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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ARHGAP5
Full Name:
Rho GTPase-activating protein 5
Alias:
GFI2; P190-B; Rho GTPase activating protein 5; Rho GTPase-activating protein 5: Rho-type GTPase-activating protein 5: p190-B: Rho GTPase-activating protein 5: Rho-type GTPase-activating protein 5: p190-B; RhoGAP5
Type:
GTPase-activating protein for G protein
Mass (Da):
172460
Number AA:
1502
UniProt ID:
Q13017
International Prot ID:
IPI00013988
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0019898
GO:0005622
Uniprot
OncoNet
Molecular Function:
GO:0005525
GO:0003924
GO:0005100
PhosphoSite+
KinaseNET
Biological Process:
GO:0007266
GO:0007155
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S12
N
K
E
P
R
P
P
S
Y
T
I
S
I
V
G
Site 2
Y13
K
E
P
R
P
P
S
Y
T
I
S
I
V
G
L
Site 3
T14
E
P
R
P
P
S
Y
T
I
S
I
V
G
L
S
Site 4
S16
R
P
P
S
Y
T
I
S
I
V
G
L
S
G
T
Site 5
T23
S
I
V
G
L
S
G
T
E
K
D
K
G
N
C
Site 6
Y49
V
R
S
K
A
D
E
Y
Y
P
E
H
T
S
V
Site 7
Y50
R
S
K
A
D
E
Y
Y
P
E
H
T
S
V
L
Site 8
S58
P
E
H
T
S
V
L
S
T
I
D
F
G
G
R
Site 9
T59
E
H
T
S
V
L
S
T
I
D
F
G
G
R
V
Site 10
T103
T
E
F
I
D
D
Q
T
F
L
P
H
R
S
T
Site 11
T110
T
F
L
P
H
R
S
T
N
L
Q
P
Y
I
K
Site 12
Y132
Q
S
A
E
K
L
M
Y
I
C
T
D
Q
L
G
Site 13
T135
E
K
L
M
Y
I
C
T
D
Q
L
G
L
E
Q
Site 14
S188
N
N
L
F
V
Q
L
S
K
S
K
K
P
V
I
Site 15
T199
K
P
V
I
I
A
A
T
K
C
D
E
C
V
D
Site 16
Y208
C
D
E
C
V
D
H
Y
L
R
E
V
Q
A
F
Site 17
S251
Q
M
L
D
K
T
R
S
K
P
K
I
I
P
Y
Site 18
Y258
S
K
P
K
I
I
P
Y
L
D
A
Y
K
T
Q
Site 19
Y262
I
I
P
Y
L
D
A
Y
K
T
Q
R
Q
L
V
Site 20
T264
P
Y
L
D
A
Y
K
T
Q
R
Q
L
V
V
T
Site 21
T271
T
Q
R
Q
L
V
V
T
A
T
D
K
F
E
K
Site 22
T282
K
F
E
K
L
V
Q
T
V
R
D
Y
H
A
T
Site 23
Y286
L
V
Q
T
V
R
D
Y
H
A
T
W
K
T
V
Site 24
T289
T
V
R
D
Y
H
A
T
W
K
T
V
S
N
K
Site 25
T292
D
Y
H
A
T
W
K
T
V
S
N
K
L
K
N
Site 26
Y303
K
L
K
N
H
P
D
Y
E
E
Y
I
N
L
E
Site 27
Y306
N
H
P
D
Y
E
E
Y
I
N
L
E
G
T
R
Site 28
T318
G
T
R
K
A
R
N
T
F
S
K
H
I
E
Q
Site 29
S320
R
K
A
R
N
T
F
S
K
H
I
E
Q
L
K
Site 30
Y338
I
R
K
R
R
E
E
Y
I
N
T
L
P
R
A
Site 31
T341
R
R
E
E
Y
I
N
T
L
P
R
A
F
N
T
Site 32
T348
T
L
P
R
A
F
N
T
L
L
P
N
L
E
E
Site 33
S362
E
I
E
H
L
N
W
S
E
A
L
K
L
M
E
Site 34
Y414
T
L
E
A
E
K
V
Y
Q
N
H
V
Q
H
L
Site 35
S423
N
H
V
Q
H
L
I
S
E
K
R
R
V
E
M
Site 36
T437
M
K
E
K
F
K
K
T
L
E
K
I
Q
F
I
Site 37
S445
L
E
K
I
Q
F
I
S
P
G
Q
P
W
E
E
Site 38
Y463
F
V
M
E
D
E
A
Y
K
Y
I
T
E
A
D
Site 39
Y465
M
E
D
E
A
Y
K
Y
I
T
E
A
D
S
K
Site 40
S471
K
Y
I
T
E
A
D
S
K
E
V
Y
G
R
H
Site 41
Y475
E
A
D
S
K
E
V
Y
G
R
H
Q
R
E
I
Site 42
Y502
F
E
H
S
E
L
F
Y
D
L
D
L
N
A
T
Site 43
T509
Y
D
L
D
L
N
A
T
P
S
S
D
K
M
S
Site 44
S511
L
D
L
N
A
T
P
S
S
D
K
M
S
E
I
Site 45
S512
D
L
N
A
T
P
S
S
D
K
M
S
E
I
H
Site 46
S516
T
P
S
S
D
K
M
S
E
I
H
T
V
L
S
Site 47
T520
D
K
M
S
E
I
H
T
V
L
S
E
E
P
R
Site 48
S523
S
E
I
H
T
V
L
S
E
E
P
R
Y
K
A
Site 49
Y528
V
L
S
E
E
P
R
Y
K
A
L
Q
K
L
A
Site 50
S540
K
L
A
P
D
R
E
S
L
L
L
K
H
I
G
Site 51
Y550
L
K
H
I
G
F
V
Y
H
P
T
K
E
T
C
Site 52
T553
I
G
F
V
Y
H
P
T
K
E
T
C
L
S
G
Site 53
S559
P
T
K
E
T
C
L
S
G
Q
N
C
T
D
I
Site 54
Y587
D
H
G
R
L
R
L
Y
H
D
S
T
N
I
D
Site 55
S590
R
L
R
L
Y
H
D
S
T
N
I
D
K
V
N
Site 56
T591
L
R
L
Y
H
D
S
T
N
I
D
K
V
N
L
Site 57
S618
A
N
E
I
R
T
Q
S
T
D
D
E
Y
A
L
Site 58
Y623
T
Q
S
T
D
D
E
Y
A
L
D
G
K
I
Y
Site 59
S641
L
R
P
V
D
A
K
S
P
Y
F
L
S
Q
L
Site 60
Y643
P
V
D
A
K
S
P
Y
F
L
S
Q
L
W
T
Site 61
S683
G
K
I
R
T
E
A
S
Q
I
R
K
D
K
Y
Site 62
Y690
S
Q
I
R
K
D
K
Y
M
A
N
L
P
F
T
Site 63
S706
I
L
A
N
Q
R
D
S
I
S
K
N
L
P
I
Site 64
S708
A
N
Q
R
D
S
I
S
K
N
L
P
I
L
R
Site 65
Y737
V
D
V
P
A
G
T
Y
P
R
K
F
N
E
T
Site 66
T744
Y
P
R
K
F
N
E
T
Q
I
K
Q
A
L
R
Site 67
S765
K
H
N
L
D
V
V
S
P
I
P
A
N
K
D
Site 68
S774
I
P
A
N
K
D
L
S
E
A
D
L
R
I
V
Site 69
S804
S
P
F
L
D
S
H
S
C
S
A
A
Q
A
G
Site 70
S806
F
L
D
S
H
S
C
S
A
A
Q
A
G
Q
N
Site 71
S815
A
Q
A
G
Q
N
N
S
L
M
L
D
K
I
I
Site 72
T832
K
R
R
R
I
Q
I
T
I
L
S
Y
H
S
S
Site 73
Y836
I
Q
I
T
I
L
S
Y
H
S
S
I
G
V
R
Site 74
S839
T
I
L
S
Y
H
S
S
I
G
V
R
K
D
E
Site 75
Y851
K
D
E
L
V
H
G
Y
I
L
V
Y
S
A
K
Site 76
S856
H
G
Y
I
L
V
Y
S
A
K
R
K
A
S
M
Site 77
S862
Y
S
A
K
R
K
A
S
M
G
M
L
R
A
F
Site 78
S887
Q
L
V
A
V
T
D
S
Q
A
D
F
F
E
N
Site 79
T909
T
E
G
E
H
I
A
T
E
I
T
A
K
F
T
Site 80
Y919
T
A
K
F
T
A
L
Y
S
L
S
Q
Y
H
R
Site 81
S920
A
K
F
T
A
L
Y
S
L
S
Q
Y
H
R
Q
Site 82
S922
F
T
A
L
Y
S
L
S
Q
Y
H
R
Q
T
E
Site 83
Y924
A
L
Y
S
L
S
Q
Y
H
R
Q
T
E
V
F
Site 84
T928
L
S
Q
Y
H
R
Q
T
E
V
F
T
L
F
F
Site 85
S936
E
V
F
T
L
F
F
S
D
V
L
E
K
K
N
Site 86
S948
K
K
N
M
I
E
N
S
Y
L
S
D
N
T
R
Site 87
Y949
K
N
M
I
E
N
S
Y
L
S
D
N
T
R
E
Site 88
S951
M
I
E
N
S
Y
L
S
D
N
T
R
E
S
T
Site 89
S957
L
S
D
N
T
R
E
S
T
H
Q
S
E
D
V
Site 90
T958
S
D
N
T
R
E
S
T
H
Q
S
E
D
V
F
Site 91
S961
T
R
E
S
T
H
Q
S
E
D
V
F
L
P
S
Site 92
S968
S
E
D
V
F
L
P
S
P
R
D
C
F
P
Y
Site 93
Y975
S
P
R
D
C
F
P
Y
N
N
Y
P
D
S
D
Site 94
Y978
D
C
F
P
Y
N
N
Y
P
D
S
D
D
D
T
Site 95
S981
P
Y
N
N
Y
P
D
S
D
D
D
T
E
A
P
Site 96
T985
Y
P
D
S
D
D
D
T
E
A
P
P
P
Y
S
Site 97
Y991
D
T
E
A
P
P
P
Y
S
P
I
G
D
D
V
Site 98
S992
T
E
A
P
P
P
Y
S
P
I
G
D
D
V
Q
Site 99
T1003
D
D
V
Q
L
L
P
T
P
S
D
R
S
R
Y
Site 100
S1005
V
Q
L
L
P
T
P
S
D
R
S
R
Y
R
L
Site 101
Y1010
T
P
S
D
R
S
R
Y
R
L
D
L
E
G
N
Site 102
Y1019
L
D
L
E
G
N
E
Y
P
I
H
S
T
P
N
Site 103
T1024
N
E
Y
P
I
H
S
T
P
N
C
H
D
H
E
Site 104
T1049
P
K
P
V
V
P
K
T
N
V
K
K
L
D
P
Site 105
T1074
G
K
N
P
R
K
Q
T
S
R
V
P
L
A
H
Site 106
S1075
K
N
P
R
K
Q
T
S
R
V
P
L
A
H
P
Site 107
S1088
H
P
E
D
M
D
P
S
D
N
Y
A
E
P
I
Site 108
Y1091
D
M
D
P
S
D
N
Y
A
E
P
I
D
T
I
Site 109
T1097
N
Y
A
E
P
I
D
T
I
F
K
Q
K
G
Y
Site 110
Y1104
T
I
F
K
Q
K
G
Y
S
D
E
I
Y
V
V
Site 111
Y1109
K
G
Y
S
D
E
I
Y
V
V
P
D
D
S
Q
Site 112
S1115
I
Y
V
V
P
D
D
S
Q
N
R
I
K
I
R
Site 113
S1124
N
R
I
K
I
R
N
S
F
V
N
N
T
Q
G
Site 114
T1129
R
N
S
F
V
N
N
T
Q
G
D
E
E
N
G
Site 115
S1138
G
D
E
E
N
G
F
S
D
R
T
S
K
S
H
Site 116
T1141
E
N
G
F
S
D
R
T
S
K
S
H
G
E
R
Site 117
S1142
N
G
F
S
D
R
T
S
K
S
H
G
E
R
R
Site 118
S1144
F
S
D
R
T
S
K
S
H
G
E
R
R
P
S
Site 119
S1151
S
H
G
E
R
R
P
S
K
Y
K
Y
K
S
K
Site 120
Y1153
G
E
R
R
P
S
K
Y
K
Y
K
S
K
T
L
Site 121
Y1155
R
R
P
S
K
Y
K
Y
K
S
K
T
L
F
S
Site 122
S1157
P
S
K
Y
K
Y
K
S
K
T
L
F
S
K
A
Site 123
T1159
K
Y
K
Y
K
S
K
T
L
F
S
K
A
K
S
Site 124
S1162
Y
K
S
K
T
L
F
S
K
A
K
S
Y
Y
R
Site 125
S1166
T
L
F
S
K
A
K
S
Y
Y
R
R
T
H
S
Site 126
Y1167
L
F
S
K
A
K
S
Y
Y
R
R
T
H
S
D
Site 127
Y1168
F
S
K
A
K
S
Y
Y
R
R
T
H
S
D
A
Site 128
T1171
A
K
S
Y
Y
R
R
T
H
S
D
A
S
D
D
Site 129
S1173
S
Y
Y
R
R
T
H
S
D
A
S
D
D
E
A
Site 130
S1176
R
R
T
H
S
D
A
S
D
D
E
A
F
T
T
Site 131
T1182
A
S
D
D
E
A
F
T
T
S
K
T
K
R
K
Site 132
T1183
S
D
D
E
A
F
T
T
S
K
T
K
R
K
G
Site 133
S1184
D
D
E
A
F
T
T
S
K
T
K
R
K
G
R
Site 134
T1186
E
A
F
T
T
S
K
T
K
R
K
G
R
H
R
Site 135
S1195
R
K
G
R
H
R
G
S
E
E
D
P
L
L
S
Site 136
S1202
S
E
E
D
P
L
L
S
P
V
E
T
W
K
G
Site 137
T1206
P
L
L
S
P
V
E
T
W
K
G
G
I
D
N
Site 138
T1217
G
I
D
N
P
A
I
T
S
D
Q
E
L
D
D
Site 139
S1218
I
D
N
P
A
I
T
S
D
Q
E
L
D
D
K
Site 140
T1244
D
K
K
Q
K
K
K
T
K
N
F
N
P
P
T
Site 141
T1251
T
K
N
F
N
P
P
T
R
R
N
W
E
S
N
Site 142
Y1259
R
R
N
W
E
S
N
Y
F
G
M
P
L
Q
D
Site 143
Y1296
G
L
C
T
E
G
L
Y
R
V
S
G
N
K
T
Site 144
S1299
T
E
G
L
Y
R
V
S
G
N
K
T
D
Q
D
Site 145
T1303
Y
R
V
S
G
N
K
T
D
Q
D
N
I
Q
K
Site 146
S1349
P
D
P
L
I
P
Y
S
L
H
P
E
L
L
E
Site 147
T1364
A
A
K
I
P
D
K
T
E
R
L
H
A
L
K
Site 148
Y1382
K
K
F
H
P
V
N
Y
D
V
F
R
Y
V
I
Site 149
Y1387
V
N
Y
D
V
F
R
Y
V
I
T
H
L
N
R
Site 150
S1429
F
E
N
R
E
F
L
S
T
T
K
I
H
Q
S
Site 151
T1430
E
N
R
E
F
L
S
T
T
K
I
H
Q
S
V
Site 152
S1436
S
T
T
K
I
H
Q
S
V
V
E
T
F
I
Q
Site 153
T1457
Y
N
G
E
I
V
E
T
T
N
I
V
A
P
P
Site 154
S1467
I
V
A
P
P
P
P
S
N
P
G
Q
L
V
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation