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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DMPK
Full Name:
Myotonin-protein kinase
Alias:
DM-kinase;DMPK;Myotonic dystrophy protein kinase
Type:
Mass (Da):
70371
Number AA:
639
UniProt ID:
Q09013
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Myotonic dystrophy protein kinase pan-specific antibody AB-NK264-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NK264-1#Myotonic dystrophy protein kinase (C407-A425, human) peptide - Powder PE-01BCR70#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01BCR70#DMPKSubtide - DMPK1 (DMPK) protein kinase substrate peptide - Powder PE-01BHC90#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01BHC90
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S24
G
S
P
W
E
A
D
S
P
R
V
K
L
R
G
Site 2
T38
G
R
E
K
G
R
Q
T
E
G
G
A
F
P
L
Site 3
S58
S
G
D
P
R
F
F
S
P
T
T
P
P
A
E
Site 4
T60
D
P
R
F
F
S
P
T
T
P
P
A
E
P
I
Site 5
T61
P
R
F
F
S
P
T
T
P
P
A
E
P
I
V
Site 6
S124
M
L
K
R
G
E
V
S
C
F
R
E
E
R
D
Site 7
Y153
F
A
F
Q
D
E
N
Y
L
Y
L
V
M
E
Y
Site 8
Y155
F
Q
D
E
N
Y
L
Y
L
V
M
E
Y
Y
V
Site 9
Y201
D
S
V
H
R
L
G
Y
V
H
R
D
I
K
P
Site 10
T244
R
S
L
V
A
V
G
T
P
D
Y
L
S
P
E
Site 11
T262
A
V
G
G
G
P
G
T
G
S
Y
G
P
E
C
Site 12
S264
G
G
G
P
G
T
G
S
Y
G
P
E
C
D
W
Site 13
Y265
G
G
P
G
T
G
S
Y
G
P
E
C
D
W
W
Site 14
Y289
F
Y
G
Q
T
P
F
Y
A
D
S
T
A
E
T
Site 15
T293
T
P
F
Y
A
D
S
T
A
E
T
Y
G
K
I
Site 16
T296
Y
A
D
S
T
A
E
T
Y
G
K
I
V
H
Y
Site 17
Y303
T
Y
G
K
I
V
H
Y
K
E
H
L
S
L
P
Site 18
S308
V
H
Y
K
E
H
L
S
L
P
L
V
D
E
G
Site 19
T333
R
L
L
C
P
P
E
T
R
L
G
R
G
G
A
Site 20
S360
D
W
D
G
L
R
D
S
V
P
P
F
T
P
D
Site 21
T365
R
D
S
V
P
P
F
T
P
D
F
E
G
A
T
Site 22
T374
D
F
E
G
A
T
D
T
C
N
F
D
L
V
E
Site 23
S396
S
G
G
G
E
T
L
S
D
I
R
E
G
A
P
Site 24
S416
P
F
V
G
Y
S
Y
S
C
M
A
L
R
D
S
Site 25
S423
S
C
M
A
L
R
D
S
E
V
P
G
P
T
P
Site 26
T429
D
S
E
V
P
G
P
T
P
M
E
L
E
A
E
Site 27
S447
E
P
H
V
Q
A
P
S
L
E
P
S
V
S
P
Site 28
S451
Q
A
P
S
L
E
P
S
V
S
P
Q
D
E
T
Site 29
S453
P
S
L
E
P
S
V
S
P
Q
D
E
T
A
E
Site 30
T458
S
V
S
P
Q
D
E
T
A
E
V
A
V
P
A
Site 31
T477
A
E
A
E
A
E
V
T
L
R
E
L
Q
E
A
Site 32
T491
A
L
E
E
E
V
L
T
R
Q
S
L
S
R
E
Site 33
S494
E
E
V
L
T
R
Q
S
L
S
R
E
M
E
A
Site 34
T504
R
E
M
E
A
I
R
T
D
N
Q
N
F
A
S
Site 35
S511
T
D
N
Q
N
F
A
S
Q
L
R
E
A
E
A
Site 36
S550
T
A
V
T
G
V
P
S
P
R
A
T
D
P
P
Site 37
T554
G
V
P
S
P
R
A
T
D
P
P
S
H
L
D
Site 38
S558
P
R
A
T
D
P
P
S
H
L
D
G
P
P
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation