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Updated November 2019
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Protein Info
Short Name:
Tiam1
Full Name:
T-lymphoma invasion and metastasis-inducing protein 1
Alias:
T-cell lymphoma invasion and metastasis 1; TIAM-1; T-lymphoma invasion and metastasis inducing protein 1
Type:
Guanine nucleotide exchange factor for Rac/Rho
Mass (Da):
177508
Number AA:
1591
UniProt ID:
Q13009
International Prot ID:
IPI00011400
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0005089
GO:0005057
PhosphoSite+
KinaseNET
Biological Process:
GO:0006915
GO:0008624
GO:0035023
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y14
Q
H
V
E
H
E
F
Y
G
E
K
H
A
S
L
Site 2
S20
F
Y
G
E
K
H
A
S
L
G
R
K
H
T
S
Site 3
T26
A
S
L
G
R
K
H
T
S
R
S
L
R
L
S
Site 4
S27
S
L
G
R
K
H
T
S
R
S
L
R
L
S
H
Site 5
S29
G
R
K
H
T
S
R
S
L
R
L
S
H
K
T
Site 6
S33
T
S
R
S
L
R
L
S
H
K
T
R
R
T
R
Site 7
T36
S
L
R
L
S
H
K
T
R
R
T
R
H
A
S
Site 8
T39
L
S
H
K
T
R
R
T
R
H
A
S
S
G
K
Site 9
S43
T
R
R
T
R
H
A
S
S
G
K
V
I
H
R
Site 10
S44
R
R
T
R
H
A
S
S
G
K
V
I
H
R
N
Site 11
S52
G
K
V
I
H
R
N
S
E
V
S
T
R
S
S
Site 12
S55
I
H
R
N
S
E
V
S
T
R
S
S
S
T
P
Site 13
T56
H
R
N
S
E
V
S
T
R
S
S
S
T
P
S
Site 14
S58
N
S
E
V
S
T
R
S
S
S
T
P
S
I
P
Site 15
S59
S
E
V
S
T
R
S
S
S
T
P
S
I
P
Q
Site 16
S60
E
V
S
T
R
S
S
S
T
P
S
I
P
Q
S
Site 17
T61
V
S
T
R
S
S
S
T
P
S
I
P
Q
S
L
Site 18
S63
T
R
S
S
S
T
P
S
I
P
Q
S
L
A
E
Site 19
S67
S
T
P
S
I
P
Q
S
L
A
E
N
G
L
E
Site 20
S77
E
N
G
L
E
P
F
S
Q
D
G
T
L
E
D
Site 21
T81
E
P
F
S
Q
D
G
T
L
E
D
F
G
S
P
Site 22
S87
G
T
L
E
D
F
G
S
P
I
W
V
D
R
V
Site 23
S102
D
M
G
L
R
P
V
S
Y
T
D
S
S
V
T
Site 24
Y103
M
G
L
R
P
V
S
Y
T
D
S
S
V
T
P
Site 25
T104
G
L
R
P
V
S
Y
T
D
S
S
V
T
P
S
Site 26
S106
R
P
V
S
Y
T
D
S
S
V
T
P
S
V
D
Site 27
S107
P
V
S
Y
T
D
S
S
V
T
P
S
V
D
S
Site 28
T109
S
Y
T
D
S
S
V
T
P
S
V
D
S
S
I
Site 29
T129
S
V
Q
S
M
P
D
T
E
E
S
R
L
Y
G
Site 30
Y135
D
T
E
E
S
R
L
Y
G
D
D
A
T
Y
L
Site 31
T140
R
L
Y
G
D
D
A
T
Y
L
A
E
G
G
R
Site 32
Y141
L
Y
G
D
D
A
T
Y
L
A
E
G
G
R
R
Site 33
S151
E
G
G
R
R
Q
H
S
Y
T
S
N
G
P
T
Site 34
Y152
G
G
R
R
Q
H
S
Y
T
S
N
G
P
T
F
Site 35
T153
G
R
R
Q
H
S
Y
T
S
N
G
P
T
F
M
Site 36
T158
S
Y
T
S
N
G
P
T
F
M
E
T
A
S
F
Site 37
T162
N
G
P
T
F
M
E
T
A
S
F
K
K
K
R
Site 38
S164
P
T
F
M
E
T
A
S
F
K
K
K
R
S
K
Site 39
S170
A
S
F
K
K
K
R
S
K
S
A
D
I
W
R
Site 40
S172
F
K
K
K
R
S
K
S
A
D
I
W
R
E
D
Site 41
S180
A
D
I
W
R
E
D
S
L
E
F
S
L
S
D
Site 42
S184
R
E
D
S
L
E
F
S
L
S
D
L
S
Q
E
Site 43
S186
D
S
L
E
F
S
L
S
D
L
S
Q
E
H
L
Site 44
S189
E
F
S
L
S
D
L
S
Q
E
H
L
T
S
N
Site 45
S195
L
S
Q
E
H
L
T
S
N
E
E
I
L
G
S
Site 46
S202
S
N
E
E
I
L
G
S
A
E
E
K
D
C
E
Site 47
S219
R
G
M
E
T
R
A
S
P
R
Q
L
S
T
C
Site 48
S224
R
A
S
P
R
Q
L
S
T
C
Q
R
A
N
S
Site 49
T225
A
S
P
R
Q
L
S
T
C
Q
R
A
N
S
L
Site 50
S231
S
T
C
Q
R
A
N
S
L
G
D
L
Y
A
Q
Site 51
Y236
A
N
S
L
G
D
L
Y
A
Q
K
N
S
G
V
Site 52
S251
T
A
N
G
G
P
G
S
K
F
A
G
Y
C
R
Site 53
Y256
P
G
S
K
F
A
G
Y
C
R
N
L
V
S
D
Site 54
S262
G
Y
C
R
N
L
V
S
D
I
P
N
L
A
N
Site 55
T280
P
P
A
A
A
E
E
T
P
P
Y
S
N
Y
N
Site 56
Y283
A
A
E
E
T
P
P
Y
S
N
Y
N
T
L
P
Site 57
S284
A
E
E
T
P
P
Y
S
N
Y
N
T
L
P
C
Site 58
Y286
E
T
P
P
Y
S
N
Y
N
T
L
P
C
R
K
Site 59
T288
P
P
Y
S
N
Y
N
T
L
P
C
R
K
S
H
Site 60
S294
N
T
L
P
C
R
K
S
H
C
L
S
E
G
A
Site 61
S298
C
R
K
S
H
C
L
S
E
G
A
T
N
P
Q
Site 62
T302
H
C
L
S
E
G
A
T
N
P
Q
I
S
H
S
Site 63
S307
G
A
T
N
P
Q
I
S
H
S
N
S
M
Q
G
Site 64
S309
T
N
P
Q
I
S
H
S
N
S
M
Q
G
R
R
Site 65
S311
P
Q
I
S
H
S
N
S
M
Q
G
R
R
A
K
Site 66
T319
M
Q
G
R
R
A
K
T
T
Q
D
V
N
A
G
Site 67
T320
Q
G
R
R
A
K
T
T
Q
D
V
N
A
G
E
Site 68
S329
D
V
N
A
G
E
G
S
E
F
A
D
S
G
I
Site 69
S334
E
G
S
E
F
A
D
S
G
I
E
G
A
T
T
Site 70
T341
S
G
I
E
G
A
T
T
D
T
D
L
L
S
R
Site 71
T343
I
E
G
A
T
T
D
T
D
L
L
S
R
R
S
Site 72
S347
T
T
D
T
D
L
L
S
R
R
S
N
A
T
N
Site 73
S350
T
D
L
L
S
R
R
S
N
A
T
N
S
S
Y
Site 74
T353
L
S
R
R
S
N
A
T
N
S
S
Y
S
P
T
Site 75
S355
R
R
S
N
A
T
N
S
S
Y
S
P
T
T
G
Site 76
S356
R
S
N
A
T
N
S
S
Y
S
P
T
T
G
R
Site 77
S358
N
A
T
N
S
S
Y
S
P
T
T
G
R
A
F
Site 78
T360
T
N
S
S
Y
S
P
T
T
G
R
A
F
V
G
Site 79
T361
N
S
S
Y
S
P
T
T
G
R
A
F
V
G
S
Site 80
S368
T
G
R
A
F
V
G
S
D
S
G
S
S
S
T
Site 81
S370
R
A
F
V
G
S
D
S
G
S
S
S
T
G
D
Site 82
S372
F
V
G
S
D
S
G
S
S
S
T
G
D
A
A
Site 83
S373
V
G
S
D
S
G
S
S
S
T
G
D
A
A
R
Site 84
S374
G
S
D
S
G
S
S
S
T
G
D
A
A
R
Q
Site 85
Y384
D
A
A
R
Q
G
V
Y
E
N
F
R
R
E
L
Site 86
S394
F
R
R
E
L
E
M
S
T
T
N
S
E
S
L
Site 87
T396
R
E
L
E
M
S
T
T
N
S
E
S
L
E
E
Site 88
S398
L
E
M
S
T
T
N
S
E
S
L
E
E
A
G
Site 89
S400
M
S
T
T
N
S
E
S
L
E
E
A
G
S
A
Site 90
S406
E
S
L
E
E
A
G
S
A
H
S
D
E
Q
S
Site 91
S409
E
E
A
G
S
A
H
S
D
E
Q
S
S
G
T
Site 92
S413
S
A
H
S
D
E
Q
S
S
G
T
L
S
S
P
Site 93
S414
A
H
S
D
E
Q
S
S
G
T
L
S
S
P
G
Site 94
T416
S
D
E
Q
S
S
G
T
L
S
S
P
G
Q
S
Site 95
S418
E
Q
S
S
G
T
L
S
S
P
G
Q
S
D
I
Site 96
S419
Q
S
S
G
T
L
S
S
P
G
Q
S
D
I
L
Site 97
S456
K
K
N
K
K
V
E
S
A
T
R
R
K
W
K
Site 98
T458
N
K
K
V
E
S
A
T
R
R
K
W
K
H
Y
Site 99
Y465
T
R
R
K
W
K
H
Y
W
V
S
L
K
G
C
Site 100
Y477
K
G
C
T
L
F
F
Y
E
S
D
G
R
S
G
Site 101
S479
C
T
L
F
F
Y
E
S
D
G
R
S
G
I
D
Site 102
S483
F
Y
E
S
D
G
R
S
G
I
D
H
N
S
I
Site 103
S531
A
F
L
F
Q
T
T
S
Q
T
E
L
E
N
W
Site 104
T559
R
H
H
H
K
E
D
T
L
R
L
L
K
S
E
Site 105
S565
D
T
L
R
L
L
K
S
E
I
K
K
L
E
Q
Site 106
S589
K
M
G
E
M
Q
L
S
S
V
T
D
S
K
K
Site 107
S590
M
G
E
M
Q
L
S
S
V
T
D
S
K
K
K
Site 108
S594
Q
L
S
S
V
T
D
S
K
K
K
K
T
I
L
Site 109
T599
T
D
S
K
K
K
K
T
I
L
D
Q
I
F
V
Site 110
S627
R
F
R
C
Y
L
A
S
L
Q
G
G
E
L
P
Site 111
T679
E
T
G
V
R
R
R
T
Q
A
M
S
R
S
A
Site 112
S683
R
R
R
T
Q
A
M
S
R
S
A
S
K
R
R
Site 113
S685
R
T
Q
A
M
S
R
S
A
S
K
R
R
S
R
Site 114
S687
Q
A
M
S
R
S
A
S
K
R
R
S
R
F
S
Site 115
S691
R
S
A
S
K
R
R
S
R
F
S
S
L
W
G
Site 116
S694
S
K
R
R
S
R
F
S
S
L
W
G
L
D
T
Site 117
S695
K
R
R
S
R
F
S
S
L
W
G
L
D
T
T
Site 118
T701
S
S
L
W
G
L
D
T
T
S
K
K
K
Q
G
Site 119
T702
S
L
W
G
L
D
T
T
S
K
K
K
Q
G
R
Site 120
S703
L
W
G
L
D
T
T
S
K
K
K
Q
G
R
P
Site 121
S711
K
K
K
Q
G
R
P
S
I
N
Q
V
F
G
E
Site 122
S726
G
T
E
A
V
K
K
S
L
E
G
I
F
D
D
Site 123
T779
P
N
N
Q
P
A
L
T
V
V
R
P
G
D
T
Site 124
T786
T
V
V
R
P
G
D
T
A
R
D
T
L
E
L
Site 125
T790
P
G
D
T
A
R
D
T
L
E
L
I
C
K
T
Site 126
Y806
Q
L
D
H
S
A
H
Y
L
R
L
K
F
L
I
Site 127
Y820
I
E
N
K
M
Q
L
Y
V
P
Q
P
E
E
D
Site 128
Y829
P
Q
P
E
E
D
I
Y
E
L
L
Y
K
E
I
Site 129
Y833
E
D
I
Y
E
L
L
Y
K
E
I
E
I
C
P
Site 130
S851
Q
S
I
H
I
E
K
S
D
T
A
A
D
T
Y
Site 131
T853
I
H
I
E
K
S
D
T
A
A
D
T
Y
G
F
Site 132
T857
K
S
D
T
A
A
D
T
Y
G
F
S
L
S
S
Site 133
Y858
S
D
T
A
A
D
T
Y
G
F
S
L
S
S
V
Site 134
S861
A
A
D
T
Y
G
F
S
L
S
S
V
E
E
D
Site 135
S863
D
T
Y
G
F
S
L
S
S
V
E
E
D
G
I
Site 136
S864
T
Y
G
F
S
L
S
S
V
E
E
D
G
I
R
Site 137
Y874
E
D
G
I
R
R
L
Y
V
N
S
V
K
E
T
Site 138
S877
I
R
R
L
Y
V
N
S
V
K
E
T
G
L
A
Site 139
T881
Y
V
N
S
V
K
E
T
G
L
A
S
K
K
G
Site 140
S939
E
G
V
E
L
L
E
S
P
P
H
R
V
D
G
Site 141
T959
E
S
P
L
A
F
L
T
S
N
P
G
H
S
L
Site 142
S965
L
T
S
N
P
G
H
S
L
C
S
E
Q
G
S
Site 143
S968
N
P
G
H
S
L
C
S
E
Q
G
S
S
A
E
Site 144
S972
S
L
C
S
E
Q
G
S
S
A
E
T
A
P
E
Site 145
S973
L
C
S
E
Q
G
S
S
A
E
T
A
P
E
E
Site 146
S988
T
E
G
P
D
L
E
S
S
D
E
T
D
H
S
Site 147
S989
E
G
P
D
L
E
S
S
D
E
T
D
H
S
S
Site 148
T992
D
L
E
S
S
D
E
T
D
H
S
S
K
S
T
Site 149
S995
S
S
D
E
T
D
H
S
S
K
S
T
E
Q
V
Site 150
S996
S
D
E
T
D
H
S
S
K
S
T
E
Q
V
A
Site 151
S998
E
T
D
H
S
S
K
S
T
E
Q
V
A
A
F
Site 152
T999
T
D
H
S
S
K
S
T
E
Q
V
A
A
F
C
Site 153
S1015
S
L
H
E
M
N
P
S
D
Q
S
P
S
P
Q
Site 154
S1018
E
M
N
P
S
D
Q
S
P
S
P
Q
D
S
T
Site 155
S1020
N
P
S
D
Q
S
P
S
P
Q
D
S
T
G
P
Site 156
S1024
Q
S
P
S
P
Q
D
S
T
G
P
Q
L
A
T
Site 157
T1031
S
T
G
P
Q
L
A
T
M
R
Q
L
S
D
A
Site 158
S1036
L
A
T
M
R
Q
L
S
D
A
D
K
L
R
K
Site 159
T1051
V
I
C
E
L
L
E
T
E
R
T
Y
V
K
D
Site 160
T1054
E
L
L
E
T
E
R
T
Y
V
K
D
L
N
C
Site 161
Y1055
L
L
E
T
E
R
T
Y
V
K
D
L
N
C
L
Site 162
Y1066
L
N
C
L
M
E
R
Y
L
K
P
L
Q
K
E
Site 163
T1077
L
Q
K
E
T
F
L
T
Q
D
E
L
D
V
L
Site 164
Y1134
S
L
G
G
S
F
L
Y
Y
A
D
R
F
K
L
Site 165
Y1142
Y
A
D
R
F
K
L
Y
S
A
F
C
A
S
H
Site 166
S1143
A
D
R
F
K
L
Y
S
A
F
C
A
S
H
T
Site 167
S1179
Q
N
P
K
Q
Q
H
S
S
T
L
E
S
Y
L
Site 168
T1181
P
K
Q
Q
H
S
S
T
L
E
S
Y
L
I
K
Site 169
S1184
Q
H
S
S
T
L
E
S
Y
L
I
K
P
I
Q
Site 170
T1207
L
R
E
L
F
A
L
T
D
A
E
S
E
E
H
Site 171
S1211
F
A
L
T
D
A
E
S
E
E
H
Y
H
L
D
Site 172
Y1215
D
A
E
S
E
E
H
Y
H
L
D
V
A
I
K
Site 173
T1223
H
L
D
V
A
I
K
T
M
N
K
V
A
S
H
Site 174
S1263
K
K
E
V
A
D
L
S
M
G
D
L
L
L
H
Site 175
S1281
I
W
L
N
P
P
A
S
L
G
K
W
K
K
E
Site 176
Y1304
K
T
A
V
V
L
V
Y
K
D
G
S
K
Q
K
Site 177
S1317
Q
K
K
K
L
V
G
S
H
R
L
S
I
Y
E
Site 178
S1321
L
V
G
S
H
R
L
S
I
Y
E
D
W
D
P
Site 179
Y1323
G
S
H
R
L
S
I
Y
E
D
W
D
P
F
R
Site 180
T1337
R
F
R
H
M
I
P
T
E
A
L
Q
V
R
A
Site 181
S1378
R
V
F
H
L
C
C
S
S
P
E
S
R
K
D
Site 182
S1379
V
F
H
L
C
C
S
S
P
E
S
R
K
D
F
Site 183
S1382
L
C
C
S
S
P
E
S
R
K
D
F
L
K
A
Site 184
S1392
D
F
L
K
A
V
H
S
I
L
R
D
K
H
R
Site 185
T1405
H
R
R
Q
L
L
K
T
E
S
L
P
S
S
Q
Site 186
S1407
R
Q
L
L
K
T
E
S
L
P
S
S
Q
Q
Y
Site 187
S1411
K
T
E
S
L
P
S
S
Q
Q
Y
V
P
F
G
Site 188
Y1414
S
L
P
S
S
Q
Q
Y
V
P
F
G
G
K
R
Site 189
S1433
K
G
A
R
P
A
M
S
R
A
V
S
A
P
S
Site 190
S1437
P
A
M
S
R
A
V
S
A
P
S
K
S
L
G
Site 191
S1442
A
V
S
A
P
S
K
S
L
G
R
R
R
R
R
Site 192
T1456
R
L
A
R
N
R
F
T
I
D
S
D
A
V
S
Site 193
S1459
R
N
R
F
T
I
D
S
D
A
V
S
A
S
S
Site 194
S1463
T
I
D
S
D
A
V
S
A
S
S
P
E
K
E
Site 195
S1465
D
S
D
A
V
S
A
S
S
P
E
K
E
S
Q
Site 196
S1466
S
D
A
V
S
A
S
S
P
E
K
E
S
Q
Q
Site 197
S1471
A
S
S
P
E
K
E
S
Q
Q
P
P
G
G
G
Site 198
T1480
Q
P
P
G
G
G
D
T
D
R
W
V
E
E
Q
Site 199
Y1493
E
Q
F
D
L
A
Q
Y
E
E
Q
D
D
I
K
Site 200
T1502
E
Q
D
D
I
K
E
T
D
I
L
S
D
D
D
Site 201
S1506
I
K
E
T
D
I
L
S
D
D
D
E
F
C
E
Site 202
S1514
D
D
D
E
F
C
E
S
V
K
G
A
S
V
D
Site 203
S1519
C
E
S
V
K
G
A
S
V
D
R
D
L
Q
E
Site 204
S1532
Q
E
R
L
Q
A
T
S
I
S
Q
R
E
R
G
Site 205
S1534
R
L
Q
A
T
S
I
S
Q
R
E
R
G
R
K
Site 206
T1542
Q
R
E
R
G
R
K
T
L
D
S
H
A
S
R
Site 207
S1545
R
G
R
K
T
L
D
S
H
A
S
R
M
A
Q
Site 208
S1560
L
K
K
Q
A
A
L
S
G
I
N
G
G
L
E
Site 209
S1568
G
I
N
G
G
L
E
S
A
S
E
E
V
I
W
Site 210
S1570
N
G
G
L
E
S
A
S
E
E
V
I
W
V
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation