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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PSMD2
Full Name:
26S proteasome non-ATPase regulatory subunit 2
Alias:
26S proteasome regulatory subunit RPN1; 26S proteasome regulatory subunit S2; 26S proteasome subunit p97; 55.11 protein; TRAP2; Tumor necrosis factor type 1 receptor-associated protein 2
Type:
Proteasome complex
Mass (Da):
100200
Number AA:
908
UniProt ID:
Q13200
International Prot ID:
IPI00012268
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000502
GO:0005829
GO:0005838
Uniprot
OncoNet
Molecular Function:
GO:0005488
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006508
GO:0006511
GO:0008152
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S16
A
P
V
Q
P
Q
Q
S
P
A
A
A
P
G
G
Site 2
T24
P
A
A
A
P
G
G
T
D
E
K
P
S
G
K
Site 3
S46
K
D
K
E
Q
E
L
S
E
E
D
K
Q
L
Q
Site 4
T68
E
R
L
G
E
K
D
T
S
L
Y
R
P
A
L
Site 5
S69
R
L
G
E
K
D
T
S
L
Y
R
P
A
L
E
Site 6
S84
E
L
R
R
Q
I
R
S
S
T
T
S
M
T
S
Site 7
S85
L
R
R
Q
I
R
S
S
T
T
S
M
T
S
V
Site 8
T86
R
R
Q
I
R
S
S
T
T
S
M
T
S
V
P
Site 9
S88
Q
I
R
S
S
T
T
S
M
T
S
V
P
K
P
Site 10
T90
R
S
S
T
T
S
M
T
S
V
P
K
P
L
K
Site 11
S91
S
S
T
T
S
M
T
S
V
P
K
P
L
K
F
Site 12
Y103
L
K
F
L
R
P
H
Y
G
K
L
K
E
I
Y
Site 13
Y110
Y
G
K
L
K
E
I
Y
E
N
M
A
P
G
E
Site 14
S127
R
F
A
A
D
I
I
S
V
L
A
M
T
M
S
Site 15
S134
S
V
L
A
M
T
M
S
G
E
R
E
C
L
K
Site 16
Y142
G
E
R
E
C
L
K
Y
R
L
V
G
S
Q
E
Site 17
S147
L
K
Y
R
L
V
G
S
Q
E
E
L
A
S
W
Site 18
S153
G
S
Q
E
E
L
A
S
W
G
H
E
Y
V
R
Site 19
Y158
L
A
S
W
G
H
E
Y
V
R
H
L
A
G
E
Site 20
T186
V
Q
R
E
P
L
L
T
L
V
K
E
I
V
P
Site 21
Y194
L
V
K
E
I
V
P
Y
N
M
A
H
N
A
E
Site 22
Y226
K
D
I
D
E
N
A
Y
A
K
V
C
L
Y
L
Site 23
Y239
Y
L
T
S
C
V
N
Y
V
P
E
P
E
N
S
Site 24
S260
L
G
V
F
R
K
F
S
R
F
P
E
A
L
R
Site 25
S308
H
G
V
F
L
E
L
S
E
D
V
E
E
Y
E
Site 26
T318
V
E
E
Y
E
D
L
T
E
I
M
S
N
V
Q
Site 27
S322
E
D
L
T
E
I
M
S
N
V
Q
L
N
S
N
Site 28
Y349
P
K
V
P
D
D
I
Y
K
T
H
L
E
N
N
Site 29
S361
E
N
N
R
F
G
G
S
G
S
Q
V
D
S
A
Site 30
S363
N
R
F
G
G
S
G
S
Q
V
D
S
A
R
M
Site 31
S367
G
S
G
S
Q
V
D
S
A
R
M
N
L
A
S
Site 32
T392
F
G
Q
D
K
L
L
T
D
D
G
N
K
W
L
Site 33
Y400
D
D
G
N
K
W
L
Y
K
N
K
D
H
G
M
Site 34
S409
N
K
D
H
G
M
L
S
A
A
A
S
L
G
M
Site 35
Y432
G
L
T
Q
I
D
K
Y
L
Y
S
S
E
D
Y
Site 36
Y434
T
Q
I
D
K
Y
L
Y
S
S
E
D
Y
I
K
Site 37
S435
Q
I
D
K
Y
L
Y
S
S
E
D
Y
I
K
S
Site 38
Y439
Y
L
Y
S
S
E
D
Y
I
K
S
G
A
L
L
Site 39
S442
S
S
E
D
Y
I
K
S
G
A
L
L
A
C
G
Site 40
S474
S
D
Y
V
L
H
N
S
N
T
M
R
L
G
S
Site 41
S492
L
G
L
A
Y
A
G
S
N
R
E
D
V
L
T
Site 42
S510
P
V
M
G
D
S
K
S
S
M
E
V
A
G
V
Site 43
T548
T
I
M
E
K
S
E
T
E
L
K
D
T
Y
A
Site 44
T553
S
E
T
E
L
K
D
T
Y
A
R
W
L
P
L
Site 45
Y554
E
T
E
L
K
D
T
Y
A
R
W
L
P
L
G
Site 46
S617
Q
Q
L
L
H
I
C
S
E
H
F
D
S
K
E
Site 47
S622
I
C
S
E
H
F
D
S
K
E
K
E
E
D
K
Site 48
Y681
T
F
G
H
L
L
R
Y
G
E
P
T
L
R
R
Site 49
T685
L
L
R
Y
G
E
P
T
L
R
R
A
V
P
L
Site 50
S700
A
L
A
L
I
S
V
S
N
P
R
L
N
I
L
Site 51
T709
P
R
L
N
I
L
D
T
L
S
K
F
S
H
D
Site 52
S711
L
N
I
L
D
T
L
S
K
F
S
H
D
A
D
Site 53
Y723
D
A
D
P
E
V
S
Y
N
S
I
F
A
M
G
Site 54
Y751
M
L
R
Q
L
A
Q
Y
H
A
K
D
P
N
N
Site 55
T777
H
L
G
K
G
T
L
T
L
C
P
Y
H
S
D
Site 56
Y781
G
T
L
T
L
C
P
Y
H
S
D
R
Q
L
M
Site 57
S783
L
T
L
C
P
Y
H
S
D
R
Q
L
M
S
Q
Site 58
S789
H
S
D
R
Q
L
M
S
Q
V
A
V
A
G
L
Site 59
T832
M
Q
P
R
M
L
V
T
F
D
E
E
L
R
P
Site 60
T861
G
Q
A
G
K
P
K
T
I
T
G
F
Q
T
H
Site 61
T884
G
E
R
A
E
L
A
T
E
E
F
L
P
V
T
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation