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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
VAC14
Full Name:
Protein VAC14 homolog
Alias:
ArPIKfyve; FLJ10305; Tax1-binding protein 2; TAX1BP2; TRX; Vac14
Type:
Mass (Da):
87973
Number AA:
782
UniProt ID:
Q08AM6
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005783
GO:0010008
GO:0005792
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0004872
PhosphoSite+
KinaseNET
Biological Process:
GO:0044419
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T11
E
K
D
F
A
P
L
T
P
N
I
V
R
A
L
Site 2
Y23
R
A
L
N
D
K
L
Y
E
K
R
K
V
A
A
Site 3
S57
K
H
V
I
Q
T
L
S
Q
E
F
A
L
S
Q
Site 4
S63
L
S
Q
E
F
A
L
S
Q
H
P
H
S
R
K
Site 5
S68
A
L
S
Q
H
P
H
S
R
K
G
G
L
I
G
Site 6
Y90
L
G
K
D
S
G
L
Y
L
K
E
L
I
E
P
Site 7
Y111
D
A
D
S
R
L
R
Y
Y
A
C
E
A
L
Y
Site 8
Y112
A
D
S
R
L
R
Y
Y
A
C
E
A
L
Y
N
Site 9
S140
N
V
L
F
D
G
L
S
K
L
A
A
D
P
D
Site 10
S152
D
P
D
P
N
V
K
S
G
S
E
L
L
D
R
Site 11
T166
R
L
L
K
D
I
V
T
E
S
N
K
F
D
L
Site 12
S168
L
K
D
I
V
T
E
S
N
K
F
D
L
V
S
Site 13
Y185
P
L
L
R
E
R
I
Y
S
N
N
Q
Y
A
R
Site 14
S186
L
L
R
E
R
I
Y
S
N
N
Q
Y
A
R
Q
Site 15
Y190
R
I
Y
S
N
N
Q
Y
A
R
Q
F
I
I
S
Site 16
S252
K
E
I
K
K
N
P
S
S
V
K
F
A
E
M
Site 17
S253
E
I
K
K
N
P
S
S
V
K
F
A
E
M
A
Site 18
Y310
A
V
L
P
C
L
A
Y
D
D
R
K
K
S
I
Site 19
S316
A
Y
D
D
R
K
K
S
I
K
E
V
A
N
V
Site 20
T333
Q
S
L
M
K
L
V
T
P
E
D
D
E
L
D
Site 21
T352
G
Q
R
Q
A
E
P
T
P
D
D
A
L
P
K
Site 22
S365
P
K
Q
E
G
T
A
S
G
G
P
D
G
S
C
Site 23
S371
A
S
G
G
P
D
G
S
C
D
S
S
F
S
S
Site 24
S374
G
P
D
G
S
C
D
S
S
F
S
S
G
I
S
Site 25
S375
P
D
G
S
C
D
S
S
F
S
S
G
I
S
V
Site 26
Y429
L
K
W
L
Y
H
L
Y
I
K
T
P
R
K
M
Site 27
T432
L
Y
H
L
Y
I
K
T
P
R
K
M
F
R
H
Site 28
T440
P
R
K
M
F
R
H
T
D
S
L
F
P
I
L
Site 29
T450
L
F
P
I
L
L
Q
T
L
S
D
E
S
D
E
Site 30
S455
L
Q
T
L
S
D
E
S
D
E
V
I
L
K
D
Site 31
S471
E
V
L
A
E
I
A
S
S
P
A
G
Q
T
D
Site 32
S472
V
L
A
E
I
A
S
S
P
A
G
Q
T
D
D
Site 33
T477
A
S
S
P
A
G
Q
T
D
D
P
G
P
L
D
Site 34
S491
D
G
P
D
L
Q
A
S
H
S
E
L
Q
V
P
Site 35
S493
P
D
L
Q
A
S
H
S
E
L
Q
V
P
T
P
Site 36
T499
H
S
E
L
Q
V
P
T
P
G
R
A
G
L
L
Site 37
T508
G
R
A
G
L
L
N
T
S
G
T
K
G
L
E
Site 38
S509
R
A
G
L
L
N
T
S
G
T
K
G
L
E
C
Site 39
S517
G
T
K
G
L
E
C
S
P
S
T
P
T
M
N
Site 40
S519
K
G
L
E
C
S
P
S
T
P
T
M
N
S
Y
Site 41
T520
G
L
E
C
S
P
S
T
P
T
M
N
S
Y
F
Site 42
Y526
S
T
P
T
M
N
S
Y
F
Y
K
F
M
I
N
Site 43
S539
I
N
L
L
K
R
F
S
S
E
R
K
L
L
E
Site 44
S540
N
L
L
K
R
F
S
S
E
R
K
L
L
E
V
Site 45
T611
N
Q
L
K
D
L
K
T
L
E
S
Q
N
L
F
Site 46
S614
K
D
L
K
T
L
E
S
Q
N
L
F
C
C
L
Site 47
Y646
T
Q
N
Y
R
H
A
Y
D
L
I
Q
K
F
G
Site 48
Y692
L
D
V
K
N
N
P
Y
L
I
K
A
L
Y
G
Site 49
T728
P
N
P
E
L
L
Q
T
E
D
S
L
K
A
A
Site 50
S731
E
L
L
Q
T
E
D
S
L
K
A
A
P
K
S
Site 51
S738
S
L
K
A
A
P
K
S
Q
K
A
D
S
P
S
Site 52
S743
P
K
S
Q
K
A
D
S
P
S
I
D
Y
A
E
Site 53
Y748
A
D
S
P
S
I
D
Y
A
E
L
L
Q
H
F
Site 54
S770
L
E
V
R
H
Q
R
S
G
R
G
D
H
L
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation