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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ABCC8
Full Name:
ATP-binding cassette sub-family C member 8
Alias:
ABC36; ATP-binding cassette, sub-family C (CFTR/MRP) member 8; HHF1; HI; HRINS; MRP8; PHHI; Sulfonylurea receptor (hyperinsulinemia); Sulfonylurea receptor 1; SUR; SUR1; TNDM2
Type:
Transporter
Mass (Da):
177008
Number AA:
1581
UniProt ID:
Q09428
International Prot ID:
IPI00219696
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0042626
GO:0015079
PhosphoSite+
KinaseNET
Biological Process:
GO:0005975
GO:0006813
GO:0055085
Phosida
TranscriptoNet
STRING
Kinexus Products
ATP-binding cassette sub-family C member 8 pan-specific antibody AB-NN340-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN340-1
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
P
L
A
F
C
G
S
E
N
H
S
A
A
Y
Site 2
S12
F
C
G
S
E
N
H
S
A
A
Y
R
V
D
Q
Site 3
Y15
S
E
N
H
S
A
A
Y
R
V
D
Q
G
V
L
Site 4
S95
E
I
A
E
G
I
L
S
D
G
V
T
E
S
H
Site 5
T99
G
I
L
S
D
G
V
T
E
S
H
H
L
H
L
Site 6
Y107
E
S
H
H
L
H
L
Y
M
P
A
G
M
A
F
Site 7
Y124
A
V
T
S
V
V
Y
Y
H
N
I
E
T
S
N
Site 8
Y195
N
V
I
R
V
R
R
Y
I
F
F
K
T
P
R
Site 9
T200
R
R
Y
I
F
F
K
T
P
R
E
V
K
P
P
Site 10
T261
P
I
A
M
R
A
L
T
N
Y
Q
R
L
C
E
Site 11
Y263
A
M
R
A
L
T
N
Y
Q
R
L
C
E
A
F
Site 12
S292
R
A
I
W
Q
A
L
S
H
A
F
G
R
R
L
Site 13
S376
Q
R
T
F
L
Q
A
S
Y
Y
V
A
I
E
T
Site 14
T393
N
L
R
G
A
I
Q
T
K
I
Y
N
K
I
M
Site 15
S403
Y
N
K
I
M
H
L
S
T
S
N
L
S
M
G
Site 16
S405
K
I
M
H
L
S
T
S
N
L
S
M
G
E
M
Site 17
S408
H
L
S
T
S
N
L
S
M
G
E
M
T
A
G
Site 18
S482
Y
F
V
A
T
K
L
S
Q
A
Q
R
S
T
L
Site 19
T488
L
S
Q
A
Q
R
S
T
L
E
Y
S
N
E
R
Site 20
Y491
A
Q
R
S
T
L
E
Y
S
N
E
R
L
K
Q
Site 21
T524
I
F
R
T
R
V
E
T
T
R
R
K
E
M
T
Site 22
T531
T
T
R
R
K
E
M
T
S
L
R
A
F
A
I
Site 23
S532
T
R
R
K
E
M
T
S
L
R
A
F
A
I
Y
Site 24
S574
K
E
A
D
F
S
P
S
V
A
F
A
S
L
S
Site 25
S615
Q
K
L
S
E
F
L
S
S
A
E
I
R
E
E
Site 26
S616
K
L
S
E
F
L
S
S
A
E
I
R
E
E
Q
Site 27
T630
Q
C
A
P
H
E
P
T
P
Q
G
P
A
S
K
Site 28
S636
P
T
P
Q
G
P
A
S
K
Y
Q
A
V
P
L
Site 29
Y638
P
Q
G
P
A
S
K
Y
Q
A
V
P
L
R
V
Site 30
T660
R
E
D
C
R
G
L
T
G
P
L
Q
S
L
V
Site 31
S669
P
L
Q
S
L
V
P
S
A
D
G
D
A
D
N
Site 32
T695
W
T
P
D
G
I
P
T
L
S
N
I
T
I
R
Site 33
S741
S
G
A
V
F
W
S
S
L
P
D
S
E
I
G
Site 34
S745
F
W
S
S
L
P
D
S
E
I
G
E
D
P
S
Site 35
S752
S
E
I
G
E
D
P
S
P
E
R
E
T
A
T
Site 36
T757
D
P
S
P
E
R
E
T
A
T
D
L
D
I
R
Site 37
Y771
R
K
R
G
P
V
A
Y
A
S
Q
K
P
W
L
Site 38
S773
R
G
P
V
A
Y
A
S
Q
K
P
W
L
L
N
Site 39
S791
E
E
N
I
I
F
E
S
P
F
N
K
Q
R
Y
Site 40
Y798
S
P
F
N
K
Q
R
Y
K
M
V
I
E
A
C
Site 41
T820
I
L
P
H
G
D
Q
T
Q
I
G
E
R
G
I
Site 42
S830
G
E
R
G
I
N
L
S
G
G
Q
R
Q
R
I
Site 43
S838
G
G
Q
R
Q
R
I
S
V
A
R
A
L
Y
Q
Site 44
T882
L
L
R
D
D
K
R
T
V
V
L
V
T
H
K
Site 45
T906
I
I
A
M
K
D
G
T
I
Q
R
E
G
T
L
Site 46
T912
G
T
I
Q
R
E
G
T
L
K
D
F
Q
R
S
Site 47
T949
T
V
T
E
R
K
A
T
E
P
P
Q
G
L
S
Site 48
S956
T
E
P
P
Q
G
L
S
R
A
M
S
S
R
D
Site 49
S960
Q
G
L
S
R
A
M
S
S
R
D
G
L
L
Q
Site 50
S961
G
L
S
R
A
M
S
S
R
D
G
L
L
Q
D
Site 51
S979
E
E
E
E
A
A
E
S
E
E
D
D
N
L
S
Site 52
Y1003
P
W
R
A
C
A
K
Y
L
S
S
A
G
I
L
Site 53
S1005
R
A
C
A
K
Y
L
S
S
A
G
I
L
L
L
Site 54
S1006
A
C
A
K
Y
L
S
S
A
G
I
L
L
L
S
Site 55
T1044
T
D
S
A
L
T
L
T
P
A
A
R
N
C
S
Site 56
S1051
T
P
A
A
R
N
C
S
L
S
Q
E
C
T
L
Site 57
S1053
A
A
R
N
C
S
L
S
Q
E
C
T
L
D
Q
Site 58
T1057
C
S
L
S
Q
E
C
T
L
D
Q
T
V
Y
A
Site 59
S1125
G
S
I
L
N
R
F
S
S
D
C
N
T
I
D
Site 60
S1126
S
I
L
N
R
F
S
S
D
C
N
T
I
D
Q
Site 61
T1130
R
F
S
S
D
C
N
T
I
D
Q
H
I
P
S
Site 62
S1137
T
I
D
Q
H
I
P
S
T
L
E
C
L
S
R
Site 63
T1138
I
D
Q
H
I
P
S
T
L
E
C
L
S
R
S
Site 64
Y1180
V
C
Y
F
I
Q
K
Y
F
R
V
A
S
R
D
Site 65
S1185
Q
K
Y
F
R
V
A
S
R
D
L
Q
Q
L
D
Site 66
T1194
D
L
Q
Q
L
D
D
T
T
Q
L
P
L
L
S
Site 67
T1195
L
Q
Q
L
D
D
T
T
Q
L
P
L
L
S
H
Site 68
T1212
E
T
V
E
G
L
T
T
I
R
A
F
R
Y
E
Site 69
Y1218
T
T
I
R
A
F
R
Y
E
A
R
F
Q
Q
K
Site 70
S1232
K
L
L
E
Y
T
D
S
N
N
I
A
S
L
F
Site 71
S1270
A
V
T
S
I
S
N
S
L
H
R
E
L
S
A
Site 72
T1320
R
I
H
G
L
L
K
T
E
A
E
S
Y
E
G
Site 73
S1324
L
L
K
T
E
A
E
S
Y
E
G
L
L
A
P
Site 74
Y1325
L
K
T
E
A
E
S
Y
E
G
L
L
A
P
S
Site 75
S1332
Y
E
G
L
L
A
P
S
L
I
P
K
N
W
P
Site 76
S1350
K
I
Q
I
Q
N
L
S
V
R
Y
D
S
S
L
Site 77
Y1353
I
Q
N
L
S
V
R
Y
D
S
S
L
K
P
V
Site 78
S1355
N
L
S
V
R
Y
D
S
S
L
K
P
V
L
K
Site 79
S1356
L
S
V
R
Y
D
S
S
L
K
P
V
L
K
H
Site 80
T1380
K
I
G
I
C
G
R
T
G
S
G
K
S
S
F
Site 81
S1382
G
I
C
G
R
T
G
S
G
K
S
S
F
S
L
Site 82
S1385
G
R
T
G
S
G
K
S
S
F
S
L
A
F
F
Site 83
S1386
R
T
G
S
G
K
S
S
F
S
L
A
F
F
R
Site 84
S1419
L
P
L
H
T
L
R
S
R
L
S
I
I
L
Q
Site 85
S1422
H
T
L
R
S
R
L
S
I
I
L
Q
D
P
V
Site 86
S1446
L
D
P
E
R
K
C
S
D
S
T
L
W
E
A
Site 87
S1448
P
E
R
K
C
S
D
S
T
L
W
E
A
L
E
Site 88
T1449
E
R
K
C
S
D
S
T
L
W
E
A
L
E
I
Site 89
T1475
G
G
L
D
A
I
I
T
E
G
G
E
N
F
S
Site 90
S1510
I
M
D
E
A
T
A
S
I
D
M
A
T
E
N
Site 91
S1567
D
K
P
E
K
L
L
S
R
K
D
S
V
F
A
Site 92
S1571
K
L
L
S
R
K
D
S
V
F
A
S
F
V
R
Site 93
S1575
R
K
D
S
V
F
A
S
F
V
R
A
D
K
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation