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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DLG1
Full Name:
Disks large homolog 1
Alias:
Discs large 1; Discs, large 1; Discs, large homolog 1; DJ1061C18.1.1; DLGH1; HDlg; Presynaptic protein SAP97; SAP97; SAP-97; Synapse-associated protein 97
Type:
Adapter/scaffold protein
Mass (Da):
100455
Number AA:
904
UniProt ID:
Q12959
International Prot ID:
IPI00030351
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016323
GO:0005911
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0008092
GO:0004385
GO:0019902
PhosphoSite+
KinaseNET
Biological Process:
GO:0031575
GO:0007015
GO:0016337
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T8
M
P
V
R
K
Q
D
T
Q
R
A
L
H
L
L
Site 2
S20
H
L
L
E
E
Y
R
S
K
L
S
Q
T
E
D
Site 3
S23
E
E
Y
R
S
K
L
S
Q
T
E
D
R
Q
L
Site 4
T25
Y
R
S
K
L
S
Q
T
E
D
R
Q
L
R
S
Site 5
S33
E
D
R
Q
L
R
S
S
I
E
R
V
I
N
I
Site 6
S70
N
P
K
C
I
D
R
S
K
P
S
E
P
I
Q
Site 7
S73
C
I
D
R
S
K
P
S
E
P
I
Q
P
V
N
Site 8
T81
E
P
I
Q
P
V
N
T
W
E
I
S
S
L
P
Site 9
S85
P
V
N
T
W
E
I
S
S
L
P
S
S
T
V
Site 10
S86
V
N
T
W
E
I
S
S
L
P
S
S
T
V
T
Site 11
S89
W
E
I
S
S
L
P
S
S
T
V
T
S
E
T
Site 12
S90
E
I
S
S
L
P
S
S
T
V
T
S
E
T
L
Site 13
T91
I
S
S
L
P
S
S
T
V
T
S
E
T
L
P
Site 14
T93
S
L
P
S
S
T
V
T
S
E
T
L
P
S
S
Site 15
S94
L
P
S
S
T
V
T
S
E
T
L
P
S
S
L
Site 16
T96
S
S
T
V
T
S
E
T
L
P
S
S
L
S
P
Site 17
S99
V
T
S
E
T
L
P
S
S
L
S
P
S
V
E
Site 18
S100
T
S
E
T
L
P
S
S
L
S
P
S
V
E
K
Site 19
S102
E
T
L
P
S
S
L
S
P
S
V
E
K
Y
R
Site 20
S104
L
P
S
S
L
S
P
S
V
E
K
Y
R
Y
Q
Site 21
Y108
L
S
P
S
V
E
K
Y
R
Y
Q
D
E
D
T
Site 22
Y110
P
S
V
E
K
Y
R
Y
Q
D
E
D
T
P
P
Site 23
T115
Y
R
Y
Q
D
E
D
T
P
P
Q
E
H
I
S
Site 24
S122
T
P
P
Q
E
H
I
S
P
Q
I
T
N
E
V
Site 25
T126
E
H
I
S
P
Q
I
T
N
E
V
I
G
P
E
Site 26
S138
G
P
E
L
V
H
V
S
E
K
N
L
S
E
I
Site 27
S143
H
V
S
E
K
N
L
S
E
I
E
N
V
H
G
Site 28
S153
E
N
V
H
G
F
V
S
H
S
H
I
S
P
I
Site 29
S155
V
H
G
F
V
S
H
S
H
I
S
P
I
K
P
Site 30
S158
F
V
S
H
S
H
I
S
P
I
K
P
T
E
A
Site 31
T209
V
N
T
D
S
L
E
T
P
T
Y
V
N
G
T
Site 32
Y212
D
S
L
E
T
P
T
Y
V
N
G
T
D
A
D
Site 33
Y220
V
N
G
T
D
A
D
Y
E
Y
E
E
I
T
L
Site 34
Y222
G
T
D
A
D
Y
E
Y
E
E
I
T
L
E
R
Site 35
T226
D
Y
E
Y
E
E
I
T
L
E
R
G
N
S
G
Site 36
S232
I
T
L
E
R
G
N
S
G
L
G
F
S
I
A
Site 37
S237
G
N
S
G
L
G
F
S
I
A
G
G
T
D
N
Site 38
T242
G
F
S
I
A
G
G
T
D
N
P
H
I
G
D
Site 39
S251
N
P
H
I
G
D
D
S
S
I
F
I
T
K
I
Site 40
T288
E
V
D
V
R
D
V
T
H
S
K
A
V
E
A
Site 41
S290
D
V
R
D
V
T
H
S
K
A
V
E
A
L
K
Site 42
S301
E
A
L
K
E
A
G
S
I
V
R
L
Y
V
K
Site 43
Y306
A
G
S
I
V
R
L
Y
V
K
R
R
K
P
V
Site 44
S314
V
K
R
R
K
P
V
S
E
K
I
M
E
I
K
Site 45
Y349
I
P
G
D
N
S
I
Y
V
T
K
I
I
E
G
Site 46
T351
G
D
N
S
I
Y
V
T
K
I
I
E
G
G
A
Site 47
T389
V
T
H
E
E
A
V
T
A
L
K
N
T
S
D
Site 48
S395
V
T
A
L
K
N
T
S
D
F
V
Y
L
K
V
Site 49
Y399
K
N
T
S
D
F
V
Y
L
K
V
A
K
P
T
Site 50
Y409
V
A
K
P
T
S
M
Y
M
N
D
G
Y
A
P
Site 51
Y414
S
M
Y
M
N
D
G
Y
A
P
P
D
I
T
N
Site 52
T420
G
Y
A
P
P
D
I
T
N
S
S
S
Q
P
V
Site 53
S422
A
P
P
D
I
T
N
S
S
S
Q
P
V
D
N
Site 54
S424
P
D
I
T
N
S
S
S
Q
P
V
D
N
H
V
Site 55
S432
Q
P
V
D
N
H
V
S
P
S
S
F
L
G
Q
Site 56
S435
D
N
H
V
S
P
S
S
F
L
G
Q
T
P
A
Site 57
T440
P
S
S
F
L
G
Q
T
P
A
S
P
A
R
Y
Site 58
S443
F
L
G
Q
T
P
A
S
P
A
R
Y
S
P
V
Site 59
Y447
T
P
A
S
P
A
R
Y
S
P
V
S
K
A
V
Site 60
S448
P
A
S
P
A
R
Y
S
P
V
S
K
A
V
L
Site 61
S451
P
A
R
Y
S
P
V
S
K
A
V
L
G
D
D
Site 62
T461
V
L
G
D
D
E
I
T
R
E
P
R
K
V
V
Site 63
S503
A
G
G
P
A
D
L
S
G
E
L
R
K
G
D
Site 64
S514
R
K
G
D
R
I
I
S
V
N
S
V
D
L
R
Site 65
S517
D
R
I
I
S
V
N
S
V
D
L
R
A
A
S
Site 66
S524
S
V
D
L
R
A
A
S
H
E
Q
A
A
A
A
Site 67
S551
Q
Y
R
P
E
E
Y
S
R
F
E
A
K
I
H
Site 68
S567
L
R
E
Q
M
M
N
S
S
I
S
S
G
S
G
Site 69
S568
R
E
Q
M
M
N
S
S
I
S
S
G
S
G
S
Site 70
S570
Q
M
M
N
S
S
I
S
S
G
S
G
S
L
R
Site 71
S571
M
M
N
S
S
I
S
S
G
S
G
S
L
R
T
Site 72
S573
N
S
S
I
S
S
G
S
G
S
L
R
T
S
Q
Site 73
S575
S
I
S
S
G
S
G
S
L
R
T
S
Q
K
R
Site 74
T578
S
G
S
G
S
L
R
T
S
Q
K
R
S
L
Y
Site 75
S579
G
S
G
S
L
R
T
S
Q
K
R
S
L
Y
V
Site 76
S583
L
R
T
S
Q
K
R
S
L
Y
V
R
A
L
F
Site 77
Y585
T
S
Q
K
R
S
L
Y
V
R
A
L
F
D
Y
Site 78
Y592
Y
V
R
A
L
F
D
Y
D
K
T
K
D
S
G
Site 79
T595
A
L
F
D
Y
D
K
T
K
D
S
G
L
P
S
Site 80
S598
D
Y
D
K
T
K
D
S
G
L
P
S
Q
G
L
Site 81
S602
T
K
D
S
G
L
P
S
Q
G
L
N
F
K
F
Site 82
S619
I
L
H
V
I
N
A
S
D
D
E
W
W
Q
A
Site 83
T630
W
W
Q
A
R
Q
V
T
P
D
G
E
S
D
E
Site 84
S635
Q
V
T
P
D
G
E
S
D
E
V
G
V
I
P
Site 85
S643
D
E
V
G
V
I
P
S
K
R
R
V
E
K
K
Site 86
T657
K
E
R
A
R
L
K
T
V
K
F
N
S
K
T
Site 87
S662
L
K
T
V
K
F
N
S
K
T
R
D
K
G
E
Site 88
S676
E
I
P
D
D
M
G
S
K
G
L
K
H
V
T
Site 89
T683
S
K
G
L
K
H
V
T
S
N
A
S
D
S
E
Site 90
S684
K
G
L
K
H
V
T
S
N
A
S
D
S
E
S
Site 91
S687
K
H
V
T
S
N
A
S
D
S
E
S
S
Y
R
Site 92
S689
V
T
S
N
A
S
D
S
E
S
S
Y
R
G
Q
Site 93
S691
S
N
A
S
D
S
E
S
S
Y
R
G
Q
E
E
Site 94
S692
N
A
S
D
S
E
S
S
Y
R
G
Q
E
E
Y
Site 95
Y693
A
S
D
S
E
S
S
Y
R
G
Q
E
E
Y
V
Site 96
Y699
S
Y
R
G
Q
E
E
Y
V
L
S
Y
E
P
V
Site 97
S702
G
Q
E
E
Y
V
L
S
Y
E
P
V
N
Q
Q
Site 98
Y713
V
N
Q
Q
E
V
N
Y
T
R
P
V
I
I
L
Site 99
T714
N
Q
Q
E
V
N
Y
T
R
P
V
I
I
L
G
Site 100
S733
R
I
N
D
D
L
I
S
E
F
P
D
K
F
G
Site 101
S741
E
F
P
D
K
F
G
S
C
V
P
H
T
T
R
Site 102
T746
F
G
S
C
V
P
H
T
T
R
P
K
R
D
Y
Site 103
Y753
T
T
R
P
K
R
D
Y
E
V
D
G
R
D
Y
Site 104
Y760
Y
E
V
D
G
R
D
Y
H
F
V
T
S
R
E
Site 105
T764
G
R
D
Y
H
F
V
T
S
R
E
Q
M
E
K
Site 106
S765
R
D
Y
H
F
V
T
S
R
E
Q
M
E
K
D
Site 107
Y784
K
F
I
E
A
G
Q
Y
N
N
H
L
Y
G
T
Site 108
Y789
G
Q
Y
N
N
H
L
Y
G
T
S
V
Q
S
V
Site 109
T791
Y
N
N
H
L
Y
G
T
S
V
Q
S
V
R
E
Site 110
S795
L
Y
G
T
S
V
Q
S
V
R
E
V
A
E
K
Site 111
Y824
R
L
Q
I
A
Q
L
Y
P
I
S
I
F
I
K
Site 112
T846
M
E
M
N
K
R
L
T
E
E
Q
A
R
K
T
Site 113
T853
T
E
E
Q
A
R
K
T
F
E
R
A
M
K
L
Site 114
T865
M
K
L
E
Q
E
F
T
E
H
F
T
A
I
V
Site 115
T876
T
A
I
V
Q
G
D
T
L
E
D
I
Y
N
Q
Site 116
Y881
G
D
T
L
E
D
I
Y
N
Q
V
K
Q
I
I
Site 117
S892
K
Q
I
I
E
E
Q
S
G
S
Y
I
W
V
P
Site 118
S894
I
I
E
E
Q
S
G
S
Y
I
W
V
P
A
K
Site 119
Y895
I
E
E
Q
S
G
S
Y
I
W
V
P
A
K
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation