog 1
Alias:
Protein spire homolog 1: Protein spire homolog 1; Spir-1
Type:
Cytoskeletal protein, actin nucleation factor
Mass (Da):
85554
Number AA:
756
UniProt ID:
Q08AE8
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005856
GO:0048471
Uniprot
OncoNet
Molecular Function:
GO:0003779
PhosphoSite+
KinaseNET
Biological Process:
GO:0006810
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T15
A
G
G
G
E
P
R
T
E
A
V
G
G
E
G
Site 2
S36
A
G
G
A
A
G
G
S
R
D
A
L
S
L
E
Site 3
S41
G
G
S
R
D
A
L
S
L
E
E
I
L
R
L
Site 4
Y49
L
E
E
I
L
R
L
Y
N
Q
P
I
N
E
E
Site 5
S84
Q
P
R
H
R
V
R
S
A
A
Q
I
R
V
W
Site 6
S118
V
A
G
K
L
G
Y
S
Q
C
M
E
T
E
V
Site 7
T123
G
Y
S
Q
C
M
E
T
E
V
I
E
S
L
G
Site 8
Y139
I
I
Y
K
A
L
D
Y
G
L
K
E
N
E
E
Site 9
S150
E
N
E
E
R
E
L
S
P
P
L
E
Q
L
I
Site 10
T163
L
I
D
H
M
A
N
T
V
E
A
D
G
S
N
Site 11
S169
N
T
V
E
A
D
G
S
N
D
E
G
Y
E
A
Site 12
Y174
D
G
S
N
D
E
G
Y
E
A
A
E
E
G
L
Site 13
S191
E
D
E
K
R
K
I
S
A
I
R
S
Y
R
D
Site 14
S195
R
K
I
S
A
I
R
S
Y
R
D
V
M
K
L
Site 15
Y196
K
I
S
A
I
R
S
Y
R
D
V
M
K
L
C
Site 16
S211
A
A
H
L
P
T
E
S
D
A
P
N
H
Y
Q
Site 17
Y217
E
S
D
A
P
N
H
Y
Q
A
V
C
R
A
L
Site 18
T236
M
E
L
H
T
F
L
T
K
I
K
S
A
K
E
Site 19
S240
T
F
L
T
K
I
K
S
A
K
E
N
L
K
K
Site 20
S254
K
I
Q
E
M
E
K
S
D
E
S
S
T
D
L
Site 21
S258
M
E
K
S
D
E
S
S
T
D
L
E
E
L
K
Site 22
Y294
K
K
V
Q
E
R
Q
Y
N
P
L
P
I
E
Y
Site 23
T304
L
P
I
E
Y
Q
L
T
P
Y
E
M
L
M
D
Site 24
T319
D
I
R
C
K
R
Y
T
L
R
K
V
M
V
N
Site 25
S355
R
P
P
L
N
P
V
S
A
R
K
L
K
P
T
Site 26
T362
S
A
R
K
L
K
P
T
P
P
R
P
R
S
L
Site 27
S368
P
T
P
P
R
P
R
S
L
H
E
R
I
L
E
Site 28
S387
E
R
K
L
R
P
V
S
P
E
E
I
R
R
S
Site 29
S394
S
P
E
E
I
R
R
S
R
L
A
M
R
P
L
Site 30
S402
R
L
A
M
R
P
L
S
M
S
Y
S
F
D
L
Site 31
S404
A
M
R
P
L
S
M
S
Y
S
F
D
L
P
D
Site 32
Y405
V
K
A
E
L
E
K
Y
Q
Q
Y
K
D
I
Y
Site 33
S406
R
P
L
S
M
S
Y
S
F
D
L
P
D
V
T
Site 34
T413
S
F
D
L
P
D
V
T
T
P
E
S
T
K
N
Site 35
T414
F
D
L
P
D
V
T
T
P
E
S
T
K
N
L
Site 36
S417
P
D
V
T
T
P
E
S
T
K
N
L
V
E
S
Site 37
S424
S
T
K
N
L
V
E
S
S
M
V
N
G
G
L
Site 38
S425
T
K
N
L
V
E
S
S
M
V
N
G
G
L
T
Site 39
S433
M
V
N
G
G
L
T
S
Q
T
K
E
N
G
L
Site 40
T435
N
G
G
L
T
S
Q
T
K
E
N
G
L
S
T
Site 41
S441
Q
T
K
E
N
G
L
S
T
S
Q
Q
V
P
A
Site 42
T442
T
K
E
N
G
L
S
T
S
Q
Q
V
P
A
Q
Site 43
S443
K
E
N
G
L
S
T
S
Q
Q
V
P
A
Q
R
Site 44
T458
K
K
L
L
R
A
P
T
L
A
E
L
D
S
S
Site 45
S464
P
T
L
A
E
L
D
S
S
E
S
E
E
E
T
Site 46
S465
T
L
A
E
L
D
S
S
E
S
E
E
E
T
L
Site 47
S467
A
E
L
D
S
S
E
S
E
E
E
T
L
H
K
Site 48
T471
S
S
E
S
E
E
E
T
L
H
K
S
T
S
S
Site 49
S475
E
E
E
T
L
H
K
S
T
S
S
S
S
V
S
Site 50
T476
E
E
T
L
H
K
S
T
S
S
S
S
V
S
P
Site 51
S477
E
T
L
H
K
S
T
S
S
S
S
V
S
P
S
Site 52
S478
T
L
H
K
S
T
S
S
S
S
V
S
P
S
F
Site 53
S479
L
H
K
S
T
S
S
S
S
V
S
P
S
F
P
Site 54
S480
H
K
S
T
S
S
S
S
V
S
P
S
F
P
E
Site 55
S482
S
T
S
S
S
S
V
S
P
S
F
P
E
E
P
Site 56
S484
S
S
S
S
V
S
P
S
F
P
E
E
P
V
L
Site 57
S495
E
P
V
L
E
A
V
S
T
R
K
K
P
P
K
Site 58
T496
P
V
L
E
A
V
S
T
R
K
K
P
P
K
F
Site 59
S507
P
P
K
F
L
P
I
S
S
T
P
Q
P
E
R
Site 60
S508
P
K
F
L
P
I
S
S
T
P
Q
P
E
R
R
Site 61
T509
K
F
L
P
I
S
S
T
P
Q
P
E
R
R
Q
Site 62
S523
Q
P
P
Q
R
R
H
S
I
E
K
E
T
P
T
Site 63
T528
R
H
S
I
E
K
E
T
P
T
N
V
R
Q
F
Site 64
T530
S
I
E
K
E
T
P
T
N
V
R
Q
F
L
P
Site 65
S539
V
R
Q
F
L
P
P
S
R
Q
S
S
R
S
L
Site 66
S542
F
L
P
P
S
R
Q
S
S
R
S
L
E
E
F
Site 67
S543
L
P
P
S
R
Q
S
S
R
S
L
E
E
F
C
Site 68
S545
P
S
R
Q
S
S
R
S
L
E
E
F
C
Y
P
Site 69
Y551
R
S
L
E
E
F
C
Y
P
V
E
C
L
A
L
Site 70
Y578
V
K
A
E
L
E
K
Y
Q
Q
Y
K
D
I
Y
Site 71
Y585
Y
Q
Q
Y
K
D
I
Y
T
A
L
K
K
G
K
Site 72
T586
Q
Q
Y
K
D
I
Y
T
A
L
K
K
G
K
L
Site 73
S630
C
K
K
M
R
L
P
S
K
P
Y
S
T
L
P
Site 74
S634
R
L
P
S
K
P
Y
S
T
L
P
I
F
S
L
Site 75
S644
P
I
F
S
L
G
P
S
A
L
Q
R
G
E
S
Site 76
S651
S
A
L
Q
R
G
E
S
S
M
R
S
E
K
P
Site 77
S652
A
L
Q
R
G
E
S
S
M
R
S
E
K
P
S
Site 78
S655
R
G
E
S
S
M
R
S
E
K
P
S
T
A
H
Site 79
S659
S
M
R
S
E
K
P
S
T
A
H
H
R
P
L
Site 80
T660
M
R
S
E
K
P
S
T
A
H
H
R
P
L
R
Site 81
S668
A
H
H
R
P
L
R
S
I
A
R
F
S
S
K
Site 82
S673
L
R
S
I
A
R
F
S
S
K
S
K
S
M
D
Site 83
S674
R
S
I
A
R
F
S
S
K
S
K
S
M
D
K
Site 84
S676
I
A
R
F
S
S
K
S
K
S
M
D
K
S
D
Site 85
S678
R
F
S
S
K
S
K
S
M
D
K
S
D
E
E
Site 86
S682
K
S
K
S
M
D
K
S
D
E
E
L
Q
F
P
Site 87
S710
V
D
C
K
K
F
I
S
E
I
I
S
S
S
R
Site 88
S714
K
F
I
S
E
I
I
S
S
S
R
R
S
L
V
Site 89
S715
F
I
S
E
I
I
S
S
S
R
R
S
L
V
L
Site 90
S716
I
S
E
I
I
S
S
S
R
R
S
L
V
L
A
Site 91
S719
I
I
S
S
S
R
R
S
L
V
L
A
N
K
R
Site 92
T733
R
A
R
L
K
R
K
T
Q
S
F
Y
M
S
S
Site 93
S735
R
L
K
R
K
T
Q
S
F
Y
M
S
S
P
G
Site 94
Y737
K
R
K
T
Q
S
F
Y
M
S
S
P
G
P
S
Site 95
S739
K
T
Q
S
F
Y
M
S
S
P
G
P
S
E
Y
Site 96
S740
T
Q
S
F
Y
M
S
S
P
G
P
S
E
Y
C
Site 97
S744
Y
M
S
S
P
G
P
S
E
Y
C
P
S
E
R
Site 98
S749
G
P
S
E
Y
C
P
S
E
R
T
I
S
E
I
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation