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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PAK2
Full Name:
Serine/threonine-protein kinase PAK 2
Alias:
C-t-PAK2; Gamma-PAK; Kinase PAK2; P21 protein (Cdc42/Rac)-activated kinase 2; P21-activated kinase 2; P21-activated protein kinase I; P58; PAK 2; PAK-2; PAK-2p27; PAK-2p34; PAK65; PAKgamma; PAKI; S6/H4 kinase
Type:
EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor);
STE
group; STE20 family; PAKA subfamily
Mass (Da):
58043
Number AA:
524
UniProt ID:
Q13177
International Prot ID:
IPI00419979
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0031225
GO:0005829
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0042802
GO:0004674
PhosphoSite+
KinaseNET
Biological Process:
GO:0006915
GO:0044419
GO:0006469
Phosida
TranscriptoNet
STRING
Kinexus Products
p21-activated kinase 2 gamma; Protein-serine/threonine kinase PAK 2 pan-specific antibody AB-NK200#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NK200#p21-activated kinase 2 gamma; Protein-serine/threonine kinase PAK 2 S141 phosphosite-specific antibody AB-PK750#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK750#p21-activated kinase 2 gamma; Protein-serine/threonine kinase PAK 2 Y130 phosphosite-specific antibody AB-PK751#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK751#p21-activated kinase 2 gamma / Protein-serine/threonine kinase PAK 2 (K138-P144, human) pS141 phosphopeptide - Powder PE-04AOJ99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AOJ99#p21-activated kinase 2 gamma / Protein-serine/threonine kinase PAK 2 (L127-N133, human) pY130 phosphopeptide - Powder PE-04AOK99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AOK99
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S2
_
_
_
_
_
_
M
S
D
N
G
E
L
E
D
Site 2
S19
P
A
P
P
V
R
M
S
S
T
I
F
S
T
G
Site 3
S20
A
P
P
V
R
M
S
S
T
I
F
S
T
G
G
Site 4
T21
P
P
V
R
M
S
S
T
I
F
S
T
G
G
K
Site 5
S24
R
M
S
S
T
I
F
S
T
G
G
K
D
P
L
Site 6
T25
M
S
S
T
I
F
S
T
G
G
K
D
P
L
S
Site 7
S32
T
G
G
K
D
P
L
S
A
N
H
S
L
K
P
Site 8
S36
D
P
L
S
A
N
H
S
L
K
P
L
P
S
V
Site 9
S42
H
S
L
K
P
L
P
S
V
P
E
E
K
K
P
Site 10
S55
K
P
R
H
K
I
I
S
I
F
S
G
T
E
K
Site 11
S58
H
K
I
I
S
I
F
S
G
T
E
K
G
S
K
Site 12
T60
I
I
S
I
F
S
G
T
E
K
G
S
K
K
K
Site 13
S64
F
S
G
T
E
K
G
S
K
K
K
E
K
E
R
Site 14
S75
E
K
E
R
P
E
I
S
P
P
S
D
F
E
H
Site 15
S78
R
P
E
I
S
P
P
S
D
F
E
H
T
I
H
Site 16
T83
P
P
S
D
F
E
H
T
I
H
V
G
F
D
A
Site 17
S109
W
A
R
L
L
Q
T
S
N
I
T
K
L
E
Q
Site 18
Y130
V
L
D
V
L
K
F
Y
D
S
N
T
V
K
Q
p21-activated kinase 2 gamma; Protein-serine/threonine kinase PAK 2 Y130 phosphosite-specific antibody AB-PK751#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK751#p21-activated kinase 2 gamma / Protein-serine/threonine kinase PAK 2 (L127-N133, human) pY130 phosphopeptide - Powder PE-04AOK99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AOK99
Site 19
S132
D
V
L
K
F
Y
D
S
N
T
V
K
Q
K
Y
Site 20
T134
L
K
F
Y
D
S
N
T
V
K
Q
K
Y
L
S
Site 21
Y139
S
N
T
V
K
Q
K
Y
L
S
F
T
P
P
E
Site 22
S141
T
V
K
Q
K
Y
L
S
F
T
P
P
E
K
D
p21-activated kinase 2 gamma; Protein-serine/threonine kinase PAK 2 S141 phosphosite-specific antibody AB-PK750#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PK750#p21-activated kinase 2 gamma / Protein-serine/threonine kinase PAK 2 (K138-P144, human) pS141 phosphopeptide - Powder PE-04AOJ99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AOJ99
Site 23
T143
K
Q
K
Y
L
S
F
T
P
P
E
K
D
G
F
Site 24
S152
P
E
K
D
G
F
P
S
G
T
P
A
L
N
A
Site 25
T154
K
D
G
F
P
S
G
T
P
A
L
N
A
K
G
Site 26
T169
T
E
A
P
A
V
V
T
E
E
E
D
D
D
E
Site 27
T178
E
E
D
D
D
E
E
T
A
P
P
V
I
A
P
Site 28
T190
I
A
P
R
P
D
H
T
K
S
I
Y
T
R
S
Site 29
S192
P
R
P
D
H
T
K
S
I
Y
T
R
S
V
I
Site 30
Y194
P
D
H
T
K
S
I
Y
T
R
S
V
I
D
P
Site 31
T195
D
H
T
K
S
I
Y
T
R
S
V
I
D
P
V
Site 32
S197
T
K
S
I
Y
T
R
S
V
I
D
P
V
P
A
Site 33
S209
V
P
A
P
V
G
D
S
H
V
D
G
A
A
K
Site 34
S217
H
V
D
G
A
A
K
S
L
D
K
Q
K
K
K
Site 35
T225
L
D
K
Q
K
K
K
T
K
M
T
D
E
E
I
Site 36
T228
Q
K
K
K
T
K
M
T
D
E
E
I
M
E
K
Site 37
T238
E
I
M
E
K
L
R
T
I
V
S
I
G
D
P
Site 38
S241
E
K
L
R
T
I
V
S
I
G
D
P
K
K
K
Site 39
Y249
I
G
D
P
K
K
K
Y
T
R
Y
E
K
I
G
Site 40
Y252
P
K
K
K
Y
T
R
Y
E
K
I
G
Q
G
A
Site 41
S260
E
K
I
G
Q
G
A
S
G
T
V
F
T
A
T
Site 42
T336
G
S
L
T
D
V
V
T
E
T
C
M
D
E
A
Site 43
S381
V
L
L
G
M
E
G
S
V
K
L
T
D
F
G
Site 44
T394
F
G
F
C
A
Q
I
T
P
E
Q
S
K
R
S
Site 45
S398
A
Q
I
T
P
E
Q
S
K
R
S
T
M
V
G
Site 46
S401
T
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
Site 47
T402
P
E
Q
S
K
R
S
T
M
V
G
T
P
Y
W
Site 48
T406
K
R
S
T
M
V
G
T
P
Y
W
M
A
P
E
Site 49
Y420
E
V
V
T
R
K
A
Y
G
P
K
V
D
I
W
Site 50
Y443
M
V
E
G
E
P
P
Y
L
N
E
N
P
L
R
Site 51
Y453
E
N
P
L
R
A
L
Y
L
I
A
T
N
G
T
Site 52
T460
Y
L
I
A
T
N
G
T
P
E
L
Q
N
P
E
Site 53
S470
L
Q
N
P
E
K
L
S
P
I
F
R
D
F
L
Site 54
S490
M
D
V
E
K
R
G
S
A
K
E
L
L
Q
H
Site 55
S507
L
K
L
A
K
P
L
S
S
L
T
P
L
I
M
Site 56
S522
A
A
K
E
A
M
K
S
N
R
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation