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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ECH1
Full Name:
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial
Alias:
enoyl Coenzyme A hydratase 1, peroxisomal; HPXEL
Type:
Isomerase; Amino Acid Metabolism - tyrosine; EC 5.3.3.-; Mitochondrial
Mass (Da):
35816
Number AA:
328
UniProt ID:
Q13011
International Prot ID:
IPI00011416
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005739
GO:0005777
GO:0042579
Uniprot
OncoNet
Molecular Function:
GO:0003824
GO:0004300
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
GO:0006082
GO:0006091
GO:0006629
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T16
R
R
L
R
D
L
L
T
R
R
L
T
G
S
N
Site 2
T20
D
L
L
T
R
R
L
T
G
S
N
Y
P
G
L
Site 3
S22
L
T
R
R
L
T
G
S
N
Y
P
G
L
S
I
Site 4
Y24
R
R
L
T
G
S
N
Y
P
G
L
S
I
S
L
Site 5
S28
G
S
N
Y
P
G
L
S
I
S
L
R
L
T
G
Site 6
S30
N
Y
P
G
L
S
I
S
L
R
L
T
G
S
S
Site 7
T34
L
S
I
S
L
R
L
T
G
S
S
A
Q
E
E
Site 8
S36
I
S
L
R
L
T
G
S
S
A
Q
E
E
A
S
Site 9
S37
S
L
R
L
T
G
S
S
A
Q
E
E
A
S
G
Site 10
S54
L
G
E
A
P
D
H
S
Y
E
S
L
R
V
T
Site 11
Y55
G
E
A
P
D
H
S
Y
E
S
L
R
V
T
S
Site 12
S57
A
P
D
H
S
Y
E
S
L
R
V
T
S
A
Q
Site 13
T61
S
Y
E
S
L
R
V
T
S
A
Q
K
H
V
L
Site 14
S62
Y
E
S
L
R
V
T
S
A
Q
K
H
V
L
H
Site 15
S108
D
C
R
A
V
V
I
S
G
A
G
K
M
F
T
Site 16
Y141
D
V
A
R
I
S
W
Y
L
R
D
I
I
T
R
Site 17
Y149
L
R
D
I
I
T
R
Y
Q
E
T
F
N
V
I
Site 18
T152
I
I
T
R
Y
Q
E
T
F
N
V
I
E
R
C
Site 19
S240
M
A
D
E
A
L
G
S
G
L
V
S
R
V
F
Site 20
S244
A
L
G
S
G
L
V
S
R
V
F
P
D
K
E
Site 21
S268
A
A
E
I
S
S
K
S
P
V
A
V
Q
S
T
Site 22
Y281
S
T
K
V
N
L
L
Y
S
R
D
H
S
V
A
Site 23
S282
T
K
V
N
L
L
Y
S
R
D
H
S
V
A
E
Site 24
S286
L
L
Y
S
R
D
H
S
V
A
E
S
L
N
Y
Site 25
S290
R
D
H
S
V
A
E
S
L
N
Y
V
A
S
W
Site 26
Y293
S
V
A
E
S
L
N
Y
V
A
S
W
N
M
S
Site 27
T304
W
N
M
S
M
L
Q
T
Q
D
L
V
K
S
V
Site 28
S310
Q
T
Q
D
L
V
K
S
V
Q
A
T
T
E
N
Site 29
T314
L
V
K
S
V
Q
A
T
T
E
N
K
E
L
K
Site 30
T322
T
E
N
K
E
L
K
T
V
T
F
S
K
L
_
Site 31
T324
N
K
E
L
K
T
V
T
F
S
K
L
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation