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Updated November 2019
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Protein Info
Short Name:
MN1
Full Name:
Probable tumor suppressor protein MN1
Alias:
Meningioma (disrupted in balanced translocation) 1; MGCR1-PEN; Probable tumor suppressor protein MN1; Tumor suppressor protein MN1; Tumour suppressor protein MN1
Type:
Transcription protein, coactivator/corepressor
Mass (Da):
136001
Number AA:
1320
UniProt ID:
Q10571
International Prot ID:
IPI00477642
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T26
G
E
R
N
F
N
E
T
G
L
S
M
N
T
H
Site 2
Y68
L
G
M
N
M
E
P
Y
G
F
H
A
R
G
H
Site 3
S76
G
F
H
A
R
G
H
S
E
L
H
A
G
G
L
Site 4
S126
G
G
P
D
P
G
A
S
C
L
H
G
G
R
L
Site 5
S145
G
A
A
G
G
L
G
S
Q
P
P
F
A
E
G
Site 6
S159
G
Y
E
H
M
A
E
S
Q
G
P
E
S
F
G
Site 7
S164
A
E
S
Q
G
P
E
S
F
G
P
Q
R
P
G
Site 8
S178
G
N
L
P
D
F
H
S
S
G
A
S
S
H
A
Site 9
S179
N
L
P
D
F
H
S
S
G
A
S
S
H
A
V
Site 10
S182
D
F
H
S
S
G
A
S
S
H
A
V
P
A
P
Site 11
S183
F
H
S
S
G
A
S
S
H
A
V
P
A
P
C
Site 12
S196
P
C
L
P
L
D
Q
S
P
N
R
A
A
S
F
Site 13
S202
Q
S
P
N
R
A
A
S
F
H
G
L
P
S
S
Site 14
S208
A
S
F
H
G
L
P
S
S
S
G
S
D
S
H
Site 15
S209
S
F
H
G
L
P
S
S
S
G
S
D
S
H
S
Site 16
S210
F
H
G
L
P
S
S
S
G
S
D
S
H
S
L
Site 17
S212
G
L
P
S
S
S
G
S
D
S
H
S
L
E
P
Site 18
S214
P
S
S
S
G
S
D
S
H
S
L
E
P
R
R
Site 19
S216
S
S
G
S
D
S
H
S
L
E
P
R
R
V
T
Site 20
T223
S
L
E
P
R
R
V
T
N
Q
G
A
V
D
S
Site 21
S230
T
N
Q
G
A
V
D
S
L
E
Y
N
Y
P
G
Site 22
Y233
G
A
V
D
S
L
E
Y
N
Y
P
G
E
A
P
Site 23
Y235
V
D
S
L
E
Y
N
Y
P
G
E
A
P
S
G
Site 24
S241
N
Y
P
G
E
A
P
S
G
H
F
D
M
F
S
Site 25
S248
S
G
H
F
D
M
F
S
P
S
D
S
E
G
Q
Site 26
S250
H
F
D
M
F
S
P
S
D
S
E
G
Q
L
P
Site 27
S252
D
M
F
S
P
S
D
S
E
G
Q
L
P
H
Y
Site 28
Y259
S
E
G
Q
L
P
H
Y
A
A
G
R
Q
V
P
Site 29
S318
G
V
F
F
E
R
F
S
G
A
R
K
M
P
V
Site 30
S330
M
P
V
G
L
E
P
S
V
G
S
R
H
P
L
Site 31
S333
G
L
E
P
S
V
G
S
R
H
P
L
M
Q
P
Site 32
S373
G
L
L
V
R
Q
N
S
C
P
P
A
L
P
R
Site 33
T388
P
Q
Q
G
E
A
G
T
P
S
G
G
L
Q
D
Site 34
S390
Q
G
E
A
G
T
P
S
G
G
L
Q
D
G
G
Site 35
S402
D
G
G
P
M
L
P
S
Q
H
A
Q
F
E
Y
Site 36
Y409
S
Q
H
A
Q
F
E
Y
P
I
H
R
L
E
N
Site 37
S418
I
H
R
L
E
N
R
S
M
H
P
Y
S
E
P
Site 38
Y422
E
N
R
S
M
H
P
Y
S
E
P
V
F
S
M
Site 39
S423
N
R
S
M
H
P
Y
S
E
P
V
F
S
M
Q
Site 40
S428
P
Y
S
E
P
V
F
S
M
Q
H
P
P
P
Q
Site 41
Y450
Q
H
F
D
A
P
P
Y
M
N
V
A
K
R
P
Site 42
S464
P
R
F
D
F
P
G
S
A
G
V
D
R
C
A
Site 43
S487
G
A
L
D
N
H
L
S
P
S
A
Y
P
G
L
Site 44
S489
L
D
N
H
L
S
P
S
A
Y
P
G
L
P
G
Site 45
Y491
N
H
L
S
P
S
A
Y
P
G
L
P
G
E
F
Site 46
T499
P
G
L
P
G
E
F
T
P
P
V
P
D
S
F
Site 47
S505
F
T
P
P
V
P
D
S
F
P
S
G
P
P
L
Site 48
S508
P
V
P
D
S
F
P
S
G
P
P
L
Q
H
P
Site 49
T610
F
E
R
E
G
G
S
T
G
A
G
R
L
G
T
Site 50
T617
T
G
A
G
R
L
G
T
F
E
Q
Q
A
P
H
Site 51
S629
A
P
H
L
A
Q
E
S
A
W
F
S
G
P
H
Site 52
S633
A
Q
E
S
A
W
F
S
G
P
H
P
P
P
G
Site 53
S650
L
P
R
R
M
G
G
S
G
L
P
A
D
C
G
Site 54
S662
D
C
G
P
H
D
P
S
L
A
P
P
P
P
P
Site 55
S672
P
P
P
P
P
G
G
S
G
V
L
F
R
G
P
Site 56
S723
G
A
G
V
G
L
P
S
A
A
S
E
R
R
P
Site 57
S726
V
G
L
P
S
A
A
S
E
R
R
P
P
P
P
Site 58
T737
P
P
P
P
D
F
A
T
S
A
L
G
G
Q
P
Site 59
S738
P
P
P
D
F
A
T
S
A
L
G
G
Q
P
G
Site 60
S755
F
G
A
A
G
R
Q
S
T
P
H
S
G
P
G
Site 61
T756
G
A
A
G
R
Q
S
T
P
H
S
G
P
G
V
Site 62
S759
G
R
Q
S
T
P
H
S
G
P
G
V
N
S
P
Site 63
S765
H
S
G
P
G
V
N
S
P
P
S
A
G
G
G
Site 64
S768
P
G
V
N
S
P
P
S
A
G
G
G
G
G
S
Site 65
S775
S
A
G
G
G
G
G
S
S
G
G
G
G
G
G
Site 66
S776
A
G
G
G
G
G
S
S
G
G
G
G
G
G
G
Site 67
Y785
G
G
G
G
G
G
A
Y
P
P
Q
P
D
F
Q
Site 68
S794
P
Q
P
D
F
Q
P
S
Q
R
T
S
A
S
K
Site 69
S798
F
Q
P
S
Q
R
T
S
A
S
K
L
G
A
L
Site 70
S800
P
S
Q
R
T
S
A
S
K
L
G
A
L
S
L
Site 71
S806
A
S
K
L
G
A
L
S
L
G
S
F
N
K
P
Site 72
S809
L
G
A
L
S
L
G
S
F
N
K
P
S
S
K
Site 73
S814
L
G
S
F
N
K
P
S
S
K
D
N
L
F
G
Site 74
S815
G
S
F
N
K
P
S
S
K
D
N
L
F
G
Q
Site 75
T847
G
A
P
N
L
N
V
T
F
N
K
K
N
P
P
Site 76
S861
P
E
G
K
R
K
L
S
Q
N
E
T
D
G
A
Site 77
T865
R
K
L
S
Q
N
E
T
D
G
A
A
V
A
G
Site 78
S876
A
V
A
G
N
P
G
S
D
Y
F
P
G
G
T
Site 79
Y878
A
G
N
P
G
S
D
Y
F
P
G
G
T
A
P
Site 80
S894
A
P
G
P
G
G
P
S
G
T
S
S
S
G
S
Site 81
T896
G
P
G
G
P
S
G
T
S
S
S
G
S
K
A
Site 82
S897
P
G
G
P
S
G
T
S
S
S
G
S
K
A
S
Site 83
S898
G
G
P
S
G
T
S
S
S
G
S
K
A
S
G
Site 84
S899
G
P
S
G
T
S
S
S
G
S
K
A
S
G
P
Site 85
S901
S
G
T
S
S
S
G
S
K
A
S
G
P
P
N
Site 86
S904
S
S
S
G
S
K
A
S
G
P
P
N
P
P
A
Site 87
S917
P
A
Q
G
D
G
T
S
L
S
P
N
Y
T
L
Site 88
S919
Q
G
D
G
T
S
L
S
P
N
Y
T
L
E
S
Site 89
Y922
G
T
S
L
S
P
N
Y
T
L
E
S
T
S
G
Site 90
T923
T
S
L
S
P
N
Y
T
L
E
S
T
S
G
N
Site 91
S926
S
P
N
Y
T
L
E
S
T
S
G
N
D
G
K
Site 92
S936
G
N
D
G
K
P
V
S
G
G
G
G
R
G
R
Site 93
S950
R
G
R
R
K
R
D
S
G
H
V
S
P
G
T
Site 94
S954
K
R
D
S
G
H
V
S
P
G
T
F
F
D
K
Site 95
T957
S
G
H
V
S
P
G
T
F
F
D
K
Y
S
A
Site 96
Y962
P
G
T
F
F
D
K
Y
S
A
A
P
D
S
G
Site 97
S963
G
T
F
F
D
K
Y
S
A
A
P
D
S
G
G
Site 98
S968
K
Y
S
A
A
P
D
S
G
G
A
P
G
V
S
Site 99
S975
S
G
G
A
P
G
V
S
P
G
Q
Q
Q
A
S
Site 100
S982
S
P
G
Q
Q
Q
A
S
G
A
A
V
G
G
S
Site 101
S989
S
G
A
A
V
G
G
S
S
A
G
E
T
R
G
Site 102
T994
G
G
S
S
A
G
E
T
R
G
A
P
T
P
H
Site 103
T999
G
E
T
R
G
A
P
T
P
H
E
K
A
L
T
Site 104
T1006
T
P
H
E
K
A
L
T
S
P
S
W
G
K
G
Site 105
S1007
P
H
E
K
A
L
T
S
P
S
W
G
K
G
A
Site 106
S1009
E
K
A
L
T
S
P
S
W
G
K
G
A
E
L
Site 107
S1027
D
Q
P
D
L
I
G
S
L
D
G
G
A
K
S
Site 108
S1034
S
L
D
G
G
A
K
S
D
S
S
S
P
N
V
Site 109
S1036
D
G
G
A
K
S
D
S
S
S
P
N
V
G
E
Site 110
S1037
G
G
A
K
S
D
S
S
S
P
N
V
G
E
F
Site 111
S1038
G
A
K
S
D
S
S
S
P
N
V
G
E
F
A
Site 112
S1046
P
N
V
G
E
F
A
S
D
E
V
S
T
S
Y
Site 113
S1050
E
F
A
S
D
E
V
S
T
S
Y
A
N
E
D
Site 114
S1052
A
S
D
E
V
S
T
S
Y
A
N
E
D
E
V
Site 115
S1060
Y
A
N
E
D
E
V
S
S
S
S
D
N
P
Q
Site 116
S1062
N
E
D
E
V
S
S
S
S
D
N
P
Q
A
L
Site 117
S1063
E
D
E
V
S
S
S
S
D
N
P
Q
A
L
V
Site 118
T1079
A
S
R
S
P
L
V
T
G
S
P
K
L
P
P
Site 119
S1081
R
S
P
L
V
T
G
S
P
K
L
P
P
R
G
Site 120
S1109
A
L
G
L
G
I
M
S
N
S
T
S
T
P
D
Site 121
S1111
G
L
G
I
M
S
N
S
T
S
T
P
D
S
Y
Site 122
T1112
L
G
I
M
S
N
S
T
S
T
P
D
S
Y
G
Site 123
S1113
G
I
M
S
N
S
T
S
T
P
D
S
Y
G
G
Site 124
T1114
I
M
S
N
S
T
S
T
P
D
S
Y
G
G
G
Site 125
S1117
N
S
T
S
T
P
D
S
Y
G
G
G
G
G
P
Site 126
Y1118
S
T
S
T
P
D
S
Y
G
G
G
G
G
P
G
Site 127
T1129
G
G
P
G
H
P
G
T
P
G
L
E
Q
V
R
Site 128
T1137
P
G
L
E
Q
V
R
T
P
T
S
S
S
G
A
Site 129
T1139
L
E
Q
V
R
T
P
T
S
S
S
G
A
P
P
Site 130
S1140
E
Q
V
R
T
P
T
S
S
S
G
A
P
P
P
Site 131
S1141
Q
V
R
T
P
T
S
S
S
G
A
P
P
P
D
Site 132
S1142
V
R
T
P
T
S
S
S
G
A
P
P
P
D
E
Site 133
S1170
Q
R
Q
Q
F
S
I
S
E
D
Q
P
L
G
L
Site 134
S1197
S
G
A
Q
N
G
D
S
E
L
G
S
C
C
S
Site 135
S1201
N
G
D
S
E
L
G
S
C
C
S
E
A
V
K
Site 136
S1218
M
S
T
I
D
L
D
S
L
M
A
E
H
S
A
Site 137
Y1228
A
E
H
S
A
A
W
Y
M
P
A
D
K
A
L
Site 138
T1244
D
S
A
D
D
D
K
T
L
A
P
W
E
K
A
Site 139
S1258
A
K
P
Q
N
P
N
S
K
E
A
H
D
L
P
Site 140
S1270
D
L
P
A
N
K
A
S
A
S
Q
P
G
S
H
Site 141
S1272
P
A
N
K
A
S
A
S
Q
P
G
S
H
L
Q
Site 142
S1276
A
S
A
S
Q
P
G
S
H
L
Q
C
L
S
V
Site 143
T1286
Q
C
L
S
V
H
C
T
D
D
V
G
D
A
K
Site 144
S1297
G
D
A
K
A
R
A
S
V
P
T
W
R
S
L
Site 145
T1300
K
A
R
A
S
V
P
T
W
R
S
L
H
S
D
Site 146
S1303
A
S
V
P
T
W
R
S
L
H
S
D
I
S
N
Site 147
S1306
P
T
W
R
S
L
H
S
D
I
S
N
R
F
G
Site 148
S1309
R
S
L
H
S
D
I
S
N
R
F
G
T
F
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation