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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
BIRC1
Full Name:
Baculoviral IAP repeat-containing protein 1
Alias:
Baculoviral IAP repeat-containing 1; BIR1A; NAIP; Neuronal apoptosis inhibitory protein; NLR family, apoptosis inhibitory; NLR family, apoptosis inhibitory protein; NLR family, BIR domain containing 1; NLRB1; Nucleotide-binding oligomerization domain, leucine rich repeat and BIR domain containing 1
Type:
Mass (Da):
159563
Number AA:
1403
UniProt ID:
Q13075
International Prot ID:
IPI00011547
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
Uniprot
OncoNet
Molecular Function:
GO:0017111
GO:0000166
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0006916
GO:0006915
GO:0007399
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
A
T
Q
Q
K
A
S
D
E
R
I
S
Q
F
Site 2
S13
K
A
S
D
E
R
I
S
Q
F
D
H
N
L
L
Site 3
S55
K
M
Q
K
G
Y
N
S
Q
M
R
S
E
A
K
Site 4
S59
G
Y
N
S
Q
M
R
S
E
A
K
R
L
K
T
Site 5
T66
S
E
A
K
R
L
K
T
F
V
T
Y
E
P
Y
Site 6
T69
K
R
L
K
T
F
V
T
Y
E
P
Y
S
S
W
Site 7
Y70
R
L
K
T
F
V
T
Y
E
P
Y
S
S
W
I
Site 8
Y138
D
V
G
N
I
A
K
Y
D
I
R
V
K
N
L
Site 9
S147
I
R
V
K
N
L
K
S
R
L
R
G
G
K
M
Site 10
S165
E
E
E
A
R
L
A
S
F
R
N
W
P
F
Y
Site 11
S229
P
K
C
E
F
L
R
S
K
K
S
S
E
E
I
Site 12
S232
E
F
L
R
S
K
K
S
S
E
E
I
T
Q
Y
Site 13
S233
F
L
R
S
K
K
S
S
E
E
I
T
Q
Y
I
Site 14
T237
K
K
S
S
E
E
I
T
Q
Y
I
Q
S
Y
K
Site 15
Y239
S
S
E
E
I
T
Q
Y
I
Q
S
Y
K
G
F
Site 16
T250
Y
K
G
F
V
D
I
T
G
E
H
F
V
N
S
Site 17
Y277
C
N
D
S
I
F
A
Y
E
E
L
R
L
D
S
Site 18
S284
Y
E
E
L
R
L
D
S
F
K
D
W
P
R
E
Site 19
S292
F
K
D
W
P
R
E
S
A
V
G
V
A
A
L
Site 20
S350
P
F
L
Q
N
M
K
S
S
A
E
V
T
P
D
Site 21
S351
F
L
Q
N
M
K
S
S
A
E
V
T
P
D
L
Site 22
T355
M
K
S
S
A
E
V
T
P
D
L
Q
S
R
G
Site 23
T370
E
L
C
E
L
L
E
T
T
S
E
S
N
L
E
Site 24
S372
C
E
L
L
E
T
T
S
E
S
N
L
E
D
S
Site 25
Y411
N
E
Q
L
R
A
A
Y
T
S
A
S
F
R
H
Site 26
T412
E
Q
L
R
A
A
Y
T
S
A
S
F
R
H
M
Site 27
S413
Q
L
R
A
A
Y
T
S
A
S
F
R
H
M
S
Site 28
S415
R
A
A
Y
T
S
A
S
F
R
H
M
S
L
L
Site 29
S420
S
A
S
F
R
H
M
S
L
L
D
I
S
S
D
Site 30
T430
D
I
S
S
D
L
A
T
D
H
L
L
G
C
D
Site 31
S442
G
C
D
L
S
I
A
S
K
H
I
S
K
P
V
Site 32
S446
S
I
A
S
K
H
I
S
K
P
V
Q
E
P
L
Site 33
Y503
N
R
F
Q
L
V
F
Y
L
S
L
S
S
T
R
Site 34
S507
L
V
F
Y
L
S
L
S
S
T
R
P
D
E
G
Site 35
S508
V
F
Y
L
S
L
S
S
T
R
P
D
E
G
L
Site 36
T509
F
Y
L
S
L
S
S
T
R
P
D
E
G
L
A
Site 37
S529
Q
L
L
E
K
E
G
S
V
T
E
M
C
V
R
Site 38
T531
L
E
K
E
G
S
V
T
E
M
C
V
R
N
I
Site 39
Y592
R
A
R
D
I
R
R
Y
L
E
T
I
L
E
I
Site 40
T595
D
I
R
R
Y
L
E
T
I
L
E
I
K
A
F
Site 41
T620
K
L
F
S
H
N
M
T
R
L
R
K
F
M
V
Site 42
Y628
R
L
R
K
F
M
V
Y
F
G
K
N
Q
S
L
Site 43
S634
V
Y
F
G
K
N
Q
S
L
Q
K
I
Q
K
T
Site 44
S669
D
D
V
A
V
F
K
S
Y
M
E
R
L
S
L
Site 45
Y670
D
V
A
V
F
K
S
Y
M
E
R
L
S
L
R
Site 46
S675
K
S
Y
M
E
R
L
S
L
R
N
K
A
T
A
Site 47
T724
V
D
E
D
E
D
L
T
M
C
L
M
S
K
F
Site 48
S729
D
L
T
M
C
L
M
S
K
F
T
A
Q
R
L
Site 49
Y740
A
Q
R
L
R
P
F
Y
R
F
L
S
P
A
F
Site 50
S744
R
P
F
Y
R
F
L
S
P
A
F
Q
E
F
L
Site 51
S762
R
L
I
E
L
L
D
S
D
R
Q
E
H
Q
D
Site 52
Y773
E
H
Q
D
L
G
L
Y
H
L
K
Q
I
N
S
Site 53
S780
Y
H
L
K
Q
I
N
S
P
M
M
T
V
S
A
Site 54
Y794
A
Y
N
N
F
L
N
Y
V
S
S
L
P
S
T
Site 55
S796
N
N
F
L
N
Y
V
S
S
L
P
S
T
K
A
Site 56
S797
N
F
L
N
Y
V
S
S
L
P
S
T
K
A
G
Site 57
S800
N
Y
V
S
S
L
P
S
T
K
A
G
P
K
I
Site 58
T801
Y
V
S
S
L
P
S
T
K
A
G
P
K
I
V
Site 59
S820
H
L
V
D
N
K
E
S
L
E
N
I
S
E
N
Site 60
Y830
N
I
S
E
N
D
D
Y
L
K
H
Q
P
E
I
Site 61
S838
L
K
H
Q
P
E
I
S
L
Q
M
Q
L
L
R
Site 62
T876
K
T
A
Y
Q
S
N
T
V
A
A
C
S
P
F
Site 63
Y902
L
G
A
L
N
L
Q
Y
F
F
D
H
P
E
S
Site 64
S909
Y
F
F
D
H
P
E
S
L
S
L
L
R
S
I
Site 65
S911
F
D
H
P
E
S
L
S
L
L
R
S
I
H
F
Site 66
T925
F
P
I
R
G
N
K
T
S
P
R
A
H
F
S
Site 67
S926
P
I
R
G
N
K
T
S
P
R
A
H
F
S
V
Site 68
S941
L
E
T
C
F
D
K
S
Q
V
P
T
I
D
Q
Site 69
Y950
V
P
T
I
D
Q
D
Y
A
S
A
F
E
P
M
Site 70
S973
E
K
E
D
N
V
K
S
Y
M
D
M
Q
R
R
Site 71
S982
M
D
M
Q
R
R
A
S
P
D
L
S
T
G
Y
Site 72
S986
R
R
A
S
P
D
L
S
T
G
Y
W
K
L
S
Site 73
T987
R
A
S
P
D
L
S
T
G
Y
W
K
L
S
P
Site 74
Y989
S
P
D
L
S
T
G
Y
W
K
L
S
P
K
Q
Site 75
S993
S
T
G
Y
W
K
L
S
P
K
Q
Y
K
I
P
Site 76
Y997
W
K
L
S
P
K
Q
Y
K
I
P
C
L
E
V
Site 77
S1043
H
S
R
G
F
I
E
S
I
R
P
A
L
E
L
Site 78
S1051
I
R
P
A
L
E
L
S
K
A
S
V
T
K
C
Site 79
T1056
E
L
S
K
A
S
V
T
K
C
S
I
S
K
L
Site 80
S1059
K
A
S
V
T
K
C
S
I
S
K
L
E
L
S
Site 81
S1085
S
L
E
S
L
E
V
S
G
T
I
Q
S
Q
D
Site 82
T1087
E
S
L
E
V
S
G
T
I
Q
S
Q
D
Q
I
Site 83
S1090
E
V
S
G
T
I
Q
S
Q
D
Q
I
F
P
N
Site 84
S1119
E
G
N
I
N
V
F
S
V
I
P
E
E
F
P
Site 85
S1139
E
K
L
L
I
Q
I
S
A
E
Y
D
P
S
K
Site 86
S1145
I
S
A
E
Y
D
P
S
K
L
V
K
L
I
Q
Site 87
T1184
L
V
S
C
K
K
L
T
E
I
K
F
S
D
S
Site 88
S1189
K
L
T
E
I
K
F
S
D
S
F
F
Q
A
V
Site 89
Y1229
E
T
S
E
K
F
A
Y
I
L
G
S
L
S
N
Site 90
S1300
K
L
E
N
L
K
L
S
I
N
H
K
I
T
E
Site 91
T1333
L
D
I
S
R
H
F
T
E
C
I
K
A
Q
A
Site 92
T1341
E
C
I
K
A
Q
A
T
T
V
K
S
L
S
Q
Site 93
S1384
M
K
E
R
H
P
Q
S
K
Y
L
T
I
L
Q
Site 94
Y1386
E
R
H
P
Q
S
K
Y
L
T
I
L
Q
K
W
Site 95
T1388
H
P
Q
S
K
Y
L
T
I
L
Q
K
W
I
L
Site 96
S1398
Q
K
W
I
L
P
F
S
P
I
I
Q
K
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation