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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CSTF3
Full Name:
Cleavage stimulation factor subunit 3
Alias:
Cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa; CstF-77
Type:
RNA binding protein
Mass (Da):
82922
Number AA:
717
UniProt ID:
Q12996
International Prot ID:
IPI00015195
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0005634
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0003723
GO:0005515
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
GO:0006379
GO:0006378
GO:0000398
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y13
A
T
E
Q
A
A
E
Y
V
P
E
K
V
K
K
Site 2
Y30
K
K
L
E
E
N
P
Y
D
L
D
A
W
S
I
Site 3
S36
P
Y
D
L
D
A
W
S
I
L
I
R
E
A
Q
Site 4
T53
P
I
D
K
A
R
K
T
Y
E
R
L
V
A
Q
Site 5
Y54
I
D
K
A
R
K
T
Y
E
R
L
V
A
Q
F
Site 6
S63
R
L
V
A
Q
F
P
S
S
G
R
F
W
K
L
Site 7
S64
L
V
A
Q
F
P
S
S
G
R
F
W
K
L
Y
Site 8
Y71
S
G
R
F
W
K
L
Y
I
E
A
E
I
K
A
Site 9
Y81
A
E
I
K
A
K
N
Y
D
K
V
E
K
L
F
Site 10
Y104
H
I
D
L
W
K
C
Y
L
S
Y
V
R
E
T
Site 11
Y107
L
W
K
C
Y
L
S
Y
V
R
E
T
K
G
K
Site 12
T111
Y
L
S
Y
V
R
E
T
K
G
K
L
P
S
Y
Site 13
S117
E
T
K
G
K
L
P
S
Y
K
E
K
M
A
Q
Site 14
Y118
T
K
G
K
L
P
S
Y
K
E
K
M
A
Q
A
Site 15
S158
K
G
V
E
A
V
G
S
Y
A
E
N
Q
R
I
Site 16
T166
Y
A
E
N
Q
R
I
T
A
V
R
R
V
Y
Q
Site 17
Y172
I
T
A
V
R
R
V
Y
Q
R
G
C
V
N
P
Site 18
Y190
I
E
Q
L
W
R
D
Y
N
K
Y
E
E
G
I
Site 19
Y193
L
W
R
D
Y
N
K
Y
E
E
G
I
N
I
H
Site 20
S210
K
K
M
I
E
D
R
S
R
D
Y
M
N
A
R
Site 21
Y213
I
E
D
R
S
R
D
Y
M
N
A
R
R
V
A
Site 22
Y223
A
R
R
V
A
K
E
Y
E
T
V
M
K
G
L
Site 23
T225
R
V
A
K
E
Y
E
T
V
M
K
G
L
D
R
Site 24
S236
G
L
D
R
N
A
P
S
V
P
P
Q
N
T
P
Site 25
T242
P
S
V
P
P
Q
N
T
P
Q
E
A
Q
Q
V
Site 26
S261
K
Y
I
Q
W
E
K
S
N
P
L
R
T
E
D
Site 27
T266
E
K
S
N
P
L
R
T
E
D
Q
T
L
I
T
Site 28
T270
P
L
R
T
E
D
Q
T
L
I
T
K
R
V
M
Site 29
T273
T
E
D
Q
T
L
I
T
K
R
V
M
F
A
Y
Site 30
Y295
G
H
H
P
D
I
W
Y
E
A
A
Q
Y
L
E
Site 31
Y300
I
W
Y
E
A
A
Q
Y
L
E
Q
S
S
K
L
Site 32
S321
M
N
N
A
K
L
F
S
D
E
A
A
N
I
Y
Site 33
Y328
S
D
E
A
A
N
I
Y
E
R
A
I
S
T
L
Site 34
S333
N
I
Y
E
R
A
I
S
T
L
L
K
K
N
M
Site 35
Y343
L
K
K
N
M
L
L
Y
F
A
Y
A
D
Y
E
Site 36
Y346
N
M
L
L
Y
F
A
Y
A
D
Y
E
E
S
R
Site 37
Y349
L
Y
F
A
Y
A
D
Y
E
E
S
R
M
K
Y
Site 38
Y356
Y
E
E
S
R
M
K
Y
E
K
V
H
S
I
Y
Site 39
Y363
Y
E
K
V
H
S
I
Y
N
R
L
L
A
I
E
Site 40
Y381
P
T
L
V
Y
I
Q
Y
M
K
F
A
R
R
A
Site 41
S393
R
R
A
E
G
I
K
S
G
R
M
I
F
K
K
Site 42
T405
F
K
K
A
R
E
D
T
R
T
R
H
H
V
Y
Site 43
T407
K
A
R
E
D
T
R
T
R
H
H
V
Y
V
T
Site 44
Y412
T
R
T
R
H
H
V
Y
V
T
A
A
L
M
E
Site 45
Y420
V
T
A
A
L
M
E
Y
Y
C
S
K
D
K
S
Site 46
Y440
F
E
L
G
L
K
K
Y
G
D
I
P
E
Y
V
Site 47
Y446
K
Y
G
D
I
P
E
Y
V
L
A
Y
I
D
Y
Site 48
Y453
Y
V
L
A
Y
I
D
Y
L
S
H
L
N
E
D
Site 49
T463
H
L
N
E
D
N
N
T
R
V
L
F
E
R
V
Site 50
S473
L
F
E
R
V
L
T
S
G
S
L
P
P
E
K
Site 51
S475
E
R
V
L
T
S
G
S
L
P
P
E
K
S
G
Site 52
S481
G
S
L
P
P
E
K
S
G
E
I
W
A
R
F
Site 53
S500
S
N
I
G
D
L
A
S
I
L
K
V
E
K
R
Site 54
T510
K
V
E
K
R
R
F
T
A
F
K
E
E
Y
E
Site 55
T521
E
E
Y
E
G
K
E
T
A
L
L
V
D
R
Y
Site 56
Y534
R
Y
K
F
M
D
L
Y
P
C
S
A
S
E
L
Site 57
S539
D
L
Y
P
C
S
A
S
E
L
K
A
L
G
Y
Site 58
Y546
S
E
L
K
A
L
G
Y
K
D
V
S
R
A
K
Site 59
S566
P
D
P
V
V
A
P
S
I
V
P
V
L
K
D
Site 60
Y581
E
V
D
R
K
P
E
Y
P
K
P
D
T
Q
Q
Site 61
T586
P
E
Y
P
K
P
D
T
Q
Q
M
I
P
F
Q
Site 62
T651
R
R
C
K
I
P
N
T
V
E
E
A
V
R
I
Site 63
S676
E
G
N
G
P
V
E
S
N
A
V
L
T
K
A
Site 64
S691
V
K
R
P
N
E
D
S
D
E
D
E
E
K
G
Site 65
Y708
V
P
P
V
H
D
I
Y
R
A
R
Q
Q
K
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation