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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CHD3
Full Name:
Chromodomain-helicase-DNA-binding protein 3
Alias:
ATP-dependent helicase CHD3; EC 3.6.1.-; HZFH; Mi-2 autoantigen 240 kDa protein; Mi2-alpha
Type:
Helicase; EC 3.6.1.-; DNA binding protein
Mass (Da):
226592
Number AA:
2000
UniProt ID:
Q12873
International Prot ID:
IPI00373870
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016581
GO:0000785
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004003
GO:0003677
PhosphoSite+
KinaseNET
Biological Process:
GO:0006333
GO:0016568
GO:0006357
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S21
K
N
D
Q
L
R
I
S
F
P
P
G
L
C
W
Site 2
S43
D
D
I
R
L
L
P
S
A
L
G
V
K
K
R
Site 3
S73
R
K
R
K
K
R
D
S
E
E
E
F
G
S
E
Site 4
S79
D
S
E
E
E
F
G
S
E
R
D
E
Y
R
E
Site 5
Y84
F
G
S
E
R
D
E
Y
R
E
K
S
E
S
G
Site 6
S88
R
D
E
Y
R
E
K
S
E
S
G
G
S
E
Y
Site 7
S90
E
Y
R
E
K
S
E
S
G
G
S
E
Y
G
T
Site 8
S93
E
K
S
E
S
G
G
S
E
Y
G
T
G
P
G
Site 9
Y95
S
E
S
G
G
S
E
Y
G
T
G
P
G
R
K
Site 10
T97
S
G
G
S
E
Y
G
T
G
P
G
R
K
R
R
Site 11
T115
R
E
K
K
E
K
K
T
K
R
R
K
K
G
E
Site 12
S134
Q
K
Q
V
E
Q
K
S
S
A
T
L
L
L
T
Site 13
S135
K
Q
V
E
Q
K
S
S
A
T
L
L
L
T
W
Site 14
S152
E
D
V
E
H
V
F
S
E
E
D
Y
H
T
L
Site 15
Y156
H
V
F
S
E
E
D
Y
H
T
L
T
N
Y
K
Site 16
T158
F
S
E
E
D
Y
H
T
L
T
N
Y
K
A
F
Site 17
T160
E
E
D
Y
H
T
L
T
N
Y
K
A
F
S
Q
Site 18
Y162
D
Y
H
T
L
T
N
Y
K
A
F
S
Q
F
M
Site 19
S197
G
A
K
W
R
E
F
S
A
N
N
P
F
K
G
Site 20
S237
S
A
T
P
I
A
P
S
G
P
P
A
L
P
P
Site 21
T260
P
P
I
R
R
A
K
T
K
E
G
K
G
P
G
Site 22
S272
G
P
G
H
K
R
R
S
K
S
P
R
V
P
D
Site 23
S274
G
H
K
R
R
S
K
S
P
R
V
P
D
G
R
Site 24
S308
G
K
R
K
K
G
G
S
Y
V
F
Q
S
D
E
Site 25
Y309
K
R
K
K
G
G
S
Y
V
F
Q
S
D
E
G
Site 26
S313
G
G
S
Y
V
F
Q
S
D
E
G
P
E
P
E
Site 27
S324
P
E
P
E
A
E
E
S
D
L
D
S
G
S
V
Site 28
S328
A
E
E
S
D
L
D
S
G
S
V
H
S
A
S
Site 29
S330
E
S
D
L
D
S
G
S
V
H
S
A
S
G
R
Site 30
S333
L
D
S
G
S
V
H
S
A
S
G
R
P
D
G
Site 31
S335
S
G
S
V
H
S
A
S
G
R
P
D
G
P
V
Site 32
Y374
G
E
E
E
V
D
G
Y
E
T
D
H
Q
D
Y
Site 33
Y381
Y
E
T
D
H
Q
D
Y
C
E
V
C
Q
Q
G
Site 34
Y439
A
K
E
E
E
E
E
Y
E
E
E
G
E
E
E
Site 35
Y458
E
E
D
D
H
M
E
Y
C
R
V
C
K
D
G
Site 36
S546
P
R
P
L
Q
G
R
S
E
R
E
F
F
V
K
Site 37
Y578
E
I
F
H
L
V
M
Y
R
N
Y
Q
R
K
N
Site 38
Y581
H
L
V
M
Y
R
N
Y
Q
R
K
N
D
M
D
Site 39
Y595
D
E
P
P
P
L
D
Y
G
S
G
E
D
D
G
Site 40
S597
P
P
P
L
D
Y
G
S
G
E
D
D
G
K
S
Site 41
S604
S
G
E
D
D
G
K
S
D
K
R
K
V
K
D
Site 42
Y614
R
K
V
K
D
P
H
Y
A
E
M
E
E
K
Y
Site 43
Y621
Y
A
E
M
E
E
K
Y
Y
R
F
G
I
K
P
Site 44
Y622
A
E
M
E
E
K
Y
Y
R
F
G
I
K
P
E
Site 45
Y647
S
V
D
K
K
G
N
Y
H
Y
L
V
K
W
R
Site 46
Y649
D
K
K
G
N
Y
H
Y
L
V
K
W
R
D
L
Site 47
Y658
V
K
W
R
D
L
P
Y
D
Q
S
T
W
E
E
Site 48
S661
R
D
L
P
Y
D
Q
S
T
W
E
E
D
E
M
Site 49
Y673
D
E
M
N
I
P
E
Y
E
E
H
K
Q
S
Y
Site 50
Y680
Y
E
E
H
K
Q
S
Y
W
R
H
R
E
L
I
Site 51
Y698
D
P
A
Q
P
R
K
Y
K
K
K
K
K
E
L
Site 52
S712
L
Q
G
D
G
P
P
S
S
P
T
N
D
P
T
Site 53
S713
Q
G
D
G
P
P
S
S
P
T
N
D
P
T
V
Site 54
T715
D
G
P
P
S
S
P
T
N
D
P
T
V
K
Y
Site 55
T719
S
S
P
T
N
D
P
T
V
K
Y
E
T
Q
P
Site 56
Y722
T
N
D
P
T
V
K
Y
E
T
Q
P
R
F
I
Site 57
T730
E
T
Q
P
R
F
I
T
A
T
G
G
T
L
H
Site 58
T732
Q
P
R
F
I
T
A
T
G
G
T
L
H
M
Y
Site 59
Y739
T
G
G
T
L
H
M
Y
Q
L
E
G
L
N
W
Site 60
T757
S
W
A
Q
G
T
D
T
I
L
A
D
E
M
G
Site 61
S777
Q
T
I
V
F
L
Y
S
L
Y
K
E
G
H
T
Site 62
Y779
I
V
F
L
Y
S
L
Y
K
E
G
H
T
K
G
Site 63
T784
S
L
Y
K
E
G
H
T
K
G
P
F
L
V
S
Site 64
Y812
Q
M
W
A
P
K
F
Y
V
V
T
Y
T
G
D
Site 65
S822
T
Y
T
G
D
K
D
S
R
A
I
I
R
E
N
Site 66
S832
I
I
R
E
N
E
F
S
F
E
D
N
A
I
K
Site 67
T866
L
T
S
Y
E
L
I
T
I
D
Q
A
A
L
G
Site 68
S874
I
D
Q
A
A
L
G
S
I
R
W
A
C
L
V
Site 69
T911
I
D
H
K
L
L
L
T
G
T
P
L
Q
N
N
Site 70
T913
H
K
L
L
L
T
G
T
P
L
Q
N
N
L
E
Site 71
T930
F
H
L
L
N
F
L
T
P
E
R
F
N
N
L
Site 72
S948
L
E
E
F
A
D
I
S
K
E
D
Q
I
K
K
Site 73
S989
L
I
V
R
V
E
L
S
P
M
Q
K
K
Y
Y
Site 74
Y995
L
S
P
M
Q
K
K
Y
Y
K
Y
I
L
T
R
Site 75
Y996
S
P
M
Q
K
K
Y
Y
K
Y
I
L
T
R
N
Site 76
S1009
R
N
F
E
A
L
N
S
R
G
G
G
N
Q
V
Site 77
S1017
R
G
G
G
N
Q
V
S
L
L
N
I
M
M
D
Site 78
Y1050
P
K
L
P
S
G
A
Y
E
G
G
A
L
I
K
Site 79
Y1098
L
L
E
D
F
L
D
Y
E
G
Y
K
Y
E
R
Site 80
Y1103
L
D
Y
E
G
Y
K
Y
E
R
I
D
G
G
I
Site 81
T1186
V
M
I
Y
R
F
V
T
R
A
S
V
E
E
R
Site 82
S1189
Y
R
F
V
T
R
A
S
V
E
E
R
I
T
Q
Site 83
T1195
A
S
V
E
E
R
I
T
Q
V
A
K
R
K
M
Site 84
T1205
A
K
R
K
M
M
L
T
H
L
V
V
R
P
G
Site 85
S1215
V
V
R
P
G
L
G
S
K
A
G
S
M
S
K
Site 86
S1219
G
L
G
S
K
A
G
S
M
S
K
Q
E
L
D
Site 87
S1221
G
S
K
A
G
S
M
S
K
Q
E
L
D
D
I
Site 88
S1251
E
N
K
E
E
D
S
S
V
I
H
Y
D
N
E
Site 89
Y1255
E
D
S
S
V
I
H
Y
D
N
E
A
I
A
R
Site 90
T1271
L
D
R
N
Q
D
A
T
E
D
T
D
V
Q
N
Site 91
Y1282
D
V
Q
N
M
N
E
Y
L
S
S
F
K
V
A
Site 92
Y1291
S
S
F
K
V
A
Q
Y
V
V
R
E
E
D
K
Site 93
Y1317
E
E
N
V
D
P
D
Y
W
E
K
L
L
R
H
Site 94
Y1326
E
K
L
L
R
H
H
Y
E
Q
Q
Q
E
D
L
Site 95
Y1349
R
V
R
K
Q
V
N
Y
N
D
A
A
Q
E
D
Site 96
S1361
Q
E
D
Q
D
N
Q
S
E
Y
S
V
G
S
E
Site 97
Y1363
D
Q
D
N
Q
S
E
Y
S
V
G
S
E
E
E
Site 98
S1364
Q
D
N
Q
S
E
Y
S
V
G
S
E
E
E
D
Site 99
S1367
Q
S
E
Y
S
V
G
S
E
E
E
D
E
D
F
Site 100
S1384
R
P
E
G
R
R
Q
S
K
R
Q
L
R
N
E
Site 101
T1448
V
R
D
L
R
G
K
T
E
K
E
F
K
A
Y
Site 102
Y1455
T
E
K
E
F
K
A
Y
V
S
L
F
M
R
H
Site 103
S1471
C
E
P
G
A
D
G
S
E
T
F
A
D
G
V
Site 104
T1473
P
G
A
D
G
S
E
T
F
A
D
G
V
P
R
Site 105
S1484
G
V
P
R
E
G
L
S
R
Q
Q
V
L
T
R
Site 106
S1522
P
E
L
M
P
D
P
S
A
D
S
K
R
S
S
Site 107
S1525
M
P
D
P
S
A
D
S
K
R
S
S
R
A
S
Site 108
S1528
P
S
A
D
S
K
R
S
S
R
A
S
S
P
T
Site 109
S1529
S
A
D
S
K
R
S
S
R
A
S
S
P
T
K
Site 110
S1532
S
K
R
S
S
R
A
S
S
P
T
K
T
S
P
Site 111
S1533
S
K
R
S
S
R
A
S
S
P
T
K
T
S
P
Site 112
T1535
S
S
R
A
S
S
P
T
K
T
S
P
T
T
P
Site 113
T1537
R
A
S
S
P
T
K
T
S
P
T
T
P
E
A
Site 114
S1538
A
S
S
P
T
K
T
S
P
T
T
P
E
A
S
Site 115
T1541
P
T
K
T
S
P
T
T
P
E
A
S
A
T
N
Site 116
S1545
S
P
T
T
P
E
A
S
A
T
N
S
P
C
T
Site 117
T1547
T
T
P
E
A
S
A
T
N
S
P
C
T
S
K
Site 118
S1549
P
E
A
S
A
T
N
S
P
C
T
S
K
P
A
Site 119
T1552
S
A
T
N
S
P
C
T
S
K
P
A
T
P
A
Site 120
S1553
A
T
N
S
P
C
T
S
K
P
A
T
P
A
P
Site 121
T1557
P
C
T
S
K
P
A
T
P
A
P
S
E
K
G
Site 122
S1561
K
P
A
T
P
A
P
S
E
K
G
E
G
I
R
Site 123
T1569
E
K
G
E
G
I
R
T
P
L
E
K
E
E
A
Site 124
T1595
R
I
G
E
K
M
E
T
E
A
D
A
P
S
P
Site 125
S1601
E
T
E
A
D
A
P
S
P
A
P
S
L
G
E
Site 126
S1605
D
A
P
S
P
A
P
S
L
G
E
R
L
E
P
Site 127
Y1634
E
M
E
P
E
P
G
Y
R
G
D
R
E
K
S
Site 128
S1641
Y
R
G
D
R
E
K
S
A
T
E
S
T
P
G
Site 129
T1643
G
D
R
E
K
S
A
T
E
S
T
P
G
E
R
Site 130
S1645
R
E
K
S
A
T
E
S
T
P
G
E
R
G
E
Site 131
T1646
E
K
S
A
T
E
S
T
P
G
E
R
G
E
E
Site 132
S1694
G
P
R
D
E
P
R
S
N
G
R
R
E
E
K
Site 133
T1702
N
G
R
R
E
E
K
T
E
K
P
R
F
M
F
Site 134
S1733
E
E
R
A
A
I
S
S
G
K
L
N
E
I
W
Site 135
Y1757
A
G
I
V
L
H
G
Y
A
R
W
Q
D
I
Q
Site 136
T1778
I
I
N
E
P
F
K
T
E
A
N
K
G
N
F
Site 137
Y1815
E
Q
L
R
R
A
A
Y
L
N
L
S
Q
E
P
Site 138
S1819
R
A
A
Y
L
N
L
S
Q
E
P
A
H
P
A
Site 139
S1842
E
A
E
C
L
A
E
S
H
Q
H
L
S
K
E
Site 140
S1847
A
E
S
H
Q
H
L
S
K
E
S
L
A
G
N
Site 141
S1873
N
Q
L
E
E
L
L
S
D
M
K
A
D
V
T
Site 142
T1880
S
D
M
K
A
D
V
T
R
L
P
A
T
L
S
Site 143
S1899
I
A
A
R
L
Q
M
S
E
R
S
I
L
S
R
Site 144
S1902
R
L
Q
M
S
E
R
S
I
L
S
R
L
A
S
Site 145
S1905
M
S
E
R
S
I
L
S
R
L
A
S
K
G
T
Site 146
S1909
S
I
L
S
R
L
A
S
K
G
T
E
P
H
P
Site 147
T1917
K
G
T
E
P
H
P
T
P
A
Y
P
P
G
P
Site 148
Y1920
E
P
H
P
T
P
A
Y
P
P
G
P
Y
A
T
Site 149
Y1925
P
A
Y
P
P
G
P
Y
A
T
P
P
G
Y
G
Site 150
T1927
Y
P
P
G
P
Y
A
T
P
P
G
Y
G
A
A
Site 151
S1951
A
A
A
G
A
N
Y
S
Q
M
P
A
G
S
F
Site 152
S1957
Y
S
Q
M
P
A
G
S
F
I
T
A
A
T
N
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation