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Updated November 2019
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Protein Info
Short Name:
AKAP13
Full Name:
A-kinase anchor protein 13
Alias:
A kinase (PRKA) anchor protein 13; AKAP-Lbc; AKP13; ARHGEF13; Breast cancer nuclear receptor-binding auxiliary protein; BRX; C-lbc; FLJ11952; Guanine nucleotide exchange factor Lbc; HA-3; Ht31; Human thyroid-anchoring protein 31; LBC; Lymphoid blast crisis oncogene; Non-oncogenic Rho GTPase-specific GTP exchange factor; P47; Protein kinase A-anchoring protein 13; PROTO-LB; PROTO-LBC
Type:
Adaptor/scaffold
Mass (Da):
307550
Number AA:
2813
UniProt ID:
Q12802
International Prot ID:
IPI00382689
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0016020
GO:0005624
Uniprot
OncoNet
Molecular Function:
GO:0005089
GO:0004691
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006915
GO:0008624
GO:0007242
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T45
G
S
T
L
R
H
C
T
S
T
R
K
V
S
S
Site 2
S46
S
T
L
R
H
C
T
S
T
R
K
V
S
S
D
Site 3
T47
T
L
R
H
C
T
S
T
R
K
V
S
S
D
T
Site 4
S51
C
T
S
T
R
K
V
S
S
D
T
L
E
T
I
Site 5
S52
T
S
T
R
K
V
S
S
D
T
L
E
T
I
A
Site 6
T54
T
R
K
V
S
S
D
T
L
E
T
I
A
P
G
Site 7
Y97
H
F
V
Q
D
E
A
Y
D
A
A
Q
F
L
A
Site 8
S122
F
T
R
F
L
D
Q
S
G
P
P
S
G
D
V
Site 9
S126
L
D
Q
S
G
P
P
S
G
D
V
N
S
L
D
Site 10
S131
P
P
S
G
D
V
N
S
L
D
K
K
L
V
L
Site 11
S157
N
V
L
G
T
D
Q
S
L
H
D
A
G
P
R
Site 12
T166
H
D
A
G
P
R
E
T
L
M
H
F
A
V
R
Site 13
T180
R
L
G
L
L
R
L
T
W
F
L
L
Q
K
P
Site 14
S194
P
G
G
R
G
A
L
S
I
H
N
Q
E
G
A
Site 15
T202
I
H
N
Q
E
G
A
T
P
V
S
L
A
L
E
Site 16
S205
Q
E
G
A
T
P
V
S
L
A
L
E
R
G
Y
Site 17
Y212
S
L
A
L
E
R
G
Y
H
K
L
H
Q
L
L
Site 18
T220
H
K
L
H
Q
L
L
T
E
E
N
A
G
E
P
Site 19
S229
E
N
A
G
E
P
D
S
W
S
S
L
S
Y
E
Site 20
S231
A
G
E
P
D
S
W
S
S
L
S
Y
E
I
P
Site 21
S232
G
E
P
D
S
W
S
S
L
S
Y
E
I
P
Y
Site 22
S234
P
D
S
W
S
S
L
S
Y
E
I
P
Y
G
D
Site 23
Y235
D
S
W
S
S
L
S
Y
E
I
P
Y
G
D
C
Site 24
Y239
S
L
S
Y
E
I
P
Y
G
D
C
S
V
R
H
Site 25
Y253
H
H
R
E
L
D
I
Y
T
L
T
S
E
S
D
Site 26
T254
H
R
E
L
D
I
Y
T
L
T
S
E
S
D
S
Site 27
T256
E
L
D
I
Y
T
L
T
S
E
S
D
S
H
H
Site 28
S257
L
D
I
Y
T
L
T
S
E
S
D
S
H
H
E
Site 29
S259
I
Y
T
L
T
S
E
S
D
S
H
H
E
H
P
Site 30
S261
T
L
T
S
E
S
D
S
H
H
E
H
P
F
P
Site 31
S308
M
M
T
A
Q
D
P
S
S
A
P
E
T
D
G
Site 32
S309
M
T
A
Q
D
P
S
S
A
P
E
T
D
G
Q
Site 33
T313
D
P
S
S
A
P
E
T
D
G
Q
F
L
P
C
Site 34
S331
P
T
D
P
Q
R
L
S
S
S
E
E
T
E
S
Site 35
S332
T
D
P
Q
R
L
S
S
S
E
E
T
E
S
T
Site 36
S333
D
P
Q
R
L
S
S
S
E
E
T
E
S
T
Q
Site 37
T336
R
L
S
S
S
E
E
T
E
S
T
Q
C
C
P
Site 38
S338
S
S
S
E
E
T
E
S
T
Q
C
C
P
G
S
Site 39
T339
S
S
E
E
T
E
S
T
Q
C
C
P
G
S
P
Site 40
S345
S
T
Q
C
C
P
G
S
P
V
A
Q
T
E
S
Site 41
T350
P
G
S
P
V
A
Q
T
E
S
P
C
D
L
S
Site 42
S352
S
P
V
A
Q
T
E
S
P
C
D
L
S
S
I
Site 43
S357
T
E
S
P
C
D
L
S
S
I
V
E
E
E
N
Site 44
S358
E
S
P
C
D
L
S
S
I
V
E
E
E
N
T
Site 45
T365
S
I
V
E
E
E
N
T
D
R
S
C
R
K
K
Site 46
S368
E
E
E
N
T
D
R
S
C
R
K
K
N
K
G
Site 47
S391
E
P
A
P
I
V
D
S
G
T
V
S
D
Q
D
Site 48
T393
A
P
I
V
D
S
G
T
V
S
D
Q
D
S
C
Site 49
S395
I
V
D
S
G
T
V
S
D
Q
D
S
C
L
Q
Site 50
S399
G
T
V
S
D
Q
D
S
C
L
Q
S
L
P
D
Site 51
S403
D
Q
D
S
C
L
Q
S
L
P
D
C
G
V
K
Site 52
T412
P
D
C
G
V
K
G
T
E
G
L
S
S
C
G
Site 53
S416
V
K
G
T
E
G
L
S
S
C
G
N
R
N
E
Site 54
S417
K
G
T
E
G
L
S
S
C
G
N
R
N
E
E
Site 55
T425
C
G
N
R
N
E
E
T
G
T
K
S
S
G
M
Site 56
T427
N
R
N
E
E
T
G
T
K
S
S
G
M
P
T
Site 57
T434
T
K
S
S
G
M
P
T
D
Q
E
S
L
S
S
Site 58
S438
G
M
P
T
D
Q
E
S
L
S
S
G
D
A
V
Site 59
S440
P
T
D
Q
E
S
L
S
S
G
D
A
V
L
Q
Site 60
S441
T
D
Q
E
S
L
S
S
G
D
A
V
L
Q
R
Site 61
T456
D
L
V
M
E
P
G
T
A
Q
Y
S
S
G
G
Site 62
S460
E
P
G
T
A
Q
Y
S
S
G
G
E
L
G
G
Site 63
S461
P
G
T
A
Q
Y
S
S
G
G
E
L
G
G
I
Site 64
S469
G
G
E
L
G
G
I
S
T
T
N
V
S
T
P
Site 65
T470
G
E
L
G
G
I
S
T
T
N
V
S
T
P
D
Site 66
T475
I
S
T
T
N
V
S
T
P
D
T
A
G
E
M
Site 67
T478
T
N
V
S
T
P
D
T
A
G
E
M
E
H
G
Site 68
T492
G
L
M
N
P
D
A
T
V
W
K
N
V
L
Q
Site 69
T515
F
E
N
S
N
I
G
T
A
G
A
S
D
V
H
Site 70
S525
A
S
D
V
H
V
T
S
K
P
V
D
K
I
S
Site 71
S532
S
K
P
V
D
K
I
S
V
P
N
C
A
P
A
Site 72
S551
D
G
N
K
P
A
E
S
S
L
A
F
S
N
E
Site 73
S552
G
N
K
P
A
E
S
S
L
A
F
S
N
E
E
Site 74
S556
A
E
S
S
L
A
F
S
N
E
E
T
S
T
E
Site 75
T565
E
E
T
S
T
E
K
T
A
E
T
E
T
S
R
Site 76
S571
K
T
A
E
T
E
T
S
R
S
R
E
E
S
A
Site 77
S573
A
E
T
E
T
S
R
S
R
E
E
S
A
D
A
Site 78
S577
T
S
R
S
R
E
E
S
A
D
A
P
V
D
Q
Site 79
S598
A
A
A
K
D
K
I
S
D
G
L
E
P
Y
T
Site 80
S635
D
V
M
P
H
Q
N
S
E
T
N
S
S
H
A
Site 81
S639
H
Q
N
S
E
T
N
S
S
H
A
Q
S
Q
K
Site 82
S640
Q
N
S
E
T
N
S
S
H
A
Q
S
Q
K
G
Site 83
S644
T
N
S
S
H
A
Q
S
Q
K
G
K
S
S
P
Site 84
S649
A
Q
S
Q
K
G
K
S
S
P
I
C
S
T
T
Site 85
S650
Q
S
Q
K
G
K
S
S
P
I
C
S
T
T
G
Site 86
S654
G
K
S
S
P
I
C
S
T
T
G
D
D
K
L
Site 87
T656
S
S
P
I
C
S
T
T
G
D
D
K
L
C
A
Site 88
T671
D
S
A
C
Q
Q
N
T
V
T
S
S
G
D
L
Site 89
S688
K
L
C
D
N
I
V
S
E
S
E
S
T
T
A
Site 90
S692
N
I
V
S
E
S
E
S
T
T
A
R
Q
P
S
Site 91
T693
I
V
S
E
S
E
S
T
T
A
R
Q
P
S
S
Site 92
T694
V
S
E
S
E
S
T
T
A
R
Q
P
S
S
Q
Site 93
S699
S
T
T
A
R
Q
P
S
S
Q
D
P
P
D
A
Site 94
S700
T
T
A
R
Q
P
S
S
Q
D
P
P
D
A
S
Site 95
S707
S
Q
D
P
P
D
A
S
H
C
E
D
P
Q
A
Site 96
T725
T
S
D
P
V
R
D
T
Q
E
R
A
D
F
C
Site 97
S783
D
Q
A
V
I
S
D
S
T
F
S
L
A
N
S
Site 98
T784
Q
A
V
I
S
D
S
T
F
S
L
A
N
S
P
Site 99
S786
V
I
S
D
S
T
F
S
L
A
N
S
P
G
S
Site 100
S790
S
T
F
S
L
A
N
S
P
G
S
E
S
V
T
Site 101
S793
S
L
A
N
S
P
G
S
E
S
V
T
K
D
D
Site 102
S795
A
N
S
P
G
S
E
S
V
T
K
D
D
A
L
Site 103
T797
S
P
G
S
E
S
V
T
K
D
D
A
L
S
F
Site 104
S803
V
T
K
D
D
A
L
S
F
V
P
S
Q
K
E
Site 105
S807
D
A
L
S
F
V
P
S
Q
K
E
K
G
T
A
Site 106
T813
P
S
Q
K
E
K
G
T
A
T
P
E
L
H
T
Site 107
T815
Q
K
E
K
G
T
A
T
P
E
L
H
T
A
T
Site 108
Y824
E
L
H
T
A
T
D
Y
R
D
G
P
D
G
N
Site 109
S832
R
D
G
P
D
G
N
S
N
E
P
D
T
R
P
Site 110
T837
G
N
S
N
E
P
D
T
R
P
L
E
D
R
A
Site 111
S848
E
D
R
A
V
G
L
S
T
S
S
T
A
A
E
Site 112
S851
A
V
G
L
S
T
S
S
T
A
A
E
L
Q
H
Site 113
T852
V
G
L
S
T
S
S
T
A
A
E
L
Q
H
G
Site 114
S864
Q
H
G
M
G
N
T
S
L
T
G
L
G
G
E
Site 115
T866
G
M
G
N
T
S
L
T
G
L
G
G
E
H
E
Site 116
S892
N
I
K
G
N
T
D
S
S
L
Q
S
V
G
K
Site 117
S893
I
K
G
N
T
D
S
S
L
Q
S
V
G
K
A
Site 118
S896
N
T
D
S
S
L
Q
S
V
G
K
A
T
L
A
Site 119
S906
K
A
T
L
A
L
D
S
V
L
T
E
E
G
K
Site 120
S918
E
G
K
L
L
V
V
S
E
S
S
A
A
Q
E
Site 121
S920
K
L
L
V
V
S
E
S
S
A
A
Q
E
Q
D
Site 122
S943
S
I
K
E
N
A
L
S
S
G
T
L
Q
E
E
Site 123
T953
T
L
Q
E
E
Q
R
T
P
P
P
G
Q
D
T
Site 124
T960
T
P
P
P
G
Q
D
T
Q
Q
F
H
E
K
S
Site 125
S967
T
Q
Q
F
H
E
K
S
I
S
A
D
C
A
K
Site 126
S969
Q
F
H
E
K
S
I
S
A
D
C
A
K
D
K
Site 127
S981
K
D
K
A
L
Q
L
S
N
S
P
G
A
S
S
Site 128
S983
K
A
L
Q
L
S
N
S
P
G
A
S
S
A
F
Site 129
S987
L
S
N
S
P
G
A
S
S
A
F
L
K
A
E
Site 130
S988
S
N
S
P
G
A
S
S
A
F
L
K
A
E
T
Site 131
S1006
K
E
V
A
P
Q
V
S
L
L
T
Q
G
G
A
Site 132
S1016
T
Q
G
G
A
A
Q
S
L
V
P
P
G
A
S
Site 133
S1023
S
L
V
P
P
G
A
S
L
A
T
E
S
R
Q
Site 134
S1051
P
C
L
L
P
D
G
S
D
G
S
D
A
L
N
Site 135
S1054
L
P
D
G
S
D
G
S
D
A
L
N
C
S
Q
Site 136
S1060
G
S
D
A
L
N
C
S
Q
P
S
P
L
D
V
Site 137
S1063
A
L
N
C
S
Q
P
S
P
L
D
V
G
V
K
Site 138
S1074
V
G
V
K
N
T
Q
S
Q
G
K
T
S
A
C
Site 139
T1078
N
T
Q
S
Q
G
K
T
S
A
C
E
V
S
G
Site 140
S1109
E
P
R
R
E
N
I
S
H
N
T
Q
D
I
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P
R
V
L
F
R
S
Site 293
S2409
S
P
R
V
L
F
R
S
N
T
E
E
A
L
K
Site 294
T2411
R
V
L
F
R
S
N
T
E
E
A
L
K
G
G
Site 295
S2423
K
G
G
P
L
M
K
S
A
I
N
E
V
E
I
Site 296
T2446
L
G
G
T
L
G
P
T
V
S
S
P
I
E
Q
Site 297
S2448
G
T
L
G
P
T
V
S
S
P
I
E
Q
D
V
Site 298
S2460
Q
D
V
V
G
P
V
S
L
P
R
R
A
E
T
Site 299
T2467
S
L
P
R
R
A
E
T
F
G
G
F
D
S
H
Site 300
S2473
E
T
F
G
G
F
D
S
H
Q
M
N
A
S
K
Site 301
T2496
D
G
Q
D
L
R
R
T
E
S
D
S
G
L
K
Site 302
S2498
Q
D
L
R
R
T
E
S
D
S
G
L
K
K
G
Site 303
S2500
L
R
R
T
E
S
D
S
G
L
K
K
G
G
N
Site 304
S2518
V
F
M
L
K
R
N
S
E
Q
V
V
Q
S
V
Site 305
Y2545
V
V
L
Q
Q
D
S
Y
I
E
D
Q
K
L
V
Site 306
S2554
E
D
Q
K
L
V
L
S
E
R
A
L
T
R
S
Site 307
T2559
V
L
S
E
R
A
L
T
R
S
L
S
R
P
S
Site 308
S2561
S
E
R
A
L
T
R
S
L
S
R
P
S
S
L
Site 309
S2563
R
A
L
T
R
S
L
S
R
P
S
S
L
I
E
Site 310
S2566
T
R
S
L
S
R
P
S
S
L
I
E
Q
E
K
Site 311
S2567
R
S
L
S
R
P
S
S
L
I
E
Q
E
K
Q
Site 312
S2576
I
E
Q
E
K
Q
R
S
L
E
K
Q
R
Q
D
Site 313
S2676
R
R
E
A
E
R
L
S
Q
R
Q
T
E
R
D
Site 314
T2680
E
R
L
S
Q
R
Q
T
E
R
D
L
C
Q
V
Site 315
T2692
C
Q
V
S
H
P
H
T
K
L
M
R
I
P
S
Site 316
S2699
T
K
L
M
R
I
P
S
F
F
P
S
P
E
E
Site 317
S2703
R
I
P
S
F
F
P
S
P
E
E
P
P
S
P
Site 318
S2709
P
S
P
E
E
P
P
S
P
S
A
P
S
I
A
Site 319
S2711
P
E
E
P
P
S
P
S
A
P
S
I
A
K
S
Site 320
S2714
P
P
S
P
S
A
P
S
I
A
K
S
G
S
L
Site 321
S2718
S
A
P
S
I
A
K
S
G
S
L
D
S
E
L
Site 322
S2720
P
S
I
A
K
S
G
S
L
D
S
E
L
S
V
Site 323
S2723
A
K
S
G
S
L
D
S
E
L
S
V
S
P
K
Site 324
S2726
G
S
L
D
S
E
L
S
V
S
P
K
R
N
S
Site 325
S2728
L
D
S
E
L
S
V
S
P
K
R
N
S
I
S
Site 326
S2733
S
V
S
P
K
R
N
S
I
S
R
T
H
K
D
Site 327
T2737
K
R
N
S
I
S
R
T
H
K
D
K
G
P
F
Site 328
S2748
K
G
P
F
H
I
L
S
S
T
S
Q
T
N
K
Site 329
S2749
G
P
F
H
I
L
S
S
T
S
Q
T
N
K
G
Site 330
S2751
F
H
I
L
S
S
T
S
Q
T
N
K
G
P
E
Site 331
T2753
I
L
S
S
T
S
Q
T
N
K
G
P
E
G
Q
Site 332
S2761
N
K
G
P
E
G
Q
S
Q
A
P
A
S
T
S
Site 333
S2766
G
Q
S
Q
A
P
A
S
T
S
A
S
T
R
L
Site 334
S2768
S
Q
A
P
A
S
T
S
A
S
T
R
L
F
G
Site 335
T2777
S
T
R
L
F
G
L
T
K
P
K
E
K
K
E
Site 336
T2791
E
K
K
K
K
N
K
T
S
R
S
Q
P
G
D
Site 337
S2792
K
K
K
K
N
K
T
S
R
S
Q
P
G
D
G
Site 338
S2794
K
K
N
K
T
S
R
S
Q
P
G
D
G
P
A
Site 339
S2802
Q
P
G
D
G
P
A
S
E
V
S
A
E
G
E
Site 340
S2805
D
G
P
A
S
E
V
S
A
E
G
E
E
I
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation