KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
PPFIA1
Full Name:
Liprin-alpha-1
Alias:
LAR-interacting protein 1; LIP1; PPFIA; Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1
Type:
Adhesion protein
Mass (Da):
135779
Number AA:
1202
UniProt ID:
Q13136
International Prot ID:
IPI00784296
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0004871
PhosphoSite+
KinaseNET
Biological Process:
GO:0007160
GO:0007165
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S24
G
G
G
G
G
H
G
S
G
S
P
S
Q
P
D
Site 2
S26
G
G
G
H
G
S
G
S
P
S
Q
P
D
A
D
Site 3
S28
G
H
G
S
G
S
P
S
Q
P
D
A
D
S
H
Site 4
S34
P
S
Q
P
D
A
D
S
H
F
E
Q
L
M
V
Site 5
T53
E
R
D
R
L
L
D
T
L
R
E
T
Q
E
T
Site 6
T57
L
L
D
T
L
R
E
T
Q
E
T
L
A
L
T
Site 7
T60
T
L
R
E
T
Q
E
T
L
A
L
T
Q
G
K
Site 8
S77
E
V
G
H
E
R
D
S
L
Q
R
Q
L
N
T
Site 9
T121
L
K
A
E
R
N
N
T
R
L
L
L
E
H
L
Site 10
S133
E
H
L
E
C
L
V
S
R
H
E
R
S
L
R
Site 11
S138
L
V
S
R
H
E
R
S
L
R
M
T
V
V
K
Site 12
T142
H
E
R
S
L
R
M
T
V
V
K
R
Q
A
Q
Site 13
S150
V
V
K
R
Q
A
Q
S
P
A
G
V
S
S
E
Site 14
S156
Q
S
P
A
G
V
S
S
E
V
E
V
L
K
A
Site 15
S166
E
V
L
K
A
L
K
S
L
F
E
H
H
K
A
Site 16
S190
R
V
A
L
E
R
C
S
L
L
E
E
E
L
G
Site 17
T215
E
Q
N
N
Q
K
K
T
L
T
D
G
V
L
D
Site 18
T230
I
N
H
E
Q
E
N
T
P
S
T
S
G
K
R
Site 19
S232
H
E
Q
E
N
T
P
S
T
S
G
K
R
S
S
Site 20
T233
E
Q
E
N
T
P
S
T
S
G
K
R
S
S
D
Site 21
S234
Q
E
N
T
P
S
T
S
G
K
R
S
S
D
G
Site 22
S238
P
S
T
S
G
K
R
S
S
D
G
S
L
S
H
Site 23
S239
S
T
S
G
K
R
S
S
D
G
S
L
S
H
E
Site 24
S242
G
K
R
S
S
D
G
S
L
S
H
E
E
D
L
Site 25
S244
R
S
S
D
G
S
L
S
H
E
E
D
L
A
K
Site 26
S260
I
E
L
Q
E
I
I
S
K
Q
S
R
E
Q
S
Site 27
S267
S
K
Q
S
R
E
Q
S
Q
M
K
E
R
L
A
Site 28
S275
Q
M
K
E
R
L
A
S
L
S
S
H
V
T
E
Site 29
S277
K
E
R
L
A
S
L
S
S
H
V
T
E
L
E
Site 30
S278
E
R
L
A
S
L
S
S
H
V
T
E
L
E
E
Site 31
T281
A
S
L
S
S
H
V
T
E
L
E
E
D
L
D
Site 32
T289
E
L
E
E
D
L
D
T
A
R
K
D
L
I
K
Site 33
S297
A
R
K
D
L
I
K
S
E
E
M
N
T
K
L
Site 34
T302
I
K
S
E
E
M
N
T
K
L
Q
R
D
V
R
Site 35
T323
E
D
M
E
E
R
I
T
T
L
E
K
R
Y
L
Site 36
T324
D
M
E
E
R
I
T
T
L
E
K
R
Y
L
A
Site 37
T337
L
A
A
Q
R
E
A
T
S
V
H
D
L
N
D
Site 38
T360
K
D
S
M
H
R
Q
T
E
D
K
N
R
Q
L
Site 39
S403
A
Q
R
V
A
A
L
S
K
A
E
E
R
H
G
Site 40
S448
E
E
H
N
K
R
L
S
D
T
V
D
K
L
L
Site 41
T450
H
N
K
R
L
S
D
T
V
D
K
L
L
S
E
Site 42
S456
D
T
V
D
K
L
L
S
E
S
N
E
R
L
Q
Site 43
S478
A
A
L
E
D
K
N
S
L
L
R
E
V
E
S
Site 44
S485
S
L
L
R
E
V
E
S
A
K
K
Q
L
E
E
Site 45
S520
H
M
R
L
R
G
A
S
L
H
H
G
R
P
H
Site 46
S530
H
G
R
P
H
L
G
S
V
P
D
F
R
F
P
Site 47
T543
F
P
M
A
D
G
H
T
D
S
Y
S
T
S
A
Site 48
S545
M
A
D
G
H
T
D
S
Y
S
T
S
A
V
L
Site 49
Y546
A
D
G
H
T
D
S
Y
S
T
S
A
V
L
R
Site 50
S547
D
G
H
T
D
S
Y
S
T
S
A
V
L
R
R
Site 51
T548
G
H
T
D
S
Y
S
T
S
A
V
L
R
R
P
Site 52
S549
H
T
D
S
Y
S
T
S
A
V
L
R
R
P
Q
Site 53
S568
A
A
L
R
D
E
P
S
K
V
Q
T
L
N
E
Site 54
T572
D
E
P
S
K
V
Q
T
L
N
E
Q
D
W
E
Site 55
S585
W
E
R
A
Q
Q
A
S
V
L
A
N
V
A
Q
Site 56
S596
N
V
A
Q
A
F
E
S
D
A
D
V
S
D
G
Site 57
S601
F
E
S
D
A
D
V
S
D
G
E
D
D
R
D
Site 58
T609
D
G
E
D
D
R
D
T
L
L
S
S
V
D
L
Site 59
S612
D
D
R
D
T
L
L
S
S
V
D
L
L
S
P
Site 60
S613
D
R
D
T
L
L
S
S
V
D
L
L
S
P
S
Site 61
S618
L
S
S
V
D
L
L
S
P
S
G
Q
A
D
A
Site 62
S620
S
V
D
L
L
S
P
S
G
Q
A
D
A
H
T
Site 63
T627
S
G
Q
A
D
A
H
T
L
A
M
M
L
Q
E
Site 64
T653
I
Q
E
E
K
E
N
T
E
Q
R
A
E
E
I
Site 65
S662
Q
R
A
E
E
I
E
S
R
V
G
S
G
S
L
Site 66
S666
E
I
E
S
R
V
G
S
G
S
L
D
N
L
G
Site 67
S668
E
S
R
V
G
S
G
S
L
D
N
L
G
R
F
Site 68
S677
D
N
L
G
R
F
R
S
M
S
S
I
P
P
Y
Site 69
S679
L
G
R
F
R
S
M
S
S
I
P
P
Y
P
A
Site 70
S680
G
R
F
R
S
M
S
S
I
P
P
Y
P
A
S
Site 71
Y684
S
M
S
S
I
P
P
Y
P
A
S
S
L
A
S
Site 72
S687
S
I
P
P
Y
P
A
S
S
L
A
S
S
S
P
Site 73
S688
I
P
P
Y
P
A
S
S
L
A
S
S
S
P
P
Site 74
S691
Y
P
A
S
S
L
A
S
S
S
P
P
G
S
G
Site 75
S692
P
A
S
S
L
A
S
S
S
P
P
G
S
G
R
Site 76
S693
A
S
S
L
A
S
S
S
P
P
G
S
G
R
S
Site 77
S697
A
S
S
S
P
P
G
S
G
R
S
T
P
R
R
Site 78
S700
S
P
P
G
S
G
R
S
T
P
R
R
I
P
H
Site 79
T701
P
P
G
S
G
R
S
T
P
R
R
I
P
H
S
Site 80
S708
T
P
R
R
I
P
H
S
P
A
R
E
V
D
R
Site 81
T720
V
D
R
L
G
V
M
T
L
L
P
P
S
R
E
Site 82
S725
V
M
T
L
L
P
P
S
R
E
E
V
R
D
D
Site 83
T734
E
E
V
R
D
D
K
T
T
I
K
C
E
T
S
Site 84
T735
E
V
R
D
D
K
T
T
I
K
C
E
T
S
P
Site 85
T740
K
T
T
I
K
C
E
T
S
P
P
S
S
P
R
Site 86
S741
T
T
I
K
C
E
T
S
P
P
S
S
P
R
A
Site 87
S744
K
C
E
T
S
P
P
S
S
P
R
A
L
R
L
Site 88
S745
C
E
T
S
P
P
S
S
P
R
A
L
R
L
D
Site 89
T761
L
H
K
G
A
L
H
T
V
S
H
E
D
I
R
Site 90
S763
K
G
A
L
H
T
V
S
H
E
D
I
R
D
I
Site 91
S773
D
I
R
D
I
R
N
S
T
G
S
Q
D
G
P
Site 92
T774
I
R
D
I
R
N
S
T
G
S
Q
D
G
P
V
Site 93
S776
D
I
R
N
S
T
G
S
Q
D
G
P
V
S
N
Site 94
S782
G
S
Q
D
G
P
V
S
N
P
S
S
S
N
S
Site 95
S785
D
G
P
V
S
N
P
S
S
S
N
S
S
Q
D
Site 96
S786
G
P
V
S
N
P
S
S
S
N
S
S
Q
D
S
Site 97
S787
P
V
S
N
P
S
S
S
N
S
S
Q
D
S
L
Site 98
S789
S
N
P
S
S
S
N
S
S
Q
D
S
L
H
K
Site 99
S790
N
P
S
S
S
N
S
S
Q
D
S
L
H
K
A
Site 100
S793
S
S
N
S
S
Q
D
S
L
H
K
A
P
K
K
Site 101
S805
P
K
K
K
G
I
K
S
S
I
G
R
L
F
G
Site 102
S806
K
K
K
G
I
K
S
S
I
G
R
L
F
G
K
Site 103
S833
A
L
G
Q
A
G
V
S
E
T
D
N
S
S
Q
Site 104
S838
G
V
S
E
T
D
N
S
S
Q
D
A
L
G
L
Site 105
S839
V
S
E
T
D
N
S
S
Q
D
A
L
G
L
S
Site 106
S846
S
Q
D
A
L
G
L
S
K
L
G
G
Q
A
E
Site 107
S915
G
A
I
M
S
A
L
S
D
T
E
I
Q
R
E
Site 108
S926
I
Q
R
E
I
G
I
S
N
P
L
H
R
L
K
Site 109
S946
Q
E
I
M
S
L
T
S
P
S
A
P
P
T
S
Site 110
S948
I
M
S
L
T
S
P
S
A
P
P
T
S
R
T
Site 111
T952
T
S
P
S
A
P
P
T
S
R
T
T
L
A
Y
Site 112
S953
S
P
S
A
P
P
T
S
R
T
T
L
A
Y
G
Site 113
T956
A
P
P
T
S
R
T
T
L
A
Y
G
D
M
N
Site 114
Y959
T
S
R
T
T
L
A
Y
G
D
M
N
H
E
W
Site 115
S974
I
G
N
E
W
L
P
S
L
G
L
P
Q
Y
R
Site 116
Y980
P
S
L
G
L
P
Q
Y
R
S
Y
F
M
E
C
Site 117
Y983
G
L
P
Q
Y
R
S
Y
F
M
E
C
L
V
D
Site 118
T998
A
R
M
L
D
H
L
T
K
K
D
L
R
G
Q
Site 119
S1011
G
Q
L
K
M
V
D
S
F
H
R
N
S
F
Q
Site 120
Y1029
M
C
L
R
R
L
N
Y
D
R
K
E
L
E
R
Site 121
S1041
L
E
R
K
R
E
E
S
Q
S
E
I
K
D
V
Site 122
S1043
R
K
R
E
E
S
Q
S
E
I
K
D
V
L
V
Site 123
T1122
N
N
L
L
V
M
G
T
D
R
R
F
D
E
D
Site 124
S1133
F
D
E
D
D
D
K
S
F
R
R
A
P
S
W
Site 125
S1139
K
S
F
R
R
A
P
S
W
R
K
K
F
R
P
Site 126
S1156
I
R
G
L
A
A
G
S
A
E
T
L
P
A
N
Site 127
T1159
L
A
A
G
S
A
E
T
L
P
A
N
F
R
V
Site 128
T1167
L
P
A
N
F
R
V
T
S
S
M
S
S
P
S
Site 129
S1168
P
A
N
F
R
V
T
S
S
M
S
S
P
S
M
Site 130
S1169
A
N
F
R
V
T
S
S
M
S
S
P
S
M
Q
Site 131
S1171
F
R
V
T
S
S
M
S
S
P
S
M
Q
P
K
Site 132
S1172
R
V
T
S
S
M
S
S
P
S
M
Q
P
K
K
Site 133
S1174
T
S
S
M
S
S
P
S
M
Q
P
K
K
M
Q
Site 134
T1189
M
D
G
N
V
S
G
T
Q
R
L
D
S
A
T
Site 135
S1194
S
G
T
Q
R
L
D
S
A
T
V
R
T
Y
S
Site 136
T1196
T
Q
R
L
D
S
A
T
V
R
T
Y
S
C
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation