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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DUSP8
Full Name:
Dual specificity protein phosphatase 8
Alias:
Dual specificity protein phosphatase hVH-5
Type:
Mass (Da):
65827
Number AA:
625
UniProt ID:
Q13202
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Dual specificity protein phosphatase 8 pan-specific antibody AB-NP042-1#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NP042-1#Dual specificity protein phosphatase 8 pan-specific antibody AB-NP042-3#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-NP042-3#Dual specificity protein phosphatase 8 (M1-A13, human) peptide - Powder PE-01BBG95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01BBG95#Dual specificity protein phosphatase 8 (C204-Y217, human) peptide - Powder PE-01BBH99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01BBH99#Dual specificity protein phosphatase 8 (G266-R280, human) peptide - Powder PE-01BBI75#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01BBI75
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S18
M
D
A
K
K
L
A
S
L
L
R
G
G
P
G
Site 2
S32
G
G
P
L
V
I
D
S
R
S
F
V
E
Y
N
Site 3
S34
P
L
V
I
D
S
R
S
F
V
E
Y
N
S
W
Site 4
Y38
D
S
R
S
F
V
E
Y
N
S
W
H
V
L
S
Site 5
S40
R
S
F
V
E
Y
N
S
W
H
V
L
S
S
V
Site 6
S76
L
I
Q
P
A
A
R
S
Q
V
E
A
T
E
P
Site 7
S92
D
V
V
V
Y
D
Q
S
T
R
D
A
S
V
L
Site 8
S97
D
Q
S
T
R
D
A
S
V
L
A
A
D
S
F
Site 9
Y169
T
R
I
L
P
H
L
Y
L
G
S
Q
K
D
V
Site 10
S172
L
P
H
L
Y
L
G
S
Q
K
D
V
L
N
K
Site 11
T183
V
L
N
K
D
L
M
T
Q
N
G
I
S
Y
V
Site 12
Y189
M
T
Q
N
G
I
S
Y
V
L
N
A
S
N
S
Site 13
S194
I
S
Y
V
L
N
A
S
N
S
C
P
K
P
D
Site 14
S196
Y
V
L
N
A
S
N
S
C
P
K
P
D
F
I
Site 15
Y217
R
V
P
I
N
D
N
Y
C
E
K
L
L
P
W
Site 16
S269
M
K
T
M
G
M
S
S
D
D
A
Y
R
F
V
Site 17
Y273
G
M
S
S
D
D
A
Y
R
F
V
K
D
R
R
Site 18
S282
F
V
K
D
R
R
P
S
I
S
P
N
F
N
F
Site 19
S284
K
D
R
R
P
S
I
S
P
N
F
N
F
L
G
Site 20
T312
A
L
Q
G
D
P
G
T
P
S
G
T
P
E
P
Site 21
S314
Q
G
D
P
G
T
P
S
G
T
P
E
P
P
P
Site 22
T316
D
P
G
T
P
S
G
T
P
E
P
P
P
S
P
Site 23
S322
G
T
P
E
P
P
P
S
P
A
A
G
A
P
L
Site 24
T336
L
P
R
L
P
P
P
T
S
E
S
A
A
T
G
Site 25
S337
P
R
L
P
P
P
T
S
E
S
A
A
T
G
N
Site 26
S339
L
P
P
P
T
S
E
S
A
A
T
G
N
A
A
Site 27
S353
A
A
R
E
G
G
L
S
A
G
G
E
P
P
A
Site 28
T363
G
E
P
P
A
P
P
T
P
P
A
T
S
A
L
Site 29
S380
G
L
R
G
L
H
L
S
S
D
R
L
Q
D
T
Site 30
S381
L
R
G
L
H
L
S
S
D
R
L
Q
D
T
N
Site 31
T387
S
S
D
R
L
Q
D
T
N
R
L
K
R
S
F
Site 32
S393
D
T
N
R
L
K
R
S
F
S
L
D
I
K
S
Site 33
S395
N
R
L
K
R
S
F
S
L
D
I
K
S
A
Y
Site 34
S400
S
F
S
L
D
I
K
S
A
Y
A
P
S
R
R
Site 35
Y402
S
L
D
I
K
S
A
Y
A
P
S
R
R
P
D
Site 36
S405
I
K
S
A
Y
A
P
S
R
R
P
D
G
P
G
Site 37
S427
P
K
L
C
K
L
D
S
P
S
G
A
A
L
G
Site 38
S436
S
G
A
A
L
G
L
S
S
P
S
P
D
S
P
Site 39
S437
G
A
A
L
G
L
S
S
P
S
P
D
S
P
D
Site 40
S439
A
L
G
L
S
S
P
S
P
D
S
P
D
A
A
Site 41
S442
L
S
S
P
S
P
D
S
P
D
A
A
P
E
A
Site 42
S463
R
P
R
P
P
A
G
S
P
A
R
S
P
A
H
Site 43
S467
P
A
G
S
P
A
R
S
P
A
H
S
L
G
L
Site 44
S471
P
A
R
S
P
A
H
S
L
G
L
N
F
G
D
Site 45
T483
F
G
D
A
A
R
Q
T
P
R
H
G
L
S
A
Site 46
S489
Q
T
P
R
H
G
L
S
A
L
S
A
P
G
L
Site 47
S492
R
H
G
L
S
A
L
S
A
P
G
L
P
G
P
Site 48
S514
A
W
A
P
P
L
D
S
P
G
T
P
S
P
D
Site 49
T517
P
P
L
D
S
P
G
T
P
S
P
D
G
P
W
Site 50
S519
L
D
S
P
G
T
P
S
P
D
G
P
W
C
F
Site 51
S527
P
D
G
P
W
C
F
S
P
E
G
A
Q
G
A
Site 52
T571
A
E
P
R
D
A
R
T
G
W
P
E
E
P
A
Site 53
T581
P
E
E
P
A
P
E
T
Q
F
K
R
R
S
C
Site 54
S587
E
T
Q
F
K
R
R
S
C
Q
M
E
F
E
E
Site 55
S618
K
Q
A
S
F
S
G
S
V
E
V
I
E
V
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation