KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
IK
Full Name:
Protein Red
Alias:
Chondrosarcoma-associated protein 2; CSA2; Cytokine IK; IK cytokine, down-regulator of HLA II; IK factor; Prer protein; RD element; Red; RER
Type:
Cytokine
Mass (Da):
65630
Number AA:
557
UniProt ID:
Q13123
International Prot ID:
IPI00011875
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005615
GO:0005634
GO:0005625
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0007267
GO:0006955
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
P
E
R
D
S
E
P
F
S
N
P
L
Site 2
S10
E
R
D
S
E
P
F
S
N
P
L
A
P
D
G
Site 3
S25
H
D
V
D
D
P
H
S
F
H
Q
S
K
L
T
Site 4
S29
D
P
H
S
F
H
Q
S
K
L
T
N
E
D
F
Site 5
T32
S
F
H
Q
S
K
L
T
N
E
D
F
R
K
L
Site 6
T42
D
F
R
K
L
L
M
T
P
R
A
A
P
T
S
Site 7
S49
T
P
R
A
A
P
T
S
A
P
P
S
K
S
R
Site 8
S53
A
P
T
S
A
P
P
S
K
S
R
H
H
E
M
Site 9
S55
T
S
A
P
P
S
K
S
R
H
H
E
M
P
R
Site 10
Y64
H
H
E
M
P
R
E
Y
N
E
D
E
D
P
A
Site 11
S79
A
R
R
R
K
K
K
S
Y
Y
A
K
L
R
Q
Site 12
Y80
R
R
R
K
K
K
S
Y
Y
A
K
L
R
Q
Q
Site 13
Y99
E
R
E
L
A
E
K
Y
R
D
R
A
K
E
R
Site 14
Y114
R
D
G
V
N
K
D
Y
E
E
T
E
L
I
S
Site 15
T117
V
N
K
D
Y
E
E
T
E
L
I
S
T
T
A
Site 16
T122
E
E
T
E
L
I
S
T
T
A
N
Y
R
A
V
Site 17
S138
P
T
A
E
A
D
K
S
A
A
E
K
R
R
Q
Site 18
S150
R
R
Q
L
I
Q
E
S
K
F
L
G
G
D
M
Site 19
T160
L
G
G
D
M
E
H
T
H
L
V
K
G
L
D
Site 20
S180
K
V
R
L
E
I
A
S
K
D
K
E
E
E
E
Site 21
Y217
T
R
L
G
R
N
V
Y
R
M
L
F
K
S
K
Site 22
S223
V
Y
R
M
L
F
K
S
K
A
Y
E
R
N
E
Site 23
Y226
M
L
F
K
S
K
A
Y
E
R
N
E
L
F
L
Site 24
Y247
V
V
D
L
D
D
E
Y
A
D
T
D
I
P
T
Site 25
T250
L
D
D
E
Y
A
D
T
D
I
P
T
T
L
I
Site 26
T255
A
D
T
D
I
P
T
T
L
I
R
S
K
A
D
Site 27
S259
I
P
T
T
L
I
R
S
K
A
D
C
P
T
M
Site 28
T265
R
S
K
A
D
C
P
T
M
E
A
Q
T
T
L
Site 29
T270
C
P
T
M
E
A
Q
T
T
L
T
T
N
D
I
Site 30
T271
P
T
M
E
A
Q
T
T
L
T
T
N
D
I
V
Site 31
S287
S
K
L
T
Q
I
L
S
Y
L
R
Q
G
T
R
Site 32
Y288
K
L
T
Q
I
L
S
Y
L
R
Q
G
T
R
N
Site 33
T293
L
S
Y
L
R
Q
G
T
R
N
K
K
L
K
K
Site 34
Y325
I
F
E
D
I
G
D
Y
V
P
S
T
T
K
T
Site 35
S328
D
I
G
D
Y
V
P
S
T
T
K
T
P
R
D
Site 36
T329
I
G
D
Y
V
P
S
T
T
K
T
P
R
D
K
Site 37
T330
G
D
Y
V
P
S
T
T
K
T
P
R
D
K
E
Site 38
T332
Y
V
P
S
T
T
K
T
P
R
D
K
E
R
E
Site 39
Y341
R
D
K
E
R
E
R
Y
R
E
R
E
R
D
R
Site 40
S382
E
E
E
K
K
R
H
S
Y
F
E
K
P
K
V
Site 41
Y383
E
E
K
K
R
H
S
Y
F
E
K
P
K
V
D
Site 42
S402
D
V
D
K
G
P
G
S
T
K
E
L
I
K
S
Site 43
S409
S
T
K
E
L
I
K
S
I
N
E
K
F
A
G
Site 44
S425
A
G
W
E
G
T
E
S
L
K
K
P
E
D
K
Site 45
Y449
S
N
S
Y
A
E
C
Y
P
A
T
M
D
D
M
Site 46
T452
Y
A
E
C
Y
P
A
T
M
D
D
M
A
V
D
Site 47
S460
M
D
D
M
A
V
D
S
D
E
E
V
D
Y
S
Site 48
Y466
D
S
D
E
E
V
D
Y
S
K
M
D
Q
G
N
Site 49
S467
S
D
E
E
V
D
Y
S
K
M
D
Q
G
N
K
Site 50
T485
L
G
R
W
D
F
D
T
Q
E
E
Y
S
E
Y
Site 51
Y489
D
F
D
T
Q
E
E
Y
S
E
Y
M
N
N
K
Site 52
Y492
T
Q
E
E
Y
S
E
Y
M
N
N
K
E
A
L
Site 53
Y506
L
P
K
A
A
F
Q
Y
G
I
K
M
S
E
G
Site 54
S511
F
Q
Y
G
I
K
M
S
E
G
R
K
T
R
R
Site 55
T516
K
M
S
E
G
R
K
T
R
R
F
K
E
T
N
Site 56
T522
K
T
R
R
F
K
E
T
N
D
K
A
E
L
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation