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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ARHGEF5
Full Name:
Rho guanine nucleotide exchange factor 5
Alias:
TIM
Type:
Intracellular protein
Mass (Da):
176799
Number AA:
1597
UniProt ID:
Q12774
International Prot ID:
IPI00418545
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
Uniprot
OncoNet
Molecular Function:
GO:0005525
GO:0005089
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007242
GO:0035023
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
E
E
A
Q
R
G
A
S
P
P
I
S
A
I
E
Site 2
S15
R
G
A
S
P
P
I
S
A
I
E
E
F
S
I
Site 3
S30
I
P
E
A
P
M
R
S
S
Q
V
S
A
L
G
Site 4
S31
P
E
A
P
M
R
S
S
Q
V
S
A
L
G
L
Site 5
S34
P
M
R
S
S
Q
V
S
A
L
G
L
E
A
Q
Site 6
S47
A
Q
E
D
E
D
P
S
Y
K
W
R
E
E
H
Site 7
Y48
Q
E
D
E
D
P
S
Y
K
W
R
E
E
H
R
Site 8
S57
W
R
E
E
H
R
L
S
A
T
Q
Q
S
E
L
Site 9
Y70
E
L
R
D
V
C
D
Y
A
I
E
T
M
P
S
Site 10
T74
V
C
D
Y
A
I
E
T
M
P
S
F
P
K
E
Site 11
S77
Y
A
I
E
T
M
P
S
F
P
K
E
G
S
A
Site 12
S83
P
S
F
P
K
E
G
S
A
D
V
E
P
N
Q
Site 13
S92
D
V
E
P
N
Q
E
S
L
V
A
E
A
C
D
Site 14
T100
L
V
A
E
A
C
D
T
P
E
H
W
E
A
V
Site 15
S110
H
W
E
A
V
P
Q
S
L
A
G
R
Q
A
R
Site 16
T118
L
A
G
R
Q
A
R
T
L
A
P
P
E
L
W
Site 17
S140
H
L
D
M
A
P
F
S
S
D
L
G
S
E
E
Site 18
S141
L
D
M
A
P
F
S
S
D
L
G
S
E
E
E
Site 19
S145
P
F
S
S
D
L
G
S
E
E
E
E
V
E
F
Site 20
S158
E
F
W
P
G
L
T
S
L
T
L
G
S
G
Q
Site 21
T160
W
P
G
L
T
S
L
T
L
G
S
G
Q
A
E
Site 22
T172
Q
A
E
E
E
E
E
T
S
S
D
N
S
G
Q
Site 23
S173
A
E
E
E
E
E
T
S
S
D
N
S
G
Q
T
Site 24
S174
E
E
E
E
E
T
S
S
D
N
S
G
Q
T
R
Site 25
S177
E
E
T
S
S
D
N
S
G
Q
T
R
Y
Y
S
Site 26
T180
S
S
D
N
S
G
Q
T
R
Y
Y
S
P
C
E
Site 27
Y182
D
N
S
G
Q
T
R
Y
Y
S
P
C
E
E
H
Site 28
Y183
N
S
G
Q
T
R
Y
Y
S
P
C
E
E
H
P
Site 29
S184
S
G
Q
T
R
Y
Y
S
P
C
E
E
H
P
A
Site 30
S199
E
T
N
Q
N
E
G
S
E
S
G
T
I
R
Q
Site 31
T203
N
E
G
S
E
S
G
T
I
R
Q
G
E
E
L
Site 32
S218
P
P
E
E
L
Q
E
S
Q
G
L
L
H
P
Q
Site 33
T245
A
G
F
R
G
E
G
T
L
R
E
D
V
C
A
Site 34
T294
Q
G
E
R
M
G
L
T
G
E
P
E
G
L
N
Site 35
S340
P
E
E
N
R
A
D
S
Q
D
E
K
S
Q
T
Site 36
S345
A
D
S
Q
D
E
K
S
Q
T
F
L
G
K
S
Site 37
T347
S
Q
D
E
K
S
Q
T
F
L
G
K
S
E
E
Site 38
S352
S
Q
T
F
L
G
K
S
E
E
V
T
G
K
Q
Site 39
T356
L
G
K
S
E
E
V
T
G
K
Q
E
D
H
G
Site 40
S381
Q
E
A
K
E
P
E
S
W
D
G
G
R
L
G
Site 41
S395
G
A
V
G
R
A
R
S
R
E
E
E
N
E
H
Site 42
S406
E
N
E
H
H
G
P
S
M
P
A
L
I
A
P
Site 43
T430
P
G
A
S
Y
L
M
T
Q
I
P
G
T
Q
T
Site 44
T435
L
M
T
Q
I
P
G
T
Q
T
E
S
R
A
E
Site 45
S439
I
P
G
T
Q
T
E
S
R
A
E
E
L
S
P
Site 46
S445
E
S
R
A
E
E
L
S
P
A
A
L
S
P
S
Site 47
S450
E
L
S
P
A
A
L
S
P
S
L
E
P
I
R
Site 48
S452
S
P
A
A
L
S
P
S
L
E
P
I
R
C
S
Site 49
S459
S
L
E
P
I
R
C
S
H
Q
P
I
S
L
L
Site 50
S468
Q
P
I
S
L
L
G
S
F
L
T
E
E
S
P
Site 51
T471
S
L
L
G
S
F
L
T
E
E
S
P
D
K
E
Site 52
S474
G
S
F
L
T
E
E
S
P
D
K
E
I
D
Q
Site 53
S483
D
K
E
I
D
Q
N
S
Q
Q
E
G
S
R
L
Site 54
S488
Q
N
S
Q
Q
E
G
S
R
L
R
K
G
T
V
Site 55
T494
G
S
R
L
R
K
G
T
V
S
S
Q
G
T
E
Site 56
S496
R
L
R
K
G
T
V
S
S
Q
G
T
E
V
V
Site 57
T510
V
F
A
S
A
S
V
T
P
P
R
T
P
D
S
Site 58
T514
A
S
V
T
P
P
R
T
P
D
S
A
P
P
S
Site 59
S517
T
P
P
R
T
P
D
S
A
P
P
S
P
A
E
Site 60
S521
T
P
D
S
A
P
P
S
P
A
E
A
Y
P
I
Site 61
Y526
P
P
S
P
A
E
A
Y
P
I
T
P
A
S
V
Site 62
T529
P
A
E
A
Y
P
I
T
P
A
S
V
S
A
R
Site 63
T546
V
A
F
P
R
R
E
T
S
C
A
A
R
A
P
Site 64
S547
A
F
P
R
R
E
T
S
C
A
A
R
A
P
E
Site 65
S557
A
R
A
P
E
T
A
S
A
P
L
S
M
D
D
Site 66
S561
E
T
A
S
A
P
L
S
M
D
D
P
S
P
C
Site 67
S566
P
L
S
M
D
D
P
S
P
C
G
T
S
E
M
Site 68
T570
D
D
P
S
P
C
G
T
S
E
M
C
Q
A
A
Site 69
Y579
E
M
C
Q
A
A
L
Y
G
F
P
S
T
G
T
Site 70
S583
A
A
L
Y
G
F
P
S
T
G
T
S
P
P
R
Site 71
T584
A
L
Y
G
F
P
S
T
G
T
S
P
P
R
P
Site 72
T586
Y
G
F
P
S
T
G
T
S
P
P
R
P
P
A
Site 73
S587
G
F
P
S
T
G
T
S
P
P
R
P
P
A
N
Site 74
S595
P
P
R
P
P
A
N
S
T
G
T
V
Q
H
L
Site 75
T598
P
P
A
N
S
T
G
T
V
Q
H
L
R
S
D
Site 76
S604
G
T
V
Q
H
L
R
S
D
S
F
P
G
S
H
Site 77
S606
V
Q
H
L
R
S
D
S
F
P
G
S
H
R
T
Site 78
S610
R
S
D
S
F
P
G
S
H
R
T
E
Q
T
P
Site 79
T616
G
S
H
R
T
E
Q
T
P
D
L
V
G
M
L
Site 80
S627
V
G
M
L
L
S
Y
S
H
S
E
L
P
Q
R
Site 81
S629
M
L
L
S
Y
S
H
S
E
L
P
Q
R
P
P
Site 82
Y641
R
P
P
K
P
A
I
Y
S
S
V
T
P
R
R
Site 83
S642
P
P
K
P
A
I
Y
S
S
V
T
P
R
R
D
Site 84
S643
P
K
P
A
I
Y
S
S
V
T
P
R
R
D
R
Site 85
T645
P
A
I
Y
S
S
V
T
P
R
R
D
R
R
S
Site 86
S652
T
P
R
R
D
R
R
S
G
R
D
Y
S
T
V
Site 87
Y656
D
R
R
S
G
R
D
Y
S
T
V
S
A
S
P
Site 88
S657
R
R
S
G
R
D
Y
S
T
V
S
A
S
P
T
Site 89
T658
R
S
G
R
D
Y
S
T
V
S
A
S
P
T
A
Site 90
S660
G
R
D
Y
S
T
V
S
A
S
P
T
A
L
S
Site 91
S662
D
Y
S
T
V
S
A
S
P
T
A
L
S
T
L
Site 92
T664
S
T
V
S
A
S
P
T
A
L
S
T
L
K
Q
Site 93
S667
S
A
S
P
T
A
L
S
T
L
K
Q
D
S
Q
Site 94
S673
L
S
T
L
K
Q
D
S
Q
E
S
I
S
N
L
Site 95
S678
Q
D
S
Q
E
S
I
S
N
L
E
R
P
S
S
Site 96
S684
I
S
N
L
E
R
P
S
S
P
P
S
I
Q
P
Site 97
S685
S
N
L
E
R
P
S
S
P
P
S
I
Q
P
W
Site 98
S688
E
R
P
S
S
P
P
S
I
Q
P
W
V
S
P
Site 99
S694
P
S
I
Q
P
W
V
S
P
H
N
P
A
F
A
Site 100
S704
N
P
A
F
A
T
E
S
P
A
Y
G
S
S
P
Site 101
Y707
F
A
T
E
S
P
A
Y
G
S
S
P
S
F
V
Site 102
S709
T
E
S
P
A
Y
G
S
S
P
S
F
V
S
M
Site 103
S710
E
S
P
A
Y
G
S
S
P
S
F
V
S
M
E
Site 104
S712
P
A
Y
G
S
S
P
S
F
V
S
M
E
D
V
Site 105
S715
G
S
S
P
S
F
V
S
M
E
D
V
R
I
H
Site 106
T735
P
P
P
Q
R
R
D
T
H
P
S
V
V
E
T
Site 107
S738
Q
R
R
D
T
H
P
S
V
V
E
T
D
G
H
Site 108
T752
H
A
R
V
V
V
P
T
L
K
Q
H
S
H
P
Site 109
S757
V
P
T
L
K
Q
H
S
H
P
P
P
L
A
L
Site 110
S766
P
P
P
L
A
L
G
S
G
L
H
A
P
H
K
Site 111
S780
K
G
P
L
P
Q
A
S
D
P
A
V
A
R
Q
Site 112
S793
R
Q
H
R
P
L
P
S
T
P
D
S
S
H
H
Site 113
T794
Q
H
R
P
L
P
S
T
P
D
S
S
H
H
A
Site 114
S797
P
L
P
S
T
P
D
S
S
H
H
A
Q
A
T
Site 115
S798
L
P
S
T
P
D
S
S
H
H
A
Q
A
T
P
Site 116
T804
S
S
H
H
A
Q
A
T
P
R
W
R
Y
N
K
Site 117
Y809
Q
A
T
P
R
W
R
Y
N
K
P
L
P
P
T
Site 118
T816
Y
N
K
P
L
P
P
T
P
D
L
P
Q
P
H
Site 119
S828
Q
P
H
L
P
P
I
S
A
P
G
S
S
R
I
Site 120
S832
P
P
I
S
A
P
G
S
S
R
I
Y
R
P
L
Site 121
S833
P
I
S
A
P
G
S
S
R
I
Y
R
P
L
P
Site 122
Y836
A
P
G
S
S
R
I
Y
R
P
L
P
P
L
P
Site 123
T849
L
P
I
I
D
P
P
T
E
P
P
P
L
P
P
Site 124
S858
P
P
P
L
P
P
K
S
R
G
R
S
R
S
T
Site 125
S862
P
P
K
S
R
G
R
S
R
S
T
R
G
G
H
Site 126
S864
K
S
R
G
R
S
R
S
T
R
G
G
H
M
N
Site 127
T865
S
R
G
R
S
R
S
T
R
G
G
H
M
N
S
Site 128
S872
T
R
G
G
H
M
N
S
G
G
H
A
K
T
R
Site 129
T886
R
P
A
C
Q
D
W
T
V
P
L
P
A
S
A
Site 130
S892
W
T
V
P
L
P
A
S
A
G
R
T
S
W
P
Site 131
S897
P
A
S
A
G
R
T
S
W
P
P
A
T
A
R
Site 132
T902
R
T
S
W
P
P
A
T
A
R
S
T
E
S
F
Site 133
S905
W
P
P
A
T
A
R
S
T
E
S
F
T
S
T
Site 134
T906
P
P
A
T
A
R
S
T
E
S
F
T
S
T
S
Site 135
S908
A
T
A
R
S
T
E
S
F
T
S
T
S
R
S
Site 136
S911
R
S
T
E
S
F
T
S
T
S
R
S
K
S
E
Site 137
T912
S
T
E
S
F
T
S
T
S
R
S
K
S
E
V
Site 138
S913
T
E
S
F
T
S
T
S
R
S
K
S
E
V
S
Site 139
S915
S
F
T
S
T
S
R
S
K
S
E
V
S
P
G
Site 140
S917
T
S
T
S
R
S
K
S
E
V
S
P
G
M
A
Site 141
S920
S
R
S
K
S
E
V
S
P
G
M
A
F
S
N
Site 142
S936
T
N
F
L
C
P
S
S
P
T
T
P
W
T
P
Site 143
T939
L
C
P
S
S
P
T
T
P
W
T
P
E
L
Q
Site 144
T942
S
S
P
T
T
P
W
T
P
E
L
Q
G
P
T
Site 145
S950
P
E
L
Q
G
P
T
S
K
D
E
A
G
V
S
Site 146
S957
S
K
D
E
A
G
V
S
E
H
P
E
A
P
A
Site 147
T971
A
R
E
P
L
R
R
T
T
P
Q
Q
G
A
S
Site 148
T972
R
E
P
L
R
R
T
T
P
Q
Q
G
A
S
G
Site 149
S978
T
T
P
Q
Q
G
A
S
G
P
G
R
S
P
V
Site 150
S983
G
A
S
G
P
G
R
S
P
V
G
Q
A
R
Q
Site 151
S1004
L
H
L
E
K
A
S
S
W
P
H
R
R
D
S
Site 152
S1011
S
W
P
H
R
R
D
S
G
R
P
P
G
D
S
Site 153
S1018
S
G
R
P
P
G
D
S
S
G
Q
A
V
A
P
Site 154
S1019
G
R
P
P
G
D
S
S
G
Q
A
V
A
P
S
Site 155
S1026
S
G
Q
A
V
A
P
S
E
G
A
N
K
H
K
Site 156
S1044
R
Q
G
L
R
R
P
S
I
L
P
E
G
S
S
Site 157
S1051
S
I
L
P
E
G
S
S
D
S
R
G
P
A
V
Site 158
S1053
L
P
E
G
S
S
D
S
R
G
P
A
V
E
K
Site 159
T1067
K
H
P
G
P
S
D
T
V
V
F
R
E
K
K
Site 160
S1083
K
E
V
M
G
G
F
S
R
R
C
S
K
L
I
Site 161
S1087
G
G
F
S
R
R
C
S
K
L
I
N
S
S
Q
Site 162
S1092
R
C
S
K
L
I
N
S
S
Q
L
L
Y
Q
E
Site 163
S1093
C
S
K
L
I
N
S
S
Q
L
L
Y
Q
E
Y
Site 164
Y1097
I
N
S
S
Q
L
L
Y
Q
E
Y
S
D
V
V
Site 165
Y1100
S
Q
L
L
Y
Q
E
Y
S
D
V
V
L
N
K
Site 166
S1101
Q
L
L
Y
Q
E
Y
S
D
V
V
L
N
K
E
Site 167
S1111
V
L
N
K
E
I
Q
S
Q
Q
R
L
E
S
L
Site 168
S1117
Q
S
Q
Q
R
L
E
S
L
S
E
T
P
G
P
Site 169
S1119
Q
Q
R
L
E
S
L
S
E
T
P
G
P
S
S
Site 170
T1121
R
L
E
S
L
S
E
T
P
G
P
S
S
P
R
Site 171
S1125
L
S
E
T
P
G
P
S
S
P
R
Q
P
R
K
Site 172
S1126
S
E
T
P
G
P
S
S
P
R
Q
P
R
K
A
Site 173
S1136
Q
P
R
K
A
L
V
S
S
E
S
Y
L
Q
R
Site 174
S1139
K
A
L
V
S
S
E
S
Y
L
Q
R
L
S
M
Site 175
Y1140
A
L
V
S
S
E
S
Y
L
Q
R
L
S
M
A
Site 176
S1145
E
S
Y
L
Q
R
L
S
M
A
S
S
G
S
L
Site 177
S1148
L
Q
R
L
S
M
A
S
S
G
S
L
W
Q
E
Site 178
S1149
Q
R
L
S
M
A
S
S
G
S
L
W
Q
E
I
Site 179
S1192
S
E
A
S
Y
L
R
S
L
N
I
A
V
D
H
Site 180
S1205
D
H
F
Q
L
S
T
S
L
R
A
T
L
S
N
Site 181
T1209
L
S
T
S
L
R
A
T
L
S
N
Q
E
H
Q
Site 182
S1211
T
S
L
R
A
T
L
S
N
Q
E
H
Q
W
L
Site 183
T1231
D
V
R
D
V
S
A
T
F
L
S
D
L
E
E
Site 184
S1234
D
V
S
A
T
F
L
S
D
L
E
E
N
F
E
Site 185
Y1264
A
P
D
F
R
R
V
Y
L
P
Y
V
T
N
Q
Site 186
Y1267
F
R
R
V
Y
L
P
Y
V
T
N
Q
T
Y
Q
Site 187
Y1273
P
Y
V
T
N
Q
T
Y
Q
E
R
T
F
Q
S
Site 188
T1277
N
Q
T
Y
Q
E
R
T
F
Q
S
L
M
N
S
Site 189
S1280
Y
Q
E
R
T
F
Q
S
L
M
N
S
N
S
N
Site 190
S1284
T
F
Q
S
L
M
N
S
N
S
N
F
R
E
V
Site 191
S1286
Q
S
L
M
N
S
N
S
N
F
R
E
V
L
E
Site 192
S1297
E
V
L
E
K
L
E
S
D
P
V
C
Q
R
L
Site 193
T1331
L
Q
N
I
L
K
R
T
Q
P
G
S
S
E
E
Site 194
S1335
L
K
R
T
Q
P
G
S
S
E
E
A
E
A
T
Site 195
T1342
S
S
E
E
A
E
A
T
K
A
H
H
A
L
E
Site 196
T1365
N
V
Q
S
M
R
R
T
E
E
L
I
Y
L
S
Site 197
Y1370
R
R
T
E
E
L
I
Y
L
S
Q
K
I
E
F
Site 198
S1372
T
E
E
L
I
Y
L
S
Q
K
I
E
F
E
C
Site 199
S1394
Q
S
R
W
L
V
K
S
G
E
L
T
A
L
E
Site 200
S1403
E
L
T
A
L
E
F
S
A
S
P
G
L
R
R
Site 201
S1405
T
A
L
E
F
S
A
S
P
G
L
R
R
K
L
Site 202
T1414
G
L
R
R
K
L
N
T
R
P
V
H
L
H
L
Site 203
S1429
F
N
D
C
L
L
L
S
R
P
R
E
G
S
R
Site 204
S1435
L
S
R
P
R
E
G
S
R
F
L
V
F
D
H
Site 205
S1446
V
F
D
H
A
P
F
S
S
I
R
G
E
K
C
Site 206
S1447
F
D
H
A
P
F
S
S
I
R
G
E
K
C
E
Site 207
T1473
R
L
F
L
R
Q
N
T
Q
G
A
Q
A
E
F
Site 208
T1486
E
F
L
F
R
T
E
T
Q
S
E
K
L
R
W
Site 209
S1488
L
F
R
T
E
T
Q
S
E
K
L
R
W
I
S
Site 210
S1495
S
E
K
L
R
W
I
S
A
L
A
M
P
R
E
Site 211
Y1510
E
L
D
L
L
E
C
Y
N
S
P
Q
V
Q
C
Site 212
S1512
D
L
L
E
C
Y
N
S
P
Q
V
Q
C
L
R
Site 213
Y1521
Q
V
Q
C
L
R
A
Y
K
P
R
E
N
D
E
Site 214
T1540
K
A
D
V
V
M
V
T
Q
Q
S
S
D
G
W
Site 215
S1554
W
L
E
G
V
R
L
S
D
G
E
R
G
W
F
Site 216
T1587
K
E
A
H
R
V
K
T
A
K
L
Q
L
V
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation