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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ERCC8
Full Name:
DNA excision repair protein ERCC-8
Alias:
Cockayne syndrome WD repeat protein CSA
Type:
Mass (Da):
44055
Number AA:
396
UniProt ID:
Q13216
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T10
G
F
L
S
A
R
Q
T
G
L
E
D
P
L
R
Site 2
S23
L
R
L
R
R
A
E
S
T
R
R
V
L
G
L
Site 3
T24
R
L
R
R
A
E
S
T
R
R
V
L
G
L
E
Site 4
Y58
I
E
P
V
E
G
R
Y
M
L
S
G
G
S
D
Site 5
Y71
S
D
G
V
I
V
L
Y
D
L
E
N
S
S
R
Site 6
S76
V
L
Y
D
L
E
N
S
S
R
Q
S
Y
Y
T
Site 7
S80
L
E
N
S
S
R
Q
S
Y
Y
T
C
K
A
V
Site 8
Y81
E
N
S
S
R
Q
S
Y
Y
T
C
K
A
V
C
Site 9
Y82
N
S
S
R
Q
S
Y
Y
T
C
K
A
V
C
S
Site 10
T83
S
S
R
Q
S
Y
Y
T
C
K
A
V
C
S
I
Site 11
S118
D
T
G
M
F
T
S
S
S
F
D
K
T
L
K
Site 12
S119
T
G
M
F
T
S
S
S
F
D
K
T
L
K
V
Site 13
T123
T
S
S
S
F
D
K
T
L
K
V
W
D
T
N
Site 14
T129
K
T
L
K
V
W
D
T
N
T
L
Q
T
A
D
Site 15
T131
L
K
V
W
D
T
N
T
L
Q
T
A
D
V
F
Site 16
Y145
F
N
F
E
E
T
V
Y
S
H
H
M
S
P
V
Site 17
S150
T
V
Y
S
H
H
M
S
P
V
S
T
K
H
C
Site 18
S153
S
H
H
M
S
P
V
S
T
K
H
C
L
V
A
Site 19
T154
H
H
M
S
P
V
S
T
K
H
C
L
V
A
V
Site 20
S179
D
L
K
S
G
S
C
S
H
I
L
Q
G
H
R
Site 21
S193
R
Q
E
I
L
A
V
S
W
S
P
R
Y
D
Y
Site 22
Y200
S
W
S
P
R
Y
D
Y
I
L
A
T
A
S
A
Site 23
T204
R
Y
D
Y
I
L
A
T
A
S
A
D
S
R
V
Site 24
S234
D
Q
H
N
G
K
K
S
Q
A
V
E
S
A
N
Site 25
T242
Q
A
V
E
S
A
N
T
A
H
N
G
K
V
N
Site 26
T262
S
D
G
L
H
L
L
T
V
G
T
D
N
R
M
Site 27
T265
L
H
L
L
T
V
G
T
D
N
R
M
R
L
W
Site 28
S275
R
M
R
L
W
N
S
S
N
G
E
N
T
L
V
Site 29
Y284
G
E
N
T
L
V
N
Y
G
K
V
C
N
N
S
Site 30
T298
S
K
K
G
L
K
F
T
V
S
C
G
C
S
S
Site 31
Y319
Y
G
S
T
I
A
V
Y
T
V
Y
S
G
E
Q
Site 32
S351
S
N
F
Q
E
L
Y
S
G
S
R
D
C
N
I
Site 33
Y366
L
A
W
V
P
S
L
Y
E
P
V
P
D
D
D
Site 34
T375
P
V
P
D
D
D
E
T
T
T
K
S
Q
L
N
Site 35
T376
V
P
D
D
D
E
T
T
T
K
S
Q
L
N
P
Site 36
S379
D
D
E
T
T
T
K
S
Q
L
N
P
A
F
E
Site 37
S390
P
A
F
E
D
A
W
S
S
S
D
E
E
G
_
Site 38
S391
A
F
E
D
A
W
S
S
S
D
E
E
G
_
_
Site 39
S392
F
E
D
A
W
S
S
S
D
E
E
G
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation