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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PMPCA
Full Name:
Mitochondrial-processing peptidase subunit alpha
Alias:
Alpha-MPP; EC 3.4.24.64; HA1523; INPP5E; MPPA
Type:
Protease
Mass (Da):
58253
Number AA:
525
UniProt ID:
Q10713
International Prot ID:
IPI00166749
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005739
GO:0005743
GO:0005759
Uniprot
OncoNet
Molecular Function:
GO:0003824
GO:0004175
GO:0004222
PhosphoSite+
KinaseNET
Biological Process:
GO:0006508
GO:0008152
GO:0009987
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S15
A
T
R
L
L
R
G
S
G
S
W
G
C
S
R
Site 2
S17
R
L
L
R
G
S
G
S
W
G
C
S
R
L
R
Site 3
S21
G
S
G
S
W
G
C
S
R
L
R
F
G
P
P
Site 4
Y30
L
R
F
G
P
P
A
Y
R
R
F
S
S
G
G
Site 5
S34
P
P
A
Y
R
R
F
S
S
G
G
A
Y
P
N
Site 6
S35
P
A
Y
R
R
F
S
S
G
G
A
Y
P
N
I
Site 7
Y39
R
F
S
S
G
G
A
Y
P
N
I
P
L
S
S
Site 8
S46
Y
P
N
I
P
L
S
S
P
L
P
G
V
P
K
Site 9
T58
V
P
K
P
V
F
A
T
V
D
G
Q
E
K
F
Site 10
T67
D
G
Q
E
K
F
E
T
K
V
T
T
L
D
N
Site 11
T70
E
K
F
E
T
K
V
T
T
L
D
N
G
L
R
Site 12
S80
D
N
G
L
R
V
A
S
Q
N
K
F
G
Q
F
Site 13
T89
N
K
F
G
Q
F
C
T
V
G
I
L
I
N
S
Site 14
S96
T
V
G
I
L
I
N
S
G
S
R
Y
E
A
K
Site 15
S98
G
I
L
I
N
S
G
S
R
Y
E
A
K
Y
L
Site 16
Y100
L
I
N
S
G
S
R
Y
E
A
K
Y
L
S
G
Site 17
Y104
G
S
R
Y
E
A
K
Y
L
S
G
I
A
H
F
Site 18
S106
R
Y
E
A
K
Y
L
S
G
I
A
H
F
L
E
Site 19
S119
L
E
K
L
A
F
S
S
T
A
R
F
D
S
K
Site 20
T120
E
K
L
A
F
S
S
T
A
R
F
D
S
K
D
Site 21
S125
S
S
T
A
R
F
D
S
K
D
E
I
L
L
T
Site 22
T132
S
K
D
E
I
L
L
T
L
E
K
H
G
G
I
Site 23
T148
D
C
Q
T
S
R
D
T
T
M
Y
A
V
S
A
Site 24
T149
C
Q
T
S
R
D
T
T
M
Y
A
V
S
A
D
Site 25
Y151
T
S
R
D
T
T
M
Y
A
V
S
A
D
S
K
Site 26
T177
V
V
L
Q
P
R
L
T
D
E
E
V
E
M
T
Site 27
T206
P
D
P
E
P
L
L
T
E
M
I
H
E
A
A
Site 28
T218
E
A
A
Y
R
E
N
T
V
G
L
H
R
F
C
Site 29
Y241
N
R
E
V
L
H
S
Y
L
R
N
Y
Y
T
P
Site 30
Y245
L
H
S
Y
L
R
N
Y
Y
T
P
D
R
M
V
Site 31
Y246
H
S
Y
L
R
N
Y
Y
T
P
D
R
M
V
L
Site 32
T247
S
Y
L
R
N
Y
Y
T
P
D
R
M
V
L
A
Site 33
S280
G
V
Q
P
A
W
G
S
A
E
A
V
D
I
D
Site 34
S289
E
A
V
D
I
D
R
S
V
A
Q
Y
T
G
G
Site 35
S305
A
K
L
E
R
D
M
S
N
V
S
L
G
P
T
Site 36
S308
E
R
D
M
S
N
V
S
L
G
P
T
P
I
P
Site 37
T312
S
N
V
S
L
G
P
T
P
I
P
E
L
T
H
Site 38
S351
M
G
G
G
G
S
F
S
A
G
G
P
G
K
G
Site 39
Y364
K
G
M
F
S
R
L
Y
L
N
V
L
N
R
H
Site 40
S383
N
A
T
S
Y
H
H
S
Y
E
D
T
G
L
L
Site 41
Y384
A
T
S
Y
H
H
S
Y
E
D
T
G
L
L
C
Site 42
S395
G
L
L
C
I
H
A
S
A
D
P
R
Q
V
R
Site 43
T421
L
M
G
G
T
V
D
T
V
E
L
E
R
A
K
Site 44
T429
V
E
L
E
R
A
K
T
Q
L
T
S
M
L
M
Site 45
T456
V
G
R
Q
V
L
A
T
R
S
R
K
L
P
H
Site 46
S482
E
D
V
K
R
V
A
S
K
M
L
R
G
K
P
Site 47
T502
G
D
L
T
D
L
P
T
Y
E
H
I
Q
T
A
Site 48
Y503
D
L
T
D
L
P
T
Y
E
H
I
Q
T
A
L
Site 49
T508
P
T
Y
E
H
I
Q
T
A
L
S
S
K
D
G
Site 50
T520
K
D
G
R
L
P
R
T
Y
R
L
F
R
_
_
Site 51
Y521
D
G
R
L
P
R
T
Y
R
L
F
R
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation