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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NFX1
Full Name:
Transcriptional repressor NF-X1
Alias:
EC 6.3.2.-; MGC20369; NFX2; Nuclear transcription factor, X-box binding 1; Transcriptional repressor NF-X1
Type:
Ligase; Transcription factor; EC 6.3.2.-
Mass (Da):
124395
Number AA:
1120
UniProt ID:
Q12986
International Prot ID:
IPI00030404
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0016874
GO:0003700
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0006954
GO:0044419
GO:0019941
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
A
E
A
P
P
V
S
G
T
F
K
F
N
T
Site 2
T10
E
A
P
P
V
S
G
T
F
K
F
N
T
D
A
Site 3
T15
S
G
T
F
K
F
N
T
D
A
A
E
F
I
P
Site 4
T34
N
S
G
L
N
C
G
T
Q
R
R
L
D
S
N
Site 5
S40
G
T
Q
R
R
L
D
S
N
R
I
G
R
R
N
Site 6
Y48
N
R
I
G
R
R
N
Y
S
S
P
P
P
C
H
Site 7
S49
R
I
G
R
R
N
Y
S
S
P
P
P
C
H
L
Site 8
S50
I
G
R
R
N
Y
S
S
P
P
P
C
H
L
S
Site 9
S57
S
P
P
P
C
H
L
S
R
Q
V
P
Y
D
E
Site 10
S72
I
S
A
V
H
Q
H
S
Y
H
P
S
G
S
K
Site 11
Y73
S
A
V
H
Q
H
S
Y
H
P
S
G
S
K
P
Site 12
S76
H
Q
H
S
Y
H
P
S
G
S
K
P
K
S
Q
Site 13
S78
H
S
Y
H
P
S
G
S
K
P
K
S
Q
Q
T
Site 14
S82
P
S
G
S
K
P
K
S
Q
Q
T
S
F
Q
S
Site 15
T85
S
K
P
K
S
Q
Q
T
S
F
Q
S
S
P
C
Site 16
S86
K
P
K
S
Q
Q
T
S
F
Q
S
S
P
C
N
Site 17
S89
S
Q
Q
T
S
F
Q
S
S
P
C
N
K
S
P
Site 18
S90
Q
Q
T
S
F
Q
S
S
P
C
N
K
S
P
K
Site 19
S95
Q
S
S
P
C
N
K
S
P
K
S
H
G
L
Q
Site 20
S98
P
C
N
K
S
P
K
S
H
G
L
Q
N
Q
P
Site 21
S123
I
R
V
K
K
A
Q
S
L
A
E
Q
T
S
D
Site 22
T128
A
Q
S
L
A
E
Q
T
S
D
T
A
G
L
E
Site 23
S129
Q
S
L
A
E
Q
T
S
D
T
A
G
L
E
S
Site 24
S136
S
D
T
A
G
L
E
S
S
T
R
S
E
S
G
Site 25
S137
D
T
A
G
L
E
S
S
T
R
S
E
S
G
T
Site 26
T138
T
A
G
L
E
S
S
T
R
S
E
S
G
T
D
Site 27
S140
G
L
E
S
S
T
R
S
E
S
G
T
D
L
R
Site 28
S142
E
S
S
T
R
S
E
S
G
T
D
L
R
E
H
Site 29
T144
S
T
R
S
E
S
G
T
D
L
R
E
H
S
P
Site 30
S150
G
T
D
L
R
E
H
S
P
S
E
S
E
K
E
Site 31
S152
D
L
R
E
H
S
P
S
E
S
E
K
E
V
V
Site 32
S154
R
E
H
S
P
S
E
S
E
K
E
V
V
G
A
Site 33
Y176
K
K
A
T
Q
F
V
Y
S
Y
G
R
G
P
K
Site 34
S177
K
A
T
Q
F
V
Y
S
Y
G
R
G
P
K
V
Site 35
Y178
A
T
Q
F
V
Y
S
Y
G
R
G
P
K
V
K
Site 36
S193
G
K
L
K
C
E
W
S
N
R
T
T
P
K
P
Site 37
T197
C
E
W
S
N
R
T
T
P
K
P
E
D
A
G
Site 38
S207
P
E
D
A
G
P
E
S
T
K
P
V
G
V
F
Site 39
S218
V
G
V
F
H
P
D
S
S
E
A
S
S
R
K
Site 40
S219
G
V
F
H
P
D
S
S
E
A
S
S
R
K
G
Site 41
S222
H
P
D
S
S
E
A
S
S
R
K
G
V
L
D
Site 42
S223
P
D
S
S
E
A
S
S
R
K
G
V
L
D
G
Site 43
Y231
R
K
G
V
L
D
G
Y
G
A
R
R
N
E
Q
Site 44
Y241
R
R
N
E
Q
R
R
Y
P
Q
K
R
P
P
W
Site 45
T270
K
Q
E
G
H
R
H
T
N
A
G
H
R
N
N
Site 46
S293
L
N
E
R
P
A
K
S
T
C
D
S
E
N
L
Site 47
T294
N
E
R
P
A
K
S
T
C
D
S
E
N
L
A
Site 48
S297
P
A
K
S
T
C
D
S
E
N
L
A
V
I
N
Site 49
S306
N
L
A
V
I
N
K
S
S
R
R
V
D
Q
E
Site 50
S307
L
A
V
I
N
K
S
S
R
R
V
D
Q
E
K
Site 51
T316
R
V
D
Q
E
K
C
T
V
R
R
Q
D
P
Q
Site 52
S326
R
Q
D
P
Q
V
V
S
P
F
S
R
G
K
Q
Site 53
S329
P
Q
V
V
S
P
F
S
R
G
K
Q
N
H
V
Site 54
T342
H
V
L
K
N
V
E
T
H
T
G
S
L
I
E
Site 55
T352
G
S
L
I
E
Q
L
T
T
E
K
Y
E
C
M
Site 56
T353
S
L
I
E
Q
L
T
T
E
K
Y
E
C
M
V
Site 57
Y356
E
Q
L
T
T
E
K
Y
E
C
M
V
C
C
E
Site 58
S392
C
I
K
K
W
A
R
S
P
A
S
Q
A
D
G
Site 59
S395
K
W
A
R
S
P
A
S
Q
A
D
G
Q
S
G
Site 60
S439
S
R
N
E
I
P
H
S
C
G
E
V
C
R
K
Site 61
T485
E
C
G
R
T
R
H
T
V
R
C
G
Q
A
V
Site 62
T544
S
R
D
V
L
C
G
T
D
V
G
K
S
D
G
Site 63
S549
C
G
T
D
V
G
K
S
D
G
F
G
D
F
S
Site 64
S556
S
D
G
F
G
D
F
S
C
L
K
I
C
G
K
Site 65
T599
R
C
C
P
C
G
Q
T
P
L
S
Q
L
L
E
Site 66
S602
P
C
G
Q
T
P
L
S
Q
L
L
E
L
G
S
Site 67
S609
S
Q
L
L
E
L
G
S
S
S
R
K
T
C
M
Site 68
S610
Q
L
L
E
L
G
S
S
S
R
K
T
C
M
D
Site 69
T614
L
G
S
S
S
R
K
T
C
M
D
P
V
P
S
Site 70
T640
G
S
L
D
F
I
H
T
C
E
K
L
C
H
E
Site 71
S654
E
G
D
C
G
P
C
S
R
T
S
V
I
S
C
Site 72
T656
D
C
G
P
C
S
R
T
S
V
I
S
C
R
C
Site 73
S660
C
S
R
T
S
V
I
S
C
R
C
S
F
R
T
Site 74
S664
S
V
I
S
C
R
C
S
F
R
T
K
E
L
P
Site 75
T667
S
C
R
C
S
F
R
T
K
E
L
P
C
T
S
Site 76
T673
R
T
K
E
L
P
C
T
S
L
K
S
E
D
A
Site 77
S674
T
K
E
L
P
C
T
S
L
K
S
E
D
A
T
Site 78
T681
S
L
K
S
E
D
A
T
F
M
C
D
K
R
C
Site 79
T769
G
T
R
P
P
E
C
T
Q
T
C
A
R
V
H
Site 80
T771
R
P
P
E
C
T
Q
T
C
A
R
V
H
E
C
Site 81
Y783
H
E
C
D
H
P
V
Y
H
S
C
H
S
E
E
Site 82
T857
E
P
C
K
Q
P
C
T
T
P
R
A
D
C
G
Site 83
S902
R
K
E
M
V
I
C
S
E
A
S
S
T
Y
Q
Site 84
T907
I
C
S
E
A
S
S
T
Y
Q
R
I
A
A
I
Site 85
S915
Y
Q
R
I
A
A
I
S
M
A
S
K
I
T
D
Site 86
S932
L
G
G
S
V
E
I
S
K
L
I
T
K
K
E
Site 87
S970
A
F
H
I
S
E
D
S
D
P
F
N
I
R
S
Site 88
S977
S
D
P
F
N
I
R
S
S
G
S
K
F
S
D
Site 89
S978
D
P
F
N
I
R
S
S
G
S
K
F
S
D
S
Site 90
S980
F
N
I
R
S
S
G
S
K
F
S
D
S
L
K
Site 91
S983
R
S
S
G
S
K
F
S
D
S
L
K
E
D
A
Site 92
S985
S
G
S
K
F
S
D
S
L
K
E
D
A
R
K
Site 93
S998
R
K
D
L
K
F
V
S
D
V
E
K
E
M
E
Site 94
S1020
K
G
K
N
S
K
K
S
H
S
F
P
P
M
N
Site 95
S1022
K
N
S
K
K
S
H
S
F
P
P
M
N
R
D
Site 96
Y1041
I
H
D
L
A
Q
V
Y
G
L
E
S
V
S
Y
Site 97
S1045
A
Q
V
Y
G
L
E
S
V
S
Y
D
S
E
P
Site 98
S1047
V
Y
G
L
E
S
V
S
Y
D
S
E
P
K
R
Site 99
Y1048
Y
G
L
E
S
V
S
Y
D
S
E
P
K
R
N
Site 100
S1050
L
E
S
V
S
Y
D
S
E
P
K
R
N
V
V
Site 101
T1059
P
K
R
N
V
V
V
T
A
I
R
G
K
S
V
Site 102
T1071
K
S
V
C
P
P
T
T
L
T
G
V
L
E
R
Site 103
S1095
I
P
H
H
R
H
Q
S
D
K
N
P
G
S
S
Site 104
S1101
Q
S
D
K
N
P
G
S
S
N
L
Q
K
I
T
Site 105
T1108
S
S
N
L
Q
K
I
T
K
E
P
I
I
D
Y
Site 106
Y1115
T
K
E
P
I
I
D
Y
F
D
V
Q
D
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation