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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MKRN3
Full Name:
Probable E3 ubiquitin-protein ligase makorin-3
Alias:
D15S9; RING finger protein 63; RNF63; ZFP127; Zinc finger protein 127; ZNF127
Type:
Ribonucleoprotein complex protein
Mass (Da):
55645
Number AA:
507
UniProt ID:
Q13064
International Prot ID:
IPI00024229
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0030529
Uniprot
OncoNet
Molecular Function:
GO:0003676
GO:0005515
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S38
D
L
P
V
C
E
P
S
G
E
S
A
A
P
D
Site 2
S41
V
C
E
P
S
G
E
S
A
A
P
D
S
A
L
Site 3
S46
G
E
S
A
A
P
D
S
A
L
P
H
A
A
R
Site 4
S78
G
L
R
P
A
P
A
S
G
G
G
A
W
P
S
Site 5
S85
S
G
G
G
A
W
P
S
P
L
P
S
R
S
S
Site 6
S89
A
W
P
S
P
L
P
S
R
S
S
G
I
W
T
Site 7
S91
P
S
P
L
P
S
R
S
S
G
I
W
T
K
Q
Site 8
S92
S
P
L
P
S
R
S
S
G
I
W
T
K
Q
I
Site 9
T96
S
R
S
S
G
I
W
T
K
Q
I
I
C
R
Y
Site 10
Y117
K
E
G
E
N
C
R
Y
S
H
D
L
S
G
R
Site 11
S118
E
G
E
N
C
R
Y
S
H
D
L
S
G
R
K
Site 12
S122
C
R
Y
S
H
D
L
S
G
R
K
M
A
T
E
Site 13
S133
M
A
T
E
G
G
V
S
P
P
G
A
S
A
G
Site 14
S138
G
V
S
P
P
G
A
S
A
G
G
G
P
S
T
Site 15
T145
S
A
G
G
G
P
S
T
A
A
H
I
E
P
P
Site 16
S219
Y
R
G
R
W
V
A
S
A
P
E
A
P
L
Q
Site 17
S228
P
E
A
P
L
Q
S
S
E
T
E
R
K
Q
M
Site 18
T230
A
P
L
Q
S
S
E
T
E
R
K
Q
M
A
V
Site 19
S300
H
E
K
D
M
E
L
S
F
A
V
Q
R
G
M
Site 20
Y319
G
I
C
M
E
V
V
Y
E
K
A
N
P
N
D
Site 21
S349
R
C
I
R
R
W
R
S
A
R
Q
F
E
N
R
Site 22
S368
C
P
Q
C
R
V
T
S
E
L
V
I
P
S
E
Site 23
S396
Q
Q
Y
K
E
A
M
S
N
K
A
C
R
Y
F
Site 24
Y402
M
S
N
K
A
C
R
Y
F
A
E
G
R
G
N
Site 25
Y418
P
F
G
D
T
C
F
Y
K
H
E
Y
P
E
G
Site 26
Y422
T
C
F
Y
K
H
E
Y
P
E
G
W
G
D
E
Site 27
S437
P
P
G
P
G
G
G
S
F
S
A
Y
W
H
Q
Site 28
S439
G
P
G
G
G
S
F
S
A
Y
W
H
Q
L
V
Site 29
Y441
G
G
G
S
F
S
A
Y
W
H
Q
L
V
E
P
Site 30
Y458
M
G
E
G
N
M
L
Y
K
S
I
K
K
E
L
Site 31
S460
E
G
N
M
L
Y
K
S
I
K
K
E
L
V
V
Site 32
S488
L
R
D
E
L
P
F
S
E
D
Q
W
D
L
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation