PhosphoNET

           
Protein Info 
   
Short Name:  Cbl-b
Full Name:  E3 ubiquitin-protein ligase CBL-B
Alias:  Cas-Br-M (murine) ecotropic retroviral transforming sequence b; Casitas B-lineage lymphoma proto-oncogene b; CBLB; RING finger protein 56; RNF56; SH3-binding protein Cbl-b; signal transduction protein Cbl-b
Type:  EC 6.3.2.-; Ubiquitin conjugating system; Ligase; Adaptor/scaffold; Ubiquitin ligase; Calcium-binding protein
Mass (Da):  109450
Number AA:  982
UniProt ID:  Q13191
International Prot ID:  IPI00292856
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005737  GO:0005634   Uniprot OncoNet
Molecular Function:  GO:0005509  GO:0016874  GO:0005515 PhosphoSite+ KinaseNET
Biological Process:  GO:0006607  GO:0007166  GO:0006955 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1T45QAAADRRTVEKTWKL
Site 2T49DRRTVEKTWKLMDKV
Site 3S70PKLQLKNSPPYILDI
Site 4Y73QLKNSPPYILDILPD
Site 5S90QHLRLILSKYDDNQK
Site 6Y92LRLILSKYDDNQKLA
Site 7Y106AQLSENEYFKIYIDS
Site 8Y110ENEYFKIYIDSLMKK
Site 9S113YFKIYIDSLMKKSKR
Site 10S118IDSLMKKSKRAIRLF
Site 11Y133KEGKERMYEEQSQDR
Site 12S137ERMYEEQSQDRRNLT
Site 13T144SQDRRNLTKLSLIFS
Site 14T174QGDNFRITKADAAEF
Site 15T265PGYMAFLTYDEVKAR
Site 16Y276VKARLQKYSTKPGSY
Site 17S277KARLQKYSTKPGSYI
Site 18T278ARLQKYSTKPGSYIF
Site 19S282KYSTKPGSYIFRLSC
Site 20Y329DGSREGFYLYPDGRS
Site 21Y331SREGFYLYPDGRSYN
Site 22S336YLYPDGRSYNPDLTG
Site 23Y337LYPDGRSYNPDLTGL
Site 24T342RSYNPDLTGLCEPTP
Site 25T348LTGLCEPTPHDHIKV
Site 26Y360IKVTQEQYELYCEMG
Site 27Y363TQEQYELYCEMGSTF
Site 28T418CRCEIKGTEPIIVDP
Site 29S433FDPRDEGSRCCSIID
Site 30S437DEGSRCCSIIDPFGM
Site 31S458DDDDREESLMMNRLA
Site 32T471LANVRKCTDRQNSPV
Site 33S476KCTDRQNSPVTSPGS
Site 34T479DRQNSPVTSPGSSPL
Site 35S480RQNSPVTSPGSSPLA
Site 36S483SPVTSPGSSPLAQRR
Site 37S484PVTSPGSSPLAQRRK
Site 38S503PLQIPHLSLPPVPPR
Site 39S521IQKGIVRSPCGSPTG
Site 40S525IVRSPCGSPTGSPKS
Site 41T527RSPCGSPTGSPKSSP
Site 42S529PCGSPTGSPKSSPCM
Site 43S532SPTGSPKSSPCMVRK
Site 44S533PTGSPKSSPCMVRKQ
Site 45S572IPPDNRLSRHIHHVE
Site 46S580RHIHHVESVPSRDPP
Site 47S583HHVESVPSRDPPMPL
Site 48T601CPRDVFGTNQLVGCR
Site 49S614CRLLGEGSPKPGITA
Site 50T620GSPKPGITASSNVNG
Site 51S622PKPGITASSNVNGRH
Site 52S623KPGITASSNVNGRHS
Site 53S630SNVNGRHSRVGSDPV
Site 54S634GRHSRVGSDPVLMRK
Site 55S662FSNGHLGSEEYDVPP
Site 56Y665GHLGSEEYDVPPRLS
Site 57S672YDVPPRLSPPPPVTT
Site 58S693CTGPLANSLSEKTRD
Site 59S695GPLANSLSEKTRDPV
Site 60Y709VEEDDDEYKIPSSHP
Site 61S713DDEYKIPSSHPVSLN
Site 62S714DEYKIPSSHPVSLNS
Site 63S718IPSSHPVSLNSQPSH
Site 64S721SHPVSLNSQPSHCHN
Site 65S724VSLNSQPSHCHNVKP
Site 66T746GHCMLNGTHGPSSEK
Site 67S750LNGTHGPSSEKKSNI
Site 68S751NGTHGPSSEKKSNIP
Site 69S755GPSSEKKSNIPDLSI
Site 70S761KSNIPDLSIYLKGDV
Site 71Y763NIPDLSIYLKGDVFD
Site 72S771LKGDVFDSASDPVPL
Site 73S773GDVFDSASDPVPLPP
Site 74T785LPPARPPTRDNPKHG
Site 75S794DNPKHGSSLNRTPSD
Site 76T798HGSSLNRTPSDYDLL
Site 77S800SSLNRTPSDYDLLIP
Site 78Y802LNRTPSDYDLLIPPL
Site 79S820AFDALPPSLPPPPPP
Site 80S831PPPPARHSLIEHSKP
Site 81S836RHSLIEHSKPPGSSS
Site 82S841EHSKPPGSSSRPSSG
Site 83S842HSKPPGSSSRPSSGQ
Site 84S843SKPPGSSSRPSSGQD
Site 85S846PGSSSRPSSGQDLFL
Site 86S847GSSSRPSSGQDLFLL
Site 87T882LPGENVKTNRTSQDY
Site 88T885ENVKTNRTSQDYDQL
Site 89S886NVKTNRTSQDYDQLP
Site 90Y889TNRTSQDYDQLPSCS
Site 91S894QDYDQLPSCSDGSQA
Site 92S896YDQLPSCSDGSQAPA
Site 93S899LPSCSDGSQAPARPP
Site 94T913PKPRPRRTAPEIHHR
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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