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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PTPN13
Full Name:
Tyrosine-protein phosphatase non-receptor type 13
Alias:
APO-1/CD95 (Fas)-associated phosphatase; EC 3.1.3.48; FAP1; FAP-1; Fas-associated phosphatase-1; Fas-associated protein-tyrosine phosphatase 1; PNP1; Protein tyrosine phosphatase 1E; Protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase); Protein-tyrosine phosphatase 1E; Protein-tyrosine phosphatase PTPL1; PTN13; PTP1E; PTP-BAS; PTP-BL; PTP-E1; PTPL1; PTPLE; Tyrosine-protein phosphatase non-receptor type 13
Type:
EC 3.1.3.48; Protein phosphatase, tyrosine (non-receptor)
Mass (Da):
276906
Number AA:
2485
UniProt ID:
Q12923
International Prot ID:
IPI00006714
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005856
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0004725
PhosphoSite+
KinaseNET
Biological Process:
GO:0006470
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S65
L
L
P
S
G
S
V
S
F
T
D
E
N
I
S
Site 2
T67
P
S
G
S
V
S
F
T
D
E
N
I
S
N
Q
Site 3
S72
S
F
T
D
E
N
I
S
N
Q
D
L
R
A
F
Site 4
T80
N
Q
D
L
R
A
F
T
A
P
E
V
L
Q
N
Site 5
S89
P
E
V
L
Q
N
Q
S
L
T
S
L
S
D
V
Site 6
S92
L
Q
N
Q
S
L
T
S
L
S
D
V
E
K
I
Site 7
S94
N
Q
S
L
T
S
L
S
D
V
E
K
I
H
I
Site 8
Y114
T
L
Y
W
G
A
D
Y
E
V
P
Q
S
Q
P
Site 9
S119
A
D
Y
E
V
P
Q
S
Q
P
I
K
L
G
D
Site 10
S160
C
S
A
H
I
R
N
S
N
C
A
P
S
F
S
Site 11
S165
R
N
S
N
C
A
P
S
F
S
Y
V
K
H
L
Site 12
S167
S
N
C
A
P
S
F
S
Y
V
K
H
L
V
K
Site 13
T183
V
L
G
N
L
S
G
T
D
Q
L
S
C
N
S
Site 14
S187
L
S
G
T
D
Q
L
S
C
N
S
E
Q
K
P
Site 15
S197
S
E
Q
K
P
D
R
S
Q
A
I
R
D
R
L
Site 16
T211
L
R
G
K
G
L
P
T
G
R
S
S
T
S
D
Site 17
S214
K
G
L
P
T
G
R
S
S
T
S
D
V
L
D
Site 18
S215
G
L
P
T
G
R
S
S
T
S
D
V
L
D
I
Site 19
T216
L
P
T
G
R
S
S
T
S
D
V
L
D
I
Q
Site 20
S228
D
I
Q
K
P
P
L
S
H
Q
T
F
L
N
K
Site 21
T231
K
P
P
L
S
H
Q
T
F
L
N
K
G
L
S
Site 22
S240
L
N
K
G
L
S
K
S
M
G
F
L
S
I
K
Site 23
S245
S
K
S
M
G
F
L
S
I
K
D
T
Q
D
E
Site 24
T249
G
F
L
S
I
K
D
T
Q
D
E
N
Y
F
K
Site 25
Y254
K
D
T
Q
D
E
N
Y
F
K
D
I
L
S
D
Site 26
S260
N
Y
F
K
D
I
L
S
D
N
S
G
R
E
D
Site 27
S263
K
D
I
L
S
D
N
S
G
R
E
D
S
E
N
Site 28
S268
D
N
S
G
R
E
D
S
E
N
T
F
S
P
Y
Site 29
T271
G
R
E
D
S
E
N
T
F
S
P
Y
Q
F
K
Site 30
S273
E
D
S
E
N
T
F
S
P
Y
Q
F
K
T
S
Site 31
Y275
S
E
N
T
F
S
P
Y
Q
F
K
T
S
G
P
Site 32
T279
F
S
P
Y
Q
F
K
T
S
G
P
E
K
K
P
Site 33
S301
S
K
K
K
I
W
A
S
S
M
D
L
L
C
T
Site 34
S302
K
K
K
I
W
A
S
S
M
D
L
L
C
T
A
Site 35
T308
S
S
M
D
L
L
C
T
A
D
R
D
F
S
S
Site 36
S314
C
T
A
D
R
D
F
S
S
G
E
T
A
T
Y
Site 37
S315
T
A
D
R
D
F
S
S
G
E
T
A
T
Y
R
Site 38
T318
R
D
F
S
S
G
E
T
A
T
Y
R
R
C
H
Site 39
T320
F
S
S
G
E
T
A
T
Y
R
R
C
H
P
E
Site 40
Y321
S
S
G
E
T
A
T
Y
R
R
C
H
P
E
A
Site 41
T330
R
C
H
P
E
A
V
T
V
R
T
S
T
T
P
Site 42
S334
E
A
V
T
V
R
T
S
T
T
P
R
K
K
E
Site 43
T335
A
V
T
V
R
T
S
T
T
P
R
K
K
E
A
Site 44
T336
V
T
V
R
T
S
T
T
P
R
K
K
E
A
R
Site 45
Y344
P
R
K
K
E
A
R
Y
S
D
G
S
I
A
L
Site 46
S345
R
K
K
E
A
R
Y
S
D
G
S
I
A
L
D
Site 47
S348
E
A
R
Y
S
D
G
S
I
A
L
D
I
F
G
Site 48
Y363
P
Q
K
M
D
P
I
Y
H
T
R
E
L
P
T
Site 49
S371
H
T
R
E
L
P
T
S
S
A
I
S
S
A
L
Site 50
S372
T
R
E
L
P
T
S
S
A
I
S
S
A
L
D
Site 51
S375
L
P
T
S
S
A
I
S
S
A
L
D
R
I
R
Site 52
S376
P
T
S
S
A
I
S
S
A
L
D
R
I
R
E
Site 53
Y404
V
E
E
P
V
R
R
Y
K
T
Y
H
G
D
V
Site 54
T406
E
P
V
R
R
Y
K
T
Y
H
G
D
V
F
S
Site 55
Y407
P
V
R
R
Y
K
T
Y
H
G
D
V
F
S
T
Site 56
S413
T
Y
H
G
D
V
F
S
T
S
S
E
S
P
S
Site 57
T414
Y
H
G
D
V
F
S
T
S
S
E
S
P
S
I
Site 58
S415
H
G
D
V
F
S
T
S
S
E
S
P
S
I
I
Site 59
S416
G
D
V
F
S
T
S
S
E
S
P
S
I
I
S
Site 60
S418
V
F
S
T
S
S
E
S
P
S
I
I
S
S
E
Site 61
S420
S
T
S
S
E
S
P
S
I
I
S
S
E
S
D
Site 62
S424
E
S
P
S
I
I
S
S
E
S
D
F
R
Q
V
Site 63
S426
P
S
I
I
S
S
E
S
D
F
R
Q
V
R
R
Site 64
S434
D
F
R
Q
V
R
R
S
E
A
S
K
R
F
E
Site 65
S437
Q
V
R
R
S
E
A
S
K
R
F
E
S
S
S
Site 66
S442
E
A
S
K
R
F
E
S
S
S
G
L
P
G
V
Site 67
S444
S
K
R
F
E
S
S
S
G
L
P
G
V
D
E
Site 68
T452
G
L
P
G
V
D
E
T
L
S
Q
G
Q
S
Q
Site 69
S454
P
G
V
D
E
T
L
S
Q
G
Q
S
Q
R
P
Site 70
S458
E
T
L
S
Q
G
Q
S
Q
R
P
S
R
Q
Y
Site 71
S462
Q
G
Q
S
Q
R
P
S
R
Q
Y
E
T
P
F
Site 72
Y465
S
Q
R
P
S
R
Q
Y
E
T
P
F
E
G
N
Site 73
T467
R
P
S
R
Q
Y
E
T
P
F
E
G
N
L
I
Site 74
S499
A
K
M
A
L
R
Q
S
R
L
S
L
Y
P
G
Site 75
S502
A
L
R
Q
S
R
L
S
L
Y
P
G
D
T
I
Site 76
Y504
R
Q
S
R
L
S
L
Y
P
G
D
T
I
K
A
Site 77
T508
L
S
L
Y
P
G
D
T
I
K
A
S
M
L
D
Site 78
S512
P
G
D
T
I
K
A
S
M
L
D
I
T
R
D
Site 79
T517
K
A
S
M
L
D
I
T
R
D
P
L
R
E
I
Site 80
T528
L
R
E
I
A
L
E
T
A
M
T
Q
R
K
L
Site 81
T531
I
A
L
E
T
A
M
T
Q
R
K
L
R
N
F
Site 82
S559
I
S
L
D
L
P
R
S
I
L
T
K
K
G
K
Site 83
T587
N
G
Q
R
L
E
L
T
C
D
T
K
T
I
C
Site 84
T592
E
L
T
C
D
T
K
T
I
C
K
D
V
F
D
Site 85
T617
H
H
L
F
A
L
A
T
L
K
D
N
E
Y
F
Site 86
Y623
A
T
L
K
D
N
E
Y
F
F
V
D
P
D
L
Site 87
T651
P
K
K
K
T
K
A
T
V
N
F
T
L
F
F
Site 88
T675
S
L
I
Q
H
T
L
T
C
H
Q
Y
Y
L
Q
Site 89
Y679
H
T
L
T
C
H
Q
Y
Y
L
Q
L
R
K
D
Site 90
T698
R
M
H
C
D
D
E
T
S
L
L
L
A
S
L
Site 91
Y714
L
Q
A
E
Y
G
D
Y
Q
P
E
V
H
G
V
Site 92
Y723
P
E
V
H
G
V
S
Y
F
R
M
E
H
Y
L
Site 93
Y729
S
Y
F
R
M
E
H
Y
L
P
A
R
V
M
E
Site 94
S741
V
M
E
K
L
D
L
S
Y
I
K
E
E
L
P
Site 95
Y742
M
E
K
L
D
L
S
Y
I
K
E
E
L
P
K
Site 96
T753
E
L
P
K
L
H
N
T
Y
V
G
A
S
E
K
Site 97
Y754
L
P
K
L
H
N
T
Y
V
G
A
S
E
K
E
Site 98
T762
V
G
A
S
E
K
E
T
E
L
E
F
L
K
V
Site 99
Y776
V
C
Q
R
L
T
E
Y
G
V
H
F
H
R
V
Site 100
S789
R
V
H
P
E
K
K
S
Q
T
G
I
L
L
G
Site 101
T823
L
R
F
P
W
R
E
T
K
K
I
S
F
S
K
Site 102
S827
W
R
E
T
K
K
I
S
F
S
K
K
K
I
T
Site 103
S829
E
T
K
K
I
S
F
S
K
K
K
I
T
L
Q
Site 104
T834
S
F
S
K
K
K
I
T
L
Q
N
T
S
D
G
Site 105
T838
K
K
I
T
L
Q
N
T
S
D
G
I
K
H
G
Site 106
S839
K
I
T
L
Q
N
T
S
D
G
I
K
H
G
F
Site 107
Y856
D
N
S
K
I
C
Q
Y
L
L
H
L
C
S
Y
Site 108
Y863
Y
L
L
H
L
C
S
Y
Q
H
K
F
Q
L
Q
Site 109
S876
L
Q
M
R
A
R
Q
S
N
Q
D
A
Q
D
I
Site 110
S887
A
Q
D
I
E
R
A
S
F
R
S
L
N
L
Q
Site 111
S890
E
R
A
S
F
R
S
L
N
L
Q
A
E
S
V
Site 112
S897
S
L
N
L
Q
A
E
S
V
R
G
F
N
M
G
Site 113
S908
F
N
M
G
R
A
I
S
T
G
S
L
A
S
S
Site 114
T909
N
M
G
R
A
I
S
T
G
S
L
A
S
S
T
Site 115
S911
G
R
A
I
S
T
G
S
L
A
S
S
T
L
N
Site 116
S914
I
S
T
G
S
L
A
S
S
T
L
N
K
L
A
Site 117
S915
S
T
G
S
L
A
S
S
T
L
N
K
L
A
V
Site 118
T916
T
G
S
L
A
S
S
T
L
N
K
L
A
V
R
Site 119
S936
A
E
I
L
K
R
L
S
C
S
E
L
S
L
Y
Site 120
S938
I
L
K
R
L
S
C
S
E
L
S
L
Y
Q
P
Site 121
S941
R
L
S
C
S
E
L
S
L
Y
Q
P
L
Q
N
Site 122
Y943
S
C
S
E
L
S
L
Y
Q
P
L
Q
N
S
S
Site 123
S958
K
E
K
N
D
K
A
S
W
E
E
K
P
R
E
Site 124
S967
E
E
K
P
R
E
M
S
K
S
Y
H
D
L
S
Site 125
S969
K
P
R
E
M
S
K
S
Y
H
D
L
S
Q
A
Site 126
Y970
P
R
E
M
S
K
S
Y
H
D
L
S
Q
A
S
Site 127
S974
S
K
S
Y
H
D
L
S
Q
A
S
L
Y
P
H
Site 128
S977
Y
H
D
L
S
Q
A
S
L
Y
P
H
R
K
N
Site 129
Y979
D
L
S
Q
A
S
L
Y
P
H
R
K
N
V
I
Site 130
T995
N
M
E
P
P
P
Q
T
V
A
E
L
V
G
K
Site 131
S1004
A
E
L
V
G
K
P
S
H
Q
M
S
R
S
D
Site 132
S1008
G
K
P
S
H
Q
M
S
R
S
D
A
E
S
L
Site 133
S1010
P
S
H
Q
M
S
R
S
D
A
E
S
L
A
G
Site 134
S1014
M
S
R
S
D
A
E
S
L
A
G
V
T
K
L
Site 135
S1024
G
V
T
K
L
N
N
S
K
S
V
A
S
L
N
Site 136
S1026
T
K
L
N
N
S
K
S
V
A
S
L
N
R
S
Site 137
S1029
N
N
S
K
S
V
A
S
L
N
R
S
P
E
R
Site 138
S1033
S
V
A
S
L
N
R
S
P
E
R
R
K
H
E
Site 139
S1041
P
E
R
R
K
H
E
S
D
S
S
S
I
E
D
Site 140
S1043
R
R
K
H
E
S
D
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Y
Q
I
K
G
S
P
N
L
T
L
P
K
Site 293
T2036
I
K
G
S
P
N
L
T
L
P
K
E
S
Y
I
Site 294
Y2049
Y
I
Q
E
D
D
I
Y
D
D
S
Q
E
A
E
Site 295
S2052
E
D
D
I
Y
D
D
S
Q
E
A
E
V
I
Q
Site 296
S2082
E
N
N
A
A
G
Y
S
C
G
P
G
T
L
K
Site 297
T2087
G
Y
S
C
G
P
G
T
L
K
M
N
G
K
L
Site 298
S2095
L
K
M
N
G
K
L
S
E
E
R
T
E
D
T
Site 299
T2099
G
K
L
S
E
E
R
T
E
D
T
D
C
D
G
Site 300
T2102
S
E
E
R
T
E
D
T
D
C
D
G
S
P
L
Site 301
S2107
E
D
T
D
C
D
G
S
P
L
P
E
Y
F
T
Site 302
Y2112
D
G
S
P
L
P
E
Y
F
T
E
A
T
K
M
Site 303
T2114
S
P
L
P
E
Y
F
T
E
A
T
K
M
N
G
Site 304
S2132
Y
C
E
E
K
V
K
S
E
S
L
I
Q
K
P
Site 305
T2144
Q
K
P
Q
E
K
K
T
D
D
D
E
I
T
W
Site 306
T2150
K
T
D
D
D
E
I
T
W
G
N
D
E
L
P
Site 307
S2166
E
R
T
N
H
E
D
S
D
K
D
H
S
F
L
Site 308
S2171
E
D
S
D
K
D
H
S
F
L
T
N
D
E
L
Site 309
T2193
V
L
P
S
G
K
Y
T
G
A
N
L
K
S
V
Site 310
Y2243
E
N
R
R
K
N
R
Y
K
N
I
L
P
Y
D
Site 311
Y2249
R
Y
K
N
I
L
P
Y
D
A
T
R
V
P
L
Site 312
T2252
N
I
L
P
Y
D
A
T
R
V
P
L
G
D
E
Site 313
Y2262
P
L
G
D
E
G
G
Y
I
N
A
S
F
I
K
Site 314
T2309
S
T
V
I
A
M
M
T
Q
E
V
E
G
E
K
Site 315
Y2322
E
K
I
K
C
Q
R
Y
W
P
N
I
L
G
K
Site 316
T2330
W
P
N
I
L
G
K
T
T
M
V
S
N
R
L
Site 317
T2362
M
T
L
E
D
I
Q
T
R
E
V
R
H
I
S
Site 318
T2381
T
A
W
P
D
H
D
T
P
S
Q
P
D
D
L
Site 319
S2383
W
P
D
H
D
T
P
S
Q
P
D
D
L
L
T
Site 320
T2390
S
Q
P
D
D
L
L
T
F
I
S
Y
M
R
H
Site 321
Y2394
D
L
L
T
F
I
S
Y
M
R
H
I
H
R
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation