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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
FCHO2
Full Name:
FCH domain only protein 2
Alias:
FCH domain only 2
Type:
Unknown function
Mass (Da):
88924
Number AA:
810
UniProt ID:
Q0JRZ9
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y22
N
S
G
F
D
V
L
Y
H
N
M
K
H
G
Q
Site 2
T44
D
F
V
R
E
R
A
T
I
E
E
A
Y
S
R
Site 3
Y49
R
A
T
I
E
E
A
Y
S
R
S
M
T
K
L
Site 4
T54
E
A
Y
S
R
S
M
T
K
L
A
K
S
A
S
Site 5
S59
S
M
T
K
L
A
K
S
A
S
N
Y
S
Q
L
Site 6
S61
T
K
L
A
K
S
A
S
N
Y
S
Q
L
G
T
Site 7
Y63
L
A
K
S
A
S
N
Y
S
Q
L
G
T
F
A
Site 8
S64
A
K
S
A
S
N
Y
S
Q
L
G
T
F
A
P
Site 9
T68
S
N
Y
S
Q
L
G
T
F
A
P
V
W
D
V
Site 10
T78
P
V
W
D
V
F
K
T
S
T
E
K
L
A
N
Site 11
Y104
L
I
K
E
V
Q
K
Y
G
E
E
Q
V
K
S
Site 12
S111
Y
G
E
E
Q
V
K
S
H
K
K
T
K
E
E
Site 13
T115
Q
V
K
S
H
K
K
T
K
E
E
V
A
G
T
Site 14
T122
T
K
E
E
V
A
G
T
L
E
A
V
Q
T
I
Site 15
Y143
L
Q
K
S
K
E
N
Y
N
A
K
C
V
E
Q
Site 16
T174
A
V
K
S
K
K
A
T
D
T
Y
K
L
Y
V
Site 17
T176
K
S
K
K
A
T
D
T
Y
K
L
Y
V
E
K
Site 18
Y177
S
K
K
A
T
D
T
Y
K
L
Y
V
E
K
Y
Site 19
Y180
A
T
D
T
Y
K
L
Y
V
E
K
Y
A
L
A
Site 20
T196
A
D
F
E
Q
K
M
T
E
T
A
Q
K
F
Q
Site 21
S219
H
I
K
E
I
I
G
S
L
S
N
A
I
K
E
Site 22
S221
K
E
I
I
G
S
L
S
N
A
I
K
E
I
H
Site 23
T289
I
K
P
R
K
R
K
T
F
A
L
P
G
I
I
Site 24
S304
K
K
E
K
D
A
E
S
V
E
C
P
D
A
D
Site 25
S312
V
E
C
P
D
A
D
S
L
N
I
P
D
V
D
Site 26
Y323
P
D
V
D
E
E
G
Y
S
I
K
P
E
T
N
Site 27
S324
D
V
D
E
E
G
Y
S
I
K
P
E
T
N
Q
Site 28
Y340
D
T
K
E
N
H
F
Y
S
S
S
D
S
D
S
Site 29
S341
T
K
E
N
H
F
Y
S
S
S
D
S
D
S
E
Site 30
S342
K
E
N
H
F
Y
S
S
S
D
S
D
S
E
D
Site 31
S343
E
N
H
F
Y
S
S
S
D
S
D
S
E
D
E
Site 32
S345
H
F
Y
S
S
S
D
S
D
S
E
D
E
E
P
Site 33
S347
Y
S
S
S
D
S
D
S
E
D
E
E
P
K
K
Site 34
Y355
E
D
E
E
P
K
K
Y
R
I
E
I
K
P
M
Site 35
S373
N
S
H
H
T
M
A
S
L
D
E
L
K
V
S
Site 36
T385
K
V
S
I
G
N
I
T
L
S
P
A
I
S
R
Site 37
S387
S
I
G
N
I
T
L
S
P
A
I
S
R
H
S
Site 38
S391
I
T
L
S
P
A
I
S
R
H
S
P
V
Q
M
Site 39
S394
S
P
A
I
S
R
H
S
P
V
Q
M
N
R
N
Site 40
S403
V
Q
M
N
R
N
L
S
N
E
E
L
T
K
S
Site 41
S410
S
N
E
E
L
T
K
S
K
P
S
A
P
P
N
Site 42
S422
P
P
N
E
K
G
T
S
D
L
L
A
W
D
P
Site 43
S434
W
D
P
L
F
G
P
S
L
D
S
S
S
S
S
Site 44
S437
L
F
G
P
S
L
D
S
S
S
S
S
S
L
T
Site 45
S438
F
G
P
S
L
D
S
S
S
S
S
S
L
T
S
Site 46
S439
G
P
S
L
D
S
S
S
S
S
S
L
T
S
S
Site 47
S440
P
S
L
D
S
S
S
S
S
S
L
T
S
S
S
Site 48
S441
S
L
D
S
S
S
S
S
S
L
T
S
S
S
S
Site 49
S442
L
D
S
S
S
S
S
S
L
T
S
S
S
S
A
Site 50
T444
S
S
S
S
S
S
L
T
S
S
S
S
A
R
P
Site 51
S445
S
S
S
S
S
L
T
S
S
S
S
A
R
P
T
Site 52
S446
S
S
S
S
L
T
S
S
S
S
A
R
P
T
T
Site 53
S447
S
S
S
L
T
S
S
S
S
A
R
P
T
T
P
Site 54
S448
S
S
L
T
S
S
S
S
A
R
P
T
T
P
L
Site 55
T452
S
S
S
S
A
R
P
T
T
P
L
S
V
G
T
Site 56
T453
S
S
S
A
R
P
T
T
P
L
S
V
G
T
I
Site 57
T459
T
T
P
L
S
V
G
T
I
V
P
P
P
R
P
Site 58
S468
V
P
P
P
R
P
A
S
R
P
K
L
T
S
G
Site 59
S474
A
S
R
P
K
L
T
S
G
K
L
S
G
I
N
Site 60
S478
K
L
T
S
G
K
L
S
G
I
N
E
I
P
R
Site 61
S488
N
E
I
P
R
P
F
S
P
P
V
T
S
N
T
Site 62
T492
R
P
F
S
P
P
V
T
S
N
T
S
P
P
P
Site 63
S493
P
F
S
P
P
V
T
S
N
T
S
P
P
P
A
Site 64
T495
S
P
P
V
T
S
N
T
S
P
P
P
A
A
P
Site 65
S496
P
P
V
T
S
N
T
S
P
P
P
A
A
P
L
Site 66
S508
A
P
L
A
R
A
E
S
S
S
S
I
S
S
S
Site 67
S509
P
L
A
R
A
E
S
S
S
S
I
S
S
S
A
Site 68
S510
L
A
R
A
E
S
S
S
S
I
S
S
S
A
S
Site 69
S511
A
R
A
E
S
S
S
S
I
S
S
S
A
S
L
Site 70
S513
A
E
S
S
S
S
I
S
S
S
A
S
L
S
A
Site 71
S514
E
S
S
S
S
I
S
S
S
A
S
L
S
A
A
Site 72
S515
S
S
S
S
I
S
S
S
A
S
L
S
A
A
N
Site 73
S517
S
S
I
S
S
S
A
S
L
S
A
A
N
T
P
Site 74
S519
I
S
S
S
A
S
L
S
A
A
N
T
P
T
V
Site 75
T525
L
S
A
A
N
T
P
T
V
G
V
S
R
G
P
Site 76
S529
N
T
P
T
V
G
V
S
R
G
P
S
P
V
S
Site 77
S533
V
G
V
S
R
G
P
S
P
V
S
L
G
N
Q
Site 78
S536
S
R
G
P
S
P
V
S
L
G
N
Q
D
T
L
Site 79
Y556
L
T
E
S
V
N
A
Y
F
K
G
A
D
P
T
Site 80
T563
Y
F
K
G
A
D
P
T
K
C
I
V
K
I
T
Site 81
S602
C
F
R
V
K
N
I
S
R
L
E
Q
I
L
P
Site 82
S616
P
N
A
Q
L
V
F
S
D
P
S
Q
C
D
S
Site 83
S619
Q
L
V
F
S
D
P
S
Q
C
D
S
N
T
K
Site 84
Y638
N
M
Q
A
V
T
V
Y
L
K
K
L
S
E
Q
Site 85
S643
T
V
Y
L
K
K
L
S
E
Q
N
P
A
A
S
Site 86
Y651
E
Q
N
P
A
A
S
Y
Y
N
V
D
V
L
K
Site 87
Y652
Q
N
P
A
A
S
Y
Y
N
V
D
V
L
K
Y
Site 88
Y659
Y
N
V
D
V
L
K
Y
Q
V
S
S
N
G
I
Site 89
S662
D
V
L
K
Y
Q
V
S
S
N
G
I
Q
S
T
Site 90
S668
V
S
S
N
G
I
Q
S
T
P
L
N
L
A
T
Site 91
T669
S
S
N
G
I
Q
S
T
P
L
N
L
A
T
Y
Site 92
T675
S
T
P
L
N
L
A
T
Y
W
K
C
S
A
S
Site 93
Y676
T
P
L
N
L
A
T
Y
W
K
C
S
A
S
T
Site 94
S682
T
Y
W
K
C
S
A
S
T
T
D
L
R
V
D
Site 95
T684
W
K
C
S
A
S
T
T
D
L
R
V
D
Y
K
Site 96
Y690
T
T
D
L
R
V
D
Y
K
Y
N
P
E
A
M
Site 97
Y692
D
L
R
V
D
Y
K
Y
N
P
E
A
M
V
A
Site 98
S721
G
G
V
T
N
M
Q
S
L
P
P
A
I
W
N
Site 99
S739
M
K
A
F
W
K
L
S
S
I
S
E
K
S
E
Site 100
S740
K
A
F
W
K
L
S
S
I
S
E
K
S
E
N
Site 101
S742
F
W
K
L
S
S
I
S
E
K
S
E
N
G
G
Site 102
S745
L
S
S
I
S
E
K
S
E
N
G
G
S
G
S
Site 103
S752
S
E
N
G
G
S
G
S
L
R
A
K
F
D
L
Site 104
S760
L
R
A
K
F
D
L
S
E
G
P
S
K
P
T
Site 105
S764
F
D
L
S
E
G
P
S
K
P
T
T
L
A
V
Site 106
T768
E
G
P
S
K
P
T
T
L
A
V
Q
F
L
S
Site 107
T779
Q
F
L
S
E
G
S
T
L
S
G
V
D
F
E
Site 108
S795
V
G
T
G
Y
R
L
S
L
I
K
K
R
F
A
Site 109
T803
L
I
K
K
R
F
A
T
G
R
Y
L
A
D
C
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation