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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RalGDS
Full Name:
Ral guanine nucleotide dissociation stimulator
Alias:
GNDS; RALGDS; RalGEF; RGF
Type:
Intracellular protein
Mass (Da):
100607
Number AA:
914
UniProt ID:
Q12967
International Prot ID:
IPI00290395
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0005085
GO:0005083
PhosphoSite+
KinaseNET
Biological Process:
GO:0007265
GO:0051056
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S23
A
E
P
L
F
P
G
S
R
R
S
R
S
V
W
Site 2
S26
L
F
P
G
S
R
R
S
R
S
V
W
D
A
V
Site 3
S28
P
G
S
R
R
S
R
S
V
W
D
A
V
R
L
Site 4
S49
S
C
P
V
V
L
H
S
F
T
Q
L
D
P
D
Site 5
S62
P
D
L
P
R
P
E
S
S
T
Q
E
I
G
E
Site 6
T64
L
P
R
P
E
S
S
T
Q
E
I
G
E
E
L
Site 7
S78
L
I
N
G
V
I
Y
S
I
S
L
R
K
V
Q
Site 8
S80
N
G
V
I
Y
S
I
S
L
R
K
V
Q
L
H
Site 9
Y99
K
G
Q
R
W
L
G
Y
E
N
E
S
A
L
N
Site 10
Y108
N
E
S
A
L
N
L
Y
E
T
C
K
V
R
T
Site 11
T110
S
A
L
N
L
Y
E
T
C
K
V
R
T
V
K
Site 12
T151
L
C
T
Y
R
A
F
T
T
T
Q
Q
V
L
D
Site 13
Y164
L
D
L
L
F
K
R
Y
G
R
C
D
A
L
T
Site 14
T171
Y
G
R
C
D
A
L
T
A
S
S
R
Y
G
C
Site 15
Y182
R
Y
G
C
I
L
P
Y
S
D
E
D
G
G
P
Site 16
S183
Y
G
C
I
L
P
Y
S
D
E
D
G
G
P
Q
Site 17
T203
A
I
S
S
I
L
G
T
W
L
D
Q
Y
S
E
Site 18
Y208
L
G
T
W
L
D
Q
Y
S
E
D
F
C
Q
P
Site 19
S235
V
Q
L
N
M
P
G
S
D
L
E
R
R
A
H
Site 20
S262
E
A
E
P
E
A
L
S
P
V
P
A
L
K
P
Site 21
T278
P
E
L
E
L
A
L
T
P
A
R
A
P
S
P
Site 22
S284
L
T
P
A
R
A
P
S
P
V
P
A
P
A
P
Site 23
T298
P
E
P
E
P
A
P
T
P
A
P
G
S
E
L
Site 24
S303
A
P
T
P
A
P
G
S
E
L
E
V
A
P
A
Site 25
S346
P
E
Q
D
P
A
P
S
Q
T
L
E
L
E
P
Site 26
S360
P
A
P
A
P
V
P
S
L
Q
P
S
W
P
S
Site 27
S367
S
L
Q
P
S
W
P
S
P
V
V
A
E
N
G
Site 28
S376
V
V
A
E
N
G
L
S
E
E
K
P
H
L
L
Site 29
S416
H
C
L
G
S
I
W
S
Q
R
D
K
K
G
K
Site 30
T429
G
K
E
H
L
A
P
T
I
R
A
T
V
T
Q
Site 31
T435
P
T
I
R
A
T
V
T
Q
F
N
S
V
A
N
Site 32
T454
T
C
L
G
N
R
S
T
K
A
P
D
R
A
R
Site 33
S493
L
S
A
L
Q
S
N
S
I
H
R
L
K
K
T
Site 34
T500
S
I
H
R
L
K
K
T
W
E
D
V
S
R
D
Site 35
S505
K
K
T
W
E
D
V
S
R
D
S
F
R
I
F
Site 36
S508
W
E
D
V
S
R
D
S
F
R
I
F
Q
K
L
Site 37
S516
F
R
I
F
Q
K
L
S
E
I
F
S
D
E
N
Site 38
S520
Q
K
L
S
E
I
F
S
D
E
N
N
Y
S
L
Site 39
S526
F
S
D
E
N
N
Y
S
L
S
R
E
L
L
I
Site 40
T542
E
G
T
S
K
F
A
T
L
E
M
N
P
K
R
Site 41
Y566
I
I
Q
G
T
V
P
Y
L
G
T
F
L
T
D
Site 42
Y584
L
D
T
A
M
K
D
Y
L
Y
G
R
L
I
N
Site 43
Y586
T
A
M
K
D
Y
L
Y
G
R
L
I
N
F
E
Site 44
S634
F
R
A
V
E
R
L
S
E
T
E
S
Y
N
L
Site 45
T636
A
V
E
R
L
S
E
T
E
S
Y
N
L
S
C
Site 46
S638
E
R
L
S
E
T
E
S
Y
N
L
S
C
E
L
Site 47
Y639
R
L
S
E
T
E
S
Y
N
L
S
C
E
L
E
Site 48
S642
E
T
E
S
Y
N
L
S
C
E
L
E
P
P
S
Site 49
S649
S
C
E
L
E
P
P
S
E
S
A
S
N
T
L
Site 50
S651
E
L
E
P
P
S
E
S
A
S
N
T
L
R
T
Site 51
S653
E
P
P
S
E
S
A
S
N
T
L
R
T
K
K
Site 52
T655
P
S
E
S
A
S
N
T
L
R
T
K
K
N
T
Site 53
T662
T
L
R
T
K
K
N
T
A
I
V
K
R
W
S
Site 54
S669
T
A
I
V
K
R
W
S
D
R
Q
A
P
S
T
Site 55
S675
W
S
D
R
Q
A
P
S
T
E
L
S
T
S
G
Site 56
T676
S
D
R
Q
A
P
S
T
E
L
S
T
S
G
S
Site 57
S679
Q
A
P
S
T
E
L
S
T
S
G
S
S
H
S
Site 58
T680
A
P
S
T
E
L
S
T
S
G
S
S
H
S
K
Site 59
S681
P
S
T
E
L
S
T
S
G
S
S
H
S
K
S
Site 60
S683
T
E
L
S
T
S
G
S
S
H
S
K
S
C
D
Site 61
S684
E
L
S
T
S
G
S
S
H
S
K
S
C
D
Q
Site 62
S686
S
T
S
G
S
S
H
S
K
S
C
D
Q
L
R
Site 63
S688
S
G
S
S
H
S
K
S
C
D
Q
L
R
C
G
Site 64
Y697
D
Q
L
R
C
G
P
Y
L
S
S
G
D
I
A
Site 65
S699
L
R
C
G
P
Y
L
S
S
G
D
I
A
D
A
Site 66
S708
G
D
I
A
D
A
L
S
V
H
S
A
G
S
S
Site 67
S711
A
D
A
L
S
V
H
S
A
G
S
S
S
S
D
Site 68
S715
S
V
H
S
A
G
S
S
S
S
D
V
E
E
I
Site 69
S716
V
H
S
A
G
S
S
S
S
D
V
E
E
I
N
Site 70
S717
H
S
A
G
S
S
S
S
D
V
E
E
I
N
I
Site 71
S725
D
V
E
E
I
N
I
S
F
V
P
E
S
P
D
Site 72
S730
N
I
S
F
V
P
E
S
P
D
G
Q
E
K
K
Site 73
S741
Q
E
K
K
F
W
E
S
A
S
Q
S
S
P
E
Site 74
S743
K
K
F
W
E
S
A
S
Q
S
S
P
E
T
S
Site 75
S745
F
W
E
S
A
S
Q
S
S
P
E
T
S
G
I
Site 76
S746
W
E
S
A
S
Q
S
S
P
E
T
S
G
I
S
Site 77
T749
A
S
Q
S
S
P
E
T
S
G
I
S
S
A
S
Site 78
S750
S
Q
S
S
P
E
T
S
G
I
S
S
A
S
S
Site 79
S753
S
P
E
T
S
G
I
S
S
A
S
S
S
T
S
Site 80
S754
P
E
T
S
G
I
S
S
A
S
S
S
T
S
S
Site 81
S756
T
S
G
I
S
S
A
S
S
S
T
S
S
S
S
Site 82
S757
S
G
I
S
S
A
S
S
S
T
S
S
S
S
A
Site 83
S758
G
I
S
S
A
S
S
S
T
S
S
S
S
A
S
Site 84
T759
I
S
S
A
S
S
S
T
S
S
S
S
A
S
T
Site 85
S760
S
S
A
S
S
S
T
S
S
S
S
A
S
T
T
Site 86
S761
S
A
S
S
S
T
S
S
S
S
A
S
T
T
P
Site 87
S762
A
S
S
S
T
S
S
S
S
A
S
T
T
P
V
Site 88
S763
S
S
S
T
S
S
S
S
A
S
T
T
P
V
A
Site 89
S765
S
T
S
S
S
S
A
S
T
T
P
V
A
A
T
Site 90
T766
T
S
S
S
S
A
S
T
T
P
V
A
A
T
R
Site 91
T767
S
S
S
S
A
S
T
T
P
V
A
A
T
R
T
Site 92
T774
T
P
V
A
A
T
R
T
H
K
R
S
V
S
G
Site 93
S778
A
T
R
T
H
K
R
S
V
S
G
L
C
N
S
Site 94
S780
R
T
H
K
R
S
V
S
G
L
C
N
S
S
S
Site 95
S787
S
G
L
C
N
S
S
S
A
L
P
L
Y
N
Q
Site 96
Y792
S
S
S
A
L
P
L
Y
N
Q
Q
V
G
D
C
Site 97
Y814
D
V
D
N
G
N
M
Y
K
S
I
L
V
T
S
Site 98
S816
D
N
G
N
M
Y
K
S
I
L
V
T
S
Q
D
Site 99
T820
M
Y
K
S
I
L
V
T
S
Q
D
K
A
P
A
Site 100
S821
Y
K
S
I
L
V
T
S
Q
D
K
A
P
A
V
Site 101
Y846
E
E
E
E
P
E
D
Y
E
L
L
Q
I
L
S
Site 102
S853
Y
E
L
L
Q
I
L
S
D
D
R
K
L
K
I
Site 103
Y868
P
E
N
A
N
V
F
Y
A
M
N
S
T
A
N
Site 104
Y876
A
M
N
S
T
A
N
Y
D
F
V
L
K
K
R
Site 105
T884
D
F
V
L
K
K
R
T
F
T
K
G
V
K
V
Site 106
T886
V
L
K
K
R
T
F
T
K
G
V
K
V
K
H
Site 107
T898
V
K
H
G
A
S
S
T
L
P
R
M
K
Q
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation