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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
AKAP6
Full Name:
A-kinase anchor protein 6
Alias:
A kinase (PRKA) anchor protein 6; ADAP6; AKAP 100; AKAP100; A-kinase anchor protein 100 kDa; KIAA0311; MAKAP; PRKA6; Protein kinase A anchoring protein 6; Protein kinase A-anchoring protein 6
Type:
Adaptor/scaffold
Mass (Da):
256720
Number AA:
2319
UniProt ID:
Q13023
International Prot ID:
IPI00297089
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0034704
GO:0031965
GO:0016529
Uniprot
OncoNet
Molecular Function:
GO:0051018
GO:0005102
PhosphoSite+
KinaseNET
Biological Process:
GO:0006605
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
V
T
L
S
P
L
R
S
Q
D
L
D
P
M
A
Site 2
S24
D
P
M
A
T
D
A
S
P
M
A
I
N
M
T
Site 3
T31
S
P
M
A
I
N
M
T
P
T
V
E
Q
G
E
Site 4
T33
M
A
I
N
M
T
P
T
V
E
Q
G
E
G
E
Site 5
S48
E
A
M
K
D
M
D
S
D
Q
Q
Y
E
K
P
Site 6
Y52
D
M
D
S
D
Q
Q
Y
E
K
P
P
P
L
H
Site 7
T80
I
E
T
W
L
R
M
T
S
E
R
V
R
D
L
Site 8
S81
E
T
W
L
R
M
T
S
E
R
V
R
D
L
T
Site 9
T88
S
E
R
V
R
D
L
T
Y
S
V
Q
Q
D
S
Site 10
Y89
E
R
V
R
D
L
T
Y
S
V
Q
Q
D
S
D
Site 11
S90
R
V
R
D
L
T
Y
S
V
Q
Q
D
S
D
S
Site 12
S95
T
Y
S
V
Q
Q
D
S
D
S
K
H
V
D
V
Site 13
S97
S
V
Q
Q
D
S
D
S
K
H
V
D
V
H
L
Site 14
Y176
L
Q
D
A
N
G
N
Y
T
R
Q
T
D
I
L
Site 15
T180
N
G
N
Y
T
R
Q
T
D
I
L
Q
A
F
S
Site 16
S197
T
K
E
G
R
L
D
S
L
T
E
V
D
D
S
Site 17
T199
E
G
R
L
D
S
L
T
E
V
D
D
S
G
Q
Site 18
S204
S
L
T
E
V
D
D
S
G
Q
L
T
I
K
C
Site 19
T208
V
D
D
S
G
Q
L
T
I
K
C
S
Q
N
Y
Site 20
S212
G
Q
L
T
I
K
C
S
Q
N
Y
L
S
L
D
Site 21
S228
G
I
T
A
F
E
L
S
D
Y
S
P
S
E
D
Site 22
Y230
T
A
F
E
L
S
D
Y
S
P
S
E
D
L
L
Site 23
S231
A
F
E
L
S
D
Y
S
P
S
E
D
L
L
S
Site 24
S233
E
L
S
D
Y
S
P
S
E
D
L
L
S
G
L
Site 25
S238
S
P
S
E
D
L
L
S
G
L
G
D
M
T
S
Site 26
T244
L
S
G
L
G
D
M
T
S
S
Q
V
K
T
K
Site 27
S245
S
G
L
G
D
M
T
S
S
Q
V
K
T
K
P
Site 28
S246
G
L
G
D
M
T
S
S
Q
V
K
T
K
P
F
Site 29
T250
M
T
S
S
Q
V
K
T
K
P
F
D
S
W
S
Site 30
S255
V
K
T
K
P
F
D
S
W
S
Y
S
E
M
E
Site 31
S257
T
K
P
F
D
S
W
S
Y
S
E
M
E
K
E
Site 32
S259
P
F
D
S
W
S
Y
S
E
M
E
K
E
F
P
Site 33
S287
D
S
I
S
T
N
G
S
E
A
V
T
E
E
V
Site 34
T291
T
N
G
S
E
A
V
T
E
E
V
S
Q
V
S
Site 35
S295
E
A
V
T
E
E
V
S
Q
V
S
L
S
V
D
Site 36
S298
T
E
E
V
S
Q
V
S
L
S
V
D
D
K
G
Site 37
S300
E
V
S
Q
V
S
L
S
V
D
D
K
G
G
C
Site 38
S313
G
C
E
E
D
N
A
S
A
V
E
E
Q
P
G
Site 39
T322
V
E
E
Q
P
G
L
T
L
G
V
S
S
S
S
Site 40
T334
S
S
S
G
E
A
L
T
N
A
A
Q
P
S
S
Site 41
S341
T
N
A
A
Q
P
S
S
E
T
V
Q
Q
E
S
Site 42
T343
A
A
Q
P
S
S
E
T
V
Q
Q
E
S
S
S
Site 43
S348
S
E
T
V
Q
Q
E
S
S
S
S
S
H
H
D
Site 44
S350
T
V
Q
Q
E
S
S
S
S
S
H
H
D
A
K
Site 45
S352
Q
Q
E
S
S
S
S
S
H
H
D
A
K
N
Q
Site 46
T368
P
V
P
C
E
N
A
T
P
K
R
T
I
R
D
Site 47
Y379
T
I
R
D
C
F
N
Y
N
E
D
S
P
T
Q
Site 48
S383
C
F
N
Y
N
E
D
S
P
T
Q
P
T
L
P
Site 49
T385
N
Y
N
E
D
S
P
T
Q
P
T
L
P
K
R
Site 50
T388
E
D
S
P
T
Q
P
T
L
P
K
R
G
L
F
Site 51
T400
G
L
F
L
K
E
E
T
F
K
N
D
L
K
G
Site 52
S422
V
D
L
K
P
E
M
S
R
S
T
P
S
L
V
Site 53
S424
L
K
P
E
M
S
R
S
T
P
S
L
V
D
P
Site 54
T425
K
P
E
M
S
R
S
T
P
S
L
V
D
P
P
Site 55
S427
E
M
S
R
S
T
P
S
L
V
D
P
P
D
R
Site 56
S443
K
L
C
L
V
L
Q
S
S
Y
P
N
S
P
S
Site 57
S448
L
Q
S
S
Y
P
N
S
P
S
A
A
S
Q
S
Site 58
S450
S
S
Y
P
N
S
P
S
A
A
S
Q
S
Y
E
Site 59
S453
P
N
S
P
S
A
A
S
Q
S
Y
E
C
L
H
Site 60
S455
S
P
S
A
A
S
Q
S
Y
E
C
L
H
K
V
Site 61
T470
G
N
G
N
L
E
N
T
V
K
F
H
I
K
E
Site 62
S479
K
F
H
I
K
E
I
S
S
S
L
G
R
L
N
Site 63
S481
H
I
K
E
I
S
S
S
L
G
R
L
N
D
C
Site 64
Y489
L
G
R
L
N
D
C
Y
K
E
K
S
R
L
K
Site 65
S493
N
D
C
Y
K
E
K
S
R
L
K
K
P
H
K
Site 66
T501
R
L
K
K
P
H
K
T
S
E
E
V
P
P
C
Site 67
S502
L
K
K
P
H
K
T
S
E
E
V
P
P
C
R
Site 68
T510
E
E
V
P
P
C
R
T
P
K
R
G
T
G
S
Site 69
T515
C
R
T
P
K
R
G
T
G
S
G
K
Q
A
K
Site 70
T524
S
G
K
Q
A
K
N
T
K
S
S
A
V
P
N
Site 71
S526
K
Q
A
K
N
T
K
S
S
A
V
P
N
G
E
Site 72
S535
A
V
P
N
G
E
L
S
Y
T
S
K
A
I
E
Site 73
T537
P
N
G
E
L
S
Y
T
S
K
A
I
E
G
P
Site 74
S538
N
G
E
L
S
Y
T
S
K
A
I
E
G
P
Q
Site 75
T546
K
A
I
E
G
P
Q
T
N
S
A
S
T
S
S
Site 76
S548
I
E
G
P
Q
T
N
S
A
S
T
S
S
L
E
Site 77
S550
G
P
Q
T
N
S
A
S
T
S
S
L
E
P
C
Site 78
S552
Q
T
N
S
A
S
T
S
S
L
E
P
C
N
Q
Site 79
S553
T
N
S
A
S
T
S
S
L
E
P
C
N
Q
R
Site 80
S570
N
A
K
L
Q
L
Q
S
E
T
S
S
S
P
A
Site 81
S573
L
Q
L
Q
S
E
T
S
S
S
P
A
F
T
Q
Site 82
S574
Q
L
Q
S
E
T
S
S
S
P
A
F
T
Q
S
Site 83
S575
L
Q
S
E
T
S
S
S
P
A
F
T
Q
S
S
Site 84
T579
T
S
S
S
P
A
F
T
Q
S
S
E
S
S
V
Site 85
S581
S
S
P
A
F
T
Q
S
S
E
S
S
V
G
S
Site 86
S582
S
P
A
F
T
Q
S
S
E
S
S
V
G
S
D
Site 87
S584
A
F
T
Q
S
S
E
S
S
V
G
S
D
N
I
Site 88
S585
F
T
Q
S
S
E
S
S
V
G
S
D
N
I
M
Site 89
S588
S
S
E
S
S
V
G
S
D
N
I
M
S
P
V
Site 90
S599
M
S
P
V
P
L
L
S
K
H
K
S
K
K
G
Site 91
S603
P
L
L
S
K
H
K
S
K
K
G
Q
A
S
S
Site 92
S610
S
K
K
G
Q
A
S
S
P
S
H
V
T
R
N
Site 93
S612
K
G
Q
A
S
S
P
S
H
V
T
R
N
G
E
Site 94
Y630
A
W
Y
G
S
D
E
Y
L
A
L
P
S
H
L
Site 95
T651
A
L
K
L
E
N
L
T
K
L
L
P
Q
K
P
Site 96
T662
P
Q
K
P
R
G
E
T
I
Q
N
I
D
D
W
Site 97
S672
N
I
D
D
W
E
L
S
E
M
N
S
D
S
E
Site 98
S676
W
E
L
S
E
M
N
S
D
S
E
I
Y
P
T
Site 99
S678
L
S
E
M
N
S
D
S
E
I
Y
P
T
Y
H
Site 100
Y681
M
N
S
D
S
E
I
Y
P
T
Y
H
V
K
K
Site 101
T683
S
D
S
E
I
Y
P
T
Y
H
V
K
K
K
H
Site 102
Y684
D
S
E
I
Y
P
T
Y
H
V
K
K
K
H
T
Site 103
S697
H
T
R
L
G
R
V
S
P
S
S
S
S
D
I
Site 104
S699
R
L
G
R
V
S
P
S
S
S
S
D
I
A
S
Site 105
S700
L
G
R
V
S
P
S
S
S
S
D
I
A
S
S
Site 106
S701
G
R
V
S
P
S
S
S
S
D
I
A
S
S
L
Site 107
S702
R
V
S
P
S
S
S
S
D
I
A
S
S
L
G
Site 108
S706
S
S
S
S
D
I
A
S
S
L
G
E
S
I
E
Site 109
S707
S
S
S
D
I
A
S
S
L
G
E
S
I
E
S
Site 110
S718
S
I
E
S
G
P
L
S
D
I
L
S
D
E
E
Site 111
S722
G
P
L
S
D
I
L
S
D
E
E
S
S
M
P
Site 112
S726
D
I
L
S
D
E
E
S
S
M
P
L
A
G
M
Site 113
Y736
P
L
A
G
M
K
K
Y
A
D
E
K
S
E
R
Site 114
S741
K
K
Y
A
D
E
K
S
E
R
A
S
S
S
E
Site 115
S745
D
E
K
S
E
R
A
S
S
S
E
K
N
E
S
Site 116
S746
E
K
S
E
R
A
S
S
S
E
K
N
E
S
H
Site 117
S747
K
S
E
R
A
S
S
S
E
K
N
E
S
H
S
Site 118
S752
S
S
S
E
K
N
E
S
H
S
A
T
K
S
A
Site 119
S754
S
E
K
N
E
S
H
S
A
T
K
S
A
L
I
Site 120
T756
K
N
E
S
H
S
A
T
K
S
A
L
I
Q
K
Site 121
S758
E
S
H
S
A
T
K
S
A
L
I
Q
K
L
M
Site 122
Y774
D
I
Q
H
Q
D
N
Y
E
A
I
W
E
K
I
Site 123
T806
M
E
T
T
E
N
W
T
P
P
K
A
E
M
D
Site 124
Y818
E
M
D
D
L
K
L
Y
L
E
T
H
L
S
F
Site 125
S824
L
Y
L
E
T
H
L
S
F
K
L
N
V
D
S
Site 126
S831
S
F
K
L
N
V
D
S
H
C
A
L
K
E
A
Site 127
S852
Q
L
L
E
L
I
A
S
H
K
A
G
L
K
D
Site 128
S880
R
Q
I
K
R
Q
H
S
W
I
L
R
A
L
D
Site 129
S899
E
I
L
A
T
D
V
S
V
E
D
E
E
G
T
Site 130
S908
E
D
E
E
G
T
G
S
P
K
A
E
V
Q
L
Site 131
S929
R
D
A
V
E
Q
M
S
L
K
L
Y
S
E
Q
Site 132
Y933
E
Q
M
S
L
K
L
Y
S
E
Q
Y
T
S
S
Site 133
S934
Q
M
S
L
K
L
Y
S
E
Q
Y
T
S
S
S
Site 134
Y937
L
K
L
Y
S
E
Q
Y
T
S
S
S
K
R
K
Site 135
T938
K
L
Y
S
E
Q
Y
T
S
S
S
K
R
K
E
Site 136
S939
L
Y
S
E
Q
Y
T
S
S
S
K
R
K
E
E
Site 137
S940
Y
S
E
Q
Y
T
S
S
S
K
R
K
E
E
F
Site 138
S941
S
E
Q
Y
T
S
S
S
K
R
K
E
E
F
A
Site 139
S951
K
E
E
F
A
D
M
S
K
V
H
S
V
G
S
Site 140
S955
A
D
M
S
K
V
H
S
V
G
S
N
G
L
L
Site 141
S966
N
G
L
L
D
F
D
S
E
Y
Q
E
L
W
D
Site 142
Y968
L
L
D
F
D
S
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Site 287
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S1914
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S1917
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S1922
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Site 292
S1930
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Site 293
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Site 294
S1945
L
M
D
S
L
D
D
S
N
T
A
G
K
E
F
Site 295
T1947
D
S
L
D
D
S
N
T
A
G
K
E
F
V
S
Site 296
S1954
T
A
G
K
E
F
V
S
Q
D
V
R
H
L
P
Site 297
T1975
H
H
F
E
N
Q
S
T
A
S
T
P
T
E
K
Site 298
T1978
E
N
Q
S
T
A
S
T
P
T
E
K
S
F
S
Site 299
S1983
A
S
T
P
T
E
K
S
F
S
E
L
A
L
E
Site 300
S1985
T
P
T
E
K
S
F
S
E
L
A
L
E
T
R
Site 301
S1999
R
F
N
N
R
Q
D
S
D
A
L
K
S
S
D
Site 302
S2004
Q
D
S
D
A
L
K
S
S
D
D
A
P
S
M
Site 303
S2005
D
S
D
A
L
K
S
S
D
D
A
P
S
M
A
Site 304
S2010
K
S
S
D
D
A
P
S
M
A
G
K
S
A
G
Site 305
T2027
L
A
L
E
Q
N
G
T
E
E
N
A
S
I
S
Site 306
S2032
N
G
T
E
E
N
A
S
I
S
N
I
S
C
C
Site 307
S2068
K
E
I
I
D
M
A
S
T
A
L
K
S
K
S
Site 308
T2069
E
I
I
D
M
A
S
T
A
L
K
S
K
S
Q
Site 309
S2073
M
A
S
T
A
L
K
S
K
S
Q
P
E
N
E
Site 310
S2075
S
T
A
L
K
S
K
S
Q
P
E
N
E
V
A
Site 311
S2086
N
E
V
A
A
P
T
S
L
T
Q
I
K
E
K
Site 312
S2098
K
E
K
V
L
E
H
S
H
R
P
I
Q
L
R
Site 313
Y2110
Q
L
R
K
G
D
F
Y
S
Y
L
S
L
S
S
Site 314
S2111
L
R
K
G
D
F
Y
S
Y
L
S
L
S
S
H
Site 315
Y2112
R
K
G
D
F
Y
S
Y
L
S
L
S
S
H
D
Site 316
S2114
G
D
F
Y
S
Y
L
S
L
S
S
H
D
S
D
Site 317
S2116
F
Y
S
Y
L
S
L
S
S
H
D
S
D
C
G
Site 318
S2120
L
S
L
S
S
H
D
S
D
C
G
E
V
T
N
Site 319
Y2128
D
C
G
E
V
T
N
Y
I
E
E
K
S
S
T
Site 320
S2134
N
Y
I
E
E
K
S
S
T
P
L
P
L
D
T
Site 321
T2135
Y
I
E
E
K
S
S
T
P
L
P
L
D
T
T
Site 322
T2141
S
T
P
L
P
L
D
T
T
D
S
G
L
D
D
Site 323
T2142
T
P
L
P
L
D
T
T
D
S
G
L
D
D
K
Site 324
S2144
L
P
L
D
T
T
D
S
G
L
D
D
K
E
D
Site 325
S2164
E
A
C
V
E
G
D
S
D
G
E
E
P
C
F
Site 326
S2172
D
G
E
E
P
C
F
S
S
A
P
P
N
E
S
Site 327
S2173
G
E
E
P
C
F
S
S
A
P
P
N
E
S
A
Site 328
S2179
S
S
A
P
P
N
E
S
A
V
P
S
E
A
A
Site 329
S2183
P
N
E
S
A
V
P
S
E
A
A
M
P
L
Q
Site 330
S2195
P
L
Q
A
T
A
C
S
S
E
F
S
D
S
S
Site 331
S2196
L
Q
A
T
A
C
S
S
E
F
S
D
S
S
L
Site 332
S2199
T
A
C
S
S
E
F
S
D
S
S
L
S
A
D
Site 333
S2201
C
S
S
E
F
S
D
S
S
L
S
A
D
D
A
Site 334
S2202
S
S
E
F
S
D
S
S
L
S
A
D
D
A
D
Site 335
S2204
E
F
S
D
S
S
L
S
A
D
D
A
D
T
V
Site 336
T2210
L
S
A
D
D
A
D
T
V
A
L
S
S
P
S
Site 337
S2214
D
A
D
T
V
A
L
S
S
P
S
S
Q
E
R
Site 338
S2215
A
D
T
V
A
L
S
S
P
S
S
Q
E
R
A
Site 339
S2218
V
A
L
S
S
P
S
S
Q
E
R
A
E
V
G
Site 340
S2236
N
G
L
P
Q
T
S
S
G
C
A
E
N
L
E
Site 341
T2245
C
A
E
N
L
E
F
T
P
S
K
L
D
S
E
Site 342
S2247
E
N
L
E
F
T
P
S
K
L
D
S
E
K
E
Site 343
S2251
F
T
P
S
K
L
D
S
E
K
E
S
S
G
K
Site 344
S2255
K
L
D
S
E
K
E
S
S
G
K
P
G
E
S
Site 345
S2256
L
D
S
E
K
E
S
S
G
K
P
G
E
S
G
Site 346
S2262
S
S
G
K
P
G
E
S
G
M
P
E
E
H
N
Site 347
S2275
H
N
A
A
S
A
K
S
K
V
Q
D
L
S
L
Site 348
S2296
D
K
A
A
L
H
P
S
P
K
T
L
T
C
E
Site 349
T2299
A
L
H
P
S
P
K
T
L
T
C
E
E
N
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation