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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
STK4
Full Name:
Serine/threonine-protein kinase 4
Alias:
EC 2.7.11.1; Kinase MST1; Kinase responsive to stress 2; KRS2; Krs-2; Mammalian sterile 20-like 1; MST1; MST-1; Serine,threonine protein kinase 4; Serine/threonine kinase 4; Serine/threonine protein kinase 4; Serine/threonine protein kinase Krs-2; STE20-like kinase MST1; Yeast Sps1,Ste20-related kinase 3; Yeast Sps1/Ste20-related kinase 3; Yeast Ste20-like; YSK3
Type:
EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor);
STE
group; STE20 family; MST subfamily
Mass (Da):
55630
Number AA:
487
UniProt ID:
Q13043
International Prot ID:
IPI00011488
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0000287
GO:0042803
PhosphoSite+
KinaseNET
Biological Process:
GO:0006915
GO:0000902
GO:0018105
Phosida
TranscriptoNet
STRING
Kinexus Products
Mammalian STE20-like protein-serine kinase 1 (KRS2); Serine-threonine-protein kinase 4 T183 phosphosite-specific antibody AB-PK871#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK871#IRS1 (979-989) KinSub - Insulin receptor substrate 1 (K979-G989, mouse) peptide; Insulin receptor substrate - Powder PE-01ADC95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01ADC95#MstSubtide - MST1 (STK4) protein kinase substrate peptide - Powder PE-01BII95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01BII95#Mammalian STE20-like protein-serine kinase 1 (KRS2) / Serine-threonine-protein kinase 4 (A179-T187, human) pT183 phosphopeptide - Powder PE-04AQW95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AQW95
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T3
_
_
_
_
_
M
E
T
V
Q
L
R
N
P
P
Site 2
S21
L
K
K
L
D
E
D
S
L
T
K
Q
P
E
E
Site 3
T23
K
L
D
E
D
S
L
T
K
Q
P
E
E
V
F
Site 4
S40
L
E
K
L
G
E
G
S
Y
G
S
V
Y
K
A
Site 5
Y41
E
K
L
G
E
G
S
Y
G
S
V
Y
K
A
I
Site 6
S43
L
G
E
G
S
Y
G
S
V
Y
K
A
I
H
K
Site 7
Y45
E
G
S
Y
G
S
V
Y
K
A
I
H
K
E
T
Site 8
S82
S
I
M
Q
Q
C
D
S
P
H
V
V
K
Y
Y
Site 9
Y88
D
S
P
H
V
V
K
Y
Y
G
S
Y
F
K
N
Site 10
Y89
S
P
H
V
V
K
Y
Y
G
S
Y
F
K
N
T
Site 11
Y92
V
V
K
Y
Y
G
S
Y
F
K
N
T
D
L
W
Site 12
T120
I
I
R
L
R
N
K
T
L
T
E
D
E
I
A
Site 13
T122
R
L
R
N
K
T
L
T
E
D
E
I
A
T
I
Site 14
S132
E
I
A
T
I
L
Q
S
T
L
K
G
L
E
Y
Site 15
Y139
S
T
L
K
G
L
E
Y
L
H
F
M
R
K
I
Site 16
T175
F
G
V
A
G
Q
L
T
D
T
M
A
K
R
N
Site 17
T177
V
A
G
Q
L
T
D
T
M
A
K
R
N
T
V
Site 18
T183
D
T
M
A
K
R
N
T
V
I
G
T
P
F
W
Mammalian STE20-like protein-serine kinase 1 (KRS2); Serine-threonine-protein kinase 4 T183 phosphosite-specific antibody AB-PK871#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK871#Mammalian STE20-like protein-serine kinase 1 (KRS2) / Serine-threonine-protein kinase 4 (A179-T187, human) pT183 phosphopeptide - Powder PE-04AQW95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AQW95
Site 19
T187
K
R
N
T
V
I
G
T
P
F
W
M
A
P
E
Site 20
Y224
M
A
E
G
K
P
P
Y
A
D
I
H
P
M
R
Site 21
T238
R
A
I
F
M
I
P
T
N
P
P
P
T
F
R
Site 22
T243
I
P
T
N
P
P
P
T
F
R
K
P
E
L
W
Site 23
S265
V
K
Q
C
L
V
K
S
P
E
Q
R
A
T
A
Site 24
T271
K
S
P
E
Q
R
A
T
A
T
Q
L
L
Q
H
Site 25
S307
V
K
L
K
R
Q
E
S
Q
Q
R
E
V
D
Q
Site 26
S320
D
Q
D
D
E
E
N
S
E
E
D
E
M
D
S
Site 27
S327
S
E
E
D
E
M
D
S
G
T
M
V
R
A
V
Site 28
T329
E
D
E
M
D
S
G
T
M
V
R
A
V
G
D
Site 29
T340
A
V
G
D
E
M
G
T
V
R
V
A
S
T
M
Site 30
S345
M
G
T
V
R
V
A
S
T
M
T
D
G
A
N
Site 31
T346
G
T
V
R
V
A
S
T
M
T
D
G
A
N
T
Site 32
T353
T
M
T
D
G
A
N
T
M
I
E
H
D
D
T
Site 33
T360
T
M
I
E
H
D
D
T
L
P
S
Q
L
G
T
Site 34
S363
E
H
D
D
T
L
P
S
Q
L
G
T
M
V
I
Site 35
T367
T
L
P
S
Q
L
G
T
M
V
I
N
A
E
D
Site 36
T380
E
D
E
E
E
E
G
T
M
K
R
R
D
E
T
Site 37
T387
T
M
K
R
R
D
E
T
M
Q
P
A
K
P
S
Site 38
S394
T
M
Q
P
A
K
P
S
F
L
E
Y
F
E
Q
Site 39
Y398
A
K
P
S
F
L
E
Y
F
E
Q
K
E
K
E
Site 40
S410
E
K
E
N
Q
I
N
S
F
G
K
S
V
P
G
Site 41
S414
Q
I
N
S
F
G
K
S
V
P
G
P
L
K
N
Site 42
S422
V
P
G
P
L
K
N
S
S
D
W
K
I
P
Q
Site 43
S423
P
G
P
L
K
N
S
S
D
W
K
I
P
Q
D
Site 44
Y433
K
I
P
Q
D
G
D
Y
E
F
L
K
S
W
T
Site 45
S438
G
D
Y
E
F
L
K
S
W
T
V
E
D
L
Q
Site 46
T440
Y
E
F
L
K
S
W
T
V
E
D
L
Q
K
R
Site 47
Y466
I
E
E
I
R
Q
K
Y
Q
S
K
R
Q
P
I
Site 48
S468
E
I
R
Q
K
Y
Q
S
K
R
Q
P
I
L
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation