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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TTC10
Full Name:
Intraflagellar transport protein 88 homolog
Alias:
D13S1056E; HTg737; IFT88; Intraflagellar transport 88; Intraflagellar transport 88 homolog; Intraflagellar transport 88 homolog (Chlamydomonas); MGC26259; Polaris; Recessive polycystic kidney disease protein Tg737; Tetratricopeptide repeat domain 10; Tetratricopeptide repeat protein 10; TG737; TPR repeat protein 10
Type:
Unknown function
Mass (Da):
93068
Number AA:
824
UniProt ID:
Q13099
International Prot ID:
IPI00646878
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007588
Phosida
TranscriptoNet
STRING
Kinexus Products
Tetratricopeptide repeat domain 10 pan-specific antibody AB-NN377-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NN377-1
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y26
E
T
D
E
D
D
L
Y
S
G
Y
N
D
Y
N
Site 2
Y29
E
D
D
L
Y
S
G
Y
N
D
Y
N
P
I
Y
Site 3
Y32
L
Y
S
G
Y
N
D
Y
N
P
I
Y
D
I
E
Site 4
Y36
Y
N
D
Y
N
P
I
Y
D
I
E
E
L
E
N
Site 5
S54
F
Q
Q
A
V
R
T
S
H
G
R
R
P
P
I
Site 6
T62
H
G
R
R
P
P
I
T
A
K
I
S
S
T
A
Site 7
S66
P
P
I
T
A
K
I
S
S
T
A
V
T
R
P
Site 8
T71
K
I
S
S
T
A
V
T
R
P
I
A
T
G
Y
Site 9
Y78
T
R
P
I
A
T
G
Y
G
S
K
T
S
L
A
Site 10
S80
P
I
A
T
G
Y
G
S
K
T
S
L
A
S
S
Site 11
T82
A
T
G
Y
G
S
K
T
S
L
A
S
S
I
G
Site 12
S83
T
G
Y
G
S
K
T
S
L
A
S
S
I
G
R
Site 13
S86
G
S
K
T
S
L
A
S
S
I
G
R
P
M
T
Site 14
S87
S
K
T
S
L
A
S
S
I
G
R
P
M
T
G
Site 15
T93
S
S
I
G
R
P
M
T
G
A
I
Q
D
G
V
Site 16
S120
T
K
A
A
L
R
G
S
A
F
D
P
L
S
Q
Site 17
S126
G
S
A
F
D
P
L
S
Q
S
R
G
P
A
S
Site 18
S128
A
F
D
P
L
S
Q
S
R
G
P
A
S
P
L
Site 19
S133
S
Q
S
R
G
P
A
S
P
L
E
A
K
K
K
Site 20
S142
L
E
A
K
K
K
D
S
P
E
E
K
I
K
Q
Site 21
T196
R
Q
R
E
Q
V
T
T
P
E
N
I
N
L
D
Site 22
S217
F
N
L
A
S
Q
Y
S
V
N
E
M
Y
A
E
Site 23
Y252
K
M
N
M
G
N
I
Y
L
K
Q
R
N
Y
S
Site 24
Y258
I
Y
L
K
Q
R
N
Y
S
K
A
I
K
F
Y
Site 25
S274
M
A
L
D
Q
V
P
S
V
N
K
Q
M
R
I
Site 26
Y304
Y
S
D
A
I
N
S
Y
E
H
I
M
S
M
A
Site 27
Y352
L
E
I
D
E
D
K
Y
I
S
P
S
D
D
P
Site 28
S354
I
D
E
D
K
Y
I
S
P
S
D
D
P
H
T
Site 29
S356
E
D
K
Y
I
S
P
S
D
D
P
H
T
N
L
Site 30
T361
S
P
S
D
D
P
H
T
N
L
V
T
E
A
I
Site 31
Y387
R
K
A
M
A
E
K
Y
I
M
T
S
A
K
L
Site 32
Y419
E
V
V
K
A
S
Q
Y
V
E
L
A
N
D
L
Site 33
Y434
E
I
N
K
A
V
T
Y
L
R
Q
K
D
Y
N
Site 34
Y440
T
Y
L
R
Q
K
D
Y
N
Q
A
V
E
I
L
Site 35
S455
K
V
L
E
K
K
D
S
R
V
K
S
A
A
A
Site 36
S459
K
K
D
S
R
V
K
S
A
A
A
T
N
L
S
Site 37
Y470
T
N
L
S
A
L
Y
Y
M
G
K
D
F
A
Q
Site 38
S488
Y
A
D
I
A
V
N
S
D
R
Y
N
P
A
A
Site 39
Y491
I
A
V
N
S
D
R
Y
N
P
A
A
L
T
N
Site 40
T502
A
L
T
N
K
G
N
T
V
F
A
N
G
D
Y
Site 41
Y509
T
V
F
A
N
G
D
Y
E
K
A
A
E
F
Y
Site 42
S524
K
E
A
L
R
N
D
S
S
C
T
E
A
L
Y
Site 43
S525
E
A
L
R
N
D
S
S
C
T
E
A
L
Y
N
Site 44
Y531
S
S
C
T
E
A
L
Y
N
I
G
L
T
Y
E
Site 45
Y565
R
N
S
A
E
V
L
Y
Q
I
A
N
I
Y
E
Site 46
S599
P
T
D
P
Q
V
L
S
K
L
G
E
L
Y
D
Site 47
Y605
L
S
K
L
G
E
L
Y
D
R
E
G
D
K
S
Site 48
Y617
D
K
S
Q
A
F
Q
Y
Y
Y
E
S
Y
R
Y
Site 49
Y618
K
S
Q
A
F
Q
Y
Y
Y
E
S
Y
R
Y
F
Site 50
Y619
S
Q
A
F
Q
Y
Y
Y
E
S
Y
R
Y
F
P
Site 51
Y624
Y
Y
Y
E
S
Y
R
Y
F
P
C
N
I
E
V
Site 52
Y651
F
W
E
K
A
I
Q
Y
F
E
R
A
S
L
I
Site 53
S656
I
Q
Y
F
E
R
A
S
L
I
Q
P
T
Q
V
Site 54
S676
V
A
S
C
F
R
R
S
G
N
Y
Q
K
A
L
Site 55
T685
N
Y
Q
K
A
L
D
T
Y
K
D
T
H
R
K
Site 56
Y686
Y
Q
K
A
L
D
T
Y
K
D
T
H
R
K
F
Site 57
T689
A
L
D
T
Y
K
D
T
H
R
K
F
P
E
N
Site 58
Y718
G
L
K
D
A
Q
E
Y
A
R
K
L
K
R
L
Site 59
S738
I
R
E
Q
R
I
K
S
G
R
D
G
S
G
G
Site 60
S743
I
K
S
G
R
D
G
S
G
G
S
R
G
K
R
Site 61
S746
G
R
D
G
S
G
G
S
R
G
K
R
E
G
S
Site 62
S753
S
R
G
K
R
E
G
S
A
S
G
D
S
G
Q
Site 63
S755
G
K
R
E
G
S
A
S
G
D
S
G
Q
N
Y
Site 64
S758
E
G
S
A
S
G
D
S
G
Q
N
Y
S
A
S
Site 65
Y762
S
G
D
S
G
Q
N
Y
S
A
S
S
K
G
E
Site 66
S763
G
D
S
G
Q
N
Y
S
A
S
S
K
G
E
R
Site 67
S765
S
G
Q
N
Y
S
A
S
S
K
G
E
R
L
S
Site 68
S766
G
Q
N
Y
S
A
S
S
K
G
E
R
L
S
A
Site 69
S772
S
S
K
G
E
R
L
S
A
R
L
R
A
L
P
Site 70
T781
R
L
R
A
L
P
G
T
N
E
P
Y
E
S
S
Site 71
Y785
L
P
G
T
N
E
P
Y
E
S
S
S
N
K
E
Site 72
S787
G
T
N
E
P
Y
E
S
S
S
N
K
E
I
D
Site 73
S796
S
N
K
E
I
D
A
S
Y
V
D
P
L
G
P
Site 74
Y797
N
K
E
I
D
A
S
Y
V
D
P
L
G
P
Q
Site 75
T810
P
Q
I
E
R
P
K
T
A
A
K
K
R
I
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation