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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
KIF5A
Full Name:
Kinesin heavy chain isoform 5A
Alias:
Kinesin heavy chain 5A; Kinesin heavy chain neuron-specific 1; Neuronal kinesin heavy chain; NKHC
Type:
Neuron projection, Kinesin complex, Membrane fraction, Microtubule, Cytoplasm, Ciliary rootlet, Nucleus protein
Mass (Da):
117378
Number AA:
1032
UniProt ID:
Q12840
International Prot ID:
IPI00029722
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005871
GO:0005624
GO:0005874
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0003777
PhosphoSite+
KinaseNET
Biological Process:
GO:0008219
GO:0007018
GO:0007268
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S39
P
I
F
Q
G
D
D
S
V
V
I
G
G
K
P
Site 2
Y78
V
K
D
V
L
A
G
Y
N
G
T
I
F
A
Y
Site 3
Y85
Y
N
G
T
I
F
A
Y
G
Q
T
S
S
G
K
Site 4
T93
G
Q
T
S
S
G
K
T
H
T
M
E
G
K
L
Site 5
T95
T
S
S
G
K
T
H
T
M
E
G
K
L
H
D
Site 6
Y121
R
D
I
F
N
H
I
Y
S
M
D
E
N
L
E
Site 7
Y135
E
F
H
I
K
V
S
Y
F
E
I
Y
L
D
K
Site 8
Y139
K
V
S
Y
F
E
I
Y
L
D
K
I
R
D
L
Site 9
T150
I
R
D
L
L
D
V
T
K
T
N
L
S
V
H
Site 10
T152
D
L
L
D
V
T
K
T
N
L
S
V
H
E
D
Site 11
S155
D
V
T
K
T
N
L
S
V
H
E
D
K
N
R
Site 12
T170
V
P
F
V
K
G
C
T
E
R
F
V
S
S
P
Site 13
S175
G
C
T
E
R
F
V
S
S
P
E
E
I
L
D
Site 14
S176
C
T
E
R
F
V
S
S
P
E
E
I
L
D
V
Site 15
S189
D
V
I
D
E
G
K
S
N
R
H
V
A
V
T
Site 16
T196
S
N
R
H
V
A
V
T
N
M
N
E
H
S
S
Site 17
S202
V
T
N
M
N
E
H
S
S
R
S
H
S
I
F
Site 18
S203
T
N
M
N
E
H
S
S
R
S
H
S
I
F
L
Site 19
S205
M
N
E
H
S
S
R
S
H
S
I
F
L
I
N
Site 20
S207
E
H
S
S
R
S
H
S
I
F
L
I
N
I
K
Site 21
T220
I
K
Q
E
N
M
E
T
E
Q
K
L
S
G
K
Site 22
S225
M
E
T
E
Q
K
L
S
G
K
L
Y
L
V
D
Site 23
S236
Y
L
V
D
L
A
G
S
E
K
V
S
K
T
G
Site 24
S240
L
A
G
S
E
K
V
S
K
T
G
A
E
G
A
Site 25
S258
E
A
K
N
I
N
K
S
L
S
A
L
G
N
V
Site 26
S260
K
N
I
N
K
S
L
S
A
L
G
N
V
I
S
Site 27
S275
A
L
A
E
G
T
K
S
Y
V
P
Y
R
D
S
Site 28
Y276
L
A
E
G
T
K
S
Y
V
P
Y
R
D
S
K
Site 29
Y279
G
T
K
S
Y
V
P
Y
R
D
S
K
M
T
R
Site 30
S282
S
Y
V
P
Y
R
D
S
K
M
T
R
I
L
Q
Site 31
T285
P
Y
R
D
S
K
M
T
R
I
L
Q
D
S
L
Site 32
S291
M
T
R
I
L
Q
D
S
L
G
G
N
C
R
T
Site 33
T298
S
L
G
G
N
C
R
T
T
M
F
I
C
C
S
Site 34
T299
L
G
G
N
C
R
T
T
M
F
I
C
C
S
P
Site 35
S308
F
I
C
C
S
P
S
S
Y
N
D
A
E
T
K
Site 36
Y309
I
C
C
S
P
S
S
Y
N
D
A
E
T
K
S
Site 37
T314
S
S
Y
N
D
A
E
T
K
S
T
L
M
F
G
Site 38
S316
Y
N
D
A
E
T
K
S
T
L
M
F
G
Q
R
Site 39
T317
N
D
A
E
T
K
S
T
L
M
F
G
Q
R
A
Site 40
T326
M
F
G
Q
R
A
K
T
I
K
N
T
A
S
V
Site 41
S332
K
T
I
K
N
T
A
S
V
N
L
E
L
T
A
Site 42
T353
Y
E
K
E
K
E
K
T
K
A
Q
K
E
T
I
Site 43
S368
A
K
L
E
A
E
L
S
R
W
R
N
G
E
N
Site 44
T379
N
G
E
N
V
P
E
T
E
R
L
A
G
E
E
Site 45
T397
G
A
E
L
C
E
E
T
P
V
N
D
N
S
S
Site 46
Y417
A
P
E
E
R
Q
K
Y
E
E
E
I
R
R
L
Site 47
Y425
E
E
E
I
R
R
L
Y
K
Q
L
D
D
K
D
Site 48
S458
D
Q
E
E
L
L
V
S
T
R
G
D
N
E
K
Site 49
S471
E
K
V
Q
R
E
L
S
H
L
Q
S
E
N
D
Site 50
S475
R
E
L
S
H
L
Q
S
E
N
D
A
A
K
D
Site 51
S502
A
V
N
Y
D
Q
K
S
Q
E
V
E
E
K
S
Site 52
S509
S
Q
E
V
E
E
K
S
Q
Q
N
Q
L
L
V
Site 53
S528
Q
K
V
A
T
M
L
S
L
E
S
E
L
Q
R
Site 54
S540
L
Q
R
L
Q
E
V
S
G
H
Q
R
K
R
I
Site 55
S562
M
K
D
L
S
E
F
S
V
I
V
G
N
G
E
Site 56
Y590
E
F
T
V
A
R
L
Y
I
S
K
I
K
S
E
Site 57
S592
T
V
A
R
L
Y
I
S
K
I
K
S
E
V
K
Site 58
S596
L
Y
I
S
K
I
K
S
E
V
K
S
V
V
K
Site 59
S600
K
I
K
S
E
V
K
S
V
V
K
R
C
R
Q
Site 60
T622
C
H
R
K
M
E
V
T
G
R
E
L
S
S
C
Site 61
S634
S
S
C
Q
L
L
I
S
Q
H
E
A
K
I
R
Site 62
T644
E
A
K
I
R
S
L
T
E
Y
M
Q
S
V
E
Site 63
Y646
K
I
R
S
L
T
E
Y
M
Q
S
V
E
L
K
Site 64
S649
S
L
T
E
Y
M
Q
S
V
E
L
K
K
R
H
Site 65
S660
K
K
R
H
L
E
E
S
Y
D
S
L
S
D
E
Site 66
Y661
K
R
H
L
E
E
S
Y
D
S
L
S
D
E
L
Site 67
S663
H
L
E
E
S
Y
D
S
L
S
D
E
L
A
K
Site 68
S665
E
E
S
Y
D
S
L
S
D
E
L
A
K
L
Q
Site 69
T689
L
K
D
K
E
P
D
T
Q
D
A
D
E
V
K
Site 70
S705
A
L
E
L
Q
M
E
S
H
R
E
A
H
H
R
Site 71
T727
E
I
N
E
K
Q
K
T
I
D
E
L
K
D
L
Site 72
Y749
L
E
K
L
Q
A
D
Y
E
K
L
K
S
E
E
Site 73
S754
A
D
Y
E
K
L
K
S
E
E
H
E
K
S
T
Site 74
S760
K
S
E
E
H
E
K
S
T
K
L
Q
E
L
T
Site 75
T767
S
T
K
L
Q
E
L
T
F
L
Y
E
R
H
E
Site 76
Y770
L
Q
E
L
T
F
L
Y
E
R
H
E
Q
S
K
Site 77
T786
D
L
K
G
L
E
E
T
V
A
R
E
L
Q
T
Site 78
T806
K
L
F
V
Q
D
V
T
T
R
V
K
K
S
A
Site 79
T807
L
F
V
Q
D
V
T
T
R
V
K
K
S
A
E
Site 80
S812
V
T
T
R
V
K
K
S
A
E
M
E
P
E
D
Site 81
S820
A
E
M
E
P
E
D
S
G
G
I
H
S
Q
K
Site 82
S825
E
D
S
G
G
I
H
S
Q
K
Q
K
I
S
F
Site 83
S831
H
S
Q
K
Q
K
I
S
F
L
E
N
N
L
E
Site 84
T868
L
E
K
R
L
R
A
T
A
E
R
V
K
A
L
Site 85
Y893
A
M
K
D
K
R
R
Y
Q
Q
E
V
D
R
I
Site 86
Y906
R
I
K
E
A
V
R
Y
K
S
S
G
K
R
G
Site 87
S908
K
E
A
V
R
Y
K
S
S
G
K
R
G
H
S
Site 88
S909
E
A
V
R
Y
K
S
S
G
K
R
G
H
S
A
Site 89
S915
S
S
G
K
R
G
H
S
A
Q
I
A
K
P
V
Site 90
Y927
K
P
V
R
P
G
H
Y
P
A
S
S
P
T
N
Site 91
S930
R
P
G
H
Y
P
A
S
S
P
T
N
P
Y
G
Site 92
S931
P
G
H
Y
P
A
S
S
P
T
N
P
Y
G
T
Site 93
T933
H
Y
P
A
S
S
P
T
N
P
Y
G
T
R
S
Site 94
Y936
A
S
S
P
T
N
P
Y
G
T
R
S
P
E
C
Site 95
T938
S
P
T
N
P
Y
G
T
R
S
P
E
C
I
S
Site 96
S940
T
N
P
Y
G
T
R
S
P
E
C
I
S
Y
T
Site 97
S945
T
R
S
P
E
C
I
S
Y
T
N
S
L
F
Q
Site 98
Y946
R
S
P
E
C
I
S
Y
T
N
S
L
F
Q
N
Site 99
T947
S
P
E
C
I
S
Y
T
N
S
L
F
Q
N
Y
Site 100
Y958
F
Q
N
Y
Q
N
L
Y
L
Q
A
T
P
S
S
Site 101
T962
Q
N
L
Y
L
Q
A
T
P
S
S
T
S
D
M
Site 102
S964
L
Y
L
Q
A
T
P
S
S
T
S
D
M
Y
F
Site 103
S965
Y
L
Q
A
T
P
S
S
T
S
D
M
Y
F
A
Site 104
S967
Q
A
T
P
S
S
T
S
D
M
Y
F
A
N
S
Site 105
Y970
P
S
S
T
S
D
M
Y
F
A
N
S
C
T
S
Site 106
S974
S
D
M
Y
F
A
N
S
C
T
S
S
G
A
T
Site 107
S977
Y
F
A
N
S
C
T
S
S
G
A
T
S
S
G
Site 108
S978
F
A
N
S
C
T
S
S
G
A
T
S
S
G
G
Site 109
T981
S
C
T
S
S
G
A
T
S
S
G
G
P
L
A
Site 110
S982
C
T
S
S
G
A
T
S
S
G
G
P
L
A
S
Site 111
S983
T
S
S
G
A
T
S
S
G
G
P
L
A
S
Y
Site 112
S989
S
S
G
G
P
L
A
S
Y
Q
K
A
N
M
D
Site 113
Y990
S
G
G
P
L
A
S
Y
Q
K
A
N
M
D
N
Site 114
S1008
T
D
I
N
D
N
R
S
D
L
P
C
G
Y
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation