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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TBC1D8B
Full Name:
TBC1 domain family member 8B
Alias:
Type:
Intracellular protein
Mass (Da):
128709
Number AA:
1120
UniProt ID:
Q0IIM8
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
Uniprot
OncoNet
Molecular Function:
GO:0005097
PhosphoSite+
KinaseNET
Biological Process:
GO:0032313
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y25
L
M
E
R
S
N
D
Y
F
V
L
Q
R
R
R
Site 2
Y34
V
L
Q
R
R
R
G
Y
G
E
E
G
G
G
G
Site 3
T43
E
E
G
G
G
G
L
T
G
L
L
V
G
T
L
Site 4
T69
P
F
R
I
L
H
Q
T
P
D
S
Q
V
Y
L
Site 5
S77
P
D
S
Q
V
Y
L
S
I
A
C
G
A
N
R
Site 6
T101
L
E
Q
N
I
M
K
T
L
S
V
F
D
S
N
Site 7
S103
Q
N
I
M
K
T
L
S
V
F
D
S
N
E
D
Site 8
S107
K
T
L
S
V
F
D
S
N
E
D
I
T
N
F
Site 9
Y162
E
K
E
K
L
V
T
Y
Y
S
C
S
Y
W
K
Site 10
Y163
K
E
K
L
V
T
Y
Y
S
C
S
Y
W
K
G
Site 11
Y230
C
S
Q
G
E
N
H
Y
F
S
M
F
L
H
I
Site 12
Y250
L
M
E
Q
L
A
N
Y
A
I
R
R
L
F
D
Site 13
T260
R
R
L
F
D
K
E
T
F
D
N
D
P
V
L
Site 14
Y268
F
D
N
D
P
V
L
Y
N
P
L
Q
I
T
K
Site 15
T274
L
Y
N
P
L
Q
I
T
K
R
G
L
E
N
R
Site 16
S284
G
L
E
N
R
A
H
S
E
Q
F
N
A
F
F
Site 17
S298
F
R
L
P
K
G
E
S
L
K
E
V
H
E
C
Site 18
Y326
K
M
C
I
S
E
N
Y
I
C
F
A
S
Q
D
Site 19
S338
S
Q
D
G
N
Q
C
S
V
I
I
P
L
R
E
Site 20
T352
E
V
L
A
I
D
K
T
N
D
S
S
K
S
V
Site 21
S355
A
I
D
K
T
N
D
S
S
K
S
V
I
I
S
Site 22
S358
K
T
N
D
S
S
K
S
V
I
I
S
I
K
G
Site 23
T367
I
I
S
I
K
G
K
T
A
F
R
F
H
E
V
Site 24
S392
R
L
R
C
G
A
A
S
T
Q
Y
H
D
I
S
Site 25
Y395
C
G
A
A
S
T
Q
Y
H
D
I
S
T
E
L
Site 26
S399
S
T
Q
Y
H
D
I
S
T
E
L
A
I
S
S
Site 27
T400
T
Q
Y
H
D
I
S
T
E
L
A
I
S
S
E
Site 28
S405
I
S
T
E
L
A
I
S
S
E
S
T
E
P
S
Site 29
S406
S
T
E
L
A
I
S
S
E
S
T
E
P
S
D
Site 30
S408
E
L
A
I
S
S
E
S
T
E
P
S
D
N
F
Site 31
T409
L
A
I
S
S
E
S
T
E
P
S
D
N
F
E
Site 32
S412
S
S
E
S
T
E
P
S
D
N
F
E
V
Q
S
Site 33
S419
S
D
N
F
E
V
Q
S
L
T
S
Q
R
E
C
Site 34
T421
N
F
E
V
Q
S
L
T
S
Q
R
E
C
S
K
Site 35
S422
F
E
V
Q
S
L
T
S
Q
R
E
C
S
K
T
Site 36
S427
L
T
S
Q
R
E
C
S
K
T
V
N
T
E
A
Site 37
T429
S
Q
R
E
C
S
K
T
V
N
T
E
A
L
M
Site 38
T446
F
H
P
Q
N
L
E
T
L
N
S
K
M
L
K
Site 39
S449
Q
N
L
E
T
L
N
S
K
M
L
K
E
K
M
Site 40
S460
K
E
K
M
K
E
Q
S
W
K
I
L
F
A
E
Site 41
S473
A
E
C
G
R
G
V
S
M
F
R
T
K
K
T
Site 42
T477
R
G
V
S
M
F
R
T
K
K
T
R
D
L
V
Site 43
Y513
D
M
A
T
N
P
D
Y
Y
T
E
V
V
E
Q
Site 44
Y514
M
A
T
N
P
D
Y
Y
T
E
V
V
E
Q
S
Site 45
T515
A
T
N
P
D
Y
Y
T
E
V
V
E
Q
S
L
Site 46
S539
I
E
R
D
L
R
R
S
L
P
E
H
P
A
F
Site 47
S548
P
E
H
P
A
F
Q
S
D
T
G
I
S
A
L
Site 48
T550
H
P
A
F
Q
S
D
T
G
I
S
A
L
R
R
Site 49
T560
S
A
L
R
R
V
L
T
A
Y
A
Y
R
N
P
Site 50
Y562
L
R
R
V
L
T
A
Y
A
Y
R
N
P
K
I
Site 51
Y564
R
V
L
T
A
Y
A
Y
R
N
P
K
I
G
Y
Site 52
Y606
C
E
R
M
L
P
D
Y
F
N
R
R
I
I
G
Site 53
T637
P
Q
L
T
E
H
M
T
D
M
T
F
F
S
S
Site 54
T640
T
E
H
M
T
D
M
T
F
F
S
S
V
S
L
Site 55
T714
N
R
F
F
D
N
V
T
N
K
D
S
P
L
P
Site 56
S718
D
N
V
T
N
K
D
S
P
L
P
S
N
V
Q
Site 57
S722
N
K
D
S
P
L
P
S
N
V
Q
Q
G
S
N
Site 58
S731
V
Q
Q
G
S
N
V
S
D
E
K
T
S
H
T
Site 59
T735
S
N
V
S
D
E
K
T
S
H
T
R
V
D
I
Site 60
T743
S
H
T
R
V
D
I
T
D
L
I
R
E
S
N
Site 61
S749
I
T
D
L
I
R
E
S
N
E
K
Y
G
N
I
Site 62
Y753
I
R
E
S
N
E
K
Y
G
N
I
R
Y
E
D
Site 63
Y758
E
K
Y
G
N
I
R
Y
E
D
I
H
S
M
R
Site 64
Y771
M
R
C
R
N
R
L
Y
V
I
Q
T
L
E
E
Site 65
S795
V
S
Q
D
V
K
L
S
L
Q
E
L
D
E
L
Site 66
Y803
L
Q
E
L
D
E
L
Y
V
I
F
K
K
E
L
Site 67
S829
V
L
K
H
H
D
P
S
L
P
Y
L
E
Q
Y
Site 68
Y832
H
H
D
P
S
L
P
Y
L
E
Q
Y
Q
I
D
Site 69
Y836
S
L
P
Y
L
E
Q
Y
Q
I
D
C
Q
Q
F
Site 70
Y847
C
Q
Q
F
R
A
L
Y
H
L
L
S
P
W
A
Site 71
S851
R
A
L
Y
H
L
L
S
P
W
A
H
S
A
N
Site 72
S856
L
L
S
P
W
A
H
S
A
N
K
D
S
L
A
Site 73
S861
A
H
S
A
N
K
D
S
L
A
L
W
T
F
R
Site 74
T866
K
D
S
L
A
L
W
T
F
R
L
L
D
E
N
Site 75
S874
F
R
L
L
D
E
N
S
D
C
L
I
N
F
K
Site 76
Y891
S
S
A
I
D
I
M
Y
N
G
S
F
T
E
K
Site 77
S894
I
D
I
M
Y
N
G
S
F
T
E
K
L
K
L
Site 78
Y911
K
L
H
I
P
P
A
Y
T
E
V
K
S
K
D
Site 79
S916
P
A
Y
T
E
V
K
S
K
D
A
S
K
G
D
Site 80
S920
E
V
K
S
K
D
A
S
K
G
D
E
L
S
K
Site 81
S926
A
S
K
G
D
E
L
S
K
E
E
L
L
Y
F
Site 82
Y932
L
S
K
E
E
L
L
Y
F
S
Q
L
H
V
S
Site 83
S934
K
E
E
L
L
Y
F
S
Q
L
H
V
S
K
P
Site 84
S949
A
N
E
K
E
A
E
S
A
K
H
S
P
E
K
Site 85
S953
E
A
E
S
A
K
H
S
P
E
K
G
K
G
K
Site 86
Y966
G
K
I
D
I
Q
A
Y
L
S
Q
W
Q
D
E
Site 87
S990
D
L
P
R
M
N
Q
S
Q
F
I
Q
F
S
K
Site 88
T998
Q
F
I
Q
F
S
K
T
L
Y
N
L
F
H
E
Site 89
Y1000
I
Q
F
S
K
T
L
Y
N
L
F
H
E
D
P
Site 90
Y1013
D
P
E
E
E
S
L
Y
Q
A
I
A
V
V
T
Site 91
S1035
E
V
G
R
K
L
H
S
P
T
S
S
A
K
G
Site 92
S1038
R
K
L
H
S
P
T
S
S
A
K
G
F
S
G
Site 93
S1039
K
L
H
S
P
T
S
S
A
K
G
F
S
G
T
Site 94
S1044
T
S
S
A
K
G
F
S
G
T
V
C
G
S
G
Site 95
T1046
S
A
K
G
F
S
G
T
V
C
G
S
G
G
P
Site 96
S1050
F
S
G
T
V
C
G
S
G
G
P
S
E
E
K
Site 97
S1054
V
C
G
S
G
G
P
S
E
E
K
T
G
S
H
Site 98
T1058
G
G
P
S
E
E
K
T
G
S
H
L
E
K
D
Site 99
S1060
P
S
E
E
K
T
G
S
H
L
E
K
D
P
C
Site 100
S1068
H
L
E
K
D
P
C
S
F
R
E
E
P
Q
W
Site 101
S1112
K
L
E
N
A
R
I
S
Q
L
R
S
R
T
K
Site 102
S1116
A
R
I
S
Q
L
R
S
R
T
K
M
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation