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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MEK5
Full Name:
Dual specificity mitogen-activated protein kinase kinase 5
Alias:
CXA1; EC 2.7.12.2; HsT17454; Kinase MEK5; MAP kinase kinase 5; MAP2K5; MAPK,ERK kinase 5; MAPK/ERK kinase 5; MAPKK 5; MAPKK5; Mitogen-activated protein kinase kinase 5; MKK5; MP2K5; PRKMK5
Type:
Protein kinase, dual-specificity; EC 2.7.12.2;
STE
group; STE7 family
Mass (Da):
50112
Number AA:
448
UniProt ID:
Q13163
International Prot ID:
IPI00219607
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0000287
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006468
Phosida
TranscriptoNet
STRING
Kinexus Products
MAPK/ERK protein-serine kinase 5 (MEK5); Dual specificity mitogen-activated protein kinase kinase 5 pan-specific antibody AB-NK104-2#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NK104-2#MAPK/ERK protein-serine kinase 5 (MEK5); Dual specificity mitogen-activated protein kinase kinase 5 pan-specific antibody AB-NK104-3#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NK104-3#MAPK/ERK protein-serine kinase 5 (MEK5); Dual specificity mitogen-activated protein kinase kinase 5 pan-specific antibody AB-NK104-4#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NK104-4#MAPK/ERK protein-serine kinase 5 (MEK5); Dual specificity mitogen-activated protein kinase kinase 5 pan-specific antibody AB-NK104-5#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NK104-5#MAPK/ERK protein-serine kinase 5 (MKK5); Dual specificity mitogen-activated protein kinase kinase 5 S311 phosphosite-specific antibody AB-PK699#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK699#MAPK/ERK protein-serine kinase 5 (MKK5) / Dual specificity mitogen-activated protein kinase kinase 5 (A150-Q164, human) peptide - Powder PE-01AVY90#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01AVY90#MAPK/ERK protein-serine kinase 5 (MKK5) / Dual specificity mitogen-activated protein kinase kinase 5 (E411-G425, human) peptide - Powder PE-01AVZ99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01AVZ99#MAPK/ERK protein-serine kinase 5 (MKK5) / Dual specificity mitogen-activated protein kinase kinase 5 (C435-P448, human) peptide - Powder PE-01AWA99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01AWA99#MAPK/ERK protein-serine kinase 5 (MKK5) / Dual specificity mitogen-activated protein kinase kinase 5 (L308-K314, human) pS311 phosphopeptide - Powder PE-04ANV99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04ANV99
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T32
N
S
G
A
V
D
W
T
V
H
S
G
P
Q
L
Site 2
Y62
A
T
T
T
A
F
E
Y
E
D
E
D
G
D
R
Site 3
T71
D
E
D
G
D
R
I
T
V
R
S
D
E
E
M
Site 4
S74
G
D
R
I
T
V
R
S
D
E
E
M
K
A
M
Site 5
Y85
M
K
A
M
L
S
Y
Y
Y
S
T
V
M
E
Q
Site 6
S129
V
N
T
R
A
G
P
S
Q
H
S
S
P
A
V
Site 7
S132
R
A
G
P
S
Q
H
S
S
P
A
V
S
D
S
Site 8
S133
A
G
P
S
Q
H
S
S
P
A
V
S
D
S
L
Site 9
S137
Q
H
S
S
P
A
V
S
D
S
L
P
S
N
S
Site 10
S139
S
S
P
A
V
S
D
S
L
P
S
N
S
L
K
Site 11
S142
A
V
S
D
S
L
P
S
N
S
L
K
K
S
S
Site 12
S144
S
D
S
L
P
S
N
S
L
K
K
S
S
A
E
Site 13
S148
P
S
N
S
L
K
K
S
S
A
E
L
K
K
I
Site 14
S149
S
N
S
L
K
K
S
S
A
E
L
K
K
I
L
Site 15
Y168
M
N
E
Q
D
I
R
Y
R
D
T
L
G
H
G
Site 16
T171
Q
D
I
R
Y
R
D
T
L
G
H
G
N
G
G
Site 17
T179
L
G
H
G
N
G
G
T
V
Y
K
A
Y
H
V
Site 18
Y181
H
G
N
G
G
T
V
Y
K
A
Y
H
V
P
S
Site 19
Y184
G
G
T
V
Y
K
A
Y
H
V
P
S
G
K
I
Site 20
Y217
M
S
E
L
E
I
L
Y
K
C
D
S
S
Y
I
Site 21
T241
E
N
R
I
S
I
C
T
E
F
M
D
G
G
S
Site 22
S248
T
E
F
M
D
G
G
S
L
D
V
Y
R
K
M
Site 23
Y252
D
G
G
S
L
D
V
Y
R
K
M
P
E
H
V
Site 24
S276
K
G
L
T
Y
L
W
S
L
K
I
L
H
R
D
Site 25
S287
L
H
R
D
V
K
P
S
N
M
L
V
N
T
R
Site 26
S311
V
S
T
Q
L
V
N
S
I
A
K
T
Y
V
G
MAPK/ERK protein-serine kinase 5 (MKK5); Dual specificity mitogen-activated protein kinase kinase 5 S311 phosphosite-specific antibody AB-PK699#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK699#MAPK/ERK protein-serine kinase 5 (MKK5) / Dual specificity mitogen-activated protein kinase kinase 5 (L308-K314, human) pS311 phosphopeptide - Powder PE-04ANV99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04ANV99
Site 27
T315
L
V
N
S
I
A
K
T
Y
V
G
T
N
A
Y
Site 28
Y316
V
N
S
I
A
K
T
Y
V
G
T
N
A
Y
M
Site 29
Y322
T
Y
V
G
T
N
A
Y
M
A
P
E
R
I
S
Site 30
Y333
E
R
I
S
G
E
Q
Y
G
I
H
S
D
V
W
Site 31
S337
G
E
Q
Y
G
I
H
S
D
V
W
S
L
G
I
Site 32
Y356
L
A
L
G
R
F
P
Y
P
Q
I
Q
K
N
Q
Site 33
S365
Q
I
Q
K
N
Q
G
S
L
M
P
L
Q
L
L
Site 34
S443
R
A
L
E
E
R
R
S
Q
Q
G
P
P
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation