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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SMF
Full Name:
HMG domain-containing protein 3
Alias:
HMG box domain containing 3; HMGX3; KIAA0194; Protein SMF
Type:
Mass (Da):
168330
Number AA:
UniProt ID:
Q12766
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005730
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0016301
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y10
R
T
Q
P
R
P
C
Y
L
N
A
P
Q
Q
C
Site 2
T27
A
E
R
P
G
R
P
T
A
G
S
H
S
F
L
Site 3
S30
P
G
R
P
T
A
G
S
H
S
F
L
L
R
P
Site 4
S32
R
P
T
A
G
S
H
S
F
L
L
R
P
G
P
Site 5
S63
E
Q
F
V
W
V
R
S
Q
A
R
A
G
L
L
Site 6
S76
L
L
R
L
R
Q
G
S
H
A
V
T
R
C
R
Site 7
T80
R
Q
G
S
H
A
V
T
R
C
R
P
L
P
V
Site 8
S96
R
E
G
R
R
D
G
S
P
W
R
S
V
V
C
Site 9
T112
Y
C
R
C
S
R
Q
T
G
A
S
V
T
T
V
Site 10
S115
C
S
R
Q
T
G
A
S
V
T
T
V
S
L
P
Site 11
T117
R
Q
T
G
A
S
V
T
T
V
S
L
P
S
S
Site 12
T118
Q
T
G
A
S
V
T
T
V
S
L
P
S
S
S
Site 13
S120
G
A
S
V
T
T
V
S
L
P
S
S
S
S
S
Site 14
S124
T
T
V
S
L
P
S
S
S
S
S
P
G
L
D
Site 15
S125
T
V
S
L
P
S
S
S
S
S
P
G
L
D
P
Site 16
S126
V
S
L
P
S
S
S
S
S
P
G
L
D
P
R
Site 17
S127
S
L
P
S
S
S
S
S
P
G
L
D
P
R
G
Site 18
S139
P
R
G
P
R
Q
A
S
V
R
S
L
R
S
E
Site 19
S142
P
R
Q
A
S
V
R
S
L
R
S
E
P
V
L
Site 20
T156
L
L
F
L
P
F
R
T
P
Y
R
D
S
E
E
Site 21
Y158
F
L
P
F
R
T
P
Y
R
D
S
E
E
G
K
Site 22
S161
F
R
T
P
Y
R
D
S
E
E
G
K
R
E
G
Site 23
S170
E
G
K
R
E
G
L
S
R
L
R
A
V
C
R
Site 24
S186
A
G
P
R
G
R
G
S
F
S
P
R
D
A
R
Site 25
S188
P
R
G
R
G
S
F
S
P
R
D
A
R
A
S
Site 26
S195
S
P
R
D
A
R
A
S
P
R
L
H
F
L
V
Site 27
S211
A
V
T
T
G
A
A
S
R
R
Q
R
G
A
R
Site 28
S223
G
A
R
V
R
Q
P
S
P
S
S
S
R
R
A
Site 29
S225
R
V
R
Q
P
S
P
S
S
S
R
R
A
K
R
Site 30
S226
V
R
Q
P
S
P
S
S
S
R
R
A
K
R
L
Site 31
S227
R
Q
P
S
P
S
S
S
R
R
A
K
R
L
R
Site 32
S240
L
R
E
C
E
R
R
S
L
H
A
P
P
A
M
Site 33
Y251
P
P
A
M
D
A
S
Y
D
G
T
E
V
T
V
Site 34
T254
M
D
A
S
Y
D
G
T
E
V
T
V
V
M
E
Site 35
T257
S
Y
D
G
T
E
V
T
V
V
M
E
E
I
E
Site 36
Y267
M
E
E
I
E
E
A
Y
C
Y
T
S
P
G
P
Site 37
Y269
E
I
E
E
A
Y
C
Y
T
S
P
G
P
P
K
Site 38
S271
E
E
A
Y
C
Y
T
S
P
G
P
P
K
K
K
Site 39
Y281
P
P
K
K
K
K
K
Y
K
I
H
G
E
K
T
Site 40
T288
Y
K
I
H
G
E
K
T
K
K
P
R
S
A
Y
Site 41
S293
E
K
T
K
K
P
R
S
A
Y
L
L
Y
Y
Y
Site 42
Y295
T
K
K
P
R
S
A
Y
L
L
Y
Y
Y
D
I
Site 43
Y298
P
R
S
A
Y
L
L
Y
Y
Y
D
I
Y
L
K
Site 44
S316
E
L
P
H
L
P
Q
S
E
I
N
K
K
I
S
Site 45
S323
S
E
I
N
K
K
I
S
E
S
W
R
L
L
S
Site 46
S325
I
N
K
K
I
S
E
S
W
R
L
L
S
V
A
Site 47
S330
S
E
S
W
R
L
L
S
V
A
E
R
S
Y
Y
Site 48
Y336
L
S
V
A
E
R
S
Y
Y
L
E
K
A
K
L
Site 49
Y337
S
V
A
E
R
S
Y
Y
L
E
K
A
K
L
E
Site 50
S352
K
E
G
L
D
P
N
S
K
L
S
A
L
T
A
Site 51
S374
F
R
K
I
L
P
R
S
D
Y
I
I
I
P
K
Site 52
Y376
K
I
L
P
R
S
D
Y
I
I
I
P
K
S
S
Site 53
S382
D
Y
I
I
I
P
K
S
S
L
Q
E
D
R
S
Site 54
S389
S
S
L
Q
E
D
R
S
C
P
Q
L
E
L
C
Site 55
S403
C
V
A
Q
N
Q
M
S
P
K
G
P
P
L
V
Site 56
T417
V
S
N
T
A
P
E
T
V
P
S
H
A
G
M
Site 57
S420
T
A
P
E
T
V
P
S
H
A
G
M
A
E
Q
Site 58
S466
D
V
L
L
E
D
A
S
L
E
V
G
E
S
H
Site 59
S472
A
S
L
E
V
G
E
S
H
Q
P
Y
Q
T
S
Site 60
Y476
V
G
E
S
H
Q
P
Y
Q
T
S
L
V
I
E
Site 61
T485
T
S
L
V
I
E
E
T
L
V
N
G
S
P
D
Site 62
S490
E
E
T
L
V
N
G
S
P
D
L
P
T
G
S
Site 63
T495
N
G
S
P
D
L
P
T
G
S
L
A
V
P
H
Site 64
S497
S
P
D
L
P
T
G
S
L
A
V
P
H
P
Q
Site 65
T513
G
E
S
V
S
V
V
T
V
M
R
D
S
S
E
Site 66
S518
V
V
T
V
M
R
D
S
S
E
S
S
S
S
A
Site 67
S519
V
T
V
M
R
D
S
S
E
S
S
S
S
A
P
Site 68
S521
V
M
R
D
S
S
E
S
S
S
S
A
P
A
T
Site 69
S522
M
R
D
S
S
E
S
S
S
S
A
P
A
T
Q
Site 70
S523
R
D
S
S
E
S
S
S
S
A
P
A
T
Q
F
Site 71
S524
D
S
S
E
S
S
S
S
A
P
A
T
Q
F
I
Site 72
S546
S
V
V
E
N
P
T
S
I
K
L
T
T
T
Y
Site 73
T550
N
P
T
S
I
K
L
T
T
T
Y
T
R
R
G
Site 74
T552
T
S
I
K
L
T
T
T
Y
T
R
R
G
H
G
Site 75
Y553
S
I
K
L
T
T
T
Y
T
R
R
G
H
G
T
Site 76
T554
I
K
L
T
T
T
Y
T
R
R
G
H
G
T
C
Site 77
T560
Y
T
R
R
G
H
G
T
C
T
S
P
G
C
S
Site 78
T562
R
R
G
H
G
T
C
T
S
P
G
C
S
F
T
Site 79
S563
R
G
H
G
T
C
T
S
P
G
C
S
F
T
Y
Site 80
Y570
S
P
G
C
S
F
T
Y
V
T
R
H
K
P
P
Site 81
S605
K
V
K
V
E
L
A
S
G
V
S
S
K
G
S
Site 82
S609
E
L
A
S
G
V
S
S
K
G
S
V
V
K
R
Site 83
S612
S
G
V
S
S
K
G
S
V
V
K
R
N
Q
Q
Site 84
T622
K
R
N
Q
Q
P
V
T
T
E
Q
N
S
S
K
Site 85
S628
V
T
T
E
Q
N
S
S
K
E
N
A
S
K
L
Site 86
T636
K
E
N
A
S
K
L
T
L
E
N
S
E
A
V
Site 87
S640
S
K
L
T
L
E
N
S
E
A
V
S
Q
L
L
Site 88
S659
P
R
E
V
G
E
E
S
E
W
E
E
V
I
I
Site 89
S692
T
K
T
P
V
V
K
S
G
V
Q
P
E
V
T
Site 90
T699
S
G
V
Q
P
E
V
T
L
G
T
T
D
N
D
Site 91
T703
P
E
V
T
L
G
T
T
D
N
D
S
P
G
A
Site 92
S707
L
G
T
T
D
N
D
S
P
G
A
D
V
P
T
Site 93
T714
S
P
G
A
D
V
P
T
P
S
E
G
T
S
T
Site 94
S716
G
A
D
V
P
T
P
S
E
G
T
S
T
S
S
Site 95
S720
P
T
P
S
E
G
T
S
T
S
S
P
L
P
A
Site 96
T721
T
P
S
E
G
T
S
T
S
S
P
L
P
A
P
Site 97
S723
S
E
G
T
S
T
S
S
P
L
P
A
P
K
K
Site 98
T738
P
T
G
A
D
L
L
T
P
G
S
R
A
P
E
Site 99
S741
A
D
L
L
T
P
G
S
R
A
P
E
L
K
G
Site 100
S755
G
R
A
R
G
K
P
S
L
L
A
A
A
R
P
Site 101
S777
P
V
N
V
G
R
G
S
S
M
G
L
P
R
A
Site 102
S778
V
N
V
G
R
G
S
S
M
G
L
P
R
A
R
Site 103
S789
P
R
A
R
Q
A
F
S
L
S
D
K
T
P
S
Site 104
S791
A
R
Q
A
F
S
L
S
D
K
T
P
S
V
R
Site 105
T794
A
F
S
L
S
D
K
T
P
S
V
R
T
C
G
Site 106
S796
S
L
S
D
K
T
P
S
V
R
T
C
G
L
K
Site 107
S805
R
T
C
G
L
K
P
S
T
L
K
Q
L
G
Q
Site 108
S818
G
Q
P
I
Q
Q
P
S
G
P
G
E
V
K
L
Site 109
S827
P
G
E
V
K
L
P
S
G
P
S
N
R
T
S
Site 110
S830
V
K
L
P
S
G
P
S
N
R
T
S
Q
V
K
Site 111
S834
S
G
P
S
N
R
T
S
Q
V
K
V
V
E
V
Site 112
Y849
K
P
D
M
F
P
P
Y
K
Y
S
C
T
V
T
Site 113
Y851
D
M
F
P
P
Y
K
Y
S
C
T
V
T
L
D
Site 114
T863
T
L
D
L
G
L
A
T
S
R
G
R
G
K
C
Site 115
S864
L
D
L
G
L
A
T
S
R
G
R
G
K
C
K
Site 116
Y877
C
K
N
P
S
C
S
Y
V
Y
T
N
R
H
K
Site 117
T904
K
D
R
T
E
K
T
T
K
A
I
E
V
S
S
Site 118
T920
L
P
D
V
L
N
A
T
E
P
L
S
T
A
Q
Site 119
S924
L
N
A
T
E
P
L
S
T
A
Q
R
E
I
Q
Site 120
T925
N
A
T
E
P
L
S
T
A
Q
R
E
I
Q
R
Site 121
S934
Q
R
E
I
Q
R
Q
S
T
L
Q
L
L
R
K
Site 122
T935
R
E
I
Q
R
Q
S
T
L
Q
L
L
R
K
V
Site 123
S970
N
S
S
R
L
I
L
S
N
V
S
E
E
T
V
Site 124
T978
N
V
S
E
E
T
V
T
I
E
Q
T
S
W
S
Site 125
S985
T
I
E
Q
T
S
W
S
N
Y
Y
E
S
P
S
Site 126
Y987
E
Q
T
S
W
S
N
Y
Y
E
S
P
S
T
Q
Site 127
Y988
Q
T
S
W
S
N
Y
Y
E
S
P
S
T
Q
C
Site 128
S990
S
W
S
N
Y
Y
E
S
P
S
T
Q
C
L
L
Site 129
S992
S
N
Y
Y
E
S
P
S
T
Q
C
L
L
C
S
Site 130
T993
N
Y
Y
E
S
P
S
T
Q
C
L
L
C
S
S
Site 131
S1009
L
F
K
G
G
Q
N
S
L
A
G
P
Q
E
C
Site 132
T1020
P
Q
E
C
W
L
L
T
A
S
R
L
Q
T
V
Site 133
S1089
S
I
N
V
V
L
K
S
V
Q
E
Q
T
E
K
Site 134
T1097
V
Q
E
Q
T
E
K
T
L
T
S
E
E
L
S
Site 135
T1099
E
Q
T
E
K
T
L
T
S
E
E
L
S
Q
L
Site 136
S1104
T
L
T
S
E
E
L
S
Q
L
Q
E
L
L
C
Site 137
S1154
E
N
V
L
A
L
K
S
V
E
F
T
W
P
E
Site 138
S1165
T
W
P
E
F
L
G
S
N
E
V
N
V
E
D
Site 139
S1251
C
K
L
D
E
I
G
S
Y
S
E
E
K
L
Q
Site 140
Y1252
K
L
D
E
I
G
S
Y
S
E
E
K
L
Q
H
Site 141
S1253
L
D
E
I
G
S
Y
S
E
E
K
L
Q
H
L
Site 142
S1273
I
P
F
G
A
E
D
S
K
D
Q
L
C
F
S
Site 143
T1302
I
R
P
P
R
H
F
T
G
G
K
I
Y
K
V
Site 144
Y1320
Q
V
V
C
G
S
K
Y
L
V
R
G
E
S
A
Site 145
S1326
K
Y
L
V
R
G
E
S
A
R
D
H
V
D
L
Site 146
S1336
D
H
V
D
L
L
A
S
S
R
H
W
P
P
V
Site 147
S1337
H
V
D
L
L
A
S
S
R
H
W
P
P
V
Y
Site 148
Y1344
S
R
H
W
P
P
V
Y
V
V
D
M
A
T
S
Site 149
S1376
G
R
N
Q
G
C
F
S
S
P
T
E
P
P
V
Site 150
S1377
R
N
Q
G
C
F
S
S
P
T
E
P
P
V
S
Site 151
T1379
Q
G
C
F
S
S
P
T
E
P
P
V
S
V
S
Site 152
S1384
S
P
T
E
P
P
V
S
V
S
C
P
E
L
L
Site 153
S1386
T
E
P
P
V
S
V
S
C
P
E
L
L
D
Q
Site 154
Y1395
P
E
L
L
D
Q
H
Y
T
V
D
M
T
E
T
Site 155
T1396
E
L
L
D
Q
H
Y
T
V
D
M
T
E
T
E
Site 156
T1413
I
Q
H
P
V
T
K
T
A
T
R
R
I
V
H
Site 157
S1431
Q
P
N
P
G
D
P
S
A
G
H
H
S
L
A
Site 158
S1436
D
P
S
A
G
H
H
S
L
A
L
C
P
E
L
Site 159
S1456
I
L
A
S
I
V
D
S
K
P
N
G
V
R
Q
Site 160
Y1474
A
F
D
N
A
T
H
Y
Y
L
Y
N
R
L
M
Site 161
Y1475
F
D
N
A
T
H
Y
Y
L
Y
N
R
L
M
D
Site 162
Y1477
N
A
T
H
Y
Y
L
Y
N
R
L
M
D
F
L
Site 163
T1485
N
R
L
M
D
F
L
T
S
R
E
I
V
N
R
Site 164
T1522
L
G
V
A
Q
I
K
T
E
T
E
E
E
G
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation