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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ILF3
Full Name:
Interleukin enhancer-binding factor 3
Alias:
Double-stranded RNA-binding protein 76; DRBF; DRBP76; Interleukin enhancer binding factor 3; Interleukin enhancer binding factor 3, 90kDa; Interleukin enhancer-binding factor 3; M-phase phosphoprotein 4; MPHOSPH4; MPP4; NF90; NFAR; NFAR-1; NF-AT-90; Nuclear factor associated with dsRNA; Nuclear factor of activated T cells-90; Nuclear factor of activated T-cells 90 kDa; TCP80; Translational control protein 80
Type:
Transcription protein
Mass (Da):
95338
Number AA:
894
UniProt ID:
Q12906
International Prot ID:
IPI00298788
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005739
GO:0005730
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003677
GO:0003725
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0000279
GO:0045892
GO:0045893
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S20
H
V
M
A
K
H
S
S
V
Y
P
T
Q
E
E
Site 2
Y22
M
A
K
H
S
S
V
Y
P
T
Q
E
E
L
E
Site 3
T24
K
H
S
S
V
Y
P
T
Q
E
E
L
E
A
V
Site 4
S57
D
E
Q
E
K
G
S
S
E
Q
A
E
S
D
N
Site 5
S62
G
S
S
E
Q
A
E
S
D
N
M
D
V
P
P
Site 6
S73
D
V
P
P
E
D
D
S
K
E
G
A
G
E
Q
Site 7
T82
E
G
A
G
E
Q
K
T
E
H
M
T
R
T
L
Site 8
T88
K
T
E
H
M
T
R
T
L
R
G
V
M
R
V
Site 9
Y144
A
A
V
T
E
D
K
Y
E
I
L
Q
S
V
D
Site 10
S149
D
K
Y
E
I
L
Q
S
V
D
D
A
A
I
V
Site 11
S166
N
T
K
E
P
P
L
S
L
T
I
H
L
T
S
Site 12
T168
K
E
P
P
L
S
L
T
I
H
L
T
S
P
V
Site 13
T188
E
K
V
L
A
G
E
T
L
S
V
N
D
P
P
Site 14
S190
V
L
A
G
E
T
L
S
V
N
D
P
P
D
V
Site 15
T238
R
V
L
R
D
L
C
T
R
V
P
T
W
G
P
Site 16
T242
D
L
C
T
R
V
P
T
W
G
P
L
R
G
W
Site 17
S258
L
E
L
L
C
E
K
S
I
G
T
A
N
R
P
Site 18
Y292
M
P
D
G
S
G
I
Y
D
P
C
E
K
E
A
Site 19
T300
D
P
C
E
K
E
A
T
D
A
I
G
H
L
D
Site 20
T315
R
Q
Q
R
E
D
I
T
Q
S
A
Q
H
A
L
Site 21
S341
L
G
M
D
P
L
P
S
K
M
P
K
K
P
K
Site 22
Y355
K
N
E
N
P
V
D
Y
T
V
Q
I
P
P
S
Site 23
T356
N
E
N
P
V
D
Y
T
V
Q
I
P
P
S
T
Site 24
S362
Y
T
V
Q
I
P
P
S
T
T
Y
A
I
T
P
Site 25
T363
T
V
Q
I
P
P
S
T
T
Y
A
I
T
P
M
Site 26
T364
V
Q
I
P
P
S
T
T
Y
A
I
T
P
M
K
Site 27
Y365
Q
I
P
P
S
T
T
Y
A
I
T
P
M
K
R
Site 28
T368
P
S
T
T
Y
A
I
T
P
M
K
R
P
M
E
Site 29
S382
E
E
D
G
E
E
K
S
P
S
K
K
K
K
K
Site 30
S384
D
G
E
E
K
S
P
S
K
K
K
K
K
I
Q
Site 31
S422
G
L
Q
Y
K
L
V
S
Q
T
G
P
V
H
A
Site 32
S435
H
A
P
I
F
T
M
S
V
E
V
D
G
N
S
Site 33
S442
S
V
E
V
D
G
N
S
F
E
A
S
G
P
S
Site 34
S446
D
G
N
S
F
E
A
S
G
P
S
K
K
T
A
Site 35
T469
L
Q
D
M
G
L
P
T
G
A
E
G
R
D
S
Site 36
S476
T
G
A
E
G
R
D
S
S
K
G
E
D
S
A
Site 37
S477
G
A
E
G
R
D
S
S
K
G
E
D
S
A
E
Site 38
S482
D
S
S
K
G
E
D
S
A
E
E
T
E
A
K
Site 39
T486
G
E
D
S
A
E
E
T
E
A
K
P
A
V
V
Site 40
S503
A
P
V
V
E
A
V
S
T
P
S
A
A
F
P
Site 41
T504
P
V
V
E
A
V
S
T
P
S
A
A
F
P
S
Site 42
S506
V
E
A
V
S
T
P
S
A
A
F
P
S
D
A
Site 43
S511
T
P
S
A
A
F
P
S
D
A
T
A
E
Q
G
Site 44
T514
A
A
F
P
S
D
A
T
A
E
Q
G
P
I
L
Site 45
T522
A
E
Q
G
P
I
L
T
K
H
G
K
N
P
V
Site 46
Y541
E
K
R
R
G
L
K
Y
E
L
I
S
E
T
G
Site 47
S545
G
L
K
Y
E
L
I
S
E
T
G
G
S
H
D
Site 48
S550
L
I
S
E
T
G
G
S
H
D
K
R
F
V
M
Site 49
S571
Q
K
F
Q
G
A
G
S
N
K
K
V
A
K
A
Site 50
Y579
N
K
K
V
A
K
A
Y
A
A
L
A
A
L
E
Site 51
T592
L
E
K
L
F
P
D
T
P
L
A
L
D
A
N
Site 52
S647
R
G
R
G
R
G
G
S
I
R
G
R
G
R
G
Site 53
Y665
G
G
A
N
H
G
G
Y
M
N
A
G
A
G
Y
Site 54
Y672
Y
M
N
A
G
A
G
Y
G
S
Y
G
Y
G
G
Site 55
S674
N
A
G
A
G
Y
G
S
Y
G
Y
G
G
N
S
Site 56
Y675
A
G
A
G
Y
G
S
Y
G
Y
G
G
N
S
A
Site 57
Y677
A
G
Y
G
S
Y
G
Y
G
G
N
S
A
T
A
Site 58
S681
S
Y
G
Y
G
G
N
S
A
T
A
G
Y
S
Q
Site 59
T683
G
Y
G
G
N
S
A
T
A
G
Y
S
Q
F
Y
Site 60
S687
N
S
A
T
A
G
Y
S
Q
F
Y
S
N
G
G
Site 61
Y690
T
A
G
Y
S
Q
F
Y
S
N
G
G
H
S
G
Site 62
S691
A
G
Y
S
Q
F
Y
S
N
G
G
H
S
G
N
Site 63
S696
F
Y
S
N
G
G
H
S
G
N
A
S
G
G
G
Site 64
S700
G
G
H
S
G
N
A
S
G
G
G
G
G
G
G
Site 65
S710
G
G
G
G
G
G
G
S
S
G
Y
G
S
Y
Y
Site 66
S711
G
G
G
G
G
G
S
S
G
Y
G
S
Y
Y
Q
Site 67
Y713
G
G
G
G
S
S
G
Y
G
S
Y
Y
Q
G
D
Site 68
S715
G
G
S
S
G
Y
G
S
Y
Y
Q
G
D
N
Y
Site 69
Y717
S
S
G
Y
G
S
Y
Y
Q
G
D
N
Y
N
S
Site 70
Y722
S
Y
Y
Q
G
D
N
Y
N
S
P
V
P
P
K
Site 71
S724
Y
Q
G
D
N
Y
N
S
P
V
P
P
K
H
A
Site 72
S744
H
G
G
Q
Q
K
P
S
Y
G
S
G
Y
Q
S
Site 73
Y745
G
G
Q
Q
K
P
S
Y
G
S
G
Y
Q
S
H
Site 74
S747
Q
Q
K
P
S
Y
G
S
G
Y
Q
S
H
Q
G
Site 75
Y749
K
P
S
Y
G
S
G
Y
Q
S
H
Q
G
Q
Q
Site 76
S751
S
Y
G
S
G
Y
Q
S
H
Q
G
Q
Q
Q
S
Site 77
S758
S
H
Q
G
Q
Q
Q
S
Y
N
Q
S
P
Y
S
Site 78
S762
Q
Q
Q
S
Y
N
Q
S
P
Y
S
N
Y
G
P
Site 79
Y764
Q
S
Y
N
Q
S
P
Y
S
N
Y
G
P
P
Q
Site 80
S765
S
Y
N
Q
S
P
Y
S
N
Y
G
P
P
Q
G
Site 81
Y767
N
Q
S
P
Y
S
N
Y
G
P
P
Q
G
K
Q
Site 82
Y777
P
Q
G
K
Q
K
G
Y
N
H
G
Q
G
S
Y
Site 83
S783
G
Y
N
H
G
Q
G
S
Y
S
Y
S
N
S
Y
Site 84
Y784
Y
N
H
G
Q
G
S
Y
S
Y
S
N
S
Y
N
Site 85
S785
N
H
G
Q
G
S
Y
S
Y
S
N
S
Y
N
S
Site 86
Y786
H
G
Q
G
S
Y
S
Y
S
N
S
Y
N
S
P
Site 87
S787
G
Q
G
S
Y
S
Y
S
N
S
Y
N
S
P
G
Site 88
S789
G
S
Y
S
Y
S
N
S
Y
N
S
P
G
G
G
Site 89
Y790
S
Y
S
Y
S
N
S
Y
N
S
P
G
G
G
G
Site 90
S792
S
Y
S
N
S
Y
N
S
P
G
G
G
G
G
S
Site 91
S799
S
P
G
G
G
G
G
S
D
Y
N
Y
E
S
K
Site 92
Y801
G
G
G
G
G
S
D
Y
N
Y
E
S
K
F
N
Site 93
Y803
G
G
G
S
D
Y
N
Y
E
S
K
F
N
Y
S
Site 94
S805
G
S
D
Y
N
Y
E
S
K
F
N
Y
S
G
S
Site 95
Y809
N
Y
E
S
K
F
N
Y
S
G
S
G
G
R
S
Site 96
S810
Y
E
S
K
F
N
Y
S
G
S
G
G
R
S
G
Site 97
S812
S
K
F
N
Y
S
G
S
G
G
R
S
G
G
N
Site 98
S816
Y
S
G
S
G
G
R
S
G
G
N
S
Y
G
S
Site 99
S820
G
G
R
S
G
G
N
S
Y
G
S
G
G
A
S
Site 100
Y821
G
R
S
G
G
N
S
Y
G
S
G
G
A
S
Y
Site 101
S823
S
G
G
N
S
Y
G
S
G
G
A
S
Y
N
P
Site 102
S827
S
Y
G
S
G
G
A
S
Y
N
P
G
S
H
G
Site 103
Y828
Y
G
S
G
G
A
S
Y
N
P
G
S
H
G
G
Site 104
S832
G
A
S
Y
N
P
G
S
H
G
G
Y
G
G
G
Site 105
Y836
N
P
G
S
H
G
G
Y
G
G
G
S
G
G
G
Site 106
S840
H
G
G
Y
G
G
G
S
G
G
G
S
S
Y
Q
Site 107
S844
G
G
G
S
G
G
G
S
S
Y
Q
G
K
Q
G
Site 108
S845
G
G
S
G
G
G
S
S
Y
Q
G
K
Q
G
G
Site 109
Y846
G
S
G
G
G
S
S
Y
Q
G
K
Q
G
G
Y
Site 110
Y853
Y
Q
G
K
Q
G
G
Y
S
Q
S
N
Y
N
S
Site 111
S854
Q
G
K
Q
G
G
Y
S
Q
S
N
Y
N
S
P
Site 112
S856
K
Q
G
G
Y
S
Q
S
N
Y
N
S
P
G
S
Site 113
Y858
G
G
Y
S
Q
S
N
Y
N
S
P
G
S
G
Q
Site 114
S860
Y
S
Q
S
N
Y
N
S
P
G
S
G
Q
N
Y
Site 115
S863
S
N
Y
N
S
P
G
S
G
Q
N
Y
S
G
P
Site 116
Y867
S
P
G
S
G
Q
N
Y
S
G
P
P
S
S
Y
Site 117
S868
P
G
S
G
Q
N
Y
S
G
P
P
S
S
Y
Q
Site 118
S872
Q
N
Y
S
G
P
P
S
S
Y
Q
S
S
Q
G
Site 119
S873
N
Y
S
G
P
P
S
S
Y
Q
S
S
Q
G
G
Site 120
Y874
Y
S
G
P
P
S
S
Y
Q
S
S
Q
G
G
Y
Site 121
S876
G
P
P
S
S
Y
Q
S
S
Q
G
G
Y
G
R
Site 122
S877
P
P
S
S
Y
Q
S
S
Q
G
G
Y
G
R
N
Site 123
Y881
Y
Q
S
S
Q
G
G
Y
G
R
N
A
D
H
S
Site 124
S888
Y
G
R
N
A
D
H
S
M
N
Y
Q
Y
R
_
Site 125
Y891
N
A
D
H
S
M
N
Y
Q
Y
R
_
_
_
_
Site 126
Y893
D
H
S
M
N
Y
Q
Y
R
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation