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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DPYD
Full Name:
Dihydropyrimidine dehydrogenase [NADP+]
Alias:
DHP; DHPDHase; Dihydropyrimidine dehydrogenase; Dihydrothymine dehydrogenase; Dihydrouracil dehydrogenase; DPD; EC 1.3.1.2; MGC70799; OTTHUMP00000058954
Type:
Other Amino Acids Metabolism - beta-alanine; Nucleotide Metabolism - pyrimidine; EC 1.3.1.2; Oxidoreductase; Cofactor and Vitamin Metabolism - pantothenate and CoA biosynthesis; Xenobiotic Metabolism - drug metabolism - other enzymes
Mass (Da):
111401
Number AA:
1025
UniProt ID:
Q12882
International Prot ID:
IPI00029772
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0051539
GO:0050660
GO:0050661
PhosphoSite+
KinaseNET
Biological Process:
GO:0006207
GO:0006222
GO:0055114
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
A
P
V
L
S
K
D
S
A
D
I
E
Site 2
T24
A
L
N
P
R
T
Q
T
H
A
T
L
C
S
T
Site 3
T27
P
R
T
Q
T
H
A
T
L
C
S
T
S
A
K
Site 4
S30
Q
T
H
A
T
L
C
S
T
S
A
K
K
L
D
Site 5
T31
T
H
A
T
L
C
S
T
S
A
K
K
L
D
K
Site 6
S32
H
A
T
L
C
S
T
S
A
K
K
L
D
K
K
Site 7
S90
A
D
A
P
C
Q
K
S
C
P
T
N
L
D
I
Site 8
S99
P
T
N
L
D
I
K
S
F
I
T
S
I
A
N
Site 9
Y110
S
I
A
N
K
N
Y
Y
G
A
A
K
M
I
F
Site 10
T145
G
G
C
N
L
Y
A
T
E
E
G
P
I
N
I
Site 11
S175
I
P
Q
I
R
N
P
S
L
P
P
P
E
K
M
Site 12
S183
L
P
P
P
E
K
M
S
E
A
Y
S
A
K
I
Site 13
S187
E
K
M
S
E
A
Y
S
A
K
I
A
L
F
G
Site 14
T215
R
L
G
Y
S
D
I
T
I
F
E
K
Q
E
Y
Site 15
Y222
T
I
F
E
K
Q
E
Y
V
G
G
L
S
T
S
Site 16
S227
Q
E
Y
V
G
G
L
S
T
S
E
I
P
Q
F
Site 17
S229
Y
V
G
G
L
S
T
S
E
I
P
Q
F
R
L
Site 18
S260
V
K
I
I
C
G
K
S
L
S
V
N
E
M
T
Site 19
S262
I
I
C
G
K
S
L
S
V
N
E
M
T
L
S
Site 20
S269
S
V
N
E
M
T
L
S
T
L
K
E
K
G
Y
Site 21
Y276
S
T
L
K
E
K
G
Y
K
A
A
F
I
G
I
Site 22
S306
Q
D
Q
G
F
Y
T
S
K
D
F
L
P
L
V
Site 23
T416
V
R
T
E
Q
D
E
T
G
K
W
N
E
D
E
Site 24
S436
L
K
A
D
V
V
I
S
A
F
G
S
V
L
S
Site 25
S440
V
V
I
S
A
F
G
S
V
L
S
D
P
K
V
Site 26
S443
S
A
F
G
S
V
L
S
D
P
K
V
K
E
A
Site 27
S452
P
K
V
K
E
A
L
S
P
I
K
F
N
R
W
Site 28
T468
L
P
E
V
D
P
E
T
M
Q
T
S
E
A
W
Site 29
T471
V
D
P
E
T
M
Q
T
S
E
A
W
V
F
A
Site 30
Y502
D
G
K
Q
A
S
W
Y
I
H
K
Y
V
Q
S
Site 31
Y506
A
S
W
Y
I
H
K
Y
V
Q
S
Q
Y
G
A
Site 32
S509
Y
I
H
K
Y
V
Q
S
Q
Y
G
A
S
V
S
Site 33
Y511
H
K
Y
V
Q
S
Q
Y
G
A
S
V
S
A
K
Site 34
S516
S
Q
Y
G
A
S
V
S
A
K
P
E
L
P
L
Site 35
S558
A
T
P
A
T
S
T
S
M
I
R
R
A
F
E
Site 36
T575
W
G
F
A
L
T
K
T
F
S
L
D
K
D
I
Site 37
S577
F
A
L
T
K
T
F
S
L
D
K
D
I
V
T
Site 38
T584
S
L
D
K
D
I
V
T
N
V
S
P
R
I
I
Site 39
S587
K
D
I
V
T
N
V
S
P
R
I
I
R
G
T
Site 40
T594
S
P
R
I
I
R
G
T
T
S
G
P
M
Y
G
Site 41
T595
P
R
I
I
R
G
T
T
S
G
P
M
Y
G
P
Site 42
S596
R
I
I
R
G
T
T
S
G
P
M
Y
G
P
G
Site 43
Y600
G
T
T
S
G
P
M
Y
G
P
G
Q
S
S
F
Site 44
Y620
I
S
E
K
T
A
A
Y
W
C
Q
S
V
T
E
Site 45
T651
S
Y
N
K
N
D
W
T
E
L
A
K
K
S
E
Site 46
S660
L
A
K
K
S
E
D
S
G
A
D
A
L
E
L
Site 47
S670
D
A
L
E
L
N
L
S
C
P
H
G
M
G
E
Site 48
S746
S
G
L
M
G
L
K
S
D
G
T
P
W
P
A
Site 49
T761
V
G
I
A
K
R
T
T
Y
G
G
V
S
G
T
Site 50
Y762
G
I
A
K
R
T
T
Y
G
G
V
S
G
T
A
Site 51
S766
R
T
T
Y
G
G
V
S
G
T
A
I
R
P
I
Site 52
T768
T
Y
G
G
V
S
G
T
A
I
R
P
I
A
L
Site 53
S801
G
G
I
D
S
A
E
S
G
L
Q
F
L
H
S
Site 54
S842
K
A
L
L
Y
L
K
S
I
E
E
L
Q
D
W
Site 55
S853
L
Q
D
W
D
G
Q
S
P
A
T
V
S
H
Q
Site 56
T856
W
D
G
Q
S
P
A
T
V
S
H
Q
K
G
K
Site 57
S858
G
Q
S
P
A
T
V
S
H
Q
K
G
K
P
V
Site 58
S878
L
M
D
K
K
L
P
S
F
G
P
Y
L
E
Q
Site 59
Y882
K
L
P
S
F
G
P
Y
L
E
Q
R
K
K
I
Site 60
S905
K
E
Q
N
V
A
F
S
P
L
K
R
N
C
F
Site 61
Y968
M
T
C
N
D
S
G
Y
Q
A
I
Q
F
D
P
Site 62
T977
A
I
Q
F
D
P
E
T
H
L
P
T
I
T
D
Site 63
T1009
I
K
M
V
S
R
T
T
P
Y
E
P
K
R
G
Site 64
Y1011
M
V
S
R
T
T
P
Y
E
P
K
R
G
V
P
Site 65
S1020
P
K
R
G
V
P
L
S
V
N
P
V
C
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation