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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TRAP1
Full Name:
Heat shock protein 75 kDa, mitochondrial
Alias:
Hsp75; TRAP-1; Tumor necrosis factor type 1 receptor-associated protein
Type:
Chaperone protein
Mass (Da):
80110
Number AA:
704
UniProt ID:
Q12931
International Prot ID:
IPI00030275
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005739
GO:0043226
GO:0043227
Uniprot
OncoNet
Molecular Function:
GO:0000166
GO:0005102
GO:0005125
PhosphoSite+
KinaseNET
Biological Process:
GO:0006457
GO:0008152
GO:0009987
Phosida
TranscriptoNet
STRING
Kinexus Products
Heat shock protein 75 kDa, mitochondrial pan-specific antibody AB-NN349-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN349-1#Heat shock protein 75 kDa, mitochondrial pan-specific antibody AB-NN349-2#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN349-2#Heat shock protein 75 kDa, mitochondrial pan-specific antibody AB-NN349-3#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN349-3
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T39
P
I
L
C
P
R
R
T
T
A
Q
L
G
P
R
Site 2
T40
I
L
C
P
R
R
T
T
A
Q
L
G
P
R
R
Site 3
S52
P
R
R
N
P
A
W
S
L
Q
A
G
R
L
F
Site 4
S60
L
Q
A
G
R
L
F
S
T
Q
T
A
E
D
K
Site 5
S73
D
K
E
E
P
L
H
S
I
I
S
S
T
E
S
Site 6
S76
E
P
L
H
S
I
I
S
S
T
E
S
V
Q
G
Site 7
S77
P
L
H
S
I
I
S
S
T
E
S
V
Q
G
S
Site 8
T78
L
H
S
I
I
S
S
T
E
S
V
Q
G
S
T
Site 9
S80
S
I
I
S
S
T
E
S
V
Q
G
S
T
S
K
Site 10
S84
S
T
E
S
V
Q
G
S
T
S
K
H
E
F
Q
Site 11
S118
V
F
I
R
E
L
I
S
N
A
S
D
A
L
E
Site 12
S121
R
E
L
I
S
N
A
S
D
A
L
E
K
L
R
Site 13
S133
K
L
R
H
K
L
V
S
D
G
Q
A
L
P
E
Site 14
T153
Q
T
N
A
E
K
G
T
I
T
I
Q
D
T
G
Site 15
S170
M
T
Q
E
E
L
V
S
N
L
G
T
I
A
R
Site 16
T174
E
L
V
S
N
L
G
T
I
A
R
S
G
S
K
Site 17
S219
A
D
R
V
E
V
Y
S
R
S
A
A
P
G
S
Site 18
S221
R
V
E
V
Y
S
R
S
A
A
P
G
S
L
G
Site 19
S226
S
R
S
A
A
P
G
S
L
G
Y
Q
W
L
S
Site 20
Y229
A
A
P
G
S
L
G
Y
Q
W
L
S
D
G
S
Site 21
S233
S
L
G
Y
Q
W
L
S
D
G
S
G
V
F
E
Site 22
S245
V
F
E
I
A
E
A
S
G
V
R
T
G
T
K
Site 23
S259
K
I
I
I
H
L
K
S
D
C
K
E
F
S
S
Site 24
S266
S
D
C
K
E
F
S
S
E
A
R
V
R
D
V
Site 25
Y277
V
R
D
V
V
T
K
Y
S
N
F
V
S
F
P
Site 26
S278
R
D
V
V
T
K
Y
S
N
F
V
S
F
P
L
Site 27
S282
T
K
Y
S
N
F
V
S
F
P
L
Y
L
N
G
Site 28
Y286
N
F
V
S
F
P
L
Y
L
N
G
R
R
M
N
Site 29
Y317
Q
H
E
E
F
Y
R
Y
V
A
Q
A
H
D
K
Site 30
Y327
Q
A
H
D
K
P
R
Y
T
L
H
Y
K
T
D
Site 31
T328
A
H
D
K
P
R
Y
T
L
H
Y
K
T
D
A
Site 32
Y331
K
P
R
Y
T
L
H
Y
K
T
D
A
P
L
N
Site 33
T333
R
Y
T
L
H
Y
K
T
D
A
P
L
N
I
R
Site 34
S341
D
A
P
L
N
I
R
S
I
F
Y
V
P
D
M
Site 35
Y344
L
N
I
R
S
I
F
Y
V
P
D
M
K
P
S
Site 36
S356
K
P
S
M
F
D
V
S
R
E
L
G
S
S
V
Site 37
S361
D
V
S
R
E
L
G
S
S
V
A
L
Y
S
R
Site 38
S362
V
S
R
E
L
G
S
S
V
A
L
Y
S
R
K
Site 39
Y366
L
G
S
S
V
A
L
Y
S
R
K
V
L
I
Q
Site 40
S401
E
D
I
P
L
N
L
S
R
E
L
L
Q
E
S
Site 41
S408
S
R
E
L
L
Q
E
S
A
L
I
R
K
L
R
Site 42
Y437
S
K
K
D
A
E
K
Y
A
K
F
F
E
D
Y
Site 43
Y444
Y
A
K
F
F
E
D
Y
G
L
F
M
R
E
G
Site 44
T454
F
M
R
E
G
I
V
T
A
T
E
Q
E
V
K
Site 45
Y470
D
I
A
K
L
L
R
Y
E
S
S
A
L
P
S
Site 46
S472
A
K
L
L
R
Y
E
S
S
A
L
P
S
G
Q
Site 47
S473
K
L
L
R
Y
E
S
S
A
L
P
S
G
Q
L
Site 48
S477
Y
E
S
S
A
L
P
S
G
Q
L
T
S
L
S
Site 49
T481
A
L
P
S
G
Q
L
T
S
L
S
E
Y
A
S
Site 50
S482
L
P
S
G
Q
L
T
S
L
S
E
Y
A
S
R
Site 51
S484
S
G
Q
L
T
S
L
S
E
Y
A
S
R
M
R
Site 52
Y486
Q
L
T
S
L
S
E
Y
A
S
R
M
R
A
G
Site 53
S488
T
S
L
S
E
Y
A
S
R
M
R
A
G
T
R
Site 54
T494
A
S
R
M
R
A
G
T
R
N
I
Y
Y
L
C
Site 55
Y498
R
A
G
T
R
N
I
Y
Y
L
C
A
P
N
R
Site 56
Y499
A
G
T
R
N
I
Y
Y
L
C
A
P
N
R
H
Site 57
S511
N
R
H
L
A
E
H
S
P
Y
Y
E
A
M
K
Site 58
Y513
H
L
A
E
H
S
P
Y
Y
E
A
M
K
K
K
Site 59
Y514
L
A
E
H
S
P
Y
Y
E
A
M
K
K
K
D
Site 60
T522
E
A
M
K
K
K
D
T
E
V
L
F
C
F
E
Site 61
T535
F
E
Q
F
D
E
L
T
L
L
H
L
R
E
F
Site 62
T552
K
K
L
I
S
V
E
T
D
I
V
V
D
H
Y
Site 63
Y559
T
D
I
V
V
D
H
Y
K
E
E
K
F
E
D
Site 64
S568
E
E
K
F
E
D
R
S
P
A
A
E
C
L
S
Site 65
S575
S
P
A
A
E
C
L
S
E
K
E
T
E
E
L
Site 66
S592
W
M
R
N
V
L
G
S
R
V
T
N
V
K
V
Site 67
T600
R
V
T
N
V
K
V
T
L
R
L
D
T
H
P
Site 68
T641
R
A
Q
L
L
Q
P
T
L
E
I
N
P
R
H
Site 69
S660
K
L
N
Q
L
R
A
S
E
P
G
L
A
Q
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation