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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MKP-2
Full Name:
Dual specificity protein phosphatase 4
Alias:
Dual specificity protein phosphatase hVH2; DUS4; DUSP4; EC 3.1.3.16; EC 3.1.3.48; MAP kinase phosphatase-2; Mitogen-activated protein kinase phosphatase-2; MKP2; VH2; VH2/TYP1
Type:
Nucleus protein
Mass (Da):
42953
Number AA:
394
UniProt ID:
Q13115
International Prot ID:
IPI00011860
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005654
Uniprot
OncoNet
Molecular Function:
GO:0017017
GO:0004725
GO:0008330
PhosphoSite+
KinaseNET
Biological Process:
GO:0000165
GO:0006470
Phosida
TranscriptoNet
STRING
Kinexus Products
Dual specificity protein phosphatase 4 pan-specific antibody AB-NP007-2#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NP007-2#Dual specificity protein phosphatase 4 pan-specific antibody AB-NP007-3#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NP007-3#Dual specificity protein phosphatase 4 pan-specific antibody AB-NP007-4#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NP007-4#Dual specificity protein phosphatase 4 (C12-G25, human) peptide - Powder PE-01BAU90#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01BAU90#Dual specificity protein phosphatase 4 (K78-E92, human) peptide - Powder PE-01BAV95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01BAV95#Dual specificity protein phosphatase 4 (S257-D271, human) peptide - Powder PE-01BAW85#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01BAW85
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
E
L
R
E
M
D
C
S
V
L
K
R
L
M
N
Site 2
S31
N
G
G
G
A
G
G
S
G
S
H
G
T
L
G
Site 3
S33
G
G
A
G
G
S
G
S
H
G
T
L
G
L
P
Site 4
T36
G
G
S
G
S
H
G
T
L
G
L
P
S
G
G
Site 5
Y60
F
L
A
H
S
A
G
Y
I
L
G
S
V
N
V
Site 6
S64
S
A
G
Y
I
L
G
S
V
N
V
R
C
N
T
Site 7
T71
S
V
N
V
R
C
N
T
I
V
R
R
R
A
K
Site 8
S80
V
R
R
R
A
K
G
S
V
S
L
E
Q
I
L
Site 9
S82
R
R
A
K
G
S
V
S
L
E
Q
I
L
P
A
Site 10
Y102
A
R
L
R
S
G
L
Y
S
A
V
I
V
Y
D
Site 11
S103
R
L
R
S
G
L
Y
S
A
V
I
V
Y
D
E
Site 12
Y108
L
Y
S
A
V
I
V
Y
D
E
R
S
P
R
A
Site 13
S112
V
I
V
Y
D
E
R
S
P
R
A
E
S
L
R
Site 14
S117
E
R
S
P
R
A
E
S
L
R
E
D
S
T
V
Site 15
S122
A
E
S
L
R
E
D
S
T
V
S
L
V
V
Q
Site 16
T123
E
S
L
R
E
D
S
T
V
S
L
V
V
Q
A
Site 17
T138
L
R
R
N
A
E
R
T
D
I
C
L
L
K
G
Site 18
Y147
I
C
L
L
K
G
G
Y
E
R
F
S
S
E
Y
Site 19
S151
K
G
G
Y
E
R
F
S
S
E
Y
P
E
F
C
Site 20
S152
G
G
Y
E
R
F
S
S
E
Y
P
E
F
C
S
Site 21
Y154
Y
E
R
F
S
S
E
Y
P
E
F
C
S
K
T
Site 22
S159
S
E
Y
P
E
F
C
S
K
T
K
A
L
A
A
Site 23
S174
I
P
P
P
V
P
P
S
A
T
E
P
L
D
L
Site 24
S184
E
P
L
D
L
G
C
S
S
C
G
T
P
L
H
Site 25
S185
P
L
D
L
G
C
S
S
C
G
T
P
L
H
D
Site 26
T188
L
G
C
S
S
C
G
T
P
L
H
D
Q
G
G
Site 27
S230
T
A
L
L
N
V
S
S
D
C
P
N
H
F
E
Site 28
Y240
P
N
H
F
E
G
H
Y
Q
Y
K
C
I
P
V
Site 29
S315
E
F
V
K
Q
R
R
S
I
I
S
P
N
F
S
Site 30
S318
K
Q
R
R
S
I
I
S
P
N
F
S
F
M
G
Site 31
S345
S
C
A
A
E
A
A
S
P
S
G
P
L
R
E
Site 32
T356
P
L
R
E
R
G
K
T
P
A
T
P
T
S
Q
Site 33
T359
E
R
G
K
T
P
A
T
P
T
S
Q
F
V
F
Site 34
S362
K
T
P
A
T
P
T
S
Q
F
V
F
S
F
P
Site 35
S379
V
G
V
H
S
A
P
S
S
L
P
Y
L
H
S
Site 36
S380
G
V
H
S
A
P
S
S
L
P
Y
L
H
S
P
Site 37
Y383
S
A
P
S
S
L
P
Y
L
H
S
P
I
T
T
Site 38
S386
S
S
L
P
Y
L
H
S
P
I
T
T
S
P
S
Site 39
S391
L
H
S
P
I
T
T
S
P
S
C
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation