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Updated November 2019
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Protein Info
Short Name:
TRO
Full Name:
Trophinin
Alias:
MAGE-D3 antigen
Type:
Mass (Da):
143716
Number AA:
1431
UniProt ID:
Q12816
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y7
_
M
D
R
R
N
D
Y
G
Y
R
V
P
L
F
Site 2
Y9
D
R
R
N
D
Y
G
Y
R
V
P
L
F
Q
G
Site 3
S23
G
P
L
P
P
P
G
S
L
G
L
P
F
P
P
Site 4
T34
P
F
P
P
D
I
Q
T
E
T
T
E
E
D
S
Site 5
T37
P
D
I
Q
T
E
T
T
E
E
D
S
V
L
L
Site 6
S69
V
V
N
R
P
K
K
S
K
T
K
K
A
P
I
Site 7
T127
P
T
T
E
V
T
N
T
Q
A
S
S
V
T
A
Site 8
S131
V
T
N
T
Q
A
S
S
V
T
A
Q
P
K
K
Site 9
T146
A
N
K
M
K
R
V
T
A
K
A
A
Q
G
S
Site 10
S153
T
A
K
A
A
Q
G
S
Q
S
P
T
G
H
E
Site 11
S155
K
A
A
Q
G
S
Q
S
P
T
G
H
E
G
G
Site 12
T157
A
Q
G
S
Q
S
P
T
G
H
E
G
G
T
I
Site 13
S190
H
A
P
I
A
N
E
S
A
S
S
Q
A
L
I
Site 14
S199
S
S
Q
A
L
I
T
S
I
K
P
K
K
A
S
Site 15
S206
S
I
K
P
K
K
A
S
K
A
K
K
A
A
N
Site 16
T248
E
T
A
S
I
H
T
T
A
A
S
I
R
T
K
Site 17
S251
S
I
H
T
T
A
A
S
I
R
T
K
K
A
S
Site 18
S258
S
I
R
T
K
K
A
S
K
A
R
K
T
I
A
Site 19
T263
K
A
S
K
A
R
K
T
I
A
K
V
I
N
T
Site 20
T272
A
K
V
I
N
T
D
T
E
H
I
E
A
L
N
Site 21
S291
A
T
R
Q
I
E
A
S
V
V
A
I
R
P
K
Site 22
S300
V
A
I
R
P
K
K
S
K
G
K
K
A
A
S
Site 23
S307
S
K
G
K
K
A
A
S
R
G
P
N
S
V
S
Site 24
S312
A
A
S
R
G
P
N
S
V
S
E
I
S
E
A
Site 25
S314
S
R
G
P
N
S
V
S
E
I
S
E
A
P
L
Site 26
S317
P
N
S
V
S
E
I
S
E
A
P
L
A
T
Q
Site 27
T334
T
N
Q
A
L
A
A
T
L
R
V
K
R
G
S
Site 28
S341
T
L
R
V
K
R
G
S
R
A
R
K
A
A
T
Site 29
T353
A
A
T
K
A
R
A
T
E
S
Q
T
P
N
A
Site 30
S355
T
K
A
R
A
T
E
S
Q
T
P
N
A
D
Q
Site 31
T357
A
R
A
T
E
S
Q
T
P
N
A
D
Q
G
A
Site 32
S398
D
D
Y
L
A
Q
L
S
L
E
P
T
T
R
T
Site 33
T402
A
Q
L
S
L
E
P
T
T
R
T
R
G
K
R
Site 34
S413
R
G
K
R
N
R
K
S
K
H
L
N
G
D
E
Site 35
S424
N
G
D
E
R
S
G
S
N
Y
R
R
I
P
W
Site 36
Y426
D
E
R
S
G
S
N
Y
R
R
I
P
W
G
R
Site 37
Y454
R
A
N
K
L
V
K
Y
L
L
V
K
D
Q
T
Site 38
T461
Y
L
L
V
K
D
Q
T
K
I
P
I
K
R
S
Site 39
Y478
L
R
D
V
I
Q
E
Y
D
E
Y
F
P
E
I
Site 40
Y481
V
I
Q
E
Y
D
E
Y
F
P
E
I
I
E
R
Site 41
S490
P
E
I
I
E
R
A
S
Y
T
L
E
K
M
F
Site 42
Y491
E
I
I
E
R
A
S
Y
T
L
E
K
M
F
R
Site 43
S508
L
K
E
I
D
K
Q
S
S
L
Y
I
L
I
S
Site 44
S509
K
E
I
D
K
Q
S
S
L
Y
I
L
I
S
T
Site 45
Y511
I
D
K
Q
S
S
L
Y
I
L
I
S
T
Q
E
Site 46
S571
L
R
P
G
V
R
H
S
L
F
G
E
V
R
K
Site 47
Y589
D
E
F
V
K
Q
K
Y
L
E
Y
K
R
V
P
Site 48
Y592
V
K
Q
K
Y
L
E
Y
K
R
V
P
N
S
R
Site 49
S598
E
Y
K
R
V
P
N
S
R
P
P
E
Y
E
F
Site 50
Y603
P
N
S
R
P
P
E
Y
E
F
F
W
G
L
R
Site 51
Y612
F
F
W
G
L
R
S
Y
H
E
T
S
K
M
K
Site 52
T615
G
L
R
S
Y
H
E
T
S
K
M
K
V
L
K
Site 53
T689
D
M
D
I
D
C
L
T
R
E
E
L
G
D
D
Site 54
S701
G
D
D
A
Q
A
W
S
R
F
S
F
E
I
E
Site 55
S704
A
Q
A
W
S
R
F
S
F
E
I
E
A
R
A
Site 56
S718
A
Q
E
N
A
D
A
S
T
N
V
N
F
S
R
Site 57
T719
Q
E
N
A
D
A
S
T
N
V
N
F
S
R
G
Site 58
S724
A
S
T
N
V
N
F
S
R
G
A
S
T
R
A
Site 59
S728
V
N
F
S
R
G
A
S
T
R
A
G
F
S
D
Site 60
S734
A
S
T
R
A
G
F
S
D
G
A
S
I
S
F
Site 61
S740
F
S
D
G
A
S
I
S
F
N
G
A
P
S
S
Site 62
S746
I
S
F
N
G
A
P
S
S
S
G
G
F
S
G
Site 63
S747
S
F
N
G
A
P
S
S
S
G
G
F
S
G
G
Site 64
S748
F
N
G
A
P
S
S
S
G
G
F
S
G
G
P
Site 65
S752
P
S
S
S
G
G
F
S
G
G
P
G
I
T
F
Site 66
T765
T
F
G
V
A
P
S
T
S
A
S
F
S
N
T
Site 67
S770
P
S
T
S
A
S
F
S
N
T
A
S
I
S
F
Site 68
T772
T
S
A
S
F
S
N
T
A
S
I
S
F
G
G
Site 69
S782
I
S
F
G
G
T
L
S
T
S
S
S
F
S
S
Site 70
T783
S
F
G
G
T
L
S
T
S
S
S
F
S
S
A
Site 71
S785
G
G
T
L
S
T
S
S
S
F
S
S
A
A
S
Site 72
S789
S
T
S
S
S
F
S
S
A
A
S
I
S
F
G
Site 73
S800
I
S
F
G
C
A
H
S
T
S
T
S
F
S
S
Site 74
T801
S
F
G
C
A
H
S
T
S
T
S
F
S
S
E
Site 75
S802
F
G
C
A
H
S
T
S
T
S
F
S
S
E
A
Site 76
S804
C
A
H
S
T
S
T
S
F
S
S
E
A
S
I
Site 77
S806
H
S
T
S
T
S
F
S
S
E
A
S
I
S
F
Site 78
S807
S
T
S
T
S
F
S
S
E
A
S
I
S
F
G
Site 79
S810
T
S
F
S
S
E
A
S
I
S
F
G
G
M
P
Site 80
S829
S
F
S
G
G
V
S
S
S
F
S
G
P
L
S
Site 81
S830
F
S
G
G
V
S
S
S
F
S
G
P
L
S
T
Site 82
S832
G
G
V
S
S
S
F
S
G
P
L
S
T
S
A
Site 83
S836
S
S
F
S
G
P
L
S
T
S
A
T
F
S
G
Site 84
T837
S
F
S
G
P
L
S
T
S
A
T
F
S
G
G
Site 85
T840
G
P
L
S
T
S
A
T
F
S
G
G
A
S
S
Site 86
T867
S
G
V
L
S
T
S
T
S
F
G
S
A
P
T
Site 87
S871
S
T
S
T
S
F
G
S
A
P
T
T
S
T
V
Site 88
S880
P
T
T
S
T
V
F
S
S
A
L
S
T
S
T
Site 89
S902
T
S
V
C
F
G
G
S
P
S
S
S
G
S
F
Site 90
S905
C
F
G
G
S
P
S
S
S
G
S
F
G
G
T
Site 91
S906
F
G
G
S
P
S
S
S
G
S
F
G
G
T
L
Site 92
S908
G
S
P
S
S
S
G
S
F
G
G
T
L
S
T
Site 93
T927
G
G
S
P
C
T
S
T
G
F
G
G
T
L
S
Site 94
S938
G
T
L
S
T
S
V
S
F
G
G
S
S
S
T
Site 95
S942
T
S
V
S
F
G
G
S
S
S
T
S
A
N
F
Site 96
S943
S
V
S
F
G
G
S
S
S
T
S
A
N
F
G
Site 97
S944
V
S
F
G
G
S
S
S
T
S
A
N
F
G
G
Site 98
S946
F
G
G
S
S
S
T
S
A
N
F
G
G
T
L
Site 99
S981
N
T
S
A
S
F
G
S
V
L
N
T
S
T
G
Site 100
S1018
G
S
P
G
T
S
V
S
F
G
S
A
L
N
T
Site 101
T1025
S
F
G
S
A
L
N
T
N
A
G
Y
G
G
A
Site 102
S1034
A
G
Y
G
G
A
V
S
T
N
T
D
F
G
G
Site 103
T1037
G
G
A
V
S
T
N
T
D
F
G
G
T
L
S
Site 104
T1122
T
A
A
D
F
G
G
T
P
S
N
S
I
G
F
Site 105
S1124
A
D
F
G
G
T
P
S
N
S
I
G
F
G
A
Site 106
S1138
A
A
P
S
T
S
V
S
F
G
G
A
H
G
T
Site 107
S1180
P
S
T
S
A
C
F
S
G
A
T
S
P
S
F
Site 108
S1186
F
S
G
A
T
S
P
S
F
C
D
G
P
S
T
Site 109
S1192
P
S
F
C
D
G
P
S
T
S
T
G
F
S
F
Site 110
T1193
S
F
C
D
G
P
S
T
S
T
G
F
S
F
G
Site 111
S1194
F
C
D
G
P
S
T
S
T
G
F
S
F
G
N
Site 112
S1198
P
S
T
S
T
G
F
S
F
G
N
G
L
S
T
Site 113
T1205
S
F
G
N
G
L
S
T
N
A
G
F
G
G
G
Site 114
S1234
A
G
F
S
G
G
L
S
T
S
S
G
F
D
G
Site 115
T1235
G
F
S
G
G
L
S
T
S
S
G
F
D
G
G
Site 116
S1237
S
G
G
L
S
T
S
S
G
F
D
G
G
L
G
Site 117
T1255
G
F
G
G
G
P
G
T
S
T
G
F
G
G
G
Site 118
T1257
G
G
G
P
G
T
S
T
G
F
G
G
G
L
G
Site 119
S1301
G
T
N
A
S
F
G
S
T
L
G
T
S
A
G
Site 120
S1310
L
G
T
S
A
G
F
S
G
G
L
S
T
S
D
Site 121
S1314
A
G
F
S
G
G
L
S
T
S
D
G
F
G
S
Site 122
T1315
G
F
S
G
G
L
S
T
S
D
G
F
G
S
R
Site 123
S1316
F
S
G
G
L
S
T
S
D
G
F
G
S
R
P
Site 124
S1326
F
G
S
R
P
N
A
S
F
D
R
G
L
S
T
Site 125
T1333
S
F
D
R
G
L
S
T
I
I
G
F
G
S
G
Site 126
S1339
S
T
I
I
G
F
G
S
G
S
N
T
S
T
G
Site 127
T1343
G
F
G
S
G
S
N
T
S
T
G
F
T
G
E
Site 128
S1344
F
G
S
G
S
N
T
S
T
G
F
T
G
E
P
Site 129
T1345
G
S
G
S
N
T
S
T
G
F
T
G
E
P
S
Site 130
T1348
S
N
T
S
T
G
F
T
G
E
P
S
T
S
T
Site 131
S1352
T
G
F
T
G
E
P
S
T
S
T
G
F
S
S
Site 132
T1353
G
F
T
G
E
P
S
T
S
T
G
F
S
S
G
Site 133
S1354
F
T
G
E
P
S
T
S
T
G
F
S
S
G
P
Site 134
T1355
T
G
E
P
S
T
S
T
G
F
S
S
G
P
S
Site 135
S1358
P
S
T
S
T
G
F
S
S
G
P
S
S
I
V
Site 136
S1359
S
T
S
T
G
F
S
S
G
P
S
S
I
V
G
Site 137
T1383
G
F
C
S
G
P
S
T
S
G
F
S
G
G
P
Site 138
S1384
F
C
S
G
P
S
T
S
G
F
S
G
G
P
S
Site 139
S1387
G
P
S
T
S
G
F
S
G
G
P
S
T
G
A
Site 140
S1391
S
G
F
S
G
G
P
S
T
G
A
G
F
G
G
Site 141
T1392
G
F
S
G
G
P
S
T
G
A
G
F
G
G
G
Site 142
T1402
G
F
G
G
G
P
N
T
G
A
G
F
G
G
G
Site 143
S1411
A
G
F
G
G
G
P
S
T
S
A
G
F
G
S
Site 144
T1412
G
F
G
G
G
P
S
T
S
A
G
F
G
S
G
Site 145
S1413
F
G
G
G
P
S
T
S
A
G
F
G
S
G
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation