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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LXR-alpha
Full Name:
Oxysterols receptor LXR-alpha
Alias:
NR1H3; Nuclear orphan receptor LXR-alpha; Oxysterols receptor LXR-alpha
Type:
Receptor, nuclear
Mass (Da):
50396
Number AA:
447
UniProt ID:
Q13133
International Prot ID:
IPI00301894
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0043565
GO:0003707
GO:0004887
PhosphoSite+
KinaseNET
Biological Process:
GO:0010887
GO:0032369
GO:0010745
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S16
V
P
D
I
P
P
D
S
A
V
E
L
W
K
P
Site 2
S29
K
P
G
A
Q
D
A
S
S
Q
A
Q
G
G
S
Site 3
S30
P
G
A
Q
D
A
S
S
Q
A
Q
G
G
S
S
Site 4
S49
E
E
A
R
M
P
H
S
A
G
G
T
A
G
V
Site 5
S74
L
T
R
A
E
P
P
S
E
P
T
E
I
R
P
Site 6
Y110
D
K
A
S
G
F
H
Y
N
V
L
S
C
E
G
Site 7
Y132
S
V
I
K
G
A
H
Y
I
C
H
S
G
G
H
Site 8
S170
M
R
E
E
C
V
L
S
E
E
Q
I
R
L
K
Site 9
S191
E
E
Q
A
H
A
T
S
L
P
P
R
A
S
S
Site 10
S197
T
S
L
P
P
R
A
S
S
P
P
Q
I
L
P
Site 11
S198
S
L
P
P
R
A
S
S
P
P
Q
I
L
P
Q
Site 12
S228
Q
Q
Q
C
N
R
R
S
F
S
D
R
L
R
V
Site 13
S230
Q
C
N
R
R
S
F
S
D
R
L
R
V
T
P
Site 14
T236
F
S
D
R
L
R
V
T
P
W
P
M
A
P
D
Site 15
S246
P
M
A
P
D
P
H
S
R
E
A
R
Q
Q
R
Site 16
T292
D
Q
I
A
L
L
K
T
S
A
I
E
V
M
L
Site 17
S293
Q
I
A
L
L
K
T
S
A
I
E
V
M
L
L
Site 18
S303
E
V
M
L
L
E
T
S
R
R
Y
N
P
G
S
Site 19
Y306
L
L
E
T
S
R
R
Y
N
P
G
S
E
S
I
Site 20
S310
S
R
R
Y
N
P
G
S
E
S
I
T
F
L
K
Site 21
S312
R
Y
N
P
G
S
E
S
I
T
F
L
K
D
F
Site 22
T314
N
P
G
S
E
S
I
T
F
L
K
D
F
S
Y
Site 23
S320
I
T
F
L
K
D
F
S
Y
N
R
E
D
F
A
Site 24
Y321
T
F
L
K
D
F
S
Y
N
R
E
D
F
A
K
Site 25
Y385
V
E
R
L
Q
H
T
Y
V
E
A
L
H
A
Y
Site 26
Y392
Y
V
E
A
L
H
A
Y
V
S
I
H
H
P
H
Site 27
S413
R
M
L
M
K
L
V
S
L
R
T
L
S
S
V
Site 28
T416
M
K
L
V
S
L
R
T
L
S
S
V
H
S
E
Site 29
S422
R
T
L
S
S
V
H
S
E
Q
V
F
A
L
R
Site 30
S440
K
K
L
P
P
L
L
S
E
I
W
D
V
H
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation