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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
USP4
Full Name:
Ubiquitin carboxyl-terminal hydrolase 4
Alias:
Deubiquitinating enzyme 4; Ubiquitin specific peptidase 4 (proto-oncogene); Ubiquitin thioesterase 4; Ubiquitin-specific-processing protease 4; Ubiquitous nuclear protein homolog; UBP4; UNP; UNPH
Type:
EC 3.1.2.15; Protease; Ubiquitin conjugating system
Mass (Da):
108565
Number AA:
963
UniProt ID:
Q13107
International Prot ID:
IPI00011836
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005764
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0004197
GO:0005515
GO:0004221
PhosphoSite+
KinaseNET
Biological Process:
GO:0006511
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T15
R
E
R
P
D
A
E
T
Q
K
S
E
L
G
P
Site 2
S18
P
D
A
E
T
Q
K
S
E
L
G
P
L
M
R
Site 3
T27
L
G
P
L
M
R
T
T
L
Q
R
G
A
Q
W
Site 4
Y35
L
Q
R
G
A
Q
W
Y
L
I
D
S
R
W
F
Site 5
Y57
G
F
D
S
W
D
M
Y
N
V
G
E
H
N
L
Site 6
S72
F
P
G
P
I
D
N
S
G
L
F
S
D
P
E
Site 7
S76
I
D
N
S
G
L
F
S
D
P
E
S
Q
T
L
Site 8
S80
G
L
F
S
D
P
E
S
Q
T
L
K
E
H
L
Site 9
T82
F
S
D
P
E
S
Q
T
L
K
E
H
L
I
D
Site 10
Y108
W
N
K
L
L
N
W
Y
G
C
V
E
G
Q
Q
Site 11
Y136
K
H
C
K
V
E
V
Y
L
L
E
L
K
L
C
Site 12
S146
E
L
K
L
C
E
N
S
D
P
T
N
V
L
S
Site 13
S153
S
D
P
T
N
V
L
S
C
H
F
S
K
A
D
Site 14
T161
C
H
F
S
K
A
D
T
I
A
T
I
E
K
E
Site 15
Y187
E
T
R
L
W
N
K
Y
M
S
N
T
Y
E
Q
Site 16
Y192
N
K
Y
M
S
N
T
Y
E
Q
L
S
K
L
D
Site 17
S196
S
N
T
Y
E
Q
L
S
K
L
D
N
T
V
Q
Site 18
T201
Q
L
S
K
L
D
N
T
V
Q
D
A
G
L
Y
Site 19
T223
E
P
Q
N
E
D
G
T
W
P
R
Q
T
L
Q
Site 20
T228
D
G
T
W
P
R
Q
T
L
Q
S
K
S
S
T
Site 21
S231
W
P
R
Q
T
L
Q
S
K
S
S
T
A
P
S
Site 22
S233
R
Q
T
L
Q
S
K
S
S
T
A
P
S
R
N
Site 23
S234
Q
T
L
Q
S
K
S
S
T
A
P
S
R
N
F
Site 24
T235
T
L
Q
S
K
S
S
T
A
P
S
R
N
F
T
Site 25
S238
S
K
S
S
T
A
P
S
R
N
F
T
T
S
P
Site 26
T242
T
A
P
S
R
N
F
T
T
S
P
K
S
S
A
Site 27
T243
A
P
S
R
N
F
T
T
S
P
K
S
S
A
S
Site 28
S244
P
S
R
N
F
T
T
S
P
K
S
S
A
S
P
Site 29
S247
N
F
T
T
S
P
K
S
S
A
S
P
Y
S
S
Site 30
S248
F
T
T
S
P
K
S
S
A
S
P
Y
S
S
V
Site 31
S250
T
S
P
K
S
S
A
S
P
Y
S
S
V
S
A
Site 32
Y252
P
K
S
S
A
S
P
Y
S
S
V
S
A
S
L
Site 33
S253
K
S
S
A
S
P
Y
S
S
V
S
A
S
L
I
Site 34
S258
P
Y
S
S
V
S
A
S
L
I
A
N
G
D
S
Site 35
S265
S
L
I
A
N
G
D
S
T
S
T
C
G
M
H
Site 36
T266
L
I
A
N
G
D
S
T
S
T
C
G
M
H
S
Site 37
S267
I
A
N
G
D
S
T
S
T
C
G
M
H
S
S
Site 38
S273
T
S
T
C
G
M
H
S
S
G
V
S
R
G
G
Site 39
S274
S
T
C
G
M
H
S
S
G
V
S
R
G
G
S
Site 40
S277
G
M
H
S
S
G
V
S
R
G
G
S
G
F
S
Site 41
S281
S
G
V
S
R
G
G
S
G
F
S
A
S
Y
N
Site 42
S284
S
R
G
G
S
G
F
S
A
S
Y
N
C
Q
E
Site 43
S286
G
G
S
G
F
S
A
S
Y
N
C
Q
E
P
P
Site 44
Y287
G
S
G
F
S
A
S
Y
N
C
Q
E
P
P
S
Site 45
S294
Y
N
C
Q
E
P
P
S
S
H
I
Q
P
G
L
Site 46
S295
N
C
Q
E
P
P
S
S
H
I
Q
P
G
L
C
Site 47
S321
N
S
A
L
Q
C
L
S
N
T
A
P
L
T
D
Site 48
T327
L
S
N
T
A
P
L
T
D
Y
F
L
K
D
E
Site 49
Y329
N
T
A
P
L
T
D
Y
F
L
K
D
E
Y
E
Site 50
Y335
D
Y
F
L
K
D
E
Y
E
A
E
I
N
R
D
Site 51
Y355
K
G
E
I
A
E
A
Y
A
E
L
I
K
Q
M
Site 52
T377
V
A
P
R
M
F
K
T
Q
V
G
R
F
A
P
Site 53
Y389
F
A
P
Q
F
S
G
Y
Q
Q
Q
D
S
Q
E
Site 54
S394
S
G
Y
Q
Q
Q
D
S
Q
E
L
L
A
F
L
Site 55
S445
N
H
R
L
R
N
D
S
V
I
V
D
T
F
H
Site 56
T450
N
D
S
V
I
V
D
T
F
H
G
L
F
K
S
Site 57
T458
F
H
G
L
F
K
S
T
L
V
C
P
E
C
A
Site 58
Y476
V
T
F
D
P
F
C
Y
L
T
L
P
L
P
L
Site 59
T503
A
D
P
H
C
R
P
T
Q
Y
R
V
T
V
P
Site 60
Y505
P
H
C
R
P
T
Q
Y
R
V
T
V
P
L
M
Site 61
Y539
N
M
V
V
A
D
V
Y
N
H
R
F
H
K
I
Site 62
Y583
E
C
V
T
L
P
V
Y
F
R
E
R
K
S
R
Site 63
S589
V
Y
F
R
E
R
K
S
R
P
S
S
T
S
S
Site 64
S592
R
E
R
K
S
R
P
S
S
T
S
S
A
S
A
Site 65
S593
E
R
K
S
R
P
S
S
T
S
S
A
S
A
L
Site 66
T594
R
K
S
R
P
S
S
T
S
S
A
S
A
L
Y
Site 67
S595
K
S
R
P
S
S
T
S
S
A
S
A
L
Y
G
Site 68
S596
S
R
P
S
S
T
S
S
A
S
A
L
Y
G
Q
Site 69
S598
P
S
S
T
S
S
A
S
A
L
Y
G
Q
P
L
Site 70
S608
Y
G
Q
P
L
L
L
S
V
P
K
H
K
L
T
Site 71
T615
S
V
P
K
H
K
L
T
L
E
S
L
Y
Q
A
Site 72
S628
Q
A
V
C
D
R
I
S
R
Y
V
K
Q
P
L
Site 73
Y630
V
C
D
R
I
S
R
Y
V
K
Q
P
L
P
D
Site 74
S641
P
L
P
D
E
F
G
S
S
P
L
E
P
G
A
Site 75
S642
L
P
D
E
F
G
S
S
P
L
E
P
G
A
C
Site 76
S652
E
P
G
A
C
N
G
S
R
N
S
C
E
G
E
Site 77
S655
A
C
N
G
S
R
N
S
C
E
G
E
D
E
E
Site 78
S675
E
E
G
K
E
Q
L
S
E
T
E
G
S
G
E
Site 79
S680
Q
L
S
E
T
E
G
S
G
E
D
E
P
G
N
Site 80
S690
D
E
P
G
N
D
P
S
E
T
T
Q
K
K
I
Site 81
T708
P
C
P
K
R
L
F
T
F
S
L
V
N
S
Y
Site 82
S710
P
K
R
L
F
T
F
S
L
V
N
S
Y
G
T
Site 83
S722
Y
G
T
A
D
I
N
S
L
A
A
D
G
K
L
Site 84
S734
G
K
L
L
K
L
N
S
R
S
T
L
A
M
D
Site 85
T737
L
K
L
N
S
R
S
T
L
A
M
D
W
D
S
Site 86
T746
A
M
D
W
D
S
E
T
R
R
L
Y
Y
D
E
Site 87
Y750
D
S
E
T
R
R
L
Y
Y
D
E
Q
E
S
E
Site 88
Y751
S
E
T
R
R
L
Y
Y
D
E
Q
E
S
E
A
Site 89
Y759
D
E
Q
E
S
E
A
Y
E
K
H
V
S
M
L
Site 90
S764
E
A
Y
E
K
H
V
S
M
L
Q
P
Q
K
K
Site 91
T775
P
Q
K
K
K
K
T
T
V
A
L
R
D
C
I
Site 92
T787
D
C
I
E
L
F
T
T
M
E
T
L
G
E
H
Site 93
Y830
V
H
L
K
R
F
S
Y
N
R
Y
W
R
D
K
Site 94
Y833
K
R
F
S
Y
N
R
Y
W
R
D
K
L
D
T
Site 95
T840
Y
W
R
D
K
L
D
T
V
V
E
F
P
I
R
Site 96
S859
S
E
F
V
C
N
L
S
A
R
P
Y
V
Y
D
Site 97
Y863
C
N
L
S
A
R
P
Y
V
Y
D
L
I
A
V
Site 98
Y885
G
V
G
H
Y
T
A
Y
A
K
N
K
L
N
G
Site 99
Y895
N
K
L
N
G
K
W
Y
Y
F
D
D
S
N
V
Site 100
Y896
K
L
N
G
K
W
Y
Y
F
D
D
S
N
V
S
Site 101
S900
K
W
Y
Y
F
D
D
S
N
V
S
L
A
S
E
Site 102
S903
Y
F
D
D
S
N
V
S
L
A
S
E
D
Q
I
Site 103
Y916
Q
I
V
T
K
A
A
Y
V
L
F
Y
Q
R
R
Site 104
Y920
K
A
A
Y
V
L
F
Y
Q
R
R
D
D
E
F
Site 105
Y928
Q
R
R
D
D
E
F
Y
K
T
P
S
L
S
S
Site 106
T930
R
D
D
E
F
Y
K
T
P
S
L
S
S
S
G
Site 107
S932
D
E
F
Y
K
T
P
S
L
S
S
S
G
S
S
Site 108
S934
F
Y
K
T
P
S
L
S
S
S
G
S
S
D
G
Site 109
S935
Y
K
T
P
S
L
S
S
S
G
S
S
D
G
G
Site 110
S936
K
T
P
S
L
S
S
S
G
S
S
D
G
G
T
Site 111
S938
P
S
L
S
S
S
G
S
S
D
G
G
T
R
P
Site 112
S939
S
L
S
S
S
G
S
S
D
G
G
T
R
P
S
Site 113
T943
S
G
S
S
D
G
G
T
R
P
S
S
S
Q
Q
Site 114
S946
S
D
G
G
T
R
P
S
S
S
Q
Q
G
F
G
Site 115
S947
D
G
G
T
R
P
S
S
S
Q
Q
G
F
G
D
Site 116
S948
G
G
T
R
P
S
S
S
Q
Q
G
F
G
D
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation