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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SFRS8
Full Name:
Splicing factor, arginine/serine-rich 8
Alias:
SFR8; Splicing factor, arginine/serine-rich 8; Splicing factor, arginine/serine-rich 8 (suppressor-of-white-apricot); Splicing factor, arginine/serine-rich 8: Suppressor of white apricot protein homolog; Suppressor of white apricot protein homolog; SWAP
Type:
RNA binding protein
Mass (Da):
104822
Number AA:
951
UniProt ID:
Q12872
International Prot ID:
IPI00290094
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003723
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006376
GO:0045449
GO:0006350
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S15
R
A
K
P
E
R
K
S
G
A
K
E
E
A
G
Site 2
Y74
H
K
I
L
I
D
R
Y
D
G
R
G
H
L
H
Site 3
S84
R
G
H
L
H
D
L
S
E
Y
D
A
E
Y
S
Site 4
Y86
H
L
H
D
L
S
E
Y
D
A
E
Y
S
T
W
Site 5
Y90
L
S
E
Y
D
A
E
Y
S
T
W
N
R
D
Y
Site 6
Y97
Y
S
T
W
N
R
D
Y
Q
L
S
E
E
E
A
Site 7
S100
W
N
R
D
Y
Q
L
S
E
E
E
A
R
I
E
Site 8
Y133
E
A
R
Q
E
E
E
Y
K
R
F
S
E
A
L
Site 9
S137
E
E
E
Y
K
R
F
S
E
A
L
A
E
D
G
Site 10
S145
E
A
L
A
E
D
G
S
Y
N
A
V
G
F
T
Site 11
Y146
A
L
A
E
D
G
S
Y
N
A
V
G
F
T
Y
Site 12
S155
A
V
G
F
T
Y
G
S
D
Y
Y
D
P
S
E
Site 13
Y157
G
F
T
Y
G
S
D
Y
Y
D
P
S
E
P
T
Site 14
Y158
F
T
Y
G
S
D
Y
Y
D
P
S
E
P
T
E
Site 15
S161
G
S
D
Y
Y
D
P
S
E
P
T
E
E
E
E
Site 16
S170
P
T
E
E
E
E
P
S
K
Q
R
E
K
N
E
Site 17
S238
K
A
K
Q
A
R
N
S
Q
F
D
F
L
R
F
Site 18
Y248
D
F
L
R
F
D
H
Y
L
N
P
Y
Y
K
F
Site 19
Y252
F
D
H
Y
L
N
P
Y
Y
K
F
I
Q
K
A
Site 20
Y253
D
H
Y
L
N
P
Y
Y
K
F
I
Q
K
A
M
Site 21
T266
A
M
K
E
G
R
Y
T
V
L
A
E
N
K
S
Site 22
S273
T
V
L
A
E
N
K
S
D
E
K
K
K
S
G
Site 23
S279
K
S
D
E
K
K
K
S
G
V
S
S
D
N
E
Site 24
S282
E
K
K
K
S
G
V
S
S
D
N
E
D
D
D
Site 25
S283
K
K
K
S
G
V
S
S
D
N
E
D
D
D
D
Site 26
Y296
D
D
E
E
D
G
N
Y
L
H
P
S
L
F
A
Site 27
S300
D
G
N
Y
L
H
P
S
L
F
A
S
K
K
C
Site 28
S304
L
H
P
S
L
F
A
S
K
K
C
N
R
L
E
Site 29
S337
V
R
K
A
Q
A
D
S
S
T
P
T
P
H
N
Site 30
S338
R
K
A
Q
A
D
S
S
T
P
T
P
H
N
A
Site 31
T339
K
A
Q
A
D
S
S
T
P
T
P
H
N
A
D
Site 32
T341
Q
A
D
S
S
T
P
T
P
H
N
A
D
G
A
Site 33
S353
D
G
A
P
V
Q
P
S
Q
V
E
Y
T
A
D
Site 34
Y357
V
Q
P
S
Q
V
E
Y
T
A
D
S
T
V
A
Site 35
T362
V
E
Y
T
A
D
S
T
V
A
A
M
Y
Y
S
Site 36
Y371
A
A
M
Y
Y
S
Y
Y
M
L
P
D
G
T
Y
Site 37
T377
Y
Y
M
L
P
D
G
T
Y
C
L
A
P
P
P
Site 38
Y378
Y
M
L
P
D
G
T
Y
C
L
A
P
P
P
P
Site 39
T390
P
P
P
G
I
D
V
T
T
Y
Y
S
T
L
P
Site 40
T391
P
P
G
I
D
V
T
T
Y
Y
S
T
L
P
A
Site 41
Y392
P
G
I
D
V
T
T
Y
Y
S
T
L
P
A
G
Site 42
T409
V
S
N
S
P
G
V
T
T
T
A
P
P
P
P
Site 43
T410
S
N
S
P
G
V
T
T
T
A
P
P
P
P
G
Site 44
T411
N
S
P
G
V
T
T
T
A
P
P
P
P
G
T
Site 45
T418
T
A
P
P
P
P
G
T
T
P
P
P
P
P
T
Site 46
T419
A
P
P
P
P
G
T
T
P
P
P
P
P
T
T
Site 47
T425
T
T
P
P
P
P
P
T
T
A
E
T
S
S
G
Site 48
T426
T
P
P
P
P
P
T
T
A
E
T
S
S
G
A
Site 49
S431
P
T
T
A
E
T
S
S
G
A
T
S
T
T
T
Site 50
S435
E
T
S
S
G
A
T
S
T
T
T
T
T
S
A
Site 51
T437
S
S
G
A
T
S
T
T
T
T
T
S
A
L
A
Site 52
Y466
V
I
D
K
L
A
E
Y
V
A
R
N
G
L
K
Site 53
S477
N
G
L
K
F
E
T
S
V
R
A
K
N
D
Q
Site 54
S514
L
Q
K
E
G
G
D
S
M
Q
A
V
S
A
P
Site 55
T526
S
A
P
E
E
A
P
T
D
S
A
P
E
K
P
Site 56
S528
P
E
E
A
P
T
D
S
A
P
E
K
P
S
D
Site 57
S554
E
V
G
A
R
A
G
S
G
G
K
K
E
A
S
Site 58
S561
S
G
G
K
K
E
A
S
S
S
K
T
V
P
D
Site 59
S562
G
G
K
K
E
A
S
S
S
K
T
V
P
D
G
Site 60
S563
G
K
K
E
A
S
S
S
K
T
V
P
D
G
K
Site 61
T565
K
E
A
S
S
S
K
T
V
P
D
G
K
L
V
Site 62
S604
R
V
K
L
D
D
D
S
D
D
D
E
E
S
K
Site 63
S610
D
S
D
D
D
E
E
S
K
E
G
Q
E
S
S
Site 64
S616
E
S
K
E
G
Q
E
S
S
S
S
A
A
N
T
Site 65
S617
S
K
E
G
Q
E
S
S
S
S
A
A
N
T
N
Site 66
S618
K
E
G
Q
E
S
S
S
S
A
A
N
T
N
P
Site 67
S619
E
G
Q
E
S
S
S
S
A
A
N
T
N
P
A
Site 68
T623
S
S
S
S
A
A
N
T
N
P
A
V
A
P
P
Site 69
T642
E
E
K
K
P
Q
L
T
Q
E
E
L
E
A
K
Site 70
T693
K
A
A
L
F
L
Q
T
L
K
N
P
L
P
E
Site 71
S709
E
A
G
K
I
E
E
S
P
F
S
V
E
E
S
Site 72
S712
K
I
E
E
S
P
F
S
V
E
E
S
S
T
T
Site 73
S716
S
P
F
S
V
E
E
S
S
T
T
P
C
P
L
Site 74
S717
P
F
S
V
E
E
S
S
T
T
P
C
P
L
L
Site 75
T718
F
S
V
E
E
S
S
T
T
P
C
P
L
L
T
Site 76
T719
S
V
E
E
S
S
T
T
P
C
P
L
L
T
G
Site 77
T725
T
T
P
C
P
L
L
T
G
G
R
P
L
P
T
Site 78
T732
T
G
G
R
P
L
P
T
L
E
V
K
P
P
D
Site 79
S742
V
K
P
P
D
R
P
S
S
K
S
K
D
P
P
Site 80
S743
K
P
P
D
R
P
S
S
K
S
K
D
P
P
R
Site 81
S745
P
D
R
P
S
S
K
S
K
D
P
P
R
E
E
Site 82
S765
K
K
K
H
K
K
R
S
R
T
R
S
R
S
P
Site 83
T767
K
H
K
K
R
S
R
T
R
S
R
S
P
K
Y
Site 84
S769
K
K
R
S
R
T
R
S
R
S
P
K
Y
H
S
Site 85
S771
R
S
R
T
R
S
R
S
P
K
Y
H
S
S
S
Site 86
Y774
T
R
S
R
S
P
K
Y
H
S
S
S
K
S
R
Site 87
S776
S
R
S
P
K
Y
H
S
S
S
K
S
R
S
R
Site 88
S777
R
S
P
K
Y
H
S
S
S
K
S
R
S
R
S
Site 89
S778
S
P
K
Y
H
S
S
S
K
S
R
S
R
S
H
Site 90
S780
K
Y
H
S
S
S
K
S
R
S
R
S
H
S
K
Site 91
S782
H
S
S
S
K
S
R
S
R
S
H
S
K
A
K
Site 92
S784
S
S
K
S
R
S
R
S
H
S
K
A
K
H
S
Site 93
S786
K
S
R
S
R
S
H
S
K
A
K
H
S
L
P
Site 94
S791
S
H
S
K
A
K
H
S
L
P
S
A
Y
R
T
Site 95
Y796
K
H
S
L
P
S
A
Y
R
T
V
R
R
S
R
Site 96
T798
S
L
P
S
A
Y
R
T
V
R
R
S
R
S
R
Site 97
S802
A
Y
R
T
V
R
R
S
R
S
R
S
R
S
P
Site 98
S804
R
T
V
R
R
S
R
S
R
S
R
S
P
R
R
Site 99
S806
V
R
R
S
R
S
R
S
R
S
P
R
R
R
A
Site 100
S808
R
S
R
S
R
S
R
S
P
R
R
R
A
H
S
Site 101
S815
S
P
R
R
R
A
H
S
P
E
R
R
R
E
E
Site 102
S824
E
R
R
R
E
E
R
S
V
P
T
A
Y
R
V
Site 103
Y829
E
R
S
V
P
T
A
Y
R
V
S
R
S
P
G
Site 104
S832
V
P
T
A
Y
R
V
S
R
S
P
G
A
S
R
Site 105
S834
T
A
Y
R
V
S
R
S
P
G
A
S
R
K
R
Site 106
S838
V
S
R
S
P
G
A
S
R
K
R
T
R
S
R
Site 107
T842
P
G
A
S
R
K
R
T
R
S
R
S
P
H
E
Site 108
S844
A
S
R
K
R
T
R
S
R
S
P
H
E
K
K
Site 109
S846
R
K
R
T
R
S
R
S
P
H
E
K
K
K
K
Site 110
S856
E
K
K
K
K
R
R
S
R
S
R
T
K
S
K
Site 111
S858
K
K
K
R
R
S
R
S
R
T
K
S
K
A
R
Site 112
T860
K
R
R
S
R
S
R
T
K
S
K
A
R
S
Q
Site 113
S862
R
S
R
S
R
T
K
S
K
A
R
S
Q
S
V
Site 114
S866
R
T
K
S
K
A
R
S
Q
S
V
S
P
S
K
Site 115
S868
K
S
K
A
R
S
Q
S
V
S
P
S
K
Q
A
Site 116
S870
K
A
R
S
Q
S
V
S
P
S
K
Q
A
A
P
Site 117
S872
R
S
Q
S
V
S
P
S
K
Q
A
A
P
R
P
Site 118
S886
P
A
A
P
A
A
H
S
A
H
S
A
S
V
S
Site 119
S889
P
A
A
H
S
A
H
S
A
S
V
S
P
V
E
Site 120
S891
A
H
S
A
H
S
A
S
V
S
P
V
E
S
R
Site 121
S893
S
A
H
S
A
S
V
S
P
V
E
S
R
G
S
Site 122
S897
A
S
V
S
P
V
E
S
R
G
S
S
Q
E
R
Site 123
S900
S
P
V
E
S
R
G
S
S
Q
E
R
S
R
G
Site 124
S901
P
V
E
S
R
G
S
S
Q
E
R
S
R
G
V
Site 125
S905
R
G
S
S
Q
E
R
S
R
G
V
S
Q
E
K
Site 126
S909
Q
E
R
S
R
G
V
S
Q
E
K
E
A
Q
I
Site 127
S917
Q
E
K
E
A
Q
I
S
S
A
I
V
S
S
V
Site 128
S918
E
K
E
A
Q
I
S
S
A
I
V
S
S
V
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation